Site specific N6-(2-hydroxy-3,4-epoxybut-1-yl)adenine oligodeoxynucleotide adducts of 1,2,3,4-diepoxybutane: Synthesis and stability at physiological pH

Chemical Research in Toxicology

Volumn 20, Issue 4, 2007, Pages 641-649

  Antsypovich, Sergey ^a   Quirk Dorr, Danaè ^a   Pitts, Crystal ^a   Tretyakova, Natalia ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; BUTADIENE DIEPOXIDE; COMPLEMENTARY DNA; CYSTEINE; GUANINE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; ADENOSINE; DEOXYADENOSINE DERIVATIVE; DRUG DERIVATIVE; EPOXIDE; N6 (2 HYDROXY 3,4 EPOXYBUT 1 YL) 2' DEOXYADENOSINE; N6-(2-HYDROXY-3,4-EPOXYBUT-1-YL)-2'-DEOXYADENOSINE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CROSS LINKING; CYTOTOXICITY; DNA ADDUCT; DNA DETERMINATION; DNA STRUCTURE; DNA SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MOLECULAR WEIGHT; MUTAGENIC ACTIVITY; PH; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; ULTRAVIOLET SPECTROSCOPY; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALIA;

ADENOSINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYADENOSINES; DNA ADDUCTS; EPOXY COMPOUNDS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 34248584964     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx060178k     Document Type: Article

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