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1
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0002684311
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A specific breeding problem of sheep on subterranean clover pastures in Western Australia
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Bennetts HW, Underwood EJ, Shier FL. A specific breeding problem of sheep on subterranean clover pastures in Western Australia. Aust Vet J 1946; 22:2-13.
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Bennetts, H.W.1
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84970609692
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Failure of sperm transport in relation to ewe infertility following prolonged grazing on oestrogenic pastures
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Lightfoot RJ, Croker KP, Neil HG. Failure of sperm transport in relation to ewe infertility following prolonged grazing on oestrogenic pastures. Aust J Agric Res 1967; 18:755-765.
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Neil, H.G.3
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3
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33846647835
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Analysis of the interaction of phytoestrogens and synthetic chemical: An in vitro/in vivo comparison
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A comprehensive study of interactions between various environmental oestrogenic agents, including phytoestrogens, highlighting the caution needed when interpreting in-vitro data to in-vivo models
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Charles GD, Gennings C, Tornesi B, et al. Analysis of the interaction of phytoestrogens and synthetic chemical: An in vitro/in vivo comparison. Toxicol Appl Pharmacol 2007; 218:280-288. A comprehensive study of interactions between various environmental oestrogenic agents, including phytoestrogens, highlighting the caution needed when interpreting in-vitro data to in-vivo models.
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Toxicol Appl Pharmacol
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, pp. 280-288
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Charles, G.D.1
Gennings, C.2
Tornesi, B.3
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4
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24044475615
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Bioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteria
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Tsangalis D, Wilcox G, Shah NP, Stojanovska L. Bioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteria. Br J Nutr 2005; 93:867-877.
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Br J Nutr
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Tsangalis, D.1
Wilcox, G.2
Shah, N.P.3
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5
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33750590173
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Kotwica J, Wrobel M, Mlynarczuk J. The influence of polychlorinated biphenyls and phytoestrogens in vitro on functioning of reproductive tract in cow. Reprod Biol 2006; 6 (Suppl 1):189-194. A bovine study demonstrating polychlorobiphenol (PCB) inhibition of steroid production by ovarian granulosa and luteal cells. Genistein had a modulatory effect on this inhibition, reducing it significantly. PCBs also elicited myometrial contractions, again the response being reduced by coadministration with genistein.
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Kotwica J, Wrobel M, Mlynarczuk J. The influence of polychlorinated biphenyls and phytoestrogens in vitro on functioning of reproductive tract in cow. Reprod Biol 2006; 6 (Suppl 1):189-194. A bovine study demonstrating polychlorobiphenol (PCB) inhibition of steroid production by ovarian granulosa and luteal cells. Genistein had a modulatory effect on this inhibition, reducing it significantly. PCBs also elicited myometrial contractions, again the response being reduced by coadministration with genistein.
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8
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27744591008
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Effect of pure genistein on bone markers and hot flushes
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Albertazzi P, Steel SA, Bottazzi M. Effect of pure genistein on bone markers and hot flushes. Climacteric 2005; 8:371-379.
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Climacteric
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Albertazzi, P.1
Steel, S.A.2
Bottazzi, M.3
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9
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33646535267
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Mathey J, Lamothe V, Coxam V, et al. Concentrations of isoflavones in plasma and urine of postmenopausal women chronically ingesting high quantities of soy isoflavones. J Pharm Biomed Anal 2006; 41:957-965. An important dietary study highlighting the ultimate difficulty in extrapolating in-vitro studies of phytoestrogens to in-vivo situations. A controlled concentration of phytoestrogen taken orally results in a wide intra-population range of plasma and urine levels, reflecting varying metabolic processes and rates.
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Mathey J, Lamothe V, Coxam V, et al. Concentrations of isoflavones in plasma and urine of postmenopausal women chronically ingesting high quantities of soy isoflavones. J Pharm Biomed Anal 2006; 41:957-965. An important dietary study highlighting the ultimate difficulty in extrapolating in-vitro studies of phytoestrogens to in-vivo situations. A controlled concentration of phytoestrogen taken orally results in a wide intra-population range of plasma and urine levels, reflecting varying metabolic processes and rates.
