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Volumn 17, Issue 5, 2007, Pages 521-532

Topoisomerase inhibitors as therapeutic weapons

Author keywords

Antibacteria; Anticancer chemotherapy; Antifungi; Antiprotozoa; DNA topoisomerases; Topoisomerase inhibitors

Indexed keywords

1,2 BIS(3,5 DIOXOPIPERAZIN 1 YL)ETHANE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ACLARUBICIN; AMSACRINE; ANTHRACYCLINE DERIVATIVE; ANTHRAQUINONE; BERBERINE; CAMPTOTHECIN; DAUNORUBICIN; DIMINAZENE ACETURATE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; EDOTECARIN; EPIPODOPHYLLOTOXIN DERIVATIVE; ETOPOSIDE; GIMATECAN; HOE 33342; IRINOTECAN; LUTEOLIN; MERBARONE; MITOXANTRONE; N (2 DIMETHYLAMINOETHYL) 4 ACRIDINECARBOXAMIDE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RAZOXANE; SURAMIN; TENIPOSIDE; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; XR 5000;

EID: 34248374799     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.17.5.521     Document Type: Review
Times cited : (10)

References (60)
  • 1
    • 33749658088 scopus 로고    scopus 로고
    • Topoisomerase enzymes as therapeutic targets for cancer chemotherapy
    • GILES GI, SHARMA RP: Topoisomerase enzymes as therapeutic targets for cancer chemotherapy. Med. Chem. (2005) 1(4):383-394.
    • (2005) Med. Chem , vol.1 , Issue.4 , pp. 383-394
    • GILES, G.I.1    SHARMA, R.P.2
  • 2
    • 33745843716 scopus 로고    scopus 로고
    • BALAÑA-FOUCE R, REDONDO CM, PÉREZ-PERTEJO Y, DÍAZ-GONZÁLEZ R, REGUERA RM: Targeting atypical trypanosomatid DNA topoisomerase I. Drug Discov. Today (2006) 11(15,16):733-740.
    • BALAÑA-FOUCE R, REDONDO CM, PÉREZ-PERTEJO Y, DÍAZ-GONZÁLEZ R, REGUERA RM: Targeting atypical trypanosomatid DNA topoisomerase I. Drug Discov. Today (2006) 11(15,16):733-740.
  • 4
    • 0344861938 scopus 로고    scopus 로고
    • Bufalin influences the repair of X-ray-induced DNA breaks in Chinese hamster cells
    • PASTOR N, CORTÉS F: Bufalin influences the repair of X-ray-induced DNA breaks in Chinese hamster cells. DNA Repair (2003) 2:1353-1360.
    • (2003) DNA Repair , vol.2 , pp. 1353-1360
    • PASTOR, N.1    CORTÉS, F.2
  • 5
    • 34248359723 scopus 로고    scopus 로고
    • Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction
    • HAYASHI S, HATASHITA M, MATSUMOTO H, SHIOURA H, KITAI R, KANO E: Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction. Int. J. Mol. Med. (2006) 18(5):909-915.
    • (2006) Int. J. Mol. Med , vol.18 , Issue.5 , pp. 909-915
    • HAYASHI, S.1    HATASHITA, M.2    MATSUMOTO, H.3    SHIOURA, H.4    KITAI, R.5    KANO, E.6
  • 6
    • 0037340490 scopus 로고    scopus 로고
    • Induction of endoreduplication by topoisomerase II catalytic inhibitors
    • CORTÉS F, PASTOR N: Induction of endoreduplication by topoisomerase II catalytic inhibitors. Mutagenesis (2003)18:105-112.
    • (2003) Mutagenesis , vol.18 , pp. 105-112
    • CORTÉS, F.1    PASTOR, N.2
  • 7
    • 0037219218 scopus 로고    scopus 로고
    • Roles of DNA topoisomerases in chromosome segregation and mitosis
    • CORTÉS F, PASTOR N, MATEOS S, DOMÍNGUEZ I: Roles of DNA topoisomerases in chromosome segregation and mitosis. Mútat. Res. (2003) 543:59-66.
