Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: Amino-lactam boroalanines

Journal of Medicinal Chemistry

Volumn 50, Issue 10, 2007, Pages 2391-2398

  Lai, Jack H ^a   Wu, Wengen ^a   Zhou, Yuhong ^a   Maw, Hlaing H ^a   Liu, Yuxin ^a   Milo Jr , Lawrence J ^a   Poplawski, Sarah E ^a,b   Henry, Gillian D ^a   Sudmeier, James L ^a   Sanford, David G ^a   Bachovchin, William W ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AZETIDINE 2 CARBONYL AMINO ETHYLBORONIC ACID; 1,3 AMINO 2 OXOPYRROLIDIN 1 YL ETHYLBORONIC ACID; ALANINE DERIVATIVE; BORONIC ACID DERIVATIVE; DEXTRO 3 AMINO 1 (1 BORONIC ETHYL)PYRROLIDIN 2 ONE(AMINO DEXTRO LACTAM BORO ALANINE); DIPEPTIDYL PEPTIDASE IV INHIBITOR; LACTAM AMINOBORONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; ATTENUATION; CONFORMATION; CYCLIZATION; DIASTEREOISOMER; DRUG POTENCY; DRUG SYNTHESIS; EPIMERIZATION; IC 50; PH; PHYSIOLOGY; STEREOCHEMISTRY;

ALANINE; ANTIGENS, CD26; BIOMIMETICS; BORIC ACIDS; BORONIC ACIDS; HUMANS; HYDROGEN-ION CONCENTRATION; LACTAMS; MODELS, MOLECULAR; PEPTIDES; PYRROLIDINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34249073082     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061321+     Document Type: Article

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