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10
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32944479494
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Critical review of health effects of soyabean phyto-oestrogens in postmenopausal women
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There is a focus on the actions in postmenopausal women
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Cassidy A, Albertazzi P, Lise Nielsen I, et al. Critical review of health effects of soyabean phyto-oestrogens in postmenopausal women. Proc Nutr Soc 2006; 65:76-92. A comprehensive review of the multiple sites of action of phytoestrogens, and a critical analysis of the evidence for each postulated site of action, highlighting where further studies are required. There is a focus on the actions in postmenopausal women.
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Proc Nutr Soc 2006; 65:76-92. A comprehensive review of the multiple sites of action of phytoestrogens, and a critical analysis of the evidence for each postulated site of action, highlighting where further studies are required
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Cassidy, A.1
Albertazzi, P.2
Lise Nielsen, I.3
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11
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31544470047
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Cassidy A, Brown JE, Hawdon A, et al. Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J Nutr 2006; 136:45-51. A dietary study examining the intra-subject differences in metabolism of different sources of phytoestrogens, including resultant serum concentrations and equol production.
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Cassidy A, Brown JE, Hawdon A, et al. Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J Nutr 2006; 136:45-51. A dietary study examining the intra-subject differences in metabolism of different sources of phytoestrogens, including resultant serum concentrations and equol production.
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12
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33750047535
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Identification of estrogen-regulated genes by microarray analysis of the uterus of immature rats exposed to endocrine disrupting chemicals
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Exposure of the rodent uterine cells to genistein, and other oestrogenic compounds, upregulates the expression of oestrogen-sensitive genes, measured by microarray
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Hong EJ, Park SH, Choi KC, et al. Identification of estrogen-regulated genes by microarray analysis of the uterus of immature rats exposed to endocrine disrupting chemicals. Reprod Biol Endocrinol 2006; 29:49. Exposure of the rodent uterine cells to genistein, and other oestrogenic compounds, upregulates the expression of oestrogen-sensitive genes, measured by microarray.
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(2006)
Reprod Biol Endocrinol
, vol.29
, pp. 49
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Hong, E.J.1
Park, S.H.2
Choi, K.C.3
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13
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33744825972
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Power KA, Ward WE, Chen JM, et al. Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model. Bone 2006; 39:117-124. This paper focuses on the oestrogenic properties of genistein in bone and the uterus, as well as those of diadzein and enterolactone. The results highlight the importance of analysing the interaction of phytoestrogens and the resultant effect on their oestrogenic potencies.
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Power KA, Ward WE, Chen JM, et al. Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model. Bone 2006; 39:117-124. This paper focuses on the oestrogenic properties of genistein in bone and the uterus, as well as those of diadzein and enterolactone. The results highlight the importance of analysing the interaction of phytoestrogens and the resultant effect on their oestrogenic potencies.
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14
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33748169273
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Effect of genistein on steroidogenic response of granulosa cell populations from porcine preovulatory follicles
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This paper presents an in-vitro porcine model of ovarian granulosa cells, and demonstrates inhibition of progesterone but not oestradiol secretion after coculture with genistein
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Nynca A, Ciereszko RE. Effect of genistein on steroidogenic response of granulosa cell populations from porcine preovulatory follicles. Reprod Biol 2006; 6:31-50. This paper presents an in-vitro porcine model of ovarian granulosa cells, and demonstrates inhibition of progesterone but not oestradiol secretion after coculture with genistein.
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(2006)
Reprod Biol
, vol.6
, pp. 31-50
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Nynca, A.1
Ciereszko, R.E.2
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15
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33750723146
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Jefferson WN, Padilla-Banks E, Newbold RR. Studies of the effects of neonatal exposure to genistein on the developing female reproductive system. J AOAC 2006; 89:1189-1196. A murine study demonstrating that neonatal genistein disrupts ovarian function, with a dose-response curve showing increased numbers of corpora lutea in response to low-dose genistein and decreased numbers in response to a high dose. In support of previous studies by the same group, doses of genistein comparable to those ingested by the general population could be disruptive to ovarian function and consequent reproductive ability.
