Human receptors of innate immunity (CD14, TLR2) are promising targets for novel recombinant immunoglobulin-based vaccine candidates

Vaccine

Volumn 25, Issue 24, 2007, Pages 4723-4734

  Tunheim, Gro ^a   Thompson, Keith M ^a   Fredriksen, Agnete B ^a   Espevik, Terje ^b   Schjetne, Karoline W ^a   Bogen, Bjarne ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Antibodies; B cells; Recombinant; T cells; Vaccine

Indexed keywords

CD14 ANTIGEN; HLA ANTIGEN CLASS 2; HOMODIMER; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TETANUS TOXIN; TOLL LIKE RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL CLONING; CHO CELL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INNATE IMMUNITY; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROLOGY;

ANIMALS; ANTIBODIES; ANTIBODIES, BACTERIAL; ANTIGENS, CD14; BACTERIAL PROTEINS; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; DIMERIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNITY, NATURAL; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULINS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; REPRESSOR PROTEINS; SEQUENCE ANALYSIS, DNA; TOLL-LIKE RECEPTOR 2; VACCINES, SYNTHETIC;

EID: 34248583154     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.04.004     Document Type: Article

References (55)

1. Bogen B., Munthe L., Sollien A., Hofgaard P., Omholt H., Dagnaes F., et al. Naive CD4+ T cells confer idiotype-specific tumor resistance in the absence of antibodies. Eur J Immunol 25 11 (1995) 3079-3086
2. Lambert P.H., Liu M., and Siegrist C.A. Can successful vaccines teach us how to induce efficient protective immune responses?. Nat Med 11 4 Suppl (2005) S54-S62
3. Kawamura H., and Berzofsky J.A. Enhancement of antigenic potency in vitro and immunogenicity in vivo by coupling the antigen to anti-immunoglobulin. J Immunol 136 1 (1986) 58-65
4. Snider D.P., and Segal D.M. Targeted antigen presentation using crosslinked antibody heteroaggregates. J Immunol 139 5 (1987) 1609-1616
5. Zanetti M. Antigenized antibodies. Nature 355 6359 (1992) 476-477
6. Zaghouani H., Steinman R., Nonacs R., Shah H., Gerhard W., and Bona C. Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule. Science 259 5092 (1993) 224-227
7. Baier G., Baier-Bitterlich G., Looney D.J., and Altman A. Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro. J Virol 69 4 (1995) 2357-2365
8. Lunde E., Munthe L.A., Vabo A., Sandlie I., and Bogen B. Antibodies engineered with IgD specificity efficiently deliver integrated T-cell epitopes for antigen presentation by B cells. Nat Biotechnol 17 7 (1999) 670-675
9. Lunde E., Western K.H., Rasmussen I.B., Sandlie I., and Bogen B. Efficient delivery of T cell epitopes to APC by use of MHC class II-specific troybodies. J Immunol 168 5 (2002) 2154-2162
10. Fredriksen AB, Sandlie I, Bogen B. DNA vaccines increase immunogenicity of idiotypic tumor antigen by targeting novel fusion proteins to antigen-presenting cells. Mol Ther 2006 [Epub ahead of print].
11. Jackson D.C., Lau Y.F., Le T., Suhrbier A., Deliyannis G., Cheers C., et al. A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses. Proc Natl Acad Sci USA 101 43 (2004) 15440-15445
12. McSorley S.J., Ehst B.D., Yu Y., and Gewirtz A.T. Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo. J Immunol 169 7 (2002) 3914-3919
13. Cuadros C., Lopez-Hernandez F.J., Dominguez A.L., McClelland M., and Lustgarten J. Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses. Infect Immunol 72 5 (2004) 2810-2816
14. Applequist S.E., Rollman E., Wareing M.D., Liden M., Rozell B., Hinkula J., et al. Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin. J Immunol 175 6 (2005) 3882-3891
15. Schjetne K.W., Thompson K.M., Nilsen N., Flo T.H., Fleckenstein B., Iversen J.G., et al. Cutting edge: link between innate and adaptive immunity: toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target. J Immunol 171 1 (2003) 32-36