    • (2003) Mútat. Res , vol.543 , pp. 59-66
    • CORTÉS, F.1    PASTOR, N.2    MATEOS, S.3    DOMÍNGUEZ, I.4
  • 8
    • 0023275078 scopus 로고
    • Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse and Chinese hamster ovary cells
    • SULLIVAN DM, LATHAM MD, ROSS WE: Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse and Chinese hamster ovary cells. Cancer Res. (1987) 47:3973-3979.
    • (1987) Cancer Res , vol.47 , pp. 3973-3979
    • SULLIVAN, D.M.1    LATHAM, M.D.2    ROSS, W.E.3
  • 9
    • 0024316466 scopus 로고
    • DNA topoisomerase poisons as antitumor drugs
    • LIU LF: DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem. (1989) 58:351-375.
    • (1989) Annu. Rev. Biochem , vol.58 , pp. 351-375
    • LIU, L.F.1
  • 10
    • 0032190561 scopus 로고    scopus 로고
    • Mechanisln of action of eukaryotic topoisnmerase II and drugs targeted to the enzyme
    • BURDEN DA, OSHEROFF N: Mechanisln of action of eukaryotic topoisnmerase II and drugs targeted to the enzyme. Biochim. Biophys. Acta. (1998) 1400:139-154.
    • (1998) Biochim. Biophys. Acta , vol.1400 , pp. 139-154
    • BURDEN, D.A.1    OSHEROFF, N.2
  • 11
    • 0030014783 scopus 로고    scopus 로고
    • DNA topoisomerases
    • WANG JC: DNA topoisomerases. Annu. Rev. Biochem. (1996) 65:635-692.
    • (1996) Annu. Rev. Biochem , vol.65 , pp. 635-692
    • WANG, J.C.1
  • 12
    • 0023102418 scopus 로고
    • Sequence dependence of Drosophila topoisomerase II in plasmid relaxation and DNA binding
    • SANDER M, HSIEH T, UDVARDY A, SCHEDL P: Sequence dependence of Drosophila topoisomerase II in plasmid relaxation and DNA binding. J. Mol. Biol. (1987) 194:219-229.
    • (1987) J. Mol. Biol , vol.194 , pp. 219-229
    • SANDER, M.1    HSIEH, T.2    UDVARDY, A.3    SCHEDL, P.4
  • 13
    • 0023902435 scopus 로고
    • A consensus sequence for cleavage by vertebrate DNA topoisomcrase II
    • SPITZNER JR, MULLER MT: A consensus sequence for cleavage by vertebrate DNA topoisomcrase II. Nucleic Acids Res. (1988) 16:5533-5556.
    • (1988) Nucleic Acids Res , vol.16 , pp. 5533-5556
    • SPITZNER, J.R.1    MULLER, M.T.2
  • 14
    • 0024849694 scopus 로고
    • Nuclease protection by Drosophila DNA topoisomerase II. Enzylne/DNA contacts at the strong topoisomerase II cleavage sites
    • LEE MP, SANDER M, HSIEH T: Nuclease protection by Drosophila DNA topoisomerase II. Enzylne/DNA contacts at the strong topoisomerase II cleavage sites. J. Biol. Chem. (1989) 264:21779-21787.
    • (1989) J. Biol. Chem , vol.264 , pp. 21779-21787
    • LEE, M.P.1    SANDER, M.2    HSIEH, T.3
  • 15
    • 0026349046 scopus 로고
    • Distribution of topoisonterase II cleavage sites in simian virus 40 DNA and the effects of drugs
    • POMMIER Y, CAPRANICO G, ORR A, KOHN KW: Distribution of topoisonterase II cleavage sites in simian virus 40 DNA and the effects of drugs. J. Mol. Biol. (1991) 222:909-924.
    • (1991) J. Mol. Biol , vol.222 , pp. 909-924
    • POMMIER, Y.1    CAPRANICO, G.2    ORR, A.3    KOHN, K.W.4
  • 16
    • 11444267240 scopus 로고    scopus 로고
    • The impact of tumor physiology on camptothecin-based drug development
    • ADAMS DJ: The impact of tumor physiology on camptothecin-based drug development. Curr. Med. Chem. Anticancer Agents (2005) 5:1-13.