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Jefferson WN, Padilla-Banks E, Newbold RR. Studies of the effects of neonatal exposure to genistein on the developing female reproductive system. J AOAC 2006; 89:1189-1196. A murine study demonstrating that neonatal genistein disrupts ovarian function, with a dose-response curve showing increased numbers of corpora lutea in response to low-dose genistein and decreased numbers in response to a high dose. In support of previous studies by the same group, doses of genistein comparable to those ingested by the general population could be disruptive to ovarian function and consequent reproductive ability.
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16
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0037399936
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Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality in mice
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Fielden MR, Samy SM, Chou KC, Zacharewski TR. Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality in mice. Food Chem Toxicol 2003; 41:447-454.
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Fielden, M.R.1
Samy, S.M.2
Chou, K.C.3
Zacharewski, T.R.4
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17
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0029551645
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Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production
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Sharpe RM, Fisher JS, Millar MM, et al. Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Environ Health Perspect 1995; 103:1136-1143.
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Sharpe, R.M.1
Fisher, J.S.2
Millar, M.M.3
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18
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6344226550
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Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes
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Wang Y, Thuillier R, Culty M. Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes. Biol Reprod 2004; 71:1652-1664.
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Wang, Y.1
Thuillier, R.2
Culty, M.3
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19
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27744472489
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Effects of phytoestrogens genistein and daidzein on production of human chorionic gonadotropin in term trophoblast cells in vitro
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Jeschke U, Briese V, Richter DU, et al. Effects of phytoestrogens genistein and daidzein on production of human chorionic gonadotropin in term trophoblast cells in vitro. Gynecol Endocrinol 2005; 21:180-184.
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Jeschke, U.1
Briese, V.2
Richter, D.U.3
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20
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33144467452
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Soucy NV, Parkinson HD, Sochaski MA, Borghoff S. Kinetics of genistein and its conjugated metabolites in pregnant Sprague-Dawley rats following single and repeated genistein administration. Toxicol Sci 2006; 90:230-240. An analysis of genistein metabolism in pregnant rodents, and the transfer of metabolites across the placenta. The results suggest that there is limited materno-placental transfer and, as such, the placenta could be a target organ of genistein.
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Soucy NV, Parkinson HD, Sochaski MA, Borghoff S. Kinetics of genistein and its conjugated metabolites in pregnant Sprague-Dawley rats following single and repeated genistein administration. Toxicol Sci 2006; 90:230-240. An analysis of genistein metabolism in pregnant rodents, and the transfer of metabolites across the placenta. The results suggest that there is limited materno-placental transfer and, as such, the placenta could be a target organ of genistein.
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21
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23744472139
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Fetal exposure to phytoestrogens - the difference in phytoestrogen status between mother and fetus
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Todaka E, Sakurai K, Fukata H, et al. Fetal exposure to phytoestrogens - the difference in phytoestrogen status between mother and fetus. Environ Res 2005; 99:195-203.
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Todaka, E.1
Sakurai, K.2
Fukata, H.3
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22
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33144461678
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Transplacental transfer of genistein and conjugated metabolites in Sprague-Dawley rats
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Borghoff S, Williams CC, Parkinson HD, Upmeier A. Transplacental transfer of genistein and conjugated metabolites in Sprague-Dawley rats. Toxicologist 2003; 71 (S-1):147.
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Toxicologist
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Borghoff, S.1
Williams, C.C.2
Parkinson, H.D.3
Upmeier, A.4
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23
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0036192766
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Transplacental transfer of the phytoestrogen daidzein in da/han rats
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Degen GH, Janning P, Diel P, et al. Transplacental transfer of the phytoestrogen daidzein in da/han rats. Arch Toxicol 2002; 76:23-29.
