Genetic analysis of the stress-responsive adrenocortical axis

Physiological Genomics

Volumn 27, Issue 3, 2006, Pages 362-369

  Solberg, Leah C ^a,b,d   Baum, Amber E ^a   Ahmadiyeh, Nasim ^a,b   Shimomura, Kazuhiro ^b   Li, Renhua ^c   Turek, Fred W ^b   Takahashi, Joseph S ^b   Churchill, Gary A ^c   Redei, Eva E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c JACKSON LABORATORY   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Corticosterone; Hypothalamic pituitary adrenal axis; Quantitative trait loci analysis; Wistar Kyoto rat

Indexed keywords

CORTICOSTERONE; GLOBULIN; CARRIER PROTEIN; CORTICOSTERONE BINDING PROTEINS; CORTICOSTERONE-BINDING PROTEINS;

ADRENAL CORTEX FUNCTION; ADRENAL GLAND WEIGHT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DNA SEQUENCE; FEMALE; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC ANALYSIS; GENOTYPE; HORMONE DETERMINATION; HYPOPHYSIS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROTEIN BINDING; QUANTITATIVE TRAIT LOCUS MAPPING; RADIOIMMUNOASSAY; RAT; SEQUENCE ANALYSIS; SEX DIFFERENCE; STRESS; ADRENAL GLAND; ANIMAL; BLOOD; CROSS BREEDING; FISCHER 344 RAT; GENETIC LINKAGE; GENETIC VARIABILITY; GENETICS; HISTOLOGY; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; ORGAN SIZE; PATHOPHYSIOLOGY; QUANTITATIVE TRAIT LOCUS; REGRESSION ANALYSIS; WISTAR KYOTO RAT;

RATTUS;

ADRENAL GLANDS; ANIMALS; CARRIER PROTEINS; CORTICOSTERONE; CROSSES, GENETIC; FEMALE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LOD SCORE; MALE; ORGAN SIZE; PITUITARY-ADRENAL SYSTEM; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED F344; RATS, INBRED WKY; REGRESSION ANALYSIS; STRESS; VARIATION (GENETICS);

EID: 34248145937     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00052.2006     Document Type: Article

References (47)

