Contact lens-induced changes in the anterior eye as observed in vivo with the confocal microscope

Progress in Retinal and Eye Research

Volumn 26, Issue 4, 2007, Pages 398-436

  Efron, Nathan ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Confocal microscope; Contact lens; Cornea; Keratocytes; Langerhans' cells

Indexed keywords

ACANTHAMOEBA; ACANTHAMOEBA KERATITIS; ANTERIOR EYE CHAMBER; BIOMICROSCOPY; CONFOCAL MICROSCOPY; CONTACT LENS; CORNEA EDEMA; CORNEA LIMBUS; DESQUAMATION; DIAGNOSTIC IMAGING; DIAGNOSTIC PROCEDURE; EPITHELIUM CELL; EYE EXAMINATION; HUMAN; IMMUNE STATUS; IN VIVO STUDY; KERATOMYCOSIS; LASER MICROSCOPY; MECHANICAL STIMULATION; NERVE PLEXUS; PRIORITY JOURNAL; REVIEW; SPECULAR MICROSCOPY; STROMA CELL;

ANTERIOR EYE SEGMENT; CONTACT LENSES; HUMANS; KERATITIS; MICROSCOPY, CONFOCAL;

EID: 34248569309     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2007.03.003     Document Type: Review

References (206)

1. Alfonso E.C., Cantu-Dibildox J., Munir W.M., Miller D., O'Brien T.P., Karp C.L., Yoo S.H., Forster R.K., Culbertson W.W., Donaldson K., Rodila J., and Lee Y. Insurgence of Fusarium keratitis associated with contact lens wear. Arch. Ophthalmol. 124 (2006) 941-947
2. Auran J.D., Starr M.B., Koester C.J., and Labombardi V.J. In-vivo scanning slit confocal microscopy of Acanthamoeba-keratitis-a case-report. Cornea 13 (1994) 183-185
3. Auran J.D., Koester C.J., Kleiman N.J., Rapaport R., Bomann J.S., Wirotsko B.M., Florakis G.J., and Koniarek J.P. Scanning slit confocal microscopic observation of cell morphology and movement within the normal human anterior cornea. Ophthalmology 102 (1995) 33-41
4. Awwad S.T., Petroll W.M., McCulley J.P., and Cavanagh H.D. Updates in acanthamoeba keratitis. Eye Contact Lens 33 (2007) 1-8
5. Bansal A.K., Mustonen R.K., and McDonald M.B. High resolution in vivo scanning confocal microscopy of the cornea in long term contact lens wear. Invest. Ophthalmol. Vis. Sci. 38 (1997) S138
6. Bastion M.L., and Mohamad M.H. Study of the factors associated with the presence of white dots in the corneas of regular soft contact lens users from an Asian country. Eye Contact Lens 32 (2006) 223-227
7. Bergmanson J.P., and Chu L.W. Corneal response to rigid contact lens wear. Br. J. Ophthalmol. 66 (1982) 667-675
8. Berlau J., Becker H.H., Stave J., Oriwol C., and Guthoff R.F. Depth and age-dependent distribution of keratocytes in healthy human corneas: a study using scanning-slit confocal microscopy in vivo. J. Cataract Refract. Surg. 28 (2002) 611-616
9. Bernal M.D., Acharya N.R., Lietman T.M., Strauss E.C., McLeod S.D., and Hwang D.G. Outbreak of Fusarium keratitis in soft contact lens wearers in San Francisco. Arch. Ophthalmol. 124 (2006) 1051-1053
10. Böhnke M., and Masters B.R. Long term contact lens wear induces a corneal degeneration with microdot deposits in the corneal stroma. Ophthalmology 104 (1997) 1887-1896
11. Böhnke M., and Masters B.R. Confocal microscopy of the cornea. Prog. Ret. Eye. Res. 18 (1999) 553-682
12. Bourassa S., and Benjamin W.J. Transient corneal surface "microdeposits" and associated epithelial surface pits occurring with gel contact lens extended wear. Int. Contact Lens Clin. 15 (1988) 338-340
13. Bourne W.M., Nelson L.R., and Hodge D.O. Central corneal endothelial changes over a ten-year period. Invest. Ophthalmol. Vis. Sci. 38 (1997) 779-782
14. Bower K.S., Donnelly S.J., Stutzman R.D., Ward T.P., and Weber E. Acanthamoeba keratitis in a US Army soldier after unauthorized use of contact lenses in the combat theater. Mil. Med. 171 (2006) 833-837
15. Brasnu, E., Bourcier, T., Dupas, B., Degorge, S., Rodallec, T., Laroche, L., Borderie, V., Baudouin, C., 2006. In vivo confocal microscopy in fungal keratitis. Br. J. Ophthalmol., doi:10.1136/bjo.2006.107243.