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24
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0035037554
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Doerge DR, Churchwell MI, Chang HC, et al. Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague-Dawley rats. Reprod Toxicol 2001; 15:105-110.
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Doerge DR, Churchwell MI, Chang HC, et al. Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague-Dawley rats. Reprod Toxicol 2001; 15:105-110.
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25
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Placental nutrient transfer and fetal growth
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Jansson T, Powell TL. Placental nutrient transfer and fetal growth. Nutrition 2000; 16:500-502.
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Jansson, T.1
Powell, T.L.2
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26
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30044436575
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Xenobiotic phenols in early pregnancy amniotic fluid
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An epidemiological study confirming phytoestrogens are present in amniotic fluid
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Engel SM, Levy B, Liu Z, et al. Xenobiotic phenols in early pregnancy amniotic fluid. Reprod Toxicol 2006; 21:110-112. An epidemiological study confirming phytoestrogens are present in amniotic fluid.
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Reprod Toxicol
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, pp. 110-112
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Engel, S.M.1
Levy, B.2
Liu, Z.3
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27
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33748746424
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Padilla-Banks E, Jefferson WN, Newbold RR. Neonatal exposure to the phytoestrogen genistein alters mammary gland growth and developmental programming of hormone receptor levels. Endocrinology 2006; 147:4871-4882. Another study highlighting the difficulties in defining the oestrogenic properties of phytoestrogens. The authors show a biphasic dose-response curve after neonatal genistein. Low-dose genistein resulted in inhibition of mammary gland development while high-dose genistein promoted development. The former was accompanied by increased expression of progesterone and oestrogen receptor beta expression while the latter group exhibited morphological alterations to mammary gland tissue through to adulthood.
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Padilla-Banks E, Jefferson WN, Newbold RR. Neonatal exposure to the phytoestrogen genistein alters mammary gland growth and developmental programming of hormone receptor levels. Endocrinology 2006; 147:4871-4882. Another study highlighting the difficulties in defining the oestrogenic properties of phytoestrogens. The authors show a biphasic dose-response curve after neonatal genistein. Low-dose genistein resulted in inhibition of mammary gland development while high-dose genistein promoted development. The former was accompanied by increased expression of progesterone and oestrogen receptor beta expression while the latter group exhibited morphological alterations to mammary gland tissue through to adulthood.
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28
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33746874872
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Tousen Y, Umeki M, Nakashima Y, et al. Effects of genistein, an isoflavone, on pregnancy outcome and organ weights of pregnant and lactating rats and development of their suckling pups. J Nutr Sci Vitaminol (Tokyo) 2006; 52:174-182. Neonatal dietary genistein had no effect on rodent pregnancy outcomes, or the growth and development of the offspring. Nevertheless, the authors highlight the fact that many other studies have shown adverse effects of neonatal genistein, and emphasize the necessity of further study.
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Tousen Y, Umeki M, Nakashima Y, et al. Effects of genistein, an isoflavone, on pregnancy outcome and organ weights of pregnant and lactating rats and development of their suckling pups. J Nutr Sci Vitaminol (Tokyo) 2006; 52:174-182. Neonatal dietary genistein had no effect on rodent pregnancy outcomes, or the growth and development of the offspring. Nevertheless, the authors highlight the fact that many other studies have shown adverse effects of neonatal genistein, and emphasize the necessity of further study.
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29
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33645889363
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Altered mammary gland development in male rats exposed to genistein and methoxyclor
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A long-term dietary rodent study showing the biphasic genistein dose-response curve
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Wang XJ, Bartolucci-Page E, Fenton SE, You L. Altered mammary gland development in male rats exposed to genistein and methoxyclor. Toxicol Sci 2006; 91:93-103. A long-term dietary rodent study showing the biphasic genistein dose-response curve.
