Gamma interferon suppresses erythropoiesis via interleukin-15

Infection and Immunity

Volumn 75, Issue 5, 2007, Pages 2630-2633

  Mullarky, Isis K ^a,b   Szaba, Frank M ^a   Kummer, Lawrence W ^a   Wilhelm, Lindsey B ^a   Parent, Michelle A ^a   Johnson, Lawrence L ^a   Smiley, Stephen T ^a  

^a TRUDEAU INSTITUTE   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 15; STAT1 PROTEIN;

ANEMIA; ARTICLE; DISEASE ASSOCIATION; ERYTHROCYTE; ERYTHROPOIESIS; HOMEOSTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETICULOCYTE; TOXOPLASMA GONDII; TOXOPLASMOSIS; UPREGULATION;

ANEMIA; ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; ERYTHROPOIESIS; INTERFERON TYPE II; INTERLEUKIN-15; MICE; MICE, INBRED C57BL; STAT1 TRANSCRIPTION FACTOR; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; UP-REGULATION;

EID: 34248374204     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01836-06     Document Type: Article

References (27)

1. Chang, K. H., M. Tam, and M. M. Stevenson. 2004. Modulation of the course and outcome of blood-stage malaria by erythropoietin-induced reticulocytosis. J. Infect. Dis. 189:735-743.
2. Claster, S. 2002. Biology of anemia, differential diagnosis, and treatment options in human immunodeficiency virus infection. J. Infect. Dis. 185(Suppl. 2):S105-S109.
3. Dai, C. H., J. O. Price, T. Brunner, and S. B. Krantz. 1998. Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis. Blood 91:1235-1242.
4. Denkers, E. Y., and R. T. Gazzinelli. 1998. Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. Clin. Microbiol. Rev. 11:569-588.
5. Felli, N., F. Pedini, A. Zeuner, E. Petrucci, U. Testa, C. Conticello, M. Biffoni, A. Di Cataldo, J. A. Winkles, C. Peschle, and R. De Maria. 2005. Multiple members of the TNF superfamily contribute to IFN-gamma-mediated inhibition of erythropoiesis. J. Immunol. 175:1464-1472.
6. Gysemans, C. A., L. Ladriere, H. Callewaert, J. Rasschaert, D. Flamez, D. E. Levy, P. Matthys, D. L. Eizirik, and C. Mathieu. 2005. Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells. Diabetes 54:2396-2403.
7. Halupa, A., M. L. Bailey, K. Huang, N. N. Iscove, D. E. Levy, and D. L. Barber. 2005. A novel role for STAT1 in regulating murine erythropoiesis: deletion of STAT1 results in overall reduction of erythroid progenitors and alters their distribution. Blood 105:552-561.
8. Johnson, L. L., K. N. Berggren, F. M. Szaba, W. Chen, and S. T. Smiley. 2003. Fibrin-mediated protection against infection-stimulated immunopathology. J. Exp. Med. 197:801-806.
9. Lee, G. R. 1983. The anemia of chronic disease. Semin. Hematol. 20:61-80.
10. Lieberman, L. A., E. N. Villegas, and C. A. Hunter. 2004. Interleukin-15-deficient mice develop protective immunity to Toxoplasma gondii. Infect. Immun. 72:6729-6732.
11. Liesenfeld, O., H. Kang, D. Park, T. A. Nguyen, C. V. Parkhe, H. Watanabe, T. Abo, A. Sher, J. S. Remington, and Y. Suzuki. 1999. TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii. Parasite Immunol. 21:365-376.
12. Manodori, A. B., and F. A. Kuypers. 2002. Altered red cell turnover in diabetic mice. J. Lab. Clin. Med. 140:161-165.
13. McCabe, R. E., and J. S. Remington. 1990. Toxoplasma gondii, p. 2090-2103. In G. L. Mandell, R. G. Douglas, and J. E. Bennett (ed.), Principles and practices of infectious diseases, 3rd ed. Churchill Livingstone, Inc., New York, NY.
14. Means, R. T., Jr. 2003. Recent developments in the anemia of chronic disease. Curr. Hematol. Rep. 2:116-121.
15. Means, R. T., Jr., S. B. Krantz, J. Luna, S. A. Marsters, and A. Ashkenazi. 1994. Inhibition of murine erythroid colony formation in vitro by interferon gamma and correction by interferon receptor immunoadhesin. Blood 83: 911-915.
16. Muller, H. M., J. H. Horina, D. Kniepeiss, M. B. Tripoli, V. Stadelbauer, M. Schweiger, and K. H. Tscheliessnigg. 2001. Characteristics and clinical relevance of chronic anemia in adult heart transplant recipients. Clin. Transplant 15:343-348.
17. Musso, T., L. Calosso, M. Zucca, M. Millesimo, D. Ravarino, M. Giovarelli, F. Malavasi, A. N. Ponzi, R. Paus, and S. Bulfone-Paus. 1999. Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15. Blood 93:3531-3539.
18. Pang, Q., S. Fagerlie, T. A. Christiansen, W. Keeble, G. Faulkner, J. Diaz, R. K. Rathbun, and G. C. Bagby. 2000. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. Mol. Cell. Biol. 20:4724-4735.
19. Petakov, M., N. Stojanovic, G. Jovcic, D. Bugarski, V. Todorovic, and O. Djurkovic-Djakovic. 2002. Hematopoiesis during acute Toxoplasma gondii infection in mice. Haematologia 32:439-455.
20. Ramana, C. V., M. P. Gil, R. D. Schreiber, and G. R. Stark. 2002. Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling. Trends Immunol. 23:96-101.
21. Schroeder, K., P. J. Hertzog, T. Ravasi, and D. A. Hume. 2004. Interferon-gamma: an overview of signals, mechanisms and function. J. Leukoc. Biol. 75:163-189.
22. Spivak, J. L. 2000. The blood in systemic disorders. Lancet 355:1707-1712.
23. Vaglio, J., D. M. Safley, M. Rahman, M. Kosiborod, P. Jones, R. Thompson, H. M. Krumholz, and J. A. Spertus. 2005. Relation of anemia at discharge to survival after acute coronary syndromes. Am. J. Cardiol. 96:496-499.
24. Van Hove, L., W. Goossens, V. Van Duppen, and R. L. Verwilghen. 1990. Reticulocyte count using thiazole orange. A flow cytometry method. Clin. Lab. Haematol. 12:287-299.
25. Weiss, G., and L. T. Goodnough. 2005. Anemia of chronic disease. N. Engl. J. Med. 352:1011-1023.
26. Wenxin, L., F. Jinxiang, W. Yong, L. Wenxiang, S. Wenbiao, and Z. Xueguang. 2005. Expression of membrane-bound IL-15 by bone marrow fibroblast-like stromal cells in aplastic anemia. Int. Immunol. 17:429-437.
27. Zoumbos, N. C., J. Y. Djeu, and N. S. Young. 1984. Interferon is the suppressor of hematopoiesis generated by stimulated lymphocytes in vitro. J. Immunol. 133:769-774.