1. Ahmadiyeh N, Churchill GA, Shimomura K, Solberg LC, Takahashi JS, and Redei EE. X-linked and lineage-dependent inheritance of coping responses to stress. Mamm Genome 14: 748-757, 2003.
2. Ahmadiyeh N, Churchill GA, Solberg LC, Baum AE, Shimonura K, Takahashi JS, and Redei EE. Lineage is an epigenetic modifier of QTL influencing behavioral coping with stress. Behav Genet 35: 189-198, 2005.
3. Ahmadiyeh N, Slone-Wilcoxon JL, Takahashi JS, and Redei EE. Maternal behavior modulates X-linked inheritance of behavioral coping in the defensive burying test. Biol Psychiatry 55: 1069-1074, 2004.
4. Bartels M, Van den Berg M, Sluyter F, Boomsma DI, and de Geus EJ. Heritability of cortisol levels: review and simultaneous analysis of twin studies. Psychoneuroendocrinology 28: 121-137, 2003.
5. Baum AE, Solberg LC, Kopp P, Ahmadiyeh N, Churchill G, Takahashi JS, Jameson JL, and Redei EE. Quantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat. Endocrinology 146: 870-878, 2005.
6. Bransome ED Jr. Regulation of adrenal growth. Differences in the effects of ACTH in normal and dexamethasone-suppressed guinea pigs. Endocrinology 83: 956-964, 1968.
7. Breuner CW and Orchinik M. Plasma binding proteins as mediators of corticosteroid action in vertebrates. J Endocrinol 175: 99-112, 2002.
8. Broman KW, Wu H, Sen S, and Churchill GA. R/qtl: QTL mapping in experimental crosses. Bioinformatics 19: 889-890, 2003.
9. Buitenhuis AJ, Rodenburg TB, van Hierden YM, Siwek M, Cornelissen SJ, Nieuwland MG, Crooijmans RP, Groenen MA, Koene P, Korte SM, Bovenhuis H, and van der Poel JJ. Mapping quantitative trait loci affecting feather pecking behavior and stress response in laying hens. Poult Sci 82: 1215-1222, 2003.
10. Chrousos GP. Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture. Ann NY Acad Sci 851: 311-335, 1998.
11. Churchill GA and Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 138: 963-971, 1994.
12. Cui ZH, Ikeda K, Kawakami K, Gonda T, Nabika T, and Masuda J. Exaggerated response to restraint stress in rats congenic for the chromosome 1 blood pressure quantitative trait locus. Clin Exp Pharmacol Physiol 30: 464-469, 2003.
13. Desautes C, Bidanelt JP, Milant D, Iannuccelli N, Amigues Y, Bourgeois F, Caritez JC, Renard C, Chevalet C, and Mormede P. Genetic linkage mapping of quantitative trait loci for behavioral and neuroendocrine stress response traits in pigs. J Anim Sci 80: 2276-2285, 2002.
14. Dumas P, Pausova Z, Kren V, Krenova D, Pravenec M, Dumont M, Ely D, Turner M, Sun Y, Tremblay J, and Hamet P. Contribution of autosomal loci and the Y chromosome to the stress response in rats. Hypertension 35: 568-573, 2000.
15. Dumas P, Sun Y, Corbeil G, Tremblay S, Pausova Z, Kren V, Krenova D, Pravenec M, Hamet P, and Tremblay J. Mapping of quantitative trait loci (QTL) of differential stress gene expression in rat recombinant inbred strains. J Hypertens 18: 545-551, 2000.
16. Federenko IS, Nagamine M, Hellhammer DH, Wadhwa PD, and Wust S. The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent. J Clin Endocrinol Metab 89: 6244-6250, 2004.
17. Gold PW, Wong ML, Chrousos GP, and Licinio J. Stress system abnormalities in melancholic and atypical depression: molecular, pathophysiological, and therapeutic implications. Mol Psychiatry 1: 257-264, 1996.
18. Hammond GL, Smith CL, Goping IS, Underhill DA, Harley MJ, Reventos J, Musto NA, Gunsalus GL, and Bardin CW. Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors. Proc Natl Acad Sci USA 84: 5153-5157, 1987.
19. Hammond GL, Smith CL, and Underhill DA. Molecular studies of corticosteroid binding globulin structure, biosynthesis and function. J Steroid Biochem Mol Biol 40: 755-762, 1991.
20. Harper JM, Galecki AT, Burke DT, Pinkosky SL, and Miller RA. Quantitative trait loci for insulin-like growth factor I, leptin, thyroxine, and corticosterone in genetically heterogeneous mice. Physiol Genomics 15: 44-51, 2003.
21. Jaworski RL, Jirout M, Closson S, Breen L, Flodman PL, Spence MA, Kren V, Krenova D, Pravenec M, and Printz MP. Heart rate and blood pressure quantitative trait loci for the airpuff startle reaction. Hypertension 39: 348-352, 2002.
22. Lander E and Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11: 241-247, 1995.
23. Marti O, Martin M, Gavalda A, Giralt M, Hidalgo J, Hsu BR, Kuhn RW, and Armario A. Inhibition of corticosteroid-binding globulin caused by a severe stressor is apparently mediated by the adrenal but not by glucocorticoid receptors. Endocrine 6: 159-164, 1997.