16. Brennan N.A., Coles M.L., and Ang J.H. An evaluation of silicone-hydrogel lenses worn on a daily wear basis. Clin. Exp. Optom. 89 (2006) 18-25
17. Bron A.J., Tripathi R.C., and Tripathi B.J. Wolff's Anatomy of the Eye and Orbit (1997), Chapman & Hall Medical, London
18. Brooks A.M.V., Westmore R., Grant G., and Robertson I.F. Deep corneal stromal opacities with contact lenses. Aust. New Zeal. J. Ophthalmol. 14 (1986) 243-249
19. Campos M., Raman S., Lee M., and McDonald P.J. Keratocyte loss after different methods of de-epithelialization. Ophthalmology 101 (1994) 890-894
20. Cardine S., Bourcier T., Chaumeil C., Zamfir O., Borderie V., and Laroche L. Clinical management and prognosis in Acanthamoeba keratitis: a retrospective study of 25 cases. J. Fr. Ophthalmol. 25 (2002) 1007-1013
21. Cavanagh H.D., Petroll W.M., Alizadeh H., He Y.G., McCulley J.P., and Jester J.V. Clinical and diagnostic use of in-vivo confocal microscopy in patients with corneal disease. Ophthalmology 100 (1993) 1444-1454
22. Cavanagh H.D., Ladage P.M., Li S.L., Yamamoto K., Molai M., Ren D.H., Petroll W.M., and Jester J.V. Effects of daily and overnight wear of a novel hyper oxygen-transmissible soft contact lens on bacterial binding and corneal epithelium: a 13-month clinical trial. Ophthalmology 109 (2002) 1957-1969
23. Chang J.H., Ren H.W., Petroll M.W., Cavanagh D.H., and Jester J.V. The application of in vivo confocal microscopy and tear LDH measurement in assessing corneal response to contact lens and contact lens solutions. Curr. Eye Res. 19 (1999) 171-181
24. Cheng K.H., Leung S.L., Hoekman H.W., Beekhuis W.H., Mulder P.G., Geerards A.J., and Kijlstra A. Incidence of contact-lens-associated microbial keratitis and its related morbidity. Lancet 354 (1999) 181-185
25. Chew S.J., Beuerman R.W., Assouline M., Kaufman H.E., Barron B.A., and Hill J.M. Early diagnosis of infectious keratitis with in vivo real time confocal microscopy. Contact Lens Assoc. Ophthalmol. J. 18 (1992) 197-201
26. Covey M., Sweeney D.F., Terry R., Sankaridurg P.R., and Holden B.A. Hypoxic effects on the anterior eye of high-Dk soft contact lens wearers are negligible. Optom. Vis. Sci. 78 (2001) 95-99
27. Craig J.P., Sherwin T., Grupcheva C.N., and McGhee C.N. An evaluation of mucin balls associated with high-DK silicone-hydrogel contact lens wear. Adv. Exp. Med. Biol. 506 (2002) 917-923
28. Dada V.K., Jain A.K., and Mehta M.R. Specular microscopy of unilateral hard contact lens wearers. Indian J. Ophthalmol. 37 (1989) 17-19
29. Dumbleton K., Jones L., Chalmers R., Williams-Lyn D., and Fonn D. Clinical characterization of spherical post-lens debris associated with lotrafilcon high-Dk silicone lenses. Contact Lens Assoc. Ophthalmol. J. 26 (2000) 186-192
30. Dumbleton K.A., Chalmers R.L., Richter D.B., and Fonn D. Vascular response to extended wear of hydrogel lenses with high and low oxygen permeability. Optom. Vis. Sci. 78 (2001) 147-151
31. Eckard A., Stave J., and Guthoff R.F. In vivo investigations of the corneal epithelium with the confocal Rostock Laser Scanning Microscope (RLSM). Cornea 25 (2006) 127-131
32. Efron N. Contact Lens Complications. second ed (2004), Butterworth-Heinemann, Edinburgh
33. Efron N. Mucin balls. In: Efron N. (Ed). Contact Lens Complications. second ed (2004), Butterworth-Heinemann, Edinburgh 55-60
34. Efron N. Stromal edema. In: Efron N. (Ed). Contact Lens Complications. second ed (2004), Butterworth-Heinemann, Edinburgh 132-140
35. Efron N. Endothelial blebs. In: Efron N. (Ed). Contact Lens Complications. second ed (2004), Butterworth-Heinemann, Edinburgh 205-210
36. Efron N. Grading scales for contact lens complications. In: Efron N. (Ed). Contact Lens Complications. second ed (2004), Butterworth-Heinemann, Edinburgh 239-244
37. Efron N. Microdot stromal degenerations (Letter to the Editor). Eye Contact Lens 31 (2005) 46
38. Efron N. The desperate last gasps of rigid contact lenses. Clin. Exp. Ophthalmol. 33 (2005) 341-342
39. Efron N., and Mutalib H.A. Confocal microscopy observations of the cornea in response to contact lens wear. die Kontaktlinse 35 1 (2001) 4-16
40. Efron N., Perez-Gomez I., Mutalib H.A., and Hollingsworth J. Confocal microscopy of the normal human cornea. Contact Lens Ant. Eye 24 (2001) 16-24 (Erratum 24, 83-85)
41. Efron N., Mutalib H.A., Perez-Gomez I., and Koh H.H. Confocal microscopic observations of the human cornea following overnight contact lens wear. Clin. Exp. Optom. 85 (2002) 149-155
42. Efron N., Perez-Gomez I., and Morgan P.B. Confocal microscopic observations of stromal keratocytes during extended contact lens wear. Clin. Exp. Optom. 85 (2002) 156-160
43. Erie J.C., Patel S.V., McLaren J.W., Nau C.B., Hodge D.O., and Bourne W.M. Keratocyte density in keratoconus. A confocal microscopy study. Am. J. Ophthalmol. 134 (2002) 689-695
44. Erie J.C., Patel S.V., and Bourne W.M. Author reply. Am. J. Ophthalmol. 135 (2003) 747
45. Erie J.C., Patel S.V., McLaren J.W., Hodge D.O., and Bourne W.M. Keratocyte density in the human cornea after photorefractive keratectomy. Arch. Ophthalmol. 121 (2003) 770-776
46. Erie J.C., Patel S.V., McLaren J.W., Hodge D.O., and Bourne W.M. Corneal keratocyte deficits after photorefractive keratectomy and laser in situ keratomileusis. Am. J. Ophthalmol. 141 (2006) 918-920