    • (2005) Curr. Med. Chem. Anticancer Agents , vol.5 , pp. 1-13
    • ADAMS, D.J.1
  • 17
    • 19144361907 scopus 로고    scopus 로고
    • Camptothecin and its analogues: A review on their chemotherapeutic potential
    • SRIRAM D, YOGEESWARI P, THIRUMURUGAN R, BAL TR: Camptothecin and its analogues: a review on their chemotherapeutic potential. Nat. Prod. Res. (2005) 19(4):393-412.
    • (2005) Nat. Prod. Res , vol.19 , Issue.4 , pp. 393-412
    • SRIRAM, D.1    YOGEESWARI, P.2    THIRUMURUGAN, R.3    BAL, T.R.4
  • 19
    • 33749034730 scopus 로고    scopus 로고
    • Topoisomerase 1 inhibitors: Camptothecins and beyond
    • POMMIER Y: Topoisomerase 1 inhibitors: camptothecins and beyond. Nat. Rev. Cancer (2006) 6(10):789-802.
    • (2006) Nat. Rev. Cancer , vol.6 , Issue.10 , pp. 789-802
    • POMMIER, Y.1
  • 20
    • 33644626203 scopus 로고    scopus 로고
    • Activity of novel cytotoxic agents in lung cancer: Epothilones and topoisomerase I inhibitors
    • WAKELEE HA, SIKIC BI: Activity of novel cytotoxic agents in lung cancer: epothilones and topoisomerase I inhibitors. Clin. Lung Cancer (2005) 7(Suppl. 1):S6-S12.
    • (2005) Clin. Lung Cancer , vol.7 , Issue.SUPPL. 1
    • WAKELEE, H.A.1    SIKIC, B.I.2
  • 21
    • 21844454211 scopus 로고    scopus 로고
    • Edotecarin: A novel topoisomerase I inhibitor
    • SAIF MW, DIASIO RB: Edotecarin: a novel topoisomerase I inhibitor. Clin. Colorectal Cancer (2005) 5(1):27-36.
    • (2005) Clin. Colorectal Cancer , vol.5 , Issue.1 , pp. 27-36
    • SAIF, M.W.1    DIASIO, R.B.2
  • 22
    • 0028174984 scopus 로고
    • DNA topoisomerases: Essential enzymes and lethal targets
    • CHEN AY, LIU LF: DNA topoisomerases: essential enzymes and lethal targets. Annu. Rev. Pharmacol. Toxicol. (1994) 34:191-218.
    • (1994) Annu. Rev. Pharmacol. Toxicol , vol.34 , pp. 191-218
    • CHEN, A.Y.1    LIU, L.F.2
  • 23
    • 0029144134 scopus 로고
    • Topoisomerase poisons: Harnessing the dark side of enzyme mechanism
    • FROELICH-AMMON SJ, OSHEROFF N: Topoisomerase poisons: harnessing the dark side of enzyme mechanism. J. Biol. Chem. (1995) 270:21429-21432.
    • (1995) J. Biol. Chem , vol.270 , pp. 21429-21432
    • FROELICH-AMMON, S.J.1    OSHEROFF, N.2
  • 24
    • 0029038757 scopus 로고
    • Mechanism of action of DNA topoisomerase inhibitors
    • BINASCHI M, ZUNINO F, CAPRANICO G: Mechanism of action of DNA topoisomerase inhibitors. Stem Cells (1995) 13:369-379.
    • (1995) Stem Cells , vol.13 , pp. 369-379
    • BINASCHI, M.1    ZUNINO, F.2    CAPRANICO, G.3
  • 25
    • 0029944106 scopus 로고    scopus 로고
    • Antitopoisomerase drug action and resistance
    • NITISS JL, BECK WT: Antitopoisomerase drug action and resistance. Eur. J. Cancer (1996) 32A:958-966.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 958-966
    • NITISS, J.L.1    BECK, W.T.2
  • 26
    • 0032189962 scopus 로고    scopus 로고
    • Catalytic inhibitors of DNA topoisomerase II
    • ANDOH T, ISHIDA R: Catalytic inhibitors of DNA topoisomerase II. Biochim. Biophys. Acta. (1998) 1400:155-171.
