In vivo confocal microscopy of the human cornea

British Journal of Ophthalmology

Volumn 87, Issue 2, 2003, Pages 225-236

  Jalbert, Isabelle ^a   Stapleton, F ^a   Papas, E ^a   Sweeney, D F ^a   Coroneo, M ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BOWMAN MEMBRANE; CONFOCAL MICROSCOPY; CONTACT LENS; CORNEA; CORNEA DYSTROPHY; CORNEA ENDOTHELIUM; CORNEA STROMA; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; ENDOTHELIUM CELL; EYE REFRACTION; HUMAN; IMAGE RECONSTRUCTION; KERATITIS; PRIORITY JOURNAL; REVIEW;

CELL COUNT; CONTACT LENSES; CORNEA; CORNEAL DISEASES; CORNEAL DYSTROPHIES, HEREDITARY; DIAGNOSIS, DIFFERENTIAL; HUMANS; KERATITIS; KERATOMILEUSIS, LASER IN SITU; MICROSCOPY, CONFOCAL; OPTICS; REFRACTIVE ERRORS; REPRODUCIBILITY OF RESULTS;

EID: 0037310973     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.87.2.225     Document Type: Review

References (177)

1. Furrer P, Mayer JM, Gurny R. Confocal microscopy as a tool for the investigation of the anterior part of the eye. J Ocul Pharmacol Ther 1997;13:559-78.
2. Petroll WM, Cavanagh HD, Jester JV. Clinical confocal microscopy. Curr Opin Ophthalmol 1998;9:59-65.
3. Böhnke M, Masters BR. Confocal microscopy of the cornea. Prog Retin Eye Res 1999;18:553-628.
4. Cavanagh HD, El-Agha MS, Petroll WM, et al. Specular microscopy, confocal microscopy, and ultrasound biomicroscopy. Cornea 2000;19:712-22.
5. Masters BR, Böhnke M. Three-dimensional confocal microscopy of the human cornea in vivo. Ophthalmic Res 2001;33:125-35.
6. Masters BR, Böhnke M. Confocal microscopy of the human cornea in vivo. Int Ophthalmol 2001;23:199-206.
7. Minsky M. Memoir on inventing the confocal scanning microscope. Scanning 1988;10:128-38.
8. Petrán M, Hadravský M, Egger MD, et al. Tandem-scanning reflected-light microscope. J Opt Soc Am 1968;58:661-4.
9. Wiegand W, Thaer AA, Kroll P, et al. Optical sectioning of the cornea with a new confocal in vivo slit-scanning videomicroscope. Ophthalmology 1995;102:568-75.
10. Maurice DM. A scanning slit optical microscope. Invest Ophthalmol 1974;13:1033-7.
11. Lemp MA, Dilly PN, Boyde A. Tandem-scanning (confocal) microscopy of the full-thickness cornea. Cornea 1985/1986;4:205-9.
12. Masters BR, Kino GS. Confocal microscopy of the eye. In: Masters BR, ed. Noninvasive diagnostic techniques in ophthalmology. New York: Springer-Verlag, 1990:152-71.
13. Jester JV, Cavanagh HD, Lemp MA. Confocal microscopic imaging of the living eye with tandem scanning confocal microscopy. In: Masters BR, ed. Noninvasive diagnostic techniques in ophthalmology. New York: Springer-Verlag, 1990:172-88.
14. Dilly PN. Tandem scanning reflected light microscopy of the cornea. Scanning 1988;10:153-6.
15. Cavanagh HD, Jester JV, Essepian J, et al. Confocal microscopy of the living eye. CLAO J 1990;16:65-73.
16. Masters BR. Scanning slit confocal microscopy of the in vivo cornea. Optical Engineering 1995;34:684-92.
17. Jester JV, Petroll WM, Garana RMR, et al. Comparison of in vitro and ex vivo cellular structure in rabbit eyes detected by tandem scanning microscopy. J Microsc 1992;165:169-81.
18. Ruggeri A, Pajaro S. Automatic recognition of cell layers in corneal confocal microscopy images. Comput Methods Programs Biomed 2002;68:25-35.
19. Mustonen RK, McDonald MB, Srivannaboon S, et al. In vivo confocal microscopy of Fuchs' endothelial dystrophy. Cornea 1998;17:493-503.
20. Klais C, Kohnen T, Ohrloff C. Comparison of endothelial cell count between confocal and specular microscopy. Invest Ophthalmol Vis Sci [ARVO abstract] 1998;39:S1031. (Abstract no 4762.)
21. Tomii S, Kinoshita S. Observations of human corneal epithelium by tandem scanning confocal microscope. Scanning 1994;16:305-6.
22. Imayasu M, Petroll WM, Jester JV, et al. The relation between contact lens oxygen transmissibility and binding of Pseudomonas aeruginosa to the cornea after overnight wear. Ophthalmology 1994;101:371-88.
23. Kaufman SC, Hamano H, Beuerman RW, et al. Transient corneal stromal and endothelial changes following soft contact lens wear: a study with confocal microscopy. CLAO J 1996;22:127-32.
24. Mustonen RK, McDonald MB, Srivannaboon S, et al. Normal human corneal cell populations evaluated by in vivo scanning slit confocal microscopy. Cornea 1998;17:485-92.
25. Ren DH, Petroll WM, Jester JV, et al. Short-term hypoxia downregulates epithelial cell desquamation in vivo, but does not increase Pseudomonas aeruginosa adherence to exfoliated human corneal epithelial cells. CLAO J 1999;25:73-9.
26. Ren DH, Petroll WM, Jester JV, et al. The relationship between contact lens oxygen permeability and binding of Pseudomonas aeruginosa to human corneal epithelial cells after overnight and extended wear. CLAO J 1999;25:80-100.
27. Niiya A, Yokoi N, Matsumoto Y, et al. Effect of beta-blocker eyedrops on corneal epithelial barrier function. Ophthalmologica 2000;214:332-6.
28. Patel SV, McLaren JW, Hodge DO, et al. Normal human keratocyte density and corneal thickness measurement by using contact microscopy in vivo. Invest Ophthalmol Vis Sci 2001;42:333-9.
29. Ciancaglini M, Carpineto P, Zuppardi E, et al. In vivo confocal microscopy of patients with amiodarone-induced keratopathy. Cornea 2001;20:368-73.
30. Ladage PM, Yamamoto K, Ren DH, et al. Effects of rigid and soft contact lens daily wear on corneal epithelium, tear lactate dehydrogenase, and bacterial binding to exfoliated epithelial cells. Ophthalmology 2001;108:1279-88.
31. Pisella P-J, Auzerie O, Bokobza Y, et al. Evaluation of corneal stroma changes in vivo after laser in situ keratomileusis with confocal microscopy. Ophthalmology 2001;108:1744-50.
32. Ciancaglini M, Carpineto P, Doronzo E, et al. Morphological evaluation of Schnyder's central crystalline dystrophy by confocal microscopy before and after phototherapeutic keratectomy. J Cataract Refract Surg 2001;27:1892-5.
33. Hollingsworth J, Perez-Gomez I, Mutalib HA, et al. A population study of the normal cornea using an in vivo, slit-scanning confocal microscope. Optom Vis Sci 2001;78:706-11.
34. 2 transmissible contact lenses on bacterial binding and corneal epithelium: a 1-year clinical trial. Ophthalmology 2002;109:27-40.
35. Milooka K, Ramirez M, Maguire LJ, et al. Keratocyte density of central human cornea after laser in situ keratomileusis. Am J Ophthalmol 2002;133:307-14.
36. Patel SV, McLaren JW, Hodge DO, et al. Confocal microscopy in vivo in corneas of long-term contact lens wearers. Invest Ophthalmol Vis Sci 2002;43:995-1003.
37. McLaren JW, Nau CB, Patel SV, et al. How precisely can we determine keratocyte density by confocal microscopy? Invest Ophthalmol Vis Scl [ARVO abstract] 2001;42:S281. (Abstract no 1525.)
38. Grupcheva CN, Wong T, Riley AF, et al. Assessing the sub-basal nerve plexus of the living healthy human cornea by in vivo confocal microscopy. Clin Experiment Ophthalmol 2002;30:187-90.
39. Beuerman RW, Laird JA, Kaufman SC, et al. Quantification of real-time confocal images of the human cornea. J Neurasci Methods 1994;54:197-203.
40. Jalbert I, Stapleton F, Papas E, et al. Surface epithelial cell size measured in vivo using confocal microscopy is an underestimate of size measured with contact lens cytology. Invest Ophthalmal Vis Sci [ARVO abstract] 2000;41:S913. (Abstract no 4855.)
41. Prydal JI, Franc F, Dilly PN, et al. Keratocyte density and size in conscious humans by digital image analysis of confocal images. Eye 1998;12:337-42.
42. Stave J, Slowik C, Somodi S, et al. Keratocyte density in the in vivo cornea. Automatic quantification with a modified confocal microscope MICROPHTHAL. Klin Monatsbl Augenheilkd 1998;213:38-44.
43. Patel SV, McLaren JW, Camp JJ, et al. Automated quantification of keratocyte density by using confocal microscopy in vivo. Invest Ophthalmol Vis Sci 1999;40:320-6.
44. Berlau J, Becket H-H, Stave J, et al. Depth and age-dependent distribution of keratocytes in healthy human corneas. J Cataract Refract Surg 2002;28:611-6.
45. Auran JD, Koester CJ, Kleiman NJ, et al. Scanning slit confocal microscopic observation of cell morphology and movement within the normal human anterior cornea. Ophthalmology 1995;102:33-41.
46. Thoft RA. The x, y, z hypothesis of corneal epithelial maintenance. Invest Ophthalmol Vis Sci 1983;24:1442-3.
47. Rosenberg ME, Tervo TMT, Immonen U, et al. Corneal structure and sensitivity in type I diabetes mellitus. Invest Ophthalmol Vis Sci 2000;41:2915-21.
48. Rosenberg ME, Tervo TMT, Gallar J, et al. Corneal morphology and sensitivity in lattice dystrophy type II (Familial Amyloidosis, Finnish Type). Invest Ophthalmol Vis Sci 2001;42:634-41.
49. Oliveira-Soto L, Efron N. Morphology of corneal nerves using confocal microscopy. Cornea 2001;20:374-84.
50. Tuominen ISJ, Tervo TMT, Teppo A-M, et al. Human tear fluid PDGF-BB, TNF-a and TGF-b1 vs corneal haze and regeneration of corneal epithelium and subbasal nerve plexus after PRK. Exp Eye Res 2001;72:631-41.
51. Rosenberg ME, Tervo TM, Muller LJ, et al. In vivo confocal microscopy after herpes keratitis. Cornea 2002;21:265-9.
52. Mathers WD, Lane JA, Zimmerman MB. Assessment of the tear film with tandem scanning confocal microscopy. Cornea 1997;16:162-8.
53. Masters BR. Confocal microscopy of the in-situ crystalline lens. J Microsc 1992;165:159-67.
54. Mathers W, Littlefield T, Lakes R, et al. Observation of the retina using the tandem scanning confocal microscope. Scanning 1996;18:362-6.
55. Li HF, Petroll WM, Møller-Pedersen T, et al. Epithelial and corneal thickness measurements by in vivo confocal microscopy through focusing (CMTF). Curr Eye Res 1997;16:214-21.
56. Jalbert I, Papas E, Sweeney DF, et al. Instrument, diurnal, and day to day repeatability of in vivo measurements of the central human cornea using slit scanning confocal microscopy and modified optical pachometry. Invest Ophthalmol Vis Sci [ARVO abstract] 2002;43:68. (Abstract no 1713.)
57. Vesaluoma M, Pérez-Santonja J, Petroll WM, et al. Corneal stromal changes induced by myopic LASIK. Invest Ophthalmol Vis Sci 2000;41:369-76.
58. Bonhke M, Masters BR, Walti R, et al. Precision and reproducibility of measurements of human corneal thickness with rapid optical low-coherence reflectometry (OLCR). J Biomed Opt 1999;4:152-6.
59. Bechmann M, Thiel MJ, Neubauer AS, et al. Central corneal thickness measurement with a retinal optical coherence tomography device versus standard ultrasonic pachymetry. Cornea 2001;20:50-4.
60. Fonn D, Wang JH, Simpson TL. Topographical thickness of the epithelium and total cornea using optical coherence tomography. Invest Ophthalmol Vis Sci [ARVO abstract] 2000;41:S675. (Abstract no 3590.)
61. Wirbelauer C, Scholz C, Hoerauf H, et al. Noncontact corneal pachymetry with slit lamp-adapted optical coherence tomography. Am J Ophthalmol 2002;133:444-50.
62. Reinstein DZ, Silverman RH, Rondeau MJ, et al. Epithelial and corneal thickness measurements by high-frequency ultrasound digital signal processing. Ophthalmology 1994;101:140-6.
63. Petroll WM, Yu A, Li J, et al. A prototype two-detector confocal microscope for in vivo corneal imaging. Scanning 2002;24:163-70.
64. Nau CB, McLaren JW, Lee BH, et al. Corneal thickness measurement: disagreement between confocal microscopy and ultrasonic pachometry. Invest Ophthalmol Vis Sci [ARVO abstract] 2002;43:6. (Abstract no 145.)
65. Corbett MC, Prydal JI, Verma S, et al. An in vivo investigation of the structures responsible for corneal haze after photorefractive keratectomy and their effect on visual function. Ophthalmology 1996;103:1366-80.
66. Prydal JI, Muir MGK, Dilly PN, et al. Confocal microscopy using oblique sections for measurement of corneal epithelial thickness in conscious humans. Acta Ophthalmol Scand 1997;75:624-8.
67. Nagel S, Wiegand W, Thaer AA. Corneal changes and corneal healing after keratomileusis in situ. In vivo studies using confocal slit-scanning microscopy. Ophthalmologe 1995;92:397-401.
68. Nagel S, Wiegand W, Thaer AA, et al. Light scattering study of the cornea in contact lens patients. In vivo studies using confocal slit scanning microscopy. Ophthalmologe 1996;93:252-6.
69. Slowik C, Somodi S, Richter A, et al. Assessment of corneal alterations following laser in situ keratomileusis by confocal slit scanning microscopy. Ger J Ophthalmol 1997;5:526-31.
70. Møller-Pedersen T, Vogel M, Li HF, et al. Quantification of stromal thinning, epithelial thickness, and corneal haze after photorefractive keratectomy using in vivo confocal microscopy. Ophthalmology 1997;104:360-8.
71. Busin M, Spitznas M, Laser H, et al. In vivo evabation of epikeratophakia lenses by means of Scheimpflug photography. Refract Corneal Surg 1989;5:155-60.
72. Smith GTH, Brown NAP, Shun-Shin GA. Light scatter from the central human cornea. Eye 1990;4:584-8.
73. Olsen T. Light scattering from the human cornea. Invest Ophthalmol Vis Sci 1982;23:81-6.
74. McCally RL, Hochheimer BF, Chamon W, et al. A simple device for objective measurements of haze following excimer laser ablation of cornea. SPIE: Ophthalmic Technologies III 1993;1877:20-5.
75. Lohmann CP, Timberlake GT, Fitzke FW, et al. Corneal light scattering after excimer laser photorefractive keratectomy: The objective measurements of haze. Refract Corneal Surg 1992;8:114-21.
76. Chang S-S, Maurice DM, Ramirez-Florez S. Quantitative measurement of corneal haze after myopic PRK. J Refract Surg 1996;12:412-6.
77. Andrade HA, McDonald MB, Liu JC, et al. Evaluation of an opacity lensometer for determining corneal clarity following excimer laser photoablation. Refract Corneal Surg 1990;6:346-51.
78. Van den Berg T. Importance of pathological intraocular light scatter for visual disability. Doc Ophthalmol 1986;61:327-33.
79. Hernández-Quintela E, Mayer F, Dighiero P, et al. Confocal microscopy of cystic disorders of the corneal epithelium. Ophthalmology 1998;105:631-6.
80. Sherif ZA, Pleyer U, Rieck P, et al. Confocol microscopy in corneal dystrophies. Klin Monatsbl Augenheilkd 1999;214:12-21.
81. Rosenberg ME, Tervo TMT, Petroll WM, et al. In vivo confocal microscopy of patients with corneal recurrent erosion syndrome or epithelial basement membrane dystrophy. Ophthalmology 2000;107:565-73.
82. Werner LP, Issid K, Werner LP, et al. Salzmann's corneal degeneration associated with epithelial basement membrane dystrophy. Cornea 2000;19:121-3.
83. Cavanagh HD, Petroll WM, Alizadeh H, et al. Clinical and diagnostic use of in vivo confocal microscopy in patients with corneal disease. Ophthalmology 1993;100:1444-54.
84. Werner LP, Werner L, Dighiero P, et al. Confocal microscopy in Bowman and stromal corneal dystrophies. Invest Ophthalmol Vis Sci 1999;106:1697-704.
85. Chiou AG-Y, Kaufman SC, Beuerman RW, et al. Differential diagnosis of linear corneal images on confocal microscopy. Cornea 1999;18:63-6.
86. Chiou AG-Y, Beuerman RW, Kaufman SC, et al. Confocal microscopy in lattice corneal dystrophy. Graefes Arch Clin Exp Ophthalmol 1999;237:697-701.
87. Rothstein A, Auran J, Wittpenn J, et al. Confocal microscopy in Meretoja syndrome. Cornea 2002;21:364-7.
88. Frueh BE, Böhnke M. In vivo confocal microscopy of fleck dystrophy. Cornea 1999;18:658-60.
89. Grupcheva CN, Malik TY, Craig JP, et al. Microstructural assessment of rare corneal dystrophies using real-time in vivo confocal microscopy. Clin Exp Ophthalmol 2001;29:281-5.
90. Vesaluoma MH, Linna TU, Sankila E-M, et al. In vivo confocal microscopy of a family with Schnyder crystallin corneal dystrophy. Ophthalmology 1999;106:944-51.
91. Chiou AG-Y, Kaufman SC, Beuerman RW, et al. Confocal microscopy in posterior polymorphous corneal dystrophy. Ophthalmologica 1999;213:211-3.
92. Grupcheva CN, Chew GS, Edwards M, et al. Imaging posterior polymorphous corneal dystrophy by in vivo can focal microscopy. Clin Exp Ophthalmol 2001;29:256-9.
93. Kaufman SC, Beuerman RW, Kaufman HE. Diagnosis of advanced Fuchs' endothelial dystrophy with the confocal microscope. Am J Ophthalmol 1993;116:652-3.
94. Chiou AG-Y, Kaufman SC, Beuerman RW, et al. Confocal microscopy in cornea guttata and Fuchs' endothelial dystrophy. Br J Ophthalmol 1999;83:185-9.
95. Grupcheva CN, Craig JP, Sherwin T, et al. Differential diagnosis of corneal oedema assisted by in vivo confocal microscopy. Clin Exp Ophthalmol 2001;29:133-7.
96. Vesaluoma MH, Sankila E-M, Gallar J, et al. Autosomal recessive cornea plana: In vivo corneal morphology and corneal sensitivity. Invest Ophthalmol Vis Sci 2000;41:2120-6.
97. Somodi S, Hahnel C, Slowik C, et al. Confocal in vivo microscopy and confocal laser-scanning fluorescence microscopy in keratoconus. Ger J Ophthalmol 1997;5:518-25.
98. Chiou AG-Y, Kaufman SC, Beuerman RW, et al. Confocal microscopy in the iridocorneal endothelial syndrome. Br J Ophthalmol 1999;83:697-702.
99. Ku JY, Grupcheva CN, McGhee CN. Microstructural analysis of Salzmann's nodular degeneration by in vivo confocal microscopy. Clin Exp Ophthalmol 2002;30:367-8.
100. Chiou AG-Y, Chang C, Kaufman SC, et al. Characterization of fibrous retrocorneal membrane by confocal microscopy. Cornea 1998;17:669-71.
101. Chiou AGY, Kaufman SC, Kaz K, et al. Characterization of epithelial downgrowth by confocal microscopy. J Cataract Refract Surg 1999;25:1172-4.
102. Kaufman SC, Beuerman RW, Goldberg D. A new form of primary, localized, corneal amyloidosis: a case report with confocal microscopy. Metab Pediatr Syst Ophthalmol 1995;18:1-4.
103. Gierek-Ciaciura S, Filipecka I. Familial corneal degeneration in 3 first-degree relatives- a case study. Klin Oczna 2001;103:51-4.
104. Mathers WD, Sutphin JE, Folberg R, et al. Outbreak of keratitis presumed to be caused by acanthamoeba. Am J Ophthalmol 1996;121:129-42.
105. Pfister DR, Cameron JD, Krachmer JH, et al. Confocal microscopy findings of acanthamoeba keratitis. Am J Ophthalmol 1996;121:119-28.
106. Winchester K, Mathers WD, Sutphin JE. Diagnosis of aspergillus keratitis in vivo with confocal microscopy. Cornea 1997;16:27-31.
107. Florakis GJ, Moazami G, Schubert H, et al. Scanning slit confocal microscopy of fungal keratitis. Arch Ophthalmol 1997;115:1461-3.
108. Kaufman SC, Laird JA, Cooper R, et al. Diagnosis of bacterial contact lens related keratitis with the white-light confocal microscope. CLAO J 1996;22:274-7.
109. Sutphin JE, Kantor AL, Mathers WD, et al. Evaluation of infectious crystalline keratitis with confocal microscopy in a case series. Cornea 1997;16:21-6.
110. Shah GK, Pfister D, Probst LE, et al. Diagnosis of microsporidial keratitis by confocol microscopy and the chromotrope stain. Am J Ophthalmol 1996;121:89-91.
111. Mathers WD, Nelson SE, Lane JL, et al. Confirmation of confocal microscopy diagnosis of acanthamoeba keratitis using polymerase chain reaction analysis. Arch Ophthalmol 2000;118:178-83.
112. Auran JD, Starr MB, Koester CJ, et al. In vivo scanning slit confocal microscopy of acanthamoeba keratitis. Cornea 1994;13:183-5.
113. Winchester K, Mathers WD, Sutphin JE, et al. Diagnosis of acanthamoeba keratitis in vivo with confocal microscopy. Cornea 1995;14:10-7.
114. Mathers WD, Goldberg MA, Sutphin JE, et al. Coexistent acanthamoeba keratitis and herpetic keratitis. Arch Ophthalmol 1997;115:714-8.
115. Kaldawy RM, Sutphin JE, Wagoner MD. Acanthamoeba keratitis after photorefractive keratectomy. J Cataract Refract Surg 2002;28:364-8.
116. Xie L, Shi W, Liu Z, et al. Lamellar keratoplasty for the treatment of fungal keratitis. Cornea 2002;21:33-7.
117. Linna T, Mikkilä H, Karma A, et al. In vivo confocal microscopy: a new possibility to confirm the diagnosis of borrelia keratitis? Cornea 1996;15:639-40.
118. Meier PA, Mathers WD, Sutphin JE, et al. An epidemic of presumed acanthamoeba keratitis that followed regional flooding: results of a case-control investigation. Arch Ophthalmol 1998;116:1090-4.
119. Dighiero P, Mayer F, Hernandez-Quintela E, et al. In vivo confocal microscopy of two patients with Thygeson's keratitis. J Fr Ophtalmol 1997;20:611-3.
120. Essepian JP, Rajpal R, O'Brien TP. Tandem scanning confocal microscopic analysis of ciprofloxacin corneal deposits in vivo. Cornea 1995;14:402-7.
121. Slowik C, Somodi S, Gruben Cv, et al. Detection of morphological corneal changes caused by chloroquine therapy using confocal in vivo microscopy. Ophthalmologe 1997;94:147-51.
122. Chiou AG-Y, Cadez R, Böhnke M. Diagnosis of dieffenbachia induced corneal injury by confocal microscopy. Br J Ophthalmol 1997;81:169.
123. Pleyer U, Baatz H, Hartmann C. Delayed mustard gas keratopathy: clinical findings and confocal microscopy. Am J Ophthalmol 1999;128:506-7.
124. Vesaluoma M, Müller L, Gallar J, et al. Effects of oleoresin capsicum pepper spray on human corneal morphology and sensitivity. Invest Ophthalmol Vis Sci 2000;41:2138-47.
125. Morishige N, Komatsubara T, Chikama T-i, et al. Direct observation of corneal nerve fibres in neurotrophic keratopathy by confocal biomicroscopy. Lancet 1999;354:1613-4.
126. Chiou AG-Y, Kaufman SC, Beuerman RW, et al. A confocal microscopic study of advancing wavelike epitheliopathy. Arch Ophthalmol 1999;117:126-7.
127. Frueh BE, Cadez R, Böhnke M. In vivo confocal microscopy after photorefractive keratectomy in humans. Arch Ophthalmol 1998;116:1425-31.
128. Mrukwa-Kominek E, Gierek-Lapinska A, Gierek-Ciaciura S, et al. Corneal scars - confocal images as the basis of qualifying for PTK or PK. Kiln Oczna 2001;103:29-34.
129. Frueh BE, Körner U, Böhnke M. Confocal microscopy of the cornea in patients with diabetes. Klin Monatsbl Augenheilkd 1995;206:317-9.
130. Chikama T, Sassa Y, Yanai R, et al. Confocal microscopic observation of increased light scattering at corneal epithelial basement membrane in diabetic patients. Invest Ophthalmol Vis Sci [ARVO abstract] 1998;39:S1031. (Abstract no 4763.)
131. Sultan G, Baudouin C, Auzerie O, et al. Cornea in Marfan disease: Orbscan and in vivo confocal microscopy analysis. Invest Ophthalmol Vis Sci 2002;43:1757-64.
132. Mastropasqua L, Carpineto P, Ciancaglini M, et al. In vivo confocal microscopy in primary congenital glaucoma with megalocornea. J Glaucoma 2002;11:83-9.
133. Lattanzio FA, Sheppard JD, Loose-Thurman PG, et al. Uveitis detection by confocal microscopy permits earlier institution of therapy following cataract surgery. Invest Ophthalmol Vis Sci [ARVO abstract] 2002;43:170. (Abstract no 4270.)
134. Linna T, Tervo T. Real-time confocal microscopic observations on human corneal nerves and wound healing after excimer laser photorefractive keratectomy. Curr Eye Res 1997;16:640-9.
135. Heinz P, Bodanowitz S, Wiegand W, et al. In vivo observation of corneal nerve regeneration after photorefractive keratectomy with a confocal videomicroscope. Get J Ophthalmol 1997;5:373-7.
136. Böhnke M, Schipper I, Thaer A. Confocal microscopy of the cornea after photorefractive keratectomy with the excimer laser. Klin Monatsbl Augenheilkd 1997;211:159-67.
137. Kauffmann T, Bodanowitz S, Hesse L, et al. Corneal reinnervation after photorefractive keratectomy and laser in situ keratomileusis: an in vivo study with a confocal videomicroscope. Ger J Ophthalmol 1997;5:508-12.
138. Böhnke M, Thaer A, Schipper I, Confocal microscopy reveals persisting stromal changes after myopic photorefractive keratectomy in zero haze corneas. Br J Ophthalmol 1998;82:1393-400.
139. Erie JC, Patel SV, McLaren JW, et al. Keratocyte density in vivo after photorefractive keratectomy in humans. Trans Am Ophthalmol Soc 1999;97:221-40.
140. Møller-Pedersen T, Cavanagh HD, Petroll WM, et al. Stromal wound healing explains refractive instability and haze development after photorefractive keratectomy: a 1-year confocal microscopic study. Ophthalmology 2000;107:1235-45.
141. Moilanen JAO, Vesaluoma MH, Vesti ET, et al. Photorefractive keratectomy in ophthalmic residents. J Refract Surg 2000;16:731-8.
142. Lee YG, Chen WYW, Petroll WM, et al. Corneal haze after photorefractive keratectomy using different epithelial removal techniques. Ophthalmology 2001;108:112-20.
143. Vinciguerra P, Torres I, Camesasca FI. Applications of confocal microscopy in refractive surgery. J Refract Surg 2002;18:S378-81.
144. Wilson SE, Kim W-J. Keratocyte apoptosis: implications on corneal wound healing, tissue organization, and disease. Invest Ophthalmol Vis Sci 1998;39:220-6.
145. Linna TU, Vesaluoma MH, Pérez-Santonja JJ, et al. Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves. Invest Ophthalmol Vis Sci 2000;41:393-7.
146. Vesaluoma MH, Petroll WM, Perez-Santonja JJ, et al. Laser in situ keratomileusis flap margin: wound healing and complications imaged by in vivo confocal microscopy. Am J Ophthalmol 2000;130:564-73.
147. Auzerie O, Pisella P-J, Bokobza Y, et al. Cornea stromal changes after LASIK. J Fr Ophtalmol 2002;25:9-14.
148. Gokmen F, Jester JV, Petroll WM, et al. In vivo confocal microscopy through-focusing to measure corneal flap thickness after laser in situ keratomileusis. J Cataract Refract Surg 2002;28:962-70.
149. Erie JC, Patel SV, McLaren JW, et al. Effect of myopic laser in situ keratomileusis on epithelial and stromal thickness. Ophthalmology 2002;109:1447-52.
150. Linna TU, Vesaluoma MH, Petroll WM, et al. Confocal microscopy of a patient with irregular astigmatism after LASIK reoperations and relaxation incisions. Cornea 2000;19:163-9.
151. Harrison DA, Periman LM. Diffuse lamellar keratitis associated with recurrent corneal erosions after laser in situ keratomileusis. J Refract Surg 2001;17:463-5.
152. Bühren J, Baumeister M, Kohnen T. Diffuse lamellar keratitis after laser in situ keratomileusis imaged by confocal microscopy. Ophthalmology 2001;108:1075-81.
153. Alió JL, Pérez-Santonja JJ, Tervo T, et al. Postoperative inflammation, microbial complications, and wound healing following laser in situ keratomileusis. J Refract Surg 2001;16:523-38.