47. Fatt I., and Bieber M.T. The steady-state distribution of oxygen and carbon dioxide in the in vivo cornea. I. The open eye in air and the closed eye. Exp. Eye. Res. 7 (1968) 103-112
48. Fleiszig S.M., Zaidi T.S., Ramphal R., and Pier G.B. Modulation of Pseudomonas aeruginosa adherence to the corneal surface by mucus. Infect. Immun. 62 (1994) 1799-1804
49. Fleming C., Austen R., and Davies S. Pre-corneal deposits during soft contact lens wear. Optom. Vis. Sci. 71 (1994) S152-S153
50. Florakis G.J., Moazami G., Schubert H., Koester C.J., and Auran J.D. Scanning slit confocal microscopy of fungal keratitis. Arch. Ophthalmol. 115 (1997) 1461-1463
51. Fonn D., du Toit R., Simpson T.L., Vega J.A., Situ P., and Chalmers R.L. Sympathetic swelling response of the control eye to soft lenses in the other eye. Invest. Ophthalmol. Vis. Sci. 40 (1999) 3116-3121
52. Gobbels M., Wahning A., and Spitznas M. Endothelial function in contact lens-induced deep corneal opacities. Fortschr. Ophthalmol. 86 (1989) 448-450
53. Grupcheva C.N., Wong T., Riley A.F., and McGhee C.N. Assessing the sub-basal nerve plexus of the living healthy human cornea by in vivo confocal microscopy. Clin. Exp. Ophthalmol. 30 (2002) 187-190
54. Guthoff R.F., and Stave J. In vivo micromorphology of the cornea: confocal microscopy principles and clinical applications. In: Reinhard T., and Larkin F. (Eds). Essentials in Ophthalmology. Cornea and External Eye Disease (2006), Springer, Berlin 173-208
55. Hahnel C., Somodi S., Weiss D.G., and Guthoff R.F. The keratocyte network of human cornea: a three-dimensional study using confocal laser scanning fluorescence microscope. Cornea 19 (2000) 185-193
56. Hamano H., Jacob J.T., Senft C.J., Hamano T., Hamano T., Mitsunaga S., Kotani S., and Kaufman H.E. Differences in contact lens-induced responses in the corneas of Asian and non-Asian subjects. Contact Lens Assoc. Ophthalmol. J. 28 (2002) 101-104
57. Hammersmith K.M. Diagnosis and management of Acanthamoeba keratitis. Curr. Opin. Ophthalmol. 17 (2006) 327-331
58. Hara M., Morishige N., Chikama T., and Nishida T. Comparison of confocal biomicroscopy and noncontact specular microscopy for evaluation of the corneal endothelium. Cornea 22 (2003) 512-515
59. Harrison D.A., Joos C., and Ambrosio R. Morphology of corneal basal epithelial cells by in vivo slit-scanning confocal microscopy. Cornea 22 (2003) 246-248
60. Hazlett L.D., McClellan S.M., Hume E.B., Dajcs J.J., O'Callaghan R.J., and Willcox M.D. Extended wear contact lens usage induces Langerhans cell migration into cornea. Exp. Eye Res. 69 (1999) 575-577
61. Hirst L.W., Auer C., Cohn J., Tseng S.C., and Khodadoust A.A. Specular microscopy of hard contact lens wearers. Ophthalmology 91 (1984) 1147-1153
62. Holden B.A., Mertz G.W., and McNally J.J. Corneal swelling response to contact lenses worn under extended wear conditions. Invest. Ophthalmol. Vis. Sci. 24 (1983) 218-226
63. Holden B.A., Sweeney D.F., Vannas A., Nilsson K.T., and Efron N. Effects of long-term extended contact lens wear on the human cornea. Invest. Ophthalmol. Vis. Sci. 26 (1985) 1489-1501
64. Holden B.A., Williams L., and Zantos S.G. The etiology of transient endothelial changes in the human cornea. Invest. Ophthalmol. Vis. Sci. 26 (1985) 1354-1359
65. Holden B.A., Sweeney D.F., Swarbrick H.A., Vannas A., Nilsson K.T., and Efron N. The vascular response to long-term extended contact lens wear. Clin. Exp. Optom. 69 (1986) 112-119
66. Holland E.J., Lee R.M., Bucci Jr. F.A., Janda A.M., Doughman D.J., Harris J.K., and Krachmer J.H. Mottled cyan opacification of the posterior cornea in contact lens wearers. Am. J. Ophthalmol. 119 (1995) 620-626
67. Hollingsworth J.G., and Efron N. Confocal microscopy of the corneas of long-term rigid contact lens wearers. Contact Lens Ant. Eye 27 (2004) 57-64
68. Hollingsworth J., Perez-Gomez I., Mutalib H.A., and Efron N. A population study of the normal cornea using an in vivo, slit-scanning confocal microscope. Optom. Vis. Sci. 78 (2001) 706-711
69. Ichijima H., Petroll W.M., Jester J.V., Ohashi J., and Cavanagh H.D. Effects of increasing Dk with rigid contact lens extended wear on rabbit corneal epithelium using confocal microscopy. Cornea 11 (1992) 282-287
70. Ichijima H., Ohashi J., Petroll W.M., and Cavanagh H.D. Morphological and biochemical evaluation for rigid gas permeable contact lens extended wear on rabbit corneal epithelium. Contact Lens Assoc. Ophthalmol. J. 19 (1993) 121-128
71. Imayasu M., Moriyama T., Ichijima H., Ohashi J., Petroll W.M., Jester J.V., and Cavanagh H.D. The effects of daily wear of rigid gas permeable contact lenses treated with contact lens care solutions containing preservatives on the rabbit cornea. Contact Lens Assoc. Ophthalmol. J. 20 (1994) 183-188
72. Imre L., and Nagymihaly A. Reliability and reproducibility of corneal endothelial image analysis by in vivo confocal microscopy. Graefes Arch. Clin. Exp. Ophthalmol. 239 (2001) 356-360
73. Irvine J.A., and Ariyasu R. Limitations in tandem scanning confocal microscopy as a diagnostic tool for microbial keratitis. Scanning 16 (1994) 307-311
74. Jalbert I., and Stapleton F. Effect of lens wear on corneal stroma: preliminary findings. Aust. New Zeal. J. Ophthalmol. 27 (1999) 211-213