    • (1998) Biochim. Biophys. Acta , vol.1400 , pp. 155-171
    • ANDOH, T.1    ISHIDA, R.2
  • 28
    • 0027140482 scopus 로고
    • Weniposide-resistant CEM cells, which express mutant DNA topoisomerase IIα, when treated with non-complex-stabilizing inhibitors of the enzyme, display no cross-resistance and reveal aberrant functions of the mutant enzyme
    • CHEN M, BECK WT: Weniposide-resistant CEM cells, which express mutant DNA topoisomerase IIα, when treated with non-complex-stabilizing inhibitors of the enzyme, display no cross-resistance and reveal aberrant functions of the mutant enzyme. Cancer Res. (1993) 53(24):5946-5953.
    • (1993) Cancer Res , vol.53 , Issue.24 , pp. 5946-5953
    • CHEN, M.1    BECK, W.T.2
  • 30
    • 0025298540 scopus 로고
    • Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4′-(9-acridinylamino)-methanesulfon-m-anisidide in human small cell lung cancer cell lines and on topoisomerase II-mediated DNA cleavage
    • JENSEN PB, SØRENSON BS, DEMANT EJ et al.: Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4′-(9-acridinylamino)-methanesulfon-m-anisidide in human small cell lung cancer cell lines and on topoisomerase II-mediated DNA cleavage. Cancer Res. (1990) 50:3311-3316.
    • (1990) Cancer Res , vol.50 , pp. 3311-3316
    • JENSEN, P.B.1    SØRENSON, B.S.2    DEMANT, E.J.3
  • 31
    • 0024329909 scopus 로고
    • In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone
    • DRAKE FH, HOFMANN GA, MONG SM et al.: In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone. Cancer Res. (1989) 49:2578-2583.
    • (1989) Cancer Res , vol.49 , pp. 2578-2583
    • DRAKE, F.H.1    HOFMANN, G.A.2    MONG, S.M.3
  • 33
    • 0025265912 scopus 로고
    • Abrogation by novobiocin of cytotoxicity due to the topoisomerase II inhibitor amsacrine in Chinese hamster cells
    • UTSUMI H, SHIBUYA ML, KOSAKA T, BUDDENBAUM WE, ELKIND MM: Abrogation by novobiocin of cytotoxicity due to the topoisomerase II inhibitor amsacrine in Chinese hamster cells. Cancer Res. (1990) 50:2577-2581.
    • (1990) Cancer Res , vol.50 , pp. 2577-2581
    • UTSUMI, H.1    SHIBUYA, M.L.2    KOSAKA, T.3    BUDDENBAUM, W.E.4    ELKIND, M.M.5
  • 34
    • 0034695444 scopus 로고    scopus 로고
    • A novel mechanism of cell killing by antitopoisomerase II bis-dioxopiperazines
    • JENSEN LH, NITISS KC, ROSE A et al.: A novel mechanism of cell killing by antitopoisomerase II bis-dioxopiperazines. J. Biol. Chem. (2000) 275:2137-2146.
    • (2000) J. Biol. Chem , vol.275 , pp. 2137-2146
    • JENSEN, L.H.1    NITISS, K.C.2    ROSE, A.3
  • 35
    • 0035976924 scopus 로고    scopus 로고
    • Topoisomerase II poisoning by ICRF-193
    • HUANG KC, GAO H, YAMASAKI EF et al.: Topoisomerase II poisoning by ICRF-193. J. Biol. Chem. (2001) 276:44488-44494.
    • (2001) J. Biol. Chem , vol.276 , pp. 44488-44494
    • HUANG, K.C.1    GAO, H.2    YAMASAKI, E.F.3
  • 36
    • 0141892891 scopus 로고    scopus 로고
    • DNA strand breaks induced by the antitopoisomerase II bis-dioxopiperazine ICRF-193
    • HAJJI N, PASTOR N, MATEOS S, DOMINGUEZ I, CORTÉS F: DNA strand breaks induced by the antitopoisomerase II bis-dioxopiperazine ICRF-193. Mutat. Res. (2003) 530:35-46.
    • (2003) Mutat. Res , vol.530 , pp. 35-46
    • HAJJI, N.1    PASTOR, N.2    MATEOS, S.3    DOMINGUEZ, I.4    CORTÉS, F.5
  • 37
    • 0028068128 scopus 로고
    • Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured CHO cells
    • CORTÉS F, PIÑERO J: Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured CHO cells. Cancer Chemother. Pharmacol. (1994) 34:411-415.
