MLF1-interacting protein is mainly localized in nucleolus through N-terminal bipartite nuclear localization signal

Anticancer Research

Volumn 27, Issue 3 B, 2007, Pages 1423-1430

  Suzuki, Hideaki ^a   Arakawa, Yasuhiro ^a   Ito, Masaki ^a   Saito, Shinobu ^a   Takeda, Nobuakira ^a   Yamada, Hisashi ^a   Horiguchi Yamada, Junko ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

MLF1; MLF1IP; Nuclear localization signal; Nucleolar localization signal; Nucleolus

Indexed keywords

BINDING PROTEIN; FIBRILLARIN; GREEN FLUORESCENT PROTEIN; PROTEIN MLF1; RED FLUORESCENT PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARCINOMA CELL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FIBROBLAST; FLUORESCENCE MICROSCOPE; HUMAN; HUMAN CELL; NUCLEAR LOCALIZATION SIGNAL; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

AMINO ACID SEQUENCE; ANIMALS; CELL NUCLEOLUS; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; CHROMOSOMAL PROTEINS, NON-HISTONE; COS CELLS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PROTEINS;

EID: 34249288334     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Nazar RN: Ribosomal RNA processing and ribosome biogenesis in eukaryotes. IUBMB Life 56: 457-465, 2004.
2. Pederson T: The plurifunctional nucleolus. Nucleic Acids Res 26: 3871-3876, 1998.
3. Visintin R and Amon A: The nucleolus: the magician's hat for cell cycle tricks. Curr Opin Cell Biol 12: 372-377, 2000.
4. Maggi LB Jr and Weber JD: Nucleolar adaptation in human cancer. Cancer Invest 23: 599-608, 2005.
5. Hiscox JA: The nucleolus - a gateway to viral infection? Arch Virol 147: 1077-1089, 2002.
6. Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M and Lamond AI: Directed proteomic analysis of the human nucleolus. Curr Biol 12: 1-11, 2002.
7. Scherl A, Coute Y, Deon C, Calle A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D and Diaz JJ: Functional proteomic analysis of human nucleolus. Mol Biol Cell 13: 4100-4109, 2002.
8. Kumar A, Agarwal S, Heyman JA, Matson S, Heidtman M, Piccirillo S, Umansky L, Drawid A, Jansen R, Liu Y, Cheung KH, Miller P, Gerstein M, Roeder GS and Snyder M: Subcellular localization of the yeast proteome. Genes Dev 16: 707-719, 2002.
9. Leung AK, Andersen JS, Mann M and Lamond AI: Bioinformatic analysis of the nucleolus. Biochem J 376: 553-569, 2003.
10. Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI and Mann M: Nucleolar proteome dynamics. Nature 433: 77-83, 2005.
11. Leung AK, Trinkle-Mulcahy L, Lam YW, Andersen JS, Mann M and Lamond AI: NOPdb: Nucleolar Proteome Database. Nucleic Acids Res 34(Database issue): D218-D220, 2006.
12. Weber JD, Taylor LJ, Roussel MF, Sherr CJ and Bar-Sagi D: Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol 1: 20-26, 1999.
13. Lohrum MA, Ashcroft M, Kubbutat MH and Vousden KH: Identification of a cryptic nucleolar-localization signal in MDM2. Nat Cell Biol 2: 179-181, 2000.
14. Arabi A, Rustum C, Hallberg E and Wright AP: Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels. J Cell Sci 116: 1707-1717, 2003.
15. Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN and White RJ: c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nat Cell Biol 7: 311-318, 2005.
16. Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ and Morris SW: The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. Oncogene 12: 265-275, 1996.
17. Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH and Morris SW: cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP. Oncogene 23: 3700-3707, 2004.
18. Pan HY, Zhang YJ, Wang XP, Deng JH, Zhou FC and Gao SJ: Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpes virus. J Virol 77: 9758-9768, 2003.
19. Minoshima Y, Hori T, Okada M, Kimura H, Haraguchi T, Hiraoka Y, Bao YC, Kawashima T, Kitamura T and Fukagawa T: The constitutive centromere component CENP-50 is required for recovery from spindle damage. Mol Cell Biol 25: 10315-10328, 2005.
20. Winteringham LN, Kobelke S, Williams JH, Ingley E and Klinken SP: Myeloid leukemia factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation. Oncogene 23: 5105-5109, 2004.
21. Yoneda-Kato N, Tomoda K, Umehara M, Arata Y and Kato JY: Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. EMBO J 24: 1739-1749, 2005.
22. Finch RA, Revankar GR and Chan PK: Nucleolar localization of nucleophosmin/B23 requires GTP. J Biol Chem 268: 5823-5827, 1993.
23. Zhang Y and Xiong Y: Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol Cell 3: 579-591, 1999.
24. Colombo E, Marine JC, Danovi D, Falini B and Pelicci PG: Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol 4: 529-533, 2002.
25. Kurki S, Peltonen K, Latonen L, Kiviharju TM, Ojala PM, Meek D and Laiho M: Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. Cancer Cell 5: 465-475, 2004.
26. Colombo E, Martinelli P, Zamponi R, Shing DC, Bonetti P, Luzi L, Volorio S, Bernard L, Pruneri G, Alcalay M and Pelicci PG: Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant. Cancer Res 66: 3044-3050, 2006.
27. von Kobbe C and Bohr VA: A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092. J Cell Sci 115: 3901-3907, 2002.
28. Birbach A, Bailey ST, Ghosh S and Schmid JA: Cytosolic, nuclear and nucleolar localization signals determine subcellular distribution and activity of the NF-κB inducing kinase NIK. J Cell Sci 117: 3615-3624, 2004.
29. Stark LA and Dunlop MG: Nucleolar sequestration of RelA (p65) regulates NF-κB-driven transcription and apoptosis. Mol Cell Biol 25: 5985-6004, 2005.
30. Liu J, Du X and Ke Y: Mapping nucleolar localization sequences of 1A6/DRIM. FEBS Lett 580: 1405-1410, 2006.
31. Mariano AR, Colombo E, Luzi L, Martinelli P, Volorio S, Bernard L, Meani N, Bergomas R, Alcalay M and Pelicci PG: Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal. Oncogene 25: 4376-4380, 2006.