75. Jalbert I., and Stapleton F. The corneal stroma during contact lens wear. Contact Lens Ant. Eye 28 (2005) 3-12
76. Jalbert I., Stapleton F., and Papas E. Surface epithelial cell size measured in vivo using confocal microscopy in an underestimate of size measured with contact lens cytology. Invest. Ophthalmol. Vis. Sci. 41 (2000) S913
77. Jalbert I., Stapleton F., Papas E., Sweeney D.F., and Coroneo M. In vivo confocal microscopy of the human cornea. Br. J. Ophthalmol. 87 (2003) 225-236
78. Jalbert I., Augusteyn R., and Stapleton F. The effect of atmospheric composition and hydrostatic pressure on keratocyte viability: preliminary experiments. Invest. Ophthalmol. Vis. Sci. ARVO (2005) (Abstracts 2190)
79. Joslin C.E., Tu E.Y., McMahon T.T., Passaro D.J., Stayner L.T., and Sugar J. Epidemiological characteristics of a Chicago-area Acanthamoeba keratitis outbreak. Am. J. Ophthalmol. 142 (2006) 212-217
80. Kallinikos P., and Efron N. On the etiology of keratocyte loss during contact lens wear. Invest. Ophthalmol. Vis. Sci. 45 (2004) 3011-3020
81. Kallinikos P., Morgan P.B., and Efron N. Assessment of stromal keratocytes and tear film inflammatory mediators during extended wear of contact lenses. Cornea 25 (2006) 1-10
82. Kaufman S.C., Hamano H., Beuerman R.W., Laird J.A., and Thompson H.W. Transient corneal stromal and endothelial changes following soft contact lens wear: a study with confocal microscopy. Contact Lens Assoc. Ophthalmol. J. 22 (1996) 127-132
83. Kaufman S.C., Laird J.A., Cooper R., and Beuerman R.W. Diagnosis of bacterial contact lens related keratitis with the white-light confocal microscope. Contact Lens Assoc. Ophthalmol. J. 22 (1996) 274-277
84. Kaufman S.C., Musch D.C., Belin M.W., Cohen E.J., Meisler D.M., Reinhart W.J., Udell I.J., and Van Meter W.S. Confocal microscopy: a report by the American Academy of Ophthalmology. Ophthalmology 111 (2004) 396-406
85. Kiely P.M., Carney L.G., and Smith G. Diurnal variations of corneal topography and thickness. Am. J. Optom. Physiol. Opt. 59 (1982) 976-982
86. Kitzmann A.S., Winter E.J., Nau C.B., McLaren J.W., Hodge D.O., and Bourne W.M. Comparison of corneal endothelial cell images from a noncontact specular microscope and a scanning confocal microscope. Cornea 24 (2005) 980-984
87. Klais C.M., Buhren J., and Kohnen T. Comparison of endothelial cell count using confocal and contact specular microscopy. Ophthalmologica 217 (2003) 99-103
88. Kobayashi A., and Sugiyama K. In vivo corneal confocal microscopic findings of palisades of Vogt and its underlying limbal stroma. Cornea 24 (2005) 237-435
89. Kobayashi A., Yokogawa H., and Sugiyama K. In vivo laser confocal microscopy of Bowman's layer of the cornea. Ophthalmology 113 (2006) 2203-2208
90. Kobayashi A., Yoshita T., and Sugiyama K. In vivo laser and white-light confocal microscopic findings of human conjunctiva. Ophthalmic Surg. Lasers Imaging. 35 (2004) 482-484
91. Kwok L.S., Pierscionek B.K., Bullimore M., Swarbrick H.A., Mountford J., and Sutton G. Orthokeratology for myopic children: wolf in sheep's clothing?. Clin. Exp. Ophthalmol. 33 (2005) 343-347
92. Ladage P.M., Yamamoto K., Ren D.H., Li L., Jester J.V., Petroll W.M., and Cavanagh H.D. Effects of rigid and soft contact lens daily wear on corneal epithelium, tear lactate dehydrogenase, and bacterial binding to exfoliated epithelial cells. Ophthalmology 108 (2001) 1279-1288
93. Ladage P.M., Petroll W.M., Jester J.V., Fisher S., Bergmanson J.P., and Cavanagh H.D. Spherical indentations of human and rabbit corneal epithelium following extended contact lens wear. Contact Lens Assoc. Ophthalmol. J. 28 (2002) 177-180
94. Ladage P.M., Yamamoto K., Ren D.H., Petroll W.M., Jester J.V., and Cavanagh H.D. Corneal epithelial homeostasis following daily and overnight contact lens wear. Contact Lens Ant. Eye 25 (2002) 11-21
95. Ladage P.M., Yamamoto N., Robertson D.M., Jester J.V., Petroll W.M., and Cavanagh H.D. Pseudomonas aeruginosa corneal binding after 24-h orthokeratology lens wear. Eye Contact Lens 30 (2004) 173-178
96. LaHood D., and Grant T. Striae and folds as indicators of corneal oedema. Optom. Vis. Sci. 67 (1990) S196
97. LaHood D., Sweeney D.F., and Holden B.A. Overnight corneal edema with hydrogel, rigid gas-permeable and silicone-elastomer contact lenses. Int. Contact Lens Clin. 15 (1988) 149-152
98. Lam D.S., Houang E., Fan D.S., Lyon D., Seal D., and Wong E. Incidence and risk factors for microbial keratitis in Hong Kong: comparison with Europe and North America. Eye 16 (2002) 608-618
99. Lebow K.A., and Plishka K. Ocular changes associated with extended wear contact lenses. Int. Contact Lens Clin. 7 (1980) 49-55
100. Leduc C., Dupas B., Ott-Benoist A.C., and Baudouin C. Advantages of the in vivo HRT2 corneal confocal microscope for investigation of the ocular surface epithelia. J. Fr. Ophtalmol. 27 (2004) 978-986
101. Lee J.S., Park W.S., Lee S.H., Oum B.S., and Cho B.M. A comparative study of corneal endothelial changes induced by different durations of soft contact lens wear. Graefes Arch. Clin. Exp. Ophthalmol. 239 (2001) 1-4
102. Lemp M.A., and Mathers W.D. Corneal epithelial cell movement in humans. Eye 3 (1989) 438-445
103. Lemp M.A., Dilly P.N., and Boyde A. Tandem-scanning (confocal) microscopy of the full-thickness cornea. Cornea 4 (1986) 205-209
104. Li J., Jester J.V., Cavanagh H.D., Black T.D., and Petroll W.M. On-line 3-dimensional confocal imaging in vivo. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2945-2953
105. Linke S., Bartsch U., Richard G., and Klemm M. In vivo confocal microscopy of pre-endothelial deposits. Graefes Arch. Clin. Exp. Ophthalmol. 245 (2007) 309-312
106. Liu Z.G., and Pflugfelder S.C. The effects of long-term contact lens wear on corneal thickness, curvature, and surface regularity. Ophthalmology 107 (2000) 105-111
107. Long B., Malet F., Lejeune M., George-Vicariot M.N., Pagot R., Peyre C., and Subirana X. Three-year follow-up of biomicroscopy signs and refractive status in patients wearing lotrafilcon A lenses. Eye Contact Lens 31 (2005) 263-267
108. MacRae S.M., Matsuda M., Shellans S., and Rich L.F. The effects of hard and soft contact lenses on the corneal endothelium. Am. J. Ophthalmol. 102 (1986) 50-57
109. MacRae S.M., Matsuda M., and Phillips D.S. The long-term effects of polymethylmethacrylate contact lens wear on the corneal endothelium. Ophthalmology 101 (1994) 365-370
110. Makrynioti D., and Efron N. In vivo confocal microscopy of the central and limbal cornea in normal subjects and contact lens wearers. Optom. Vis. Sci. 81 (2004) (Abstracts p. 293)
111. Maldonado-Codina C., Morgan P.B., Schnider C.M., and Efron N. Short-term physiologic response in neophyte subjects fitted with hydrogel and silicone hydrogel contact lenses. Optom. Vis. Sci. 81 (2004) 911-921
112. Malik N.S., Moss S.J., Ahmed N., Furth A.J., Wall R.S., and Meek K.M. Ageing of the human corneal stroma: structural and biochemical changes. Biochem. Biophys. Acta. 1138 (1992) 222-228
113. Masters B.R., and Farmer M.A. Three-dimensional confocal microscopy and visualization of the in situ cornea. Comp. Med. Imag. Graph. 17 (1993) 211-219
114. Masters B.R., and Thaer A.A. Real-time scanning slit confocal microscopy of the in vivo human cornea. Appl. Opt. 33 (1994) 695-701
115. Mastropasqua L., Nubile M., Lanzini M., Carpineto P., Ciancaglini M., Pannellini T., Di Nicola M., and Dua H.S. Epithelial dendritic cell distribution in normal and inflamed human cornea: in vivo confocal microscopy study. Am. J. Ophthalmol. 142 (2006) 736-744
116. Mathers W.D., Nelson S.E., Lane J.L., Wilson M.E., Allen R.C., and Folberg R. Confirmation of confocal microscopy diagnosis of Acanthamoeba keratitis using polymerase chain reaction analysis. Arch. Ophthalmol. 118 (2000) 178-183
117. Matsuda H. Electron microscopic study of the corneal nerve with special reference to the nerve endings. Nippon Ganka Gakkai Zasshi 72 (1968) 880-893
118. McLaren J.W., Nau C.B., Kitzmann A.S., and Bourne W.M. Keratocyte density: comparison of two confocal microscopes. Eye Contact Lens 31 (2005) 28-33
119. McMahon T.T., Polse K.A., McNamara N., and Viana M.A. Recovery from induced corneal edema and endothelial morphology after long-term PMMA contact lens wear. Optom. Vis. Sci. 73 (1996) 184-188
120. Messmer E.M., Mackert M.J., Zapp D.M., and Kampik A. In vivo confocal microscopy of normal conjunctiva and conjunctivitis. Cornea 25 (2006) 781-788
121. Millar T.J., Papas E.B., Ozkan J., Jalbert I., and Ball M. Clinical appearance and microscopic analysis of mucin balls associated with contact lens wear. Cornea 22 (2003) 740-745
122. Millodot M. Effect of soft lenses on corneal sensitivity. Acta Ophthalmol. (Copenh.) 52 (1974) 603-608
123. Millodot M. Long-term wear of hard contact lenses and corneal integrity. Contacto 22 (1978) 7-12
124. Millodot M., and O'Leary D.J. Loss of corneal sensitivity with lid closure in humans. Exp. Eye Res. 29 (1979) 417-421
125. Minsky M. Memoir on inventing the confocal scanning microscope. Scanning 10 (1988) 128-138
126. Mitooka K., Ramirez M., Maguire L.J., Erie J.C., Patel S.V., McLaren J.W., Hodge D.O., and Bourne W.M. Keratocyte density of central human cornea after laser in situ keratomileusis. Am. J. Ophthalmol. 133 (2002) 307-314
127. Møller-Pedersen T. A comparative study of human corneal keratocyte and endothelial cell density during aging. Cornea 19 (1997) 333-338
128. Morgan P.B., and Efron N. Comparative clinical performance of two silicone hydrogel contact lenses for continuous wear. Clin. Exp. Optom. 85 (2002) 183-192
129. Morgan P.B., Efron N., Hill E.A., Raynor M.K., Whiting M.A., and Tullo A.B. Incidence of keratitis of varying severity among contact lens wearers. Br. J. Ophthalmol. 89 (2005) 430-436
130. Müller L.J., Vrensen G.F., Pels L., Cardozo B.N., and Willekens B. Architecture of human corneal nerves. Invest. Ophthalmol. Vis Sci. 38 (1997) 985-994
131. Murphy P.J., Patel S., and Marshall J. A new non-contact corneal aesthesiometer (NCCA). Ophthal. Physiol. Opt. 16 (1996) 101-107
132. Murphy P.J., Patel S., and Marshall J. The effect of long-term, daily contact lens wear on corneal sensitivity. Cornea 20 (2001) 264-269
133. Mustonen R.K., McDonald M.B., Srivannaboon S., Tan A.L., Doubrava M.W., and Kim K.M. Normal human corneal cell populations evaluated by in vivo scanning slit confocal microscopy. Cornea 17 (1998) 485-492
134. Mutalib, H.A., 1999. Confocal microscopy observations in contact lens wear. Ph.D. Thesis, University of Manchester Institute of Science and Technology.