    • (1994) Cancer Chemother. Pharmacol , vol.34 , pp. 411-415
    • CORTÉS, F.1    PIÑERO, J.2
  • 38
    • 0038615843 scopus 로고    scopus 로고
    • Dual topoisomerase I/II inhibitors in cancer therapy
    • DENNY WA, BAGULEY BC: Dual topoisomerase I/II inhibitors in cancer therapy. Curr. Top. Med. Chem. (2003) 3(3):339-353.
    • (2003) Curr. Top. Med. Chem , vol.3 , Issue.3 , pp. 339-353
    • DENNY, W.A.1    BAGULEY, B.C.2
  • 39
    • 0037304851 scopus 로고    scopus 로고
    • Phase II study of XR 5000(DACA), an inhibitor of topoisomerase I and II, administered as a 120 h infusion in patients with non-small cell lung cancer
    • DITTRICH C, COUDERT B, PAZ-ARES L et al.: Phase II study of XR 5000(DACA), an inhibitor of topoisomerase I and II, administered as a 120 h infusion in patients with non-small cell lung cancer. Eur. J. Cancer (2003) 39(3):330-334.
    • (2003) Eur. J. Cancer , vol.39 , Issue.3 , pp. 330-334
    • DITTRICH, C.1    COUDERT, B.2    PAZ-ARES, L.3
  • 40
    • 0025303197 scopus 로고
    • Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II
    • WASSERMANN K, MARKOVITS J, JAXEL C, CAPRANICO G, KOHN KW, POMMIER Y: Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II. Mol. Pharmacol. (1990) 38:38-45.
    • (1990) Mol. Pharmacol , vol.38 , pp. 38-45
    • WASSERMANN, K.1    MARKOVITS, J.2    JAXEL, C.3    CAPRANICO, G.4    KOHN, K.W.5    POMMIER, Y.6
  • 41
    • 0033899555 scopus 로고    scopus 로고
    • F11782, a dual inhibitor of topoisomerase I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumour activity, relative to three other dual topoisomerase inhibitors, intoplicin, aclarubicin and TAS-103
    • ETIÉVANT C, KRUCZYNSKI A, BARRET JM et al.: F11782, a dual inhibitor of topoisomerase I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumour activity, relative to three other dual topoisomerase inhibitors, intoplicin, aclarubicin and TAS-103. Cancer Chemother. Pharmacol. (2000) 46:102-113.
    • (2000) Cancer Chemother. Pharmacol , vol.46 , pp. 102-113
    • ETIÉVANT, C.1    KRUCZYNSKI, A.2    BARRET, J.M.3
  • 42
    • 18144375218 scopus 로고    scopus 로고
    • Induction of genotoxic and cytotoxic damage by aclarubicin, a dual topoisomerase inhibitor
    • HAJJI N, MATEOS S, PASTOR N, DOMÍNGUEZ I, CORTÉS F: Induction of genotoxic and cytotoxic damage by aclarubicin, a dual topoisomerase inhibitor. Mutat. Res. (2005) 583:26-35.
    • (2005) Mutat. Res , vol.583 , pp. 26-35
    • HAJJI, N.1    MATEOS, S.2    PASTOR, N.3    DOMÍNGUEZ, I.4    CORTÉS, F.5
  • 43
    • 0041831131 scopus 로고    scopus 로고
    • Antitumor triptycene bisquinones: A novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities
    • WANG B, PERCHELLET EM, WANG Y, TAMURA M, HUA DH, PERCHELLET JP: Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities. Anticancer Drugs (2003) 14(7):503-514.
    • (2003) Anticancer Drugs , vol.14 , Issue.7 , pp. 503-514
    • WANG, B.1    PERCHELLET, E.M.2    WANG, Y.3    TAMURA, M.4    HUA, D.H.5    PERCHELLET, J.P.6
  • 44
    • 0141884959 scopus 로고    scopus 로고
    • The quinnlone family: From antibacterial to anticancer agents
    • SISSI C, PALUMBO M: The quinnlone family: from antibacterial to anticancer agents. Curr. Med. Chem. Anticancer Agents (2003) 3(6):439-450.