16. Tunheim G., Schjetne K.W., Fredriksen A.B., Sandlie I., and Bogen B. Human CD14 is an efficient target for recombinant immunoglobulin vaccine constructs that deliver T cell epitopes. J Leukoc Biol 77 3 (2005) 303-310
17. Takeda K., Kaisho T., and Akira S. Toll-like receptors. Annu Rev Immunol 21 (2003) 335-376
18. Hertz C.J., Kiertscher S.M., Godowski P.J., Bouis D.A., Norgard M.V., Roth M.D., et al. Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J Immunol 166 4 (2001) 2444-2450
19. Michelsen K.S., Aicher A., Mohaupt M., Hartung T., Dimmeler S., Kirschning C.J., et al. The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2. J Biol Chem 276 28 (2001) 25680-25686
20. Kitchens R.L., Wang P., and Munford R.S. Bacterial lipopolysaccharide can enter monocytes via two CD14-dependent pathways. J Immunol 161 10 (1998) 5534-5545
21. Devitt A., Moffatt O.D., Raykundalia C., Capra J.D., Simmons D.L., and Gregory C.D. Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature 392 6675 (1998) 505-509
22. Grunwald U., Fan X., Jack R.S., Workalemahu G., Kallies A., Stelter F., et al. Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism. J Immunol 157 9 (1996) 4119-4125
23. Schjetne K.W., Thompson K.M., Aarvak T., Fleckenstein B., Sollid L.M., and Bogen B. A mouse C-kappa-specific T cell clone indicates that DC-SIGN is an efficient target for antibody-mediated delivery of T cell epitopes for MHC class II presentation. Int Immunol 14 12 (2002) 1423-1430
24. Schjetne K.W., Gundersen H.T., Iversen J.G., Thompson K.M., and Bogen B. Antibody-mediated delivery of antigen to chemokine receptors on antigen-presenting cells results in enhanced CD4+ T cell responses. Eur J Immunol 33 11 (2003) 3101-3108
25. Medvedev A.E., Flo T., Ingalls R.R., Golenbock D.T., Teti G., Vogel S.N., et al. Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls. J Immunol 160 9 (1998) 4535-4542
26. Lien E., Sellati T.J., Yoshimura A., Flo T.H., Rawadi G., Finberg R.W., et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 274 47 (1999) 33419
27. Flo T.H., Halaas O., Torp S., Ryan L., Lien E., Dybdahl B., et al. Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 69 3 (2001) 474-481
28. Berntzen G., Lunde E., Flobakk M., Andersen J.T., Lauvrak V., and Sandlie I. Prolonged and increased expression of soluble Fc receptors, IgG and a TCR-Ig fusion protein by transiently transfected adherent 293E cells. J Immunol Methods 298 1-2 (2005) 93-104
29. Galfre G., and Milstein C. Preparation of monoclonal antibodies: strategies and procedures. Methods Enzymol 73 Pt B (1981) 3-46
30. Ostermeier C., and Michel H. Improved cloning of antibody variable regions from hybridomas by an antisense-directed RNase H digestion of the P3-X63-Ag8.653 derived pseudogene mRNA. Nucleic Acids Res 24 10 (1996) 1979-1980
31. Norderhaug L., Olafsen T., Michaelsen T.E., and Sandlie I. Versatile vectors for transient and stable expression of recombinant antibody molecules in mammalian cells. J Immunol Methods 204 1 (1997) 77-87
32. Chatfield S.N., Charles I.G., Makoff A.J., Oxer M.D., Dougan G., Pickard D., et al. Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: development of a single-dose oral tetanus vaccine. Biotechnology (NY) 10 8 (1992) 888-892
33. Helting T.B., and Zwisler O. Structure of tetanus toxin. I. Breakdown of the toxin molecule and discrimination between polypeptide fragments. J Biol Chem 252 1 (1977) 187-193
34. Panina-Bordignon P., Demotz S., Corradin G., and Lanzavecchia A. Study on the immunogenicity of human class-II-restricted T-cell epitopes: processing constraints, degenerate binding, and promiscuous recognition. Cold Spring Harb Symp Quant Biol 54 Pt 1 (1989) 445-451
35. Bogen B., and Lambris J.D. Minimum length of an idiotypic peptide and a model for its binding to a major histocompatibility complex class II molecule. EMBO J 8 7 (1989) 1947-1952
