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Volumn 7, Issue 5, 2007, Pages 346-353

Clinical utility of biochemical markers of bone metabolism for improving the management of patients with advanced multiple myeloma

Author keywords

Bone markers; Telopeptides; Zoledronic acid

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; AMINO TERMINAL TELOPEPTIDE; ANTINEOPLASTIC AGENT; BIOCHEMICAL MARKER; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; CARBOXY TERMINAL TELOPEPTIDE; CREATININE; DEOXYPYRIDINOLINE; HYDROXYPROLINE; IBANDRONIC ACID; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PAMIDRONIC ACID; PYRIDINOLINE; SIALOPROTEIN; ZOLEDRONIC ACID;

EID: 34248143552     PISSN: 15579190     EISSN: None     Source Type: Journal    
DOI: 10.3816/CLM.2007.n.011     Document Type: Review
Times cited : (27)

References (72)
  • 1
    • 5444262558 scopus 로고    scopus 로고
    • Bisphosphonates: Clinical experience
    • Coleman RE. Bisphosphonates: clinical experience. Oncologist 2004; 9(suppl 4):14-27.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 4 , pp. 14-27
    • Coleman, R.E.1
  • 2
    • 0025783336 scopus 로고
    • Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma
    • Bataille R, Chappard D, Marcelli C, et al. Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma. J Clin Invest 1991; 88:62-66.
    • (1991) J Clin Invest , vol.88 , pp. 62-66
    • Bataille, R.1    Chappard, D.2    Marcelli, C.3
  • 3
    • 0028350484 scopus 로고
    • Biologic, histologic and densitometric effects of oral risedronate on bone in patients with multiple myeloma
    • Roux C, Ravaud P, Cohen-Solal M, et al, Biologic, histologic and densitometric effects of oral risedronate on bone in patients with multiple myeloma. Bone 1994; 15:41-49.
    • (1994) Bone , vol.15 , pp. 41-49
    • Roux, C.1    Ravaud, P.2    Cohen-Solal, M.3
  • 4
    • 0026690115 scopus 로고
    • Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption
    • Taube T, Beneton MN, McCloskey EV, et al. Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption. Eur J Haematol 1992; 49:192-198.
    • (1992) Eur J Haematol , vol.49 , pp. 192-198
    • Taube, T.1    Beneton, M.N.2    McCloskey, E.V.3
  • 5
    • 0020436606 scopus 로고
    • Quantitative histology of myeloma-induced bone changes
    • Valentin-Opran A, Charhon SA, Meunier PJ, et al. Quantitative histology of myeloma-induced bone changes. Br J Haematol 1982; 52:601-610.
    • (1982) Br J Haematol , vol.52 , pp. 601-610
    • Valentin-Opran, A.1    Charhon, S.A.2    Meunier, P.J.3
  • 6
    • 0035425227 scopus 로고    scopus 로고
    • Biology of osteoclast activation in cancer
    • Roodman GD. Biology of osteoclast activation in cancer. J Clin Oncol 2001; 19:3562-3571.
    • (2001) J Clin Oncol , vol.19 , pp. 3562-3571
    • Roodman, G.D.1
  • 7
    • 1842505726 scopus 로고    scopus 로고
    • Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1alpha and MIP-1beta correlates with lytic bone lesions in patients with multiple myeloma
    • Hashimoto T, Abe M, Oshima T, et al. Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1alpha and MIP-1beta correlates with lytic bone lesions in patients with multiple myeloma. Br J Haematol 2004; 125:38-41.
    • (2004) Br J Haematol , vol.125 , pp. 38-41
    • Hashimoto, T.1    Abe, M.2    Oshima, T.3
  • 8
    • 0031735152 scopus 로고    scopus 로고
    • Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells
    • Horwood NJ, Elliott J, Martin TJ, et al. Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells. Endocrinology 1998; 139:4743-4746.
    • (1998) Endocrinology , vol.139 , pp. 4743-4746
    • Horwood, N.J.1    Elliott, J.2    Martin, T.J.3
  • 9
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet WS, Lacey DL, Dunstan CR, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997; 89:309-319.
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3
  • 10
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey DL, Timms E, Tan HL, et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998; 93:165-176.
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3
  • 11
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
    • Giuliani N, Bataille R, Mancini C, et al. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 2001; 98:3527-3533.
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3
  • 12
    • 0035949510 scopus 로고    scopus 로고
    • Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    • Pearse RN, Sordillo EM, Yaccoby S, et al. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Proc Natl Acad Sci USA 2001; 98:11581-11586.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11581-11586
    • Pearse, R.N.1    Sordillo, E.M.2    Yaccoby, S.3
  • 13
    • 0035496947 scopus 로고    scopus 로고
    • Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease
    • Seidel C, Hjertner O, Abildgaard N, et al. Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease. Blood 2001; 98:2269-2271.
    • (2001) Blood , vol.98 , pp. 2269-2271
    • Seidel, C.1    Hjertner, O.2    Abildgaard, N.3
  • 14
    • 85030523276 scopus 로고    scopus 로고
    • Biochemical markers of bone turnover in the diagnosis of myeloma bone disease
    • 16 suppl):585s Abstract #6600
    • Dizdar O, Barista I, Kalyoncu U, et al. Biochemical markers of bone turnover in the diagnosis of myeloma bone disease. J Clin Oncol 2005; 23(16 suppl):585s (Abstract #6600).
    • (2005) J Clin Oncol , pp. 23
    • Dizdar, O.1    Barista, I.2    Kalyoncu, U.3
  • 15
    • 4544360663 scopus 로고    scopus 로고
    • Role of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin and macrophage protein 1-alpha (MIP-1a) in monoclonal gammopathy of undetermined significance (MGUS)
    • Politou M, Terpos E, Anagnostopoulos A, et al. Role of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin and macrophage protein 1-alpha (MIP-1a) in monoclonal gammopathy of undetermined significance (MGUS). Br J Haematol 2004; 126:686-689.
    • (2004) Br J Haematol , vol.126 , pp. