Improvements to the Sample Manipulation Design of a LEAP CTC HTS PAL Autosampler Used for High-Throughput Qualitative and Quantitative Liquid Chromatography-Mass Spectrometry Assays

JALA - Journal of the Association for Laboratory Automation

Volumn 12, Issue 3, 2007, Pages 152-156

  Drexler, Dieter M ^a   Edinger, Kurt J ^a   Mongillo, James J ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

autosampler; high throughput; LC MS

Indexed keywords

ASSAYS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

AUTOSAMPLER; SAMPLE MANIPULATION DESIGN;

SAMPLING;

POLITEF; SODIUM CHLORIDE;

ACCURACY; ARTICLE; DEVICE; DRUG ABSORPTION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG QUALITY; DRUG STABILITY; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; INJECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULE; PARTICULATE MATTER; PREDICTION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SAMPLE; SAMPLER; SYRINGE;

EID: 34248398078     PISSN: 15355535     EISSN: 15402452     Source Type: Journal    
DOI: 10.1016/j.jala.2007.01.002     Document Type: Article

References (8)

1. Herbst J.J., and Dickinson K. Automated high-throughput ADME-tox profiling for optimization of preclinical candidate success. Am. Pharma. Rev. 8 (2005) 96-101
2. Wunberg T., Hendrix M., Hillisch A., Lobell M., Meier H., Schmeck C., Wild H., and Hinzen B. Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits. Drug Discovery Today 11 (2006) 175-180
3. Atterwill C.K., and Wing M.G. In vitro preclinical lead optimisation technologies (PLOTs) in pharmaceutical development. Toxicol. Lett. 127 (2002) 143-151
4. Kerns E.H. High throughput physicochemical profiling for drug discovery. J. Pharm. Sci. 90 (2001) 1838-1858
5. Ackermann B.L., Berna M.J., and Murphy A.T. Recent advances in use of LC/MS/MS for quantitative high-throughput bioanalytical support of drug discovery. Curr. Top. Med. Chem. 2 (2002) 53-66
6. Jemal M. High-throughput quantitative bioanalysis by LC/MS/MS. Biomed. Chromatogr 14 (2000) 422-429
7. Drexler, D. M.; Belcastro, J. V.; Dickinson, K. E.; Edinger, K. J.; Hnatyshyn, S. Y.; Josephs, J. L.; Langish, R. A.; McNaney, C. A.; Santone, K. S.; Shipkova, P. A.; Tymiak, A. A.; Zvyaga, T. A.; Sanders, M. An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates. Assay Drug Dev. Technol., in press.
8. Polson C., Sarkar P., Incledon B., Raguvaran V., and Grant R. Optimization of protein precipitation based upon effectiveness of protein removal and ionization effect in liquid chromatography-tandem mass spectrometry. J. Chrom. B. 785 (2003) 263-275