36. Tjelle T.E., Corthay A., Lunde E., Sandlie I., Michaelsen T.E., Mathiesen I., et al. Monoclonal antibodies produced by muscle after plasmid injection and electroporation. Mol Ther 9 3 (2004) 328-336
37. McGregor D.P., Molloy P.E., Cunningham C., and Harris W.J. Spontaneous assembly of bivalent single chain antibody fragments in Escherichia coli. Mol Immunol 31 3 (1994) 219-226
38. Visintin A., Mazzoni A., Spitzer J.H., Wyllie D.H., Dower S.K., and Segal D.M. Regulation of Toll-like receptors in human monocytes and dendritic cells. J Immunol 166 1 (2001) 249-255
39. Siedlar M., Frankenberger M., Benkhart E., Espevik T., Quirling M., Brand K., et al. Tolerance induced by the lipopeptide Pam3Cys is due to ablation of IL-1R-associated kinase-1. J Immunol 173 4 (2004) 2736-2745
40. Muller K.M., Arndt K.M., Strittmatter W., and Pluckthun A. The first constant domain (C(H)1 and C(L)) of an antibody used as heterodimerization domain for bispecific miniantibodies. FEBS Lett 422 2 (1998) 259-264
41. Knarr G., Gething M.J., Modrow S., and Buchner J. BiP binding sequences in antibodies. J Biol Chem 270 46 (1995) 27589-27594
42. Schoonjans R., Willems A., Schoonooghe S., Fiers W., Grooten J., and Mertens N. Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives. J Immunol 165 12 (2000) 7050-7057
43. Wright S.D., Ramos R.A., Tobias P.S., Ulevitch R.J., and Mathison J.C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249 4975 (1990) 1431-1433
44. Anderson R., Gao X.M., Papakonstantinopoulou A., Roberts M., and Dougan G. Immune response in mice following immunization with DNA encoding fragment C of tetanus toxin. Infect Immunol 64 8 (1996) 3168-3173
45. Khan C.M., Villarreal-Ramos B., Pierce R.J., Demarco D.H., McNeill H., Ali T., et al. Construction, expression, and immunogenicity of multiple tandem copies of the Schistosoma mansoni peptide 115-131 of the P28 glutathione S-transferase expressed as C-terminal fusions to tetanus toxin fragment C in a live aro-attenuated vaccine strain of Salmonella. J Immunol 153 12 (1994) 5634-5642
46. Spellerberg M.B., Zhu D., Thompsett A., King C.A., Hamblin T.J., and Stevenson F.K. DNA vaccines against lymphoma: promotion of anti-idiotypic antibody responses induced by single chain Fv genes by fusion to tetanus toxin fragment C. J Immunol 159 4 (1997) 1885-1892
47. Farzad Z., and James K. Isotype responses of mice to tetanus-toxoid preparations. J Med Microbiol 22 3 (1986) 189-193
48. Lanzavecchia A., Abrignani S., Scheidegger D., Obrist R., Dorken B., and Moldenhauer G. Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets. J Exp Med 167 2 (1988) 345-352
49. Flo T.H., Halaas O., Lien E., Ryan L., Teti G., Golenbock D.T., et al. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. J Immunol 164 4 (2000) 2064-2069
50. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity. Nature 392 6673 (1998) 245-252
51. Hawiger D., Inaba K., Dorsett Y., Guo M., Mahnke K., Rivera M., et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 194 6 (2001) 769-779
52. Pozzi L.A., Maciaszek J.W., and Rock K.L. Both dendritic cells and macrophages can stimulate naive CD8 T cells in vivo to proliferate, develop effector function, and differentiate into memory cells. J Immunol 175 4 (2005) 2071-2081
53. Francisco J.A., Gilliland L.K., Stebbins M.R., Norris N.A., Ledbetter J.A., and Siegall C.B. Activity of a single-chain immunotoxin that selectively kills lymphoma and other B-lineage cells expressing the CD40 antigen. Cancer Res 55 14 (1995) 3099-3104
54. Tripathi P.K., Qin H., Deng S., Xu C., Bhattacharya-Chatterjee M., Foon K.A., et al. Antigen mimicry by an anti-idiotypic antibody single chain variable fragment. Mol Immunol 35 13 (1998) 853-863
55. Rasmussen I.B., Lunde E., Michaelsen T.E., Bogen B., and Sandlie I. The principle of delivery of T cell epitopes to antigen-presenting cells applied to peptides from influenza virus, ovalbumin, and hen egg lysozyme: Implications for peptide vaccination. Proc Natl Acad Sci USA 98 18 (2001) 10296-10301