Sex-specific difference in the interconversion of cortisol and cortisone in men and women

Obesity

Volumn 15, Issue 4, 2007, Pages 820-824

  Vierhapper, Heinrich ^a   Heinze, Georg ^a   Nowotny, Peter ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cortisol; Cortisone; Interconversion; Metabolic clearance rates; Production rates

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTISONE; HYDROCORTISONE; ION; TETRAHYDROCORTISOL; TETRAHYDROCORTISONE;

ADULT; ARTICLE; BLOOD; BODY MASS; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS FRAGMENTOGRAPHY; METHODOLOGY; OBESITY; SEX DIFFERENCE; URINE;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADULT; BODY MASS INDEX; CHROMATOGRAPHY, LIQUID; CORTISONE; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROCORTISONE; IONS; MALE; OBESITY; SEX FACTORS; TETRAHYDROCORTISOL; TETRAHYDROCORTISONE;

EID: 34248363645     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2007.592     Document Type: Article

References (24)

1. Lamb EJ, Noonan KA, Burrin JM. Urine-free cortisol excretion: evidence of sex-dependence. Ann Clin Biochem. 1994;31:455-8.
2. Vierhapper H, Nowotny P, Waldhäusl W. Sex-specific differences in cortisol production rates in humans. Metabolism. 1998;47:974-6.
3. Purnell JQ, Brandon DD, Isabelle LM, Loriaux DL, Samuels MH. Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women. J Clin Endocrinol Metab. 2004;89:281-7.
4. Vierhapper H, Nowotny P, Waldhäusl W. Production rates of cortisol in hypogonadism. Metabolism. 2004;53:1174-6.
5. Weaver JU, Taylor NF, Monson JP, Wood PJ, Kelly WF. Sexual dimorphism in 11 beta hydroxysteroid dehydrogenase activity and its relation to fat distribution and insulin sensitivity: a study in hypopituitary subjects. Clin Endocrinol (Oxf). 1998;49:13-20.
6. Toogood AA, Taylor NF, Shalet SM, Monson JP. Sexual dimorphism of cortisol metabolism is maintained in elderly subjects and is not oestrogen dependent. Clin Endocrinol (Oxf). 2000;51:61-6.
7. Tomlinson JW, Sinha B, Bujalska I, Hewison M, Stewart PM. Expression of 11 beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity. J Clin Endocrinol Metab. 2002;87:5630-5.
8. Stewart PM, Boulton A, Kumar S, Clark PMS, Shackleton CHL. Cortisol metabolism in human obesity: impaired cortisone → cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab. 1999;84:1022-7.
9. Rask E, Walker BR, Soderberg S, et al. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab. 2002;87:3330-6.
10. Paulmyer-Lacroix O, Boullu S, Oliver C, Alessi MC, Grino M. Expression of the mRNA coding for 11 beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. J Clin Endocrinol Metab. 2002;87:2701-5.
11. Lindsay RS, Wake DJ, Nair S, et al. Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab. 2003;88:2738-44.
12. Livingstone DEW, Jones G, Smith K, et al. Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology. 2003;141:560-3.
13. Kannisto K, Pietilainen KH, Ehrenborg E, et al. Overexpression of 11 beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. J Clin Endocrinol Metab. 2004;89:4414-21.
14. Vierhapper H, Nowotny P, Waldhausl W. Stimulation of gonadal steroid synthesis by chronic excess of ACTH in patients with adrenocortical insufficiency. J Clin Invest. 1986; 77:1063-70.
15. Vierhapper H, Nowotny P. The stress of being a doctor: steroid excretion rates in internal medicine residents on and off duty. Am J Med. 2000;109:492-4.
16. Stewart PM, Krozowski ZS. 11β-hydroxysteroid dehydrogenase. Vitam Horm. 1999;57:249-324.
17. Vierhapper H, Nowotny P, Waldhäusl W. Production rates of cortisol in obesity. Obes Res. 2004;12:1421-5.
18. Kasuya Y, Shibasaki H, Furuta T. The use of deuterium-labeled cortisol for in vivo evaluation of renal 11β-HSD activity in man: urinary excretion of cortisol, cortisone and their A-ring reduced metabolites. Steroids. 2000;65:89-97.
19. Kasuya Y, Yokokawa A, Takayama S, Shibasaki H, Furuta T. Evaluation of 11 beta-HSD activities in vivo following oral administration of cortisol-C-13(4),H-2(1) to a human subject. Steroids. 2003;68:167-76.
20. Andrew R, Smith K, Jones GC, Walker BR. Distinguishing the activities of 11 beta-hydroxysteroid dehydrogenases in vivo using isotopically labeled cortisol. J Clin Endocrinol Metab. 2002;87:277-85.
21. Marin P, Darin M, Amemiya T, Anderson B, Jern S, Bjorntop P. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism. 1992;41: 882-6.
22. Pasquali R, Cantobelli S, Casimirri F, et al. The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab. 1993;77:341-6.
23. Strain G, Zumoff B, Kream J, Strain J, Levin J, Fukushima D. Sex difference in the influence of obesity on the 24 hr mean plasma concentration of cortisol. Metabolism. 1982; 31:209-12.
24. Andrew R, Phillips DIW, Walker BR. Obesity and gender influence cortisol secretion and metabolism in man. J Clin Endocrinol Metab. 1998;83:1806-9.