135. Myrowitz E.H., Melia M., and O'Brien T.P. The relationship between long-term contact lens wear and corneal thickness. Contact Lens Assoc. Ophthalmol. J. 28 (2002) 217-220
136. Nagel S., Wiegand W., Thaer A.A., and Geyer O.C. Light scattering study of the cornea in contact lens patients. In vivo studies using confocal slit scanning microscopy. Ophthalmologe 93 (1996) 252-256
137. Nagington J., Watson P.G., Playfair T.J., McGill J., Jones B.R., and Steele A.D. Amoebic infection of the eye. Lancet 2 (1974) 1537-1540
138. Nakano E., Oliveira M., Portellinha W., de Freitas D., and Nakano K. Confocal microscopy in early diagnosis of Acanthamoeba keratitis. J. Refract. Surg. 20 (2004) S737-S740
139. Nguyen T.H., Dudek L.T., Krisciunas T.C., Matiaco P., Planck S.R., Mathers W.D., and Rosenbaum J.T. In vivo confocal microscopy: increased conjunctival or episcleral leukocyte adhesion in patients who wear contact lenses with lower oxygen permeability (Dk) values. Cornea 23 (2004) 695-700
140. Nichols J.J., and King-Smith P.E. The effect of eye closure on the post-lens tear film thickness during silicone hydrogel contact lens wear. Cornea 22 (2003) 539-544
141. O'Leary D.J., Madgewick R., Walface J., and Ang J. Size and number of epithelial cells washed from the cornea after contact lens wear. Optom. Vis. Sci. 75 (1998) 692-696
142. Oliveira-Soto L., and Efron N. Morphology of corneal nerves using confocal microscopy. Cornea 20 (2001) 374-384
143. Oliveira-Soto L., and Efron N. Assessing the cornea by in vivo confocal microscopy. Clin. Exp. Ophthalmol. 31 (2003) 83-86
144. Oliveira-Soto L., and Efron N. Morphology of corneal nerves in soft contact lens wear. A comparative study using confocal microscopy. Ophthal. Physiol. Opt. 23 (2003) 163-174
145. Olsen T., and Ehlers N. The thickness of the human cornea as determined by a specular method. Acta Ophthalmol. (Copenh.) 62 (1984) 859-871
146. Papas E. On the relationship between soft contact lens oxygen transmissibility and induced limbal hyperaemia. Exp. Eye Res. 67 (1998) 125-131
147. Papas E.B., Vajdic C.M., Austen R., and Holden B.A. High-oxygen-transmissibility soft contact lenses do not induce limbal hyperaemia. Curr. Eye Res. 16 (1997) 942-948
148. Parmar D.N., Awwad S.T., Petroll W.M., Bowman R.W., McCulley J.P., and Cavanagh H.D. Tandem scanning confocal corneal microscopy in the diagnosis of suspected Acanthamoeba keratitis. Ophthalmology 113 (2006) 538-547
149. Patel, D.V., 2006. In vivo confocal microscopy of the cornea in health and disease. Ph.D. Thesis, The University of Auckland.
