Metabolism of 1,3-butadiene: Inhalation pharmacokinetics and tissue dosimetry of butadiene epoxides in rats and mice

Toxicology

Volumn 113, Issue 1-3, 1996, Pages 306-309

  Himmelstein, Matthew W ^a,b   Turner, Max J ^a   Asgharian, Bahman ^a   Bond, James A ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

butadiene; epoxide metabolites; glutathione depletion; inhalation; mice; rats; species differences

Indexed keywords

1,3 BUTADIENE; EPOXIDE; GLUTATHIONE;

ANIMAL EXPERIMENT; BLOOD; CONFERENCE PAPER; CONTROLLED STUDY; DOSIMETRY; INHALATION; LIVER; LUNG; MALE; METABOLITE; MOUSE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; TISSUE LEVEL; TOXICOKINETICS; XENOBIOTIC METABOLISM;

ANIMALIA;

EID: 0030605125     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(96)03462-2     Document Type: Conference Paper

References (11)

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2. Deutschmann, S. and Laib, R.J. (1989) Concentration-dependent depletion of non-protein sulfhydryl (NPSH) content in lung, heart, and liver tissue of rats and mice after acute inhalation exposure to butadiene. Toxicol. Lett. 45, 175-183.
3. Duescher, R.J. and Elfarra, A.A. (1994) Human liver microsomes are efficient catalysts for 1,3-butadiene oxidation: evidence for major roles by cytochrome P450 2A6 and 2E1. Arch. Biochem. Biophys. 311, 342-349.
4. Himmelstein, M.W., Turner, M.J., Asgharian, B. and Bond, J.A. (1994) Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation. Carcinogenesis 15, 1479-1486.
5. Himmelstein, M.W., Asgharian, B. and Bond, J.A. (1995) High concentrations of butadiene epoxides in livers and lungs of mice compared to rats exposed to 1,3-butadiene. Toxicol. Appl. Pharmacol. 132, 281-288.
6. Kreiling, R., Laib, R.J. and Bolt, H.M. (1988) Depletion of hepatic non-protein sulfhydryl content during exposure of rats and mice to butadiene. Toxicol. Lett. 41, 209-214.
7. Kreuzer, P.E., Kessler, W., Welter, H.F., Baur, C. and Filser, J.G. (1991) Enzyme specific kinetics of 1,2-epoxybutene-3 reveal species differences between rats and mice sensitive to butadiene-induced carcinogenesis. Arch. Toxicol. 61, 7-11.
8. Melnick, R.L., Huff, J., Chou, B.J. and Miller, R.A. (1990) Carcinogenicity of 1,3-butadiene in C57B1/6 × C3HF1 mice at low exposure concentrations. Cancer Res. 50, 6592-6599.
9. Owen, P.E., Glaister, J.R., Gaunt, I.F. and Pullinger, D.H. (1987) Inhalation toxicity studies with 1,3-butadiene. 3. Two year toxicity/carcinogenicity study in rats. Am. Ind. Hyg. Assoc. J. 48, 407-413.
10. Seaton, M.J., Follansbee, M.H. and Bond, J.A. (1995) Oxidation of 1,2-epoxy-3-butene to 1,2:3,4-diepoxybutane by cDNA-expressed human cytochrome P450 2E1 and 3A4 and human, mouse, and rat liver microsomes. Carcinogenesis 16, 2287-2293.
11. Thornton-Manning, J.R., Dahl, A.R., Bechtold, W.E., Griffith Jr, W.C. and Henderson, R.F. (1995) Disposition of butadiene monoepoxide and butadiene diepoxide in various tissues of rats and mice following low level inhalation exposure to 1,3-butadiene. Carcinogenesis 16, 1723-1731.