24. Mogil JS, Richards SP, O'Toole LA, Helms ML, Mitchell SR, Kest B, and Belknap JK. Identification of a sex-specific quantitative trait locus mediating nonopioid stress-induced analgesia in female mice. J Neurosci 17: 7995-8002, 1997.
25. Ober C, Abney M, and McPeek MS. The genetic dissection of complex traits in a founder population. Am J Hum Genet 69: 1068-1079, 2001.
26. Ousova O, Guyonnet-Duperat V, Iannuccelli N, Bidanel JP, Milan D, Genet C, Llamas B, Yerle M, Gellin J, Chardon P, Emptoz-Bonneton A, Pugeat M, Mormede P, and Moisan MP. Corticosteroid binding globulin: a new target for cortisol-driven obesity. Mol Endocrinol 18: 1687-1696, 2004.
27. Potenza MN, Brodkin ES, Joe B, Luo X, Remmers EF, Wilder RL, Nestler EJ, and Gelernter J. Genomic regions controlling corticosterone levels in rats. Biol Psychiatry 55: 634-641, 2004.
28. Redei E, Pare WP, Aird F, and Kluczynski J. Strain differences in hypothalamic-pituitary-adrenal activity and stress ulcer. Am J Physiol Regul Integr Comp Physiol 266: R353-R360, 1994.
29. Roberts AJ, Phillips TJ, Belknap JK, Finn DA, and Keith LD. Genetic analysis of the corticosterone response to ethanol in BXD recombinant inbred mice. Behav Neurosci 109: 1199-1208, 1995.
30. Sen S and Churchill GA. A statistical framework for quantitative trait mapping. Genetics 159: 371-387, 2001.
31. Skelton FR and Bernardis LL. Effect of age, sex, hypophysectomy and gonadectomy on plasma corticosterone levels and adrenal weights following the administration of ACTH and stress. Experientia 22: 551-552, 1966.
32. Smith CL and Hammond GL. An amino acid substitution in biobreeding rat corticosteroid binding globulin results in reduced steroid binding affinity. J Biol Chem 266: 18555-18559, 1991.
33. Smith CL and Hammond GL. Rat corticosteroid binding globulin: primary structure and messenger ribonucleic acid levels in the liver under different physiological conditions. Mol Endocrinol 3: 420-426, 1989.
34. Solberg LC, Ahmadiyeh N, Baum AE, Vitaterna MH, Takahashi JS, Turek FW, and Redei EE. Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto X Fischer 344 cross. Mol Psychiatry 8: 423-433, 2003.
35. Solberg LC, Baum AE, Ahmadiyeh N, Shimomura K, Li R, Turek FW, Churchill GA, Takahashi JS, and Redei EE. Sex- and lineage-specific inheritance of depression-like behavior in the rat. Mamm Genome 15: 648-662, 2004.
36. Spencer RL, Miller AH, Moday H, McEwen BS, Blanchard RJ, Blanchard DC, and Sakai RR. Chronic social stress produces reductions in available splenic type II corticosteroid receptor binding and plasma corticosteroid binding globulin levels. Psychoneuroendocrinology 21: 95-109, 1996.
37. Steckler T. The molecular neurobiology of stress-evidence from genetic and epigenetic models. Behav Pharmacol 12: 381-427, 2001.
38. Sugiyama F, Churchill GA, Li R, Libby LJ, Carver T, Yagami K, John SW, and Paigen B. QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice. Physiol Genomics 10: 5-12, 2002.
39. Tannenbaum B, Rowe W, Sharma S, Diorio J, Steverman A, Walker M, and Meaney MJ. Dynamic variations in plasma corticosteroid-binding globulin and basal HPA activity following acute stress in adult rats. J Neuroendocrinol 9: 163-168, 1997.
40. Tarricone BJ, Hingtgen JN, Belknap JK, Mitchell SR, and Nurnberger JI Jr. Quantitative trait loci associated with the behavioral response of B X D recombinant inbred mice to restraint stress: a preliminary communication. Behav Genet 25: 489-495, 1995.
41. Tizabi Y and Aguilera G. Desensitization of the hypothalamic-pituitary-adrenal axis following prolonged administration of corticotropin-releasing hormone or vasopressin. Neuroendocrinology 56: 611-618, 1992.
42. Viau V. Functional cross-talk between the hypothalamic-pituitary- gonadal and -adrenal axes. J Neuroendocrinol 14: 506-513, 2002.
43. Willenberg HS, Bornstein SR, Dumser T, Ehrhart-Bornstein M, Barocka A, Chrousos GP, and Scherbaum WA. Morphological changes in adrenals from victims of suicide in relation to altered apoptosis. Endocr Res 24: 963-967, 1998.
44. Wood PR and Shire JG. Persistent inverse maternal effect on corticosterone production in vitro. Experientia 40: 1000-1001, 1984.
45. Yoshikawa T, Watanabe A, Ishitsuka Y, Nakaya A, and Nakatani N. Identification of multiple genetic loci linked to the propensity for "behavioral despair" in mice. Genome Res 12: 357-366, 2002.
46. Young EA, Aggen SH, Prescott CA, and Kendler KS. Similarity in saliva cortisol measures in monozygotic twins and the influence of past major depression. Biol Psychiatry 48: 70-74, 2000.
47. Zeng ZB. Precision mapping of quantitative trait loci. Genetics 136: 1457-1468, 1994.