    • (2003) Curr. Med. Chem. Anticancer Agents , vol.3 , Issue.6 , pp. 439-450
    • SISSI, C.1    PALUMBO, M.2
  • 45
    • 0033744515 scopus 로고    scopus 로고
    • Potent antipneunmococcal activity of gemifloxacin is associated with dual targeting of gyrase and topoisomerase IV, an in vivo target preference for gyrase, and enhanced stabilization of cleavable complexes in vitro
    • HEATON VJ, AMBLERJE, FISHER LM: Potent antipneunmococcal activity of gemifloxacin is associated with dual targeting of gyrase and topoisomerase IV, an in vivo target preference for gyrase, and enhanced stabilization of cleavable complexes in vitro. Antimicrob. Agents Chemother. (2000) 44(11):3112-3117.
    • (2000) Antimicrob. Agents Chemother , vol.44 , Issue.11 , pp. 3112-3117
    • HEATON, V.J.1    AMBLERJE, F.L.2
  • 46
    • 4644269691 scopus 로고    scopus 로고
    • Fluoroquinolones as chemotherapeutics against mycobacterial infections
    • JACOBS MR: Fluoroquinolones as chemotherapeutics against mycobacterial infections. Curr. Pharm. Des. (2004) 10(26):3213-3220.
    • (2004) Curr. Pharm. Des , vol.10 , Issue.26 , pp. 3213-3220
    • JACOBS, M.R.1
  • 47
    • 30444434889 scopus 로고    scopus 로고
    • Isothiazolopyridones: Synthesis, structure, and biological activity of a new class of antibacterial agents
    • WILES JA, HASHIMOTO A, THANASSI JA et al.: Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents. J. Med. Chem. (2006) 49(1):39-42.
    • (2006) J. Med. Chem , vol.49 , Issue.1 , pp. 39-42
    • WILES, J.A.1    HASHIMOTO, A.2    THANASSI, J.A.3
  • 48
    • 33645791657 scopus 로고    scopus 로고
    • In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class
    • MANI N, GROSS CH, PARSONS JD et al.: In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class. Antimicrob. Agents Chemother. (2006) 50(4):1228-1237.
    • (2006) Antimicrob. Agents Chemother , vol.50 , Issue.4 , pp. 1228-1237
    • MANI, N.1    GROSS, C.H.2    PARSONS, J.D.3
  • 49
    • 33644681603 scopus 로고    scopus 로고
    • Bacterial cell killing mediated by topoisomerase I DNA cleavage activity
    • CHENG B, SHUKLA S, VASUNILASHORN S, MUKHOPADHYAY S, TSE-DINH YC: Bacterial cell killing mediated by topoisomerase I DNA cleavage activity. J. Biol. Chem. (2005) 280(46):38489-38495.
    • (2005) J. Biol. Chem , vol.280 , Issue.46 , pp. 38489-38495
    • CHENG, B.1    SHUKLA, S.2    VASUNILASHORN, S.3    MUKHOPADHYAY, S.4    TSE-DINH, Y.C.5
  • 50
    • 0038003203 scopus 로고    scopus 로고
    • A nowel active DNA topoisomerase I in Leishmania donovani
    • VILLA H, OTERO MARCOS AR, REGUERA RM et al.: A nowel active DNA topoisomerase I in Leishmania donovani. J. Biol. Chem. (2003) 278:3521-3526.
    • (2003) J. Biol. Chem , vol.278 , pp. 3521-3526
    • VILLA, H.1    OTERO MARCOS, A.R.2    REGUERA, R.M.3
  • 51
    • 0034862972 scopus 로고    scopus 로고
    • Treatment of visceral leishmaniasis with sterically stabilized liposomes containing camptothecin
    • PROULX ME, DESORMEAUX A, MARQUIS JE OLIVIER M, BERG ERON MG: Treatment of visceral leishmaniasis with sterically stabilized liposomes containing camptothecin. Antimicrob. Agents Chemother. (2001) 45(9):2623-2627.