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Toxicol Sci
, vol.91
, pp. 93-103
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Wang, X.J.1
Bartolucci-Page, E.2
Fenton, S.E.3
You, L.4
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30
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32944481234
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Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV
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A rodent neurophysiological study demonstrating feminization of the male anteroventral periventricular nucleus of the hypothalamus (AVPV) and defeminization of oestrogen receptor and thyroid hormone receptor expression
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Patisaul HB, Fortino AE, Polston EK. Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV. Neurotoxicol Teratol 2006; 28:111-118. A rodent neurophysiological study demonstrating feminization of the male anteroventral periventricular nucleus of the hypothalamus (AVPV) and defeminization of oestrogen receptor and thyroid hormone receptor expression.
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Neurotoxicol Teratol
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, pp. 111-118
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Patisaul, H.B.1
Fortino, A.E.2
Polston, E.K.3
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Fraser LR, Beyret R, Milligan SR, Adeoya-Osiguwa SA. Effects of estrogenic xenobiotics on human and mouse spermatozoa. Hum Reprod 2006; 21:1184-1193. In-vitro studies showing genistein accelerates capacitation and the acrosome reaction in both murine and human sperm, thus rendering those sperm unable to fertilize ova. It is suggested that genistein and diadzein act by stimulating cAMP production. When administered together, and mimicking the likely situation in vivo, the phytoestrogens elicit a stronger response, thus reinforcing the importance of further research in this area.
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Fraser LR, Beyret R, Milligan SR, Adeoya-Osiguwa SA. Effects of estrogenic xenobiotics on human and mouse spermatozoa. Hum Reprod 2006; 21:1184-1193. In-vitro studies showing genistein accelerates capacitation and the acrosome reaction in both murine and human sperm, thus rendering those sperm unable to fertilize ova. It is suggested that genistein and diadzein act by stimulating cAMP production. When administered together, and mimicking the likely situation in vivo, the phytoestrogens elicit a stronger response, thus reinforcing the importance of further research in this area.
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32
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Human sperm plasma membrane progesterone receptor(s) and the acrosome reaction
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Identification and characterization of a novel functional estrogen receptor on human sperm membrane that interferes with progesterone effects
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Effects of estrogenic compounds on human spermatozoa: Evidence for interaction with a nongenomic receptor for estrogen on human sperm membrane
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Forti, G.3
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Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II
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Requirement of protein tyrosine kinase and phosphatase activities for human sperm exocytosis
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33644778746
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Heparin- and superoxide aniondependent capacitation of cryopreserved bovine spermatozoa: Requirement of dehydrogenases and protein kinases
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A molecular study into the intracellular mechanisms involved in the redox status of sperm cells, and changes during capacitation and the acrosome reaction, using genistein as a test tyrosine kinase inhibitor
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O'Flaherty C, Beorlegui N, Beconi MT. Heparin- and superoxide aniondependent capacitation of cryopreserved bovine spermatozoa: Requirement of dehydrogenases and protein kinases. Free Radic Res 2006; 40:427-432. A molecular study into the intracellular mechanisms involved in the redox status of sperm cells, and changes during capacitation and the acrosome reaction, using genistein as a test tyrosine kinase inhibitor.
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Newbold RR, Padilla-Banks E, Jefferson WN. Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology 2006; 147 (Supp 6):S11-S17. An important in-vivo study demonstrating that perinatal diethylstilbestrol can induce neoplasia of uterine cells in later life and can also increase the incidence of uterine tumours in subsequent generations, highlighting the importance of accumulation studies on phytoestrogens, and also the relevance of longitudinal dietary studies.
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Newbold RR, Padilla-Banks E, Jefferson WN. Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology 2006; 147 (Supp 6):S11-S17. An important in-vivo study demonstrating that perinatal diethylstilbestrol can induce neoplasia of uterine cells in later life and can also increase the incidence of uterine tumours in subsequent generations, highlighting the importance of accumulation studies on phytoestrogens, and also the relevance of longitudinal dietary studies.
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40
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A high hypospadias rate in the Netherlands
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