TCRβ chain that forms peptide-independent alloreactive TCR transfers reduced reactivity with irrelevant peptide/MHC complex

Journal of Immunology

Volumn 178, Issue 10, 2007, Pages 6109-6114

  Sentori, Fabio R ^a   Popmihajlov, Zoran ^a,d   Badovinac, Vladimir P ^b   Smith, Courtney ^c   Radoja, Sasa ^c   Harty, John T ^b   Vukmanović, Stanislav ^a,c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c CHILDREN S RESEARCH INSTITUTE   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; SILVER; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ALLOIMMUNITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL LEVEL; CONTROLLED STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 34248172485     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.10.6109     Document Type: Article

References (39)

1. Hennecke, J., and D. C. Wiley. 2001. T cell receptor-MHC interactions up close. Cell 104: 1-4.
2. Bankovich, A. J., and K. C. Garcia. 2003. Not just any T cell receptor will do. Immunity 18: 7-11.
3. Housset, D., and B. Malissen. 2003. What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity? Trends Immunol. 24: 429-437.
4. Rudolph, M. G., R. L. Stanfield, and I. A. Wilson. 2006. How TCRs bind MHCs, peptides, and coreceptors. Annu. Rev. Immunol. 24: 419-466.
5. Sadofsky, M. J. 2001. The RAG proteins in V(D)J recombination: more than just a nuclease. Nucleic Acids Res. 29: 1399-1409.
6. Kim, D. R., S. J. Park, and M. A. Oettinger. 2000. V(D)J recombination: site-specific cleavage and repair. Mol. Cell. 10: 367-374.
7. Bevan, M. J. 1997. In thymic selection, peptide diversity gives and takes away. Immunity 7: 175-178.
8. Burrows, S. R., R. Khanna, S. L. Silins, and D. J. Moss. 1999. The influence of antiviral T-cell responses on the alloreactive repertoire. Immunol. Today 20: 203-207.
9. Bevan, M. J. 1977. Killer cells reactive to altered self antigens could also be alloreactive. Proc. Natl. Acad. Sci. USA 74: 2094-2098.
10. b-restricted anti-vesicular stomatitis virus and alloreactive cytotoxic T cells. J. Immunol. 138: 3654-3660.
11. Ashwell, J. D., C. Chen, and R. H. Schwartz. 1986. High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class I molecules. J. Immunol. 136: 389-395.
12. Mullbacher, A. 1981. Natural tolerance: a model for Ir gene effects in the cytotoxic T cell response to H-Y antigen. Transplantation 32: 58-60.
13. Matzinger, P., and M. J. Bevan. 1977. Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens? Cell. Immunol. 29: 1-5.
14. Bevan, M. J. 1984. High determinant density may explain the phenomenon of alloreactivity. Immunol. Today 5: 128-130.
15. b by alloreactive cytotoxic T lymphocytes. Nature 341: 749-752.
16. Rotzschke, O., K. Falk, S. Faath, and H.-G. Rammensee. 1991. On the nature of peptides involved in T cell alloreactivity. J. Exp. Med. 174: 1059-1071.
17. + cytotoxic T lymphocytes in association with a class I MHC protein. Cell 69: 989-998.
18. Felix, N. J., A. Suri, J. J. Walters, S. Horvath, M. L. Gross, and P. M. Allen. 2006. I-Ep-bound self-peptides: identification, characterization, and role in alloreactivity. J. Immunol. 176: 1062-1071.
19. Elliott, T. J., and H. N. Eisen. 1990. Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule. Proc. Natl. Acad. Sci. USA 87: 5213-5217.
20. Smith, P. A., A. Brunmark, M. R. Jackson, and T. A. Potter. 1997. Peptide-independent recognition by alloreactive cytotoxic T lymphocytes. J. Exp. Med. 185: 1023-1033.
21. Whitelegg, A., and L. D. Barber. 2004. The structural basis of T-cell allorecognition. Tissue Antigens 63: 101-108.
22. Nesic, D., M. Maric, F. R. Santori, and S. Vukmanovic. 2002. Factors influencing the patterns of T lymphocyte allorecognition. Transplant 73: 797-803.
23. + T cells. J. Immunol. Methods 238: 107-117.
24. Pircher, H., K. Burki, R. Lang, H. Hengartner, and R. M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342: 559-561.
25. + T lymphocyte effector responses. J. Immunol. 159: 582-590.
26. Santoli, F. R., K. Holmberg, D. Ostrov, N. R. J. Gascoigne, and S. Vukmanovic. 2004. Distinct footprints of T cell receptor engagement with highly homologous ligands. J. Immunol. 172: 7466-7475.
27. Day, P. M., F. Esquivel, J. Lukszo, J. R. Bennink, and J. W. Yewdell. 1995. Effect of TAP on the generation and intracellular trafficking of peptide-receptive major histocompatibility complex class I molecules. Immunity 2: 137-147.
28. d in cell lysates and at the cell surface. J. Exp. Med. 175: 191-202.
29. d molecules at the cell surface. J. Exp. Med. 178: 2035-2046.
30. Jameson, S. C., and M. J. Bevan. 1992. Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a Kb-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifs. Eur. J. Immunol. 22: 2663-2667.
31. Daniel, C., S. Horvath, and P. M. Allen. 1998. A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR. Immunity 8: 543-552.
32. + T cell response to Listeria monocytogenes infection. J. Immunol. 173: 5679-5687.
33. Harty, J. T., and M. J. Bevan. 1995. Specific immunity to Listeria monocytogenes in the absence of IFNγ. Immunity 3: 109-117.
34. b recognition. J. Immunol. 152: 1790-1801.
35. + T cells expressing identical endogenous TCR-α chains. J. Immunol. 157: 4726-4735.
36. Gutgemann, I., A. M. Fahrer, J. D. Altman, M. M. Davis, and Y. H. Chien. 1998. Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen. Immunity 8: 667-673.
37. Sant'Angelo, D. B., B. Lucas, P. G. Waterbury, B. Cohen, T. Brabb, J. Goverman, R. N. Germain, and C. A. J. Janeway. 1998. A molecular map of T cell development. Immunity 9: 179-186.
38. Baldwin, K. K., B. P. Trenchak, J. D. Altman, and M. M. Davis. 1999. Negative selection of T cells occurs throughout thymic development. J. Immunol. 163: 689-698.
39. Bouneaud, C., P. Kourilsky, and P. Bousso. 2000. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 13: 829-840.