    • (2001) Antimicrob. Agents Chemother , vol.45 , Issue.9 , pp. 2623-2627
    • PROULX, M.E.1    DESORMEAUX, A.2    MARQUIS, J.E.3    OLIVIER, M.4    BERG, E.M.5
  • 52
    • 0034199017 scopus 로고    scopus 로고
    • Luteolin, an abundant dietary component is a potent antileishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis
    • MITTRA B, SAHA A, CHOWDHURY AR et al.: Luteolin, an abundant dietary component is a potent antileishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis. Mol. Med. (2000) 6(6):527-541.
    • (2000) Mol. Med , vol.6 , Issue.6 , pp. 527-541
    • MITTRA, B.1    SAHA, A.2    CHOWDHURY, A.R.3
  • 53
    • 33646521745 scopus 로고    scopus 로고
    • Current advances in antifungal targets mad drug development
    • SUNDRIYAL S, SHARMA RK, JAIN R: Current advances in antifungal targets mad drug development. Curr. Med. Chem. (2006) 13(11):1321-1335.
    • (2006) Curr. Med. Chem , vol.13 , Issue.11 , pp. 1321-1335
    • SUNDRIYAL, S.1    SHARMA, R.K.2    JAIN, R.3
  • 55
    • 0028961670 scopus 로고
    • Identification of the aminocatechol A-3253 as an in vitro poison of DNA topoisomerase I from Candida albicans
    • FOSTEL J, MONTGOMERY D: Identification of the aminocatechol A-3253 as an in vitro poison of DNA topoisomerase I from Candida albicans. Antimicrob. Agents Chemother. (1995) 39(3):586-592.
    • (1995) Antimicrob. Agents Chemother , vol.39 , Issue.3 , pp. 586-592
    • FOSTEL, J.1    MONTGOMERY, D.2
  • 56
    • 0031006104 scopus 로고    scopus 로고
    • Differential poisoning of human and Aspergillus nidulans DNA topoisomerase I by bi- and terbenzimidazoles
    • GOLDMAN GH, YU C, WU HY, SANDERS MM, LA VOIE EJ, LIU LF: Differential poisoning of human and Aspergillus nidulans DNA topoisomerase I by bi- and terbenzimidazoles. Biochemistry (1997) 36(21):6488-6494.
    • (1997) Biochemistry , vol.36 , Issue.21 , pp. 6488-6494
    • GOLDMAN, G.H.1    YU, C.2    WU, H.Y.3    SANDERS, M.M.4    LA VOIE, E.J.5    LIU, L.F.6
  • 58
    • 33947190051 scopus 로고    scopus 로고
    • Bortezomib in combination with pegylated liposomal Doxorubicin for the treaunent of multiple myeloma
    • MANOCHAKIA RN, MILLER KC, CHANAN-KHAN AA: Bortezomib in combination with pegylated liposomal Doxorubicin for the treaunent of multiple myeloma. Clin. Lymphoma Myeloma. (2007) 7(4):266-271.
    • (2007) Clin. Lymphoma Myeloma , vol.7 , Issue.4 , pp. 266-271
    • MANOCHAKIA, R.N.1    MILLER, K.C.2    CHANAN-KHAN, A.A.3
  • 59
    • 13544251744 scopus 로고    scopus 로고
    • Prosurvival and prodeath effects of hypoxia-inducible factor-1α stabilization in a murine hippocampal cell line
    • AMINOVA LR, CHAVEZ JC, LEE J et al.: Prosurvival and prodeath effects of hypoxia-inducible factor-1α stabilization in a murine hippocampal cell line. J. Biol. Chem. (2005) 280(5):3996-4003.
    • (2005) J. Biol. Chem , vol.280 , Issue.5 , pp. 3996-4003
    • AMINOVA, L.R.1    CHAVEZ, J.C.2    LEE, J.3
  • 60
    • 1242271198 scopus 로고    scopus 로고
    • Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1. Mechanism and therapeutic implications
    • RAPISARDA A, URANCHIMEG B, SORDET O, POMMIER Y, SHOEMAKER R H, MELILLO G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1. Mechanism and therapeutic implications. Cancer Res. (2004) 64:1475-1482.
    • (2004) Cancer Res , vol.64 , pp. 1475-1482
    • RAPISARDA, A.1    URANCHIMEG, B.2    SORDET, O.3    POMMIER, Y.4    SHOEMAKER, R.H.5    MELILLO, G.6


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