Liver nuclear and microsomal CYP2E1-mediated metabolism of xenobiotics in rats chronically drinking an alcohol-containing liquid diet

Toxicology and Industrial Health

Volumn 22, Issue 9, 2006, Pages 367-374

  Díaz Gómez, María I ^a   Fanelli, Silvia L ^a   delgado de Layño, Aurora M A ^a   Castro, José A ^a   Castro, Gerardo D ^a  

^a Instituto de Investigaciones Cientificas y Tecnicas de Las Fuerzas Armadas   (Argentina)

Author keywords

alcohol; aniline; carbon tetrachloride; CYP2E1; liver; N nitrosodimethylamine; nuclear; nuclei; o toluidine

Indexed keywords

2 METHYLANILINE; 4 NITROCATHECOL; 4 NITROPHENOL; ALCOHOL; ANILINE; CARBON TETRACHLORIDE; CATECHOLAMINE; CYTOCHROME P450 2E1; MICROSOME ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ALCOHOL CONSUMPTION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET; ENZYME ACTIVITY; HYDROXYLATION; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PROTEIN BINDING; RAT;

ALCOHOLISM; ANILINE COMPOUNDS; ANIMALS; CARBON TETRACHLORIDE; CELL NUCLEUS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYTOCHROME P-450 CYP2E1; DISEASE MODELS, ANIMAL; ETHANOL; HEPATOCYTES; HYDROXYLATION; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; TOLUIDINES; XENOBIOTICS;

ANIMALIA; RATTUS;

EID: 34248186623     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233706070982     Document Type: Article

References (33)

