In vitro preclinical lead optimisation technologies (PLOTs) in pharmaceutical development

Toxicology Letters

Volumn 127, Issue 1-3, 2002, Pages 143-151

  Atterwill, Christopher K ^a   Wing, Mark G ^a  

^a HUNTINGDON LIFE SCIENCES   (United Kingdom)

Author keywords

In vitro; Lead optimisation; Pharmaceuticals; Preclinical lead optimisation (PLOT)

Indexed keywords

DRUG;

CONFERENCE PAPER; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXCRETION; DRUG METABOLISM; DRUG SAFETY; HUMAN; NONHUMAN; PHARMACY; PHOTOTOXICITY; PRIORITY JOURNAL; SENSITIZATION; TOXICOLOGY;

ANIMALS; DRUG EVALUATION, PRECLINICAL; DRUGS, INVESTIGATIONAL; HUMANS; LEGISLATION, DRUG; MUTAGENICITY TESTS; PHARMACOGENETICS; TECHNOLOGY, PHARMACEUTICAL; TOXICOLOGY;

EID: 0037186905     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00494-5     Document Type: Conference Paper

References (7)

1. Review: Gene Expression Applied to Toxicology
2. Early toxic stress or genes-modulation and screening technologies
3. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
4. Validation of the SOS/umu test using test results of 486 chemicals and comparison with Ames test and carcinogenicity data