150. Patel D.V., and McGhee C.N. Mapping the normal human corneal sub-basal nerve plexus by in vivo laser scanning confocal microscopy. Invest. Ophthalmol. Vis. Sci. 46 (2005) 4485-4488
151. Patel D.V., and McGhee C.N. Contemporary in vivo confocal microscopy of the living human cornea using white light and laser scanning techniques: a major review. Clin. Exp. Ophthalmol. 35 (2007) 71-88
152. Patel S.V., McLaren J.W., Hodge D.O., and Bourne W.M. Normal human keratocyte density and corneal thickness measurement by using confocal microscopy in vivo. Invest. Ophthalmol. Vis. Sci. 42 (2001) 333-339
153. Patel S.V., McLaren J.W., Hodge D.O., and Bourne W.M. Confocal microscopy in vivo in corneas of long-term contact lens wearers. Invest. Ophthalmol. Vis. Sci. 43 (2002) 995-1003
154. Patel D.V., Grupcheva C.N., and McGhee C.N. In vivo confocal microscopy of posterior polymorphous dystrophy. Cornea 24 (2005) 550-554
155. Patel D.V., Sherwin T., and McGhee C.N. Laser scanning in vivo confocal microscopy of the normal human corneoscleral limbus. Invest. Ophthalmol. Vis. Sci. 47 (2006) 2823-2827
156. Perez J.G., Meijome J.M., Jalbert I., Sweeney D.F., and Erickson P. Corneal epithelial thinning profile induced by long-term wear of hydrogel lenses. Cornea 22 (2003) 304-307
157. Perez-Gomez I., and Efron N. Changes to corneal morphology following refractive surgery (myopic laser in situ keratomileusis) as viewed with a confocal microscope. Optom. Vis. Sci. 80 (2003) 690-697
158. Petran M., Hadravsky M., Egger M.D., and Galambos R. Tandem-scanning reflected-light microscopy. J. Opt. Soc. Am. 58 (1968) 661-664
159. Petroll W.M., Boettcher K., Barry P., Cavanagh H.D., and Jester J.V. Quantitative assessment of anteroposterior keratocyte density in the normal rabbit cornea. Cornea 14 (1995) 3-9
160. Petroll W.M., Yu A., Li J., Jester J.V., Cavanagh H.D., and Black T. A prototype two-detector confocal microscope for in vivo corneal imaging. Scanning 24 (2002) 163-170
161. Pfister D.R., Cameron J.D., Krachmer J.H., and Holland E.J. Confocal microscopy findings of Acanthamoeba keratitis. Am. J. Ophthalmol. 121 (1996) 119-128
162. Pimenides P., Steele C.F., McGhee C.N.J., and Bryce I.G. Deep corneal stromal opacities associated with long term contact lens wear. Br. J. Ophthalmol. 80 (1996) 21-24
163. Pisella P.J., Auzerie O., Bokobza Y., Debbasch C., and Baudouin C. Evaluation of corneal stromal changes in vivo after laser in situ keratomileusis with confocal microscopy. Ophthalmology 108 (2001) 1744-1750
164. Pritchard N., Jones L., Dumbleton K., and Fonn D. Epithelial inclusions in association with mucin ball development in high-oxygen permeability hydrogel lenses. Optom. Vis. Sci. 77 (2000) 68-72
165. Rath R., Stave J., Guthoff R., Giebel J., and Tost F. In vivo imaging of the conjunctival epithelium using confocal laser scanning microscopy. Ophthalmologe 103 (2006) 401-405
166. Remeijer L., Van Rij G., Beekhuis W.H., Polak B.C., and van Nes J. Deep corneal stromal opacities in long-term contact lens wear. Ophthalmology 97 (1990) 281-285
167. Ren D.H., Petroll W.M., Jester J.V., Ho-Fan J., and Cavanagh H.D. The relationship between contact lens oxygen permeability and binding of Pseudomonas aeruginosa to human corneal epithelial cells after overnight and extended wear. Contact Lens Assoc. Ophthalmol. J. 25 (1999) 80-100 (Erratum 25, 175)
168. 2 transmissible contact lenses on bacterial binding and corneal epithelium: a 1-year clinical trial. Ophthalmology 109 (2002) 27-39
169. Romano A.C., Espana E.M., Yoo S.H., Budak M.T., Wolosin J.M., and Tseng S.C. Different cell sizes in human limbal and central corneal basal epithelia measured by confocal microscopy and flow cytometry. Invest. Ophthalmol. Vis. Sci. 44 (2003) 5125-5129
170. Rong B., and Yan X.M. In vivo study of normal human limbal and central corneas using laser confocal microscope. Zhonghua Yan. Ke. Za. Zhi. 42 (2006) 17-21
171. Sanchis-Gimeno J.A., Lleo A., Alonso L., Rahhal M.S., and Martinez-Soriano E. Differences in corneal anatomy in a pair of monozygotic twins due to continuous contact lens wear. Cornea 22 (2003) 243-245
172. Sankaridurg P.R., Rao G.N., Rao H.N., Sweeney D.F., and Holden B.A. ATPase-positive dendritic cells in the limbal and corneal epithelium of guinea pigs after extended wear of hydrogel lenses. Cornea 19 (2000) 374-377
173. Sarver M.D. Striate corneal lines among patients wearing hydrophilic contact lenses. Am. J. Optom. Physiol. Opt. 48 (1971) 762-765
174. Schoessler J.P. Corneal endothelial polymegethism associated with extended wear. Int. Contact Lens Clin. 10 (1983) 144-156
175. Schoessler J.P., and Barr J.T. Corneal thickness changes with extended contact lens wear. Am. J. Optom. Physiol. Opt. 57 (1980) 729-733
176. Schoessler J.P., and Woloschak M.J. Corneal endothelium in veteran PMMA contact lens wearers. Int. Contact Lens Clin. 8 (1981) 19-25
177. Setala K., Vasara K., Vesti E., and Ruusuvaara P. Effects of long-term contact lens wear on the corneal endothelium. Acta. Ophthalmol. Scand. 76 (1998) 299-303
178. Stachs O., Zhivov A., Kraak R., Stave J., and Guthoff R. In vivo three-dimensional confocal laser scanning microscopy of the epithelial nerve structure in the human cornea. Graefes Arch. Clin. Exp. Ophthalmol. 245 (2007) 569-575