1. Bolt, H.M., Roos, P.H. and Their, R. 2003: The cytochrome P450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine. International Archives of Occupational and Environmental Health 7, 174-85.
2. Castro, G.D., Costantini, M.H., Delgado de Layño, A.M.A. and Castro, J.A. 2002: Rat liver microsomal and nuclear activation of methanol to hydroxymethyl free radicals. Toxicology Letters 129, 227-36.
3. Castro, G.D., Delgado de Layño, A.M.A. and Castro, J.A. 1998: Liver nuclear ethanol metabolizing system (NEMS) producing acetaldehyde and 1-hydroxyethyl free radicals. Toxicology 129, 137-44.
4. Castro, G.D., Díaz Gómez, M.I. and Castro, J.A. 1989: Species differences in the interaction between CCl 4 reactive metabolites and liver DNA and nuclear protein fractions. Carcinogenesis 10, 289-94.
5. Castro, G.D., Díaz Gómez, M.I. and Castro, J.A. 1990: Biotransformation of carbon tetrachloride and lipid peroxidation promotion by liver nuclear preparations from different animal species. Cancer Letters 53, 9-15.
6. Danford, N. 1991: The genetic toxicology of ortho-toluidine. Mutation Research 258, 207-36.
7. Díaz Gómez, M.I. and Castro, J.A. 1980a: Covalent binding of carbon tetrachloride metabolites to liver nuclear DNA, proteins and lipids. Toxicology and Applied Pharmacology 56, 199-206.
8. Díaz Gómez, M.I. and Castro, J.A. 1980b: Covalent binding of chloroform metabolites to nuclear proteins. No evidence for binding to nucleic acids. Cancer Letters 9, 213-18.
9. Díaz Gómez, M.I. and Castro, J.A. 1980c: Nuclear activation of carbon tetrachloride and chloroform. Research Communications in Chemical Pathology and Pharmacology 27, 191-94.
10. Díaz Gómez, M.I., Fanelli, S.L., Castro, G.D. et al. 1999: A liver nuclear ethanol metabolizing system. Formation of metabolites that bind covalently to macromolecules and lipids. Toxicology 138, 19-28.
11. Díaz Gómez, M.I., Valles, E.G., Fanelli, S.L. et al. 2002: Alcohol induction of liver nuclear ethanol and Nnitrosodimethylamine metabolism to reactive metabolites. Teratogenesis Carcinogenesis and Mutagenesis 22, 139-45.
12. Ekström, G., Von Bahr, C. and Ingelman-Sundberg, M. 1989: Human liver microsomal cytochrome P450IIE1. Immunological evaluation of its contribution to microsomal ethanol oxidation, carbon tetrachloride reduction and NADPH oxidase activity. Biochemical Pharmacology 38, 689-93.
13. Fanelli, S.L. and Castro, J.A. 1993: Carbon tetrachloride promoted malondialdehyde formation in liver microsomal and nuclear preparations from Sprague Dawley or Osborne Mendel male rats. Research Communications in Chemical Pathology and Pharmacology 82, 233-36.
14. Gad, S.C. 2001: Statistics for toxicologists. In Hayes, A.W., editor, Principles and methods in toxicology, fourth edition. Taylor & Francis, 273-320.
15. González, F.J. 2005: Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutation Research 569, 101-10.
16. Guenguerich, F.P. 1995: Human cytochrome P450 enzymes. In Ortiz de Montellano, P.R., editor, Cytochrome P450 structure. Mechanism and biochemistry, second edition. Plenum Press, 473-535.
17. Gupta, R.L., Gupta, A.K., Pathak, D.P. and Jumeja, T.R. 1987: Mutagenic studies of ortho-toluidine and its potential metabolites. Indian Journal in Experimental Biology 25, 618-22.
18. Gut, I., Nedelcheva, V., Soucek, P. et al. 1996: The role of CYP2E1 and 2B1 in metabolic activation of benzene derivatives. Archives of Toxicology 71, 45-56.
19. Hasumura, Y., Teschke, R., Lieber, C.S. 1974: Increased carbon tetrachloride hepatotoxicity, and its mechanism, after chronic ethanol consumption. Gastroenterology 66, 226-34.
20. Iarc 1982: Some aromatic amines, anthraquinones and nitroso compounds, and inorganic fluorides used in drinking-water and dental preparations. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Volume 27. IARC, 155-75.
21. Ingelman-Sundberg, M., Johansson, I., Penttila, K.E. et al. 1988: Centrilobular expression of ethanol inducible cytochrome P450(IIE1) in rat liver. Biochemical Biophysical Research Communications 157, 55-60.
22. Jodynis-Liebert, J. and Bennasir, H.A. 2000: Gas chromatographic method for the determination of toluidines in spiked urine samples. Journal of Chromatography B Biomedical Science Application 738, 427-30.
23. Koop, D.R. and Coon, M.J. 1986: Ethanol oxidation and toxicity: role of alcohol P-450 oxygenase. Alcohol Clinical Experimental Research 10, 44s-49s.
24. Lieber, C.S. 2004: The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role. Drug Metabolism Reviews 36, 511-29.
25. Lieber, C.S. and De Carli, L.M. 1982: The feeding of alcohol in liquid diets: two decades of applications and 1982 update. Alcohol Clinical and Experimental Research 6, 523-31.
26. Lieber, C.S. and De Carli, L.M. 1989: Liquid diet technique of ethanol administration: 1989 update. Alcohol and Alcoholism 24, 197-211.
27. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. 1951: Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265-75.
28. Mishin, V.M., Koivisto, T. and Lieber, C.S. 1996: The determination of cytochrome P4502E1-dependent p-nitrophenol hydroxylation by high-performance liquid chromatography with electrochemical detection. Analytical Biochemistry 233, 212-15.
29. Morimoto, M., Hagbjörk, A.L., Wan, Y.J. et al. 1995: Modulation of experimental alcohol-induced liver disease by cytochrome P4502E1 inhibitors. Hepatology 21, 1610-17.
30. Ohkuma, Y., Hiraku, Y., Oikawa, S. et al. 1999: Distinct mechanisms of oxidative DNA damage by two metabolites of carcinogenic o-toluidine. Archives of Biochemistry and Biophysics 372, 97-106.
31. Stillwell, W.G., Bryant, M.S. and Wishnok, J.S. 1987: GC-MS analysis of biologically important aromatic amines. Application to human dosimetry. Biomedical Environmental Mass Spectrometry 14, 221-27.
32. Tsutsumi, M., Lasker, J.M., Shimizu, M. et al. 1989: The intralobular distribution of ethanol-inducible P4502E1 in rat and human liver. Hepatology 10, 437-46.
33. Viviani, A., Lutz, W.K. and Schlatter, C. 1978: Time course of the induction of aryl hydrocarbon hydroxylase in rat liver nuclei and microsomes by phenobarbital, 3-methylcholanthrene, 2,3,7,8-tetrachlorodibenzo-p-dioxin, dieldrin and other inducers. Biochemical Pharmacology 27, 191-94.