Isothiazolopyridones: Synthesis, structure, and biological activity of a new class of antibacterial agents

Journal of Medicinal Chemistry

Volumn 49, Issue 1, 2006, Pages 39-42

  Wiles, Jason A ^a   Hashimoto, Akihiro ^a   Thanassi, Jane A ^a   Cheng, Jijun ^a   Incarvito, Christopher D ^b   Deshpande, Milind ^a   Pucci, Michael J ^a   Bradbury, Barton J ^a  

^a Achillion Pharmaceuticals   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PYRIDONE DERIVATIVE; 4 PYRIDONE DERIVATIVE; 7 CHLORO 9 ETHYL 1 THIA 2,4A DIAZACYCLOPENTA[B]NAPHTHALENE 3,4 DIONE; ANTIINFECTIVE AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; ISOTHIAZOLE DERIVATIVE; ISOTHIAZOLOPYRIDONE; ISOTHIAZOLOPYRIDONE DERIVATIVE; ISOTHIAZOLOQUINOLONE; QUINOLIZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SOLID STATE; X RAY DIFFRACTION;

ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DNA GYRASE; DNA TOPOISOMERASE IV; DNA TOPOISOMERASES, TYPE II; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 30444434889     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051066d     Document Type: Article

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