154. Grupcheva CN, Malik TY, Craig JP, et al. In vivo confocal microscopy of corneal epithelial ingrowth through a laser in situ keratomileusis flap buttonhole. J Cataract Refract Surg 2001;27:1318-22.
155. Kohnen T, Bühren J, Baumeister M. Confocal microscopic imaging of reticular folds in a laser in situ keratomileusis flap. J Refract Surg 2001;17:689-91.
156. Bühren J, Baumeister M, Cichocki M, et al. Confocal microscopic characteristics of stage 1 to 4 diffuse lamellar keratitis after laser in situ keratomileusis. J Cataract Refract Surg 2002;28:1390-9.
157. Chung MS, Pepose JS, Al-Agha S, et al. Confocal microscopic findings in a case of delayed-onset bilateral diffuse lamellar keratitis after laser in situ keratomileusis. J Cataract Refract Surg 2002;28:1467-70.
158. Sachdev N, McGhee CN, Craig JP, et al. Epithelial defect, diffuse lamellar keratitis, and epithelial ingrowth following post-LASIK epithelial toxicity. J Cataract Refract Surg 2002;28:1463-6.
159. Ruckhofer J, Bohnke M, Alzner E, et al. Confocal microscopy after implantation of intrastromal corneal ring segments. Ophthalmology 2000;107:2144-51.
160. Lee JB, Seong GJ, Lee JH, et al. Comparison of laser epithelial keratomileusis and photorefractive keratectomy for low to moderate myopia. J Cataract Refract Surg 2001;27:565-70.
161. Slowik C, Somodi S, Richter A, et al. Confacal in vivo microscopy after 15 mm sclerocarneoplasty à chaud in necrotizing keratitis. Klin Monatsbl Augenheilkd 1996;208:246-50.
162. Richter A, Slowik C, Somodi S, et al. Corneal reinnervation following penetrating keratoplasty - correlation of esthesiometry and confocal microscopy. Ger J Ophthalmol 1997;5:513-7.
163. Richter A, Slowik C, Somodi S, et al. In vivo imaging of corneal innervation in the human using confocal microscopy. Ophthalmologe 1997;94:141-6.
164. Ehlers N, Ehlers H, Hjortdal J, et al. Grafting of the posterior cornea. Description of a new technique with 12-month clinical results. Acta Ophthalmol 2000;78:543-6.
165. Bourne WM. Cellular changes in transplanted human corneas. Cornea 2001;20:560-9.
166. Holden BA. The Glenn A. Fry award lecture 1988: the ocular response to contact lens wear. Optom Vis Sci 1988;66:717-33.
167. Bruce AS, Brennan NA. Corneal pathophysiology with contact lens wear. Surv Ophthalmol 1990;35:25-58.
168. Liesegang TJ. Physiologic changes of the cornea with contact lens wear. CLAO J 2002;28:12-27.
169. Efron N, Mutalib HA, Perez-Gomez I, et al. Confocal microscopic observations of the human cornea following overnight contact lens wear. Clin Exp Optom 2002;85:149-55.
170. Efron N, Perez-Gomez I, Morgan PB. Confocal microscopic observations of stromal keratocytes during extended contact lens wear. Clin Exp Optom 2002;85:156-60.
171. Böhnke M, Masters BR. Long-term contact lens wear induces a corneal degeneration with microdot deposits in the corneal stroma. Ophthalmology 1997;104:1887-96.
172. Jalbert I, Stapleton F. Effect of lens wear on corneal stroma: preliminary findings. Aust NZ J Ophthalmol 1999;27:211-3.
173. Sweeney DF, Keay L, Jalbert I, et al. Clinical performance of silicone hydrogel lenses. In: Sweeney D, ed. Silicone hydrogels: the rebirth of continuous wear contact lenses. Oxford: Butterworth-Heinemann, 2000:90-149.
174. Pritchard N, Jones L, Dumbleton K, et al. Epithelial inclusions in association with mucin ball development in high-oxygen permeability hydrogel lenses. Optom Vis Sci 2000;77:68-72.
175. Marsich MM, Bullimore MA. The repeatability of corneal thickness measures. Cornea 2000;19:792-5.
176. Wheeler NC, Morantes CM, Kristensen RM, et al. Reliability coefficients of three corneal pachymeters. Am J Ophthalmol 1992;113:645-51.
177. Ladage PM, Petroll WM, Jester JV, et al. Spherical indentations of human and rabbit corneal epithelium following extended contact lens wear. CLAO J 2002;28:177-80.