179. Stave J., Zinser G., Grummer G., and Guthoff R. Modified Heidelberg Retinal Tomograph HRT. Initial results of in vivo presentation of corneal structures. Ophthalmologe 99 (2002) 276-280
180. Su P.Y., Hu F.R., Chen Y.M., Han J.H., and Chen W.L. Dendritiform cells found in central cornea by in-vivo confocal microscopy in a patient with mixed bacterial keratitis. Ocul. Immunol. Inflamm. 14 (2006) 241-244
181. Sun X., Zhao H., Deng S., Zhang Y., Wang Z., Li R., Luo S., and Jin X. Infectious keratitis related to orthokeratology. Ophthal. Physiol. Opt. 26 (2006) 133-136
182. Sutphin J.E., Kantor A.L., Mathers W.D., and Mehaffey M.G. Evaluation of infectious crystalline keratitis with confocal microscopy in a case series. Cornea 16 (1997) 21-26
183. Swarbrick H.A. Orthokeratology (corneal refractive therapy): what is it and how does it work?. Eye Contact Lens 30 (2004) 181-185
184. Swarbrick H.A., Wong G., and O'Leary D.J. Corneal response to orthokeratology. Optom. Vis. Sci. 75 (1998) 791-799
185. Sweeney D.F., du Toit R., Keay L., Jalbert I., Sankaridurg P.R., Stern J., Skotinsky C., Stephensen A., Covey M., Holden B.A., and Rao G.N. Clinical performance of silicone hydrogel lenses. In: Sweeney D.F. (Ed). Silicone Hydrogels. Continuous-Wear Contact Lenses (2004), Butterworth-Heinemann, Edinburgh 164-216
186. Szliter E.A., Barrett R.P., Gabriel M.M., Zhang Y., and Hazlett L.D. Pseudomonas aeruginosa-induced inflammation in the rat extended-wear contact lens model. Eye Contact Lens 32 (2006) 12-18
187. Tan J., Keay L., Jalbert I., Naduvilath T.J., Sweeney D.F., and Holden B.A. Mucin balls with wear of conventional and silicone hydrogel contact lenses. Optom. Vis. Sci. 80 (2003) 291-297
188. Tomii S., and Kinoshita S. Observations of human corneal epithelium by tandem scanning confocal microscope. Scanning 16 (1994) 305-306
189. Trittibach P. Microdot stromal degenerations (Response from the Author). Eye Contact Lens 31 (2005) 47
190. Trittibach P., Cadez R., Eschmann R., Sarra G.M., Boehnke M., and Frueh B.E. Determination of microdot stromal degenerations within corneas of long-term contact lens wearers by confocal microscopy. Eye Contact Lens 30 (2004) 127-131
191. Tsubota K., and Yamada M. Corneal epithelial alterations induced by disposable contact-lens wear. Ophthalmology 99 (1992) 1193-1196
192. Vanathi M., Tandon R., Sharma N., Titiyal J.S., Pandey R.M., and Vajpayee R.B. In-vivo slit scanning confocal microscopy of normal corneas in Indian eyes. Indian J. Ophthalmol. 51 (2003) 225-230
193. van Klink F., Alizadeh H., He Y., Mellon J.A., Silvany R.E., McCulley J.P., and Niederkorn J.Y. The role of contact lenses, trauma, and Langerhans cells in a Chinese hamster model of Acanthamoeba keratitis. Invest. Ophthalmol. Vis. Sci. 34 (1993) 1937-1944
194. Vannas A., Holden B.A., and Makitie J. The ultrastructure of contact lens induced changes in the human corneal endothelium. Acta Ophthalmol. 62 (1984) 320-333
195. Vesaluoma M.H., Petroll W.M., Perez-Santonja J.J., Valle T.U., Alio J.L., and Tervo T.M. Laser in situ keratomileusis flap margin: wound healing and complications imaged by in vivo confocal microscopy. Am. J. Ophthalmol. 130 (2000) 564-573
196. Watt K., and Swarbrick H.A. Microbial keratitis in overnight orthokeratology: review of the first 50 cases. Eye Contact Lens 31 (2005) 201-208
197. Weed, K.H., Macewen, C.J., Cox, A., McGhee, C.N., 2006. Quantitative analysis of corneal microstructure in keratoconus utilising in vivo confocal microscopy. Eye doi:10.1038/sj.eye.6702286.
198. Wiffen S.J., Hodge D.O., and Bourne W.M. The effect of contact lens wear on the central and peripheral corneal endothelium. Cornea 19 (2000) 47-51
199. Wilson S.E., He Y.G., Weng J., Li Q., McDowall A.W., Vital M., and Chwang E.L. Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing. Exp. Eye Res. 62 (1996) 325-327
200. Wilson G., Ladage P.M., and Cavanagh H.D. The epithelium in extended wear. In: Sweeney D.F. (Ed). Silicone Hydrogels. Continuous-Wear Contact Lenses (2004), Butterworth-Heinemann, Edinburgh 28-56
201. Winchester K., Mathers W.D., Sutphin J.E., and Daley T.E. Diagnosis of Acanthamoeba keratitis in vivo with confocal microscopy. Cornea 14 (1995) 10-17
202. Xuguang S., Lin C., Yan Z., Zhiquan W., Ran L., Shiyan L., and Xiuying J. Acanthamoeba keratitis as a complication of orthokeratology. Am. J. Ophthalmol. 136 (2003) 1159-1161
203. Yeniad B., Adam Y.S., Bilgin L.K., and Gozum N. Effect of 30-day continuous wear of silicone hydrogel contact lenses on corneal thickness. Eye Contact Lens 30 (2004) 6-9
204. Zantos S.G., and Holden B.A. Transient endothelial changes soon after wearing soft contact lenses. Am. J. Optom. Physiol. Opt. 54 (1977) 856-858
205. Zhivov A., Stave J., Vollmar B., and Guthoff R. In vivo confocal microscopic evaluation of Langerhans' cell density and distribution in the normal human corneal epithelium. Graefes Arch. Clin. Exp. Ophthalmol. 243 (2005) 1056-1061
206. Zhivov A., Stave J., Vollmar B., and Guthoff R. In vivo confocal microscopic evaluation of Langerhans cell density and distribution in the corneal epithelium of healthy volunteers and contact lens wearers. Cornea 26 (2007) 47-54