Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal

Oncogene

Volumn 25, Issue 31, 2006, Pages 4376-4380

  Mariano, A R ^a   Colombo, E ^a   Luzi, L ^a,b   Martinelli, P ^a   Volorio, S ^b   Bernard, L ^b   Meani, N ^b   Bergomas, R ^b   Alcalay, M ^b   Pelicci, P G ^a,b,c  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

AML; CRM1; NES; NPM; Nucleus cytoplasmic shuttling

Indexed keywords

AMINO ACID; CYTOPLASM PROTEIN; NUCLEAR PROTEIN; NUCLEOPHOSMIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DONOR SITE; EXON; GENE MUTATION; GERM LINE; LEUKEMOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SOMATIC CELL GENETICS;

ACUTE DISEASE; BASE SEQUENCE; CYTOPLASM; HUMANS; LEUKEMIA, MYELOID; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR EXPORT SIGNALS; NUCLEAR PROTEINS;

EID: 33645521836     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209453     Document Type: Article

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