The hexosamine biosynthesis pathway negatively regulates IL-2 production by Jurkat T cells

Cellular Immunology

Volumn 245, Issue 1, 2007, Pages 1-6

  Huang, Ji Biao ^a   Clark, Andrea J ^a   Petty, Howard R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Cell activation; Inflammation; Metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSAMINE; GLUCOSE; HEXOSAMINE; INTERLEUKIN 2;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; HUMAN; HUMAN CELL; INFLAMMATION; LEUKEMIA CELL LINE; METABOLIC ACTIVATION; PRIORITY JOURNAL;

DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GLUCOSAMINE; GLUCOSE; HEXOSAMINES; HUMANS; INTERLEUKIN-2; JURKAT CELLS; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES;

EID: 34248657545     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2007.03.006     Document Type: Article

References (23)

1. Kiyotaki C., Peisach J., and Bloom B.R. Oxygen metabolism in cloned macrophage cell lines: glucose dependence of superoxide production, metabolic and spectral analysis. J. Immunol. 132 (1984) 857-866
2. Tan A.S., Ahmed N., and Berridge M.V. Acute regulation of glucose transport after activaton of human peripheral blood neutrophils by phorbol myristate acetate, fMLP, and granulocyte-macrophage colony-stimulation factor. Blood 91 (1998) 649-655
3. Petty H.R., Kindzelskii A.L., Espinoza J., and Romero R. Trophoblast contact de-activates human neutrophils. J. Immunol. 176 (2006) 3205-3214
4. Kindzelskii A.L., Huang J.B., Chaiworapongsa T., Kim Y.M., Romero R., and Petty H.R. Pregnancy alters glucose-6-phosphate dehydrogenase, trafficking, cell metabolism and oxidant release of maternal neutrophils. J. Clin. Invest. 110 (2002) 1801-1811
5. Huang J.B., Romero R., and Petty H.R. Human neutrophil transaldolase undergoes retrograde trafficking during pregnancy, but anterograde trafficking in cells from non-pregnant women. Metabolism 54 (2005) 1027-1033
6. Marshall S., Bacote V., and Traxinger R.R. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. J. Biol. Chem. 266 (1991) 4706-4712
7. Love D.C., and Hanover J.A. The hexosamine signaling pathway: deciphering the "O-GlcNAc Code. Sci. STKE 312 (2005) 1-14
8. Filippis A., Clark S., and Proietto J. Increased flux through the hexosamine biosynthesis pathway inhibits glucose transport acutely by activation of protein kinase C. Biochem. J. 324 (1997) 981-985
9. Vemuri S., and Marchase R.B. The inhibition of capacitative calcium entry due to ATP depletion but not due to glucosamine is reversed by staurosporine. J. Biol. Chem. 274 (1999) 20165-20170
10. Hua J., Sakamoto K., and Nagoaka I. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. J. Leuk. Biol. 71 (2002) 632-640
11. Ma L., Rudert W.A., Harnaha J., Wright M., Machen J., Lakomy R., Qian S., Lu L., Robbins P.D., Trucco M., and Giannoukakis N. Immunosuppressive effects of glucosamine. J. Biol. Chem. 277 (2002) 39343-39349
12. Forchhammer L., Thorn M., Met O., Gad M., Weidner M.S., and Claesson M.H. Immunobiological effects of glucosamine in vitro. Scand. J. Immunol. 58 (2003) 404-411
13. James L.R., Tang D., Ingram A., Ly H., Thai K., Cai L., and Scholey J.W. Flux through the hexosamine pathway is a determinant of nuclear factor κB-dependent promoter activation. Diabetes 51 (2002) 1146-1156
14. Kolm-Litty V., Sauer U., Nerlich A., Lehmann R., and Schleicher E.D. High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. J. Clin. Invest. 101 (1998) 160-169
15. Daniels M.C., Kansal P., Smith T.M., Paterson AJ., Kudlow J.E., and McClain D.A. Glucose regulation of transforming growth factor-alpha expression is mediated by products of the hexosamine biosynthesis pathway. Mol. Endocrinol. 7 (1993) 1041-1048
16. Weigert C., Friess U., Brodbeck K., Haring H.U., and Schliecher E.D. Glutamine: fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-β1 and fibronectin expression in mesangial cells. Diabetologia 46 (2003) 852-855
17. Yi H.A., Yi S.D., Jang B.C., Song D.K., Shin D.H., Mun K.C., Kim S.P., Suh S.I., and Bae J.H. Inhibitory effects of glucosamine on lipopolysaccharide-induced activation in microglial cells. Clin. Exp. Pharmacol. Physiol. 32 (2005) 1097-1103
18. 2+ oscillation. EMBO J. 22 (2003) 3825-3832
19. Kneass Z.T., and Marchase R.B. Neutrophils exhibit rapid agonist-induced increases in protein-associated O-GlcNAc. J. Biol. Chem. 279 (2004) 45759-45765
20. Kearse K.P., and Hart G.W. Lymphocyte activation induces rapid changes in nuclear and cytoplasmic glycoproteins. Proc. Natl. Acad. Sci. USA 88 (1991) 1701-1705
21. Prud'homme G.J., and Piccirillo C.A. The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases. J. Autoimmunol. 14 (2000) 23-42
22. Zhang G.X., Yu S., Gran B., and Rostami A. Glucosamine abrogates the acute phase of experimental autoimmune encephalomyelitis by induction of Th2 response. J. Immunol. 175 (2005) 7202-7208
23. Buttgereit F., Burmester G.R., and Brand M.D. Bioenergetics of immune functions: fundamental and therapeutic aspects. Immunol. Today 21 (2000) 192-199