Down-regulation of expression of rat pyruvate dehydrogenase E1α gene by self-complementary adeno-associated virus-mediated small interfering RNA delivery

Mitochondrion

Volumn 7, Issue 4, 2007, Pages 253-259

  Han, Zongchao ^a   Gorbatyuk, Marina ^a   Thomas Jr , James ^a   Lewin, Alfred S ^a   Srivastava, Arun ^a   Stacpoole, Peter W ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

AAV; Gene therapy; Pyruvate dehydrogenase deficiency; RNAi

Indexed keywords

CYCLOPHILIN B; MESSENGER RNA; OLIGONUCLEOTIDE; PARVOVIRUS VECTOR; PYRUVATE DEHYDROGENASE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EXPRESSION VECTOR; FEASIBILITY STUDY; FIBROBLAST CULTURE; GENE CASSETTE; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC COMPLEMENTATION; GENETIC TRANSFECTION; IN VITRO STUDY; LUNG FIBROBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY; RAT; RNA CLEAVAGE; SEROTYPE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CELL LINE; DEPENDOVIRUS; DOWN-REGULATION; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC VECTORS; HUMANS; KINETICS; LUNG; PYRUVATE DEHYDROGENASE (LIPOAMIDE); RATS; RNA, SMALL INTERFERING; TRANSITION TEMPERATURE;

ADENO-ASSOCIATED VIRUS; ANIMALIA; RATTUS;

EID: 34248660538     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mito.2007.02.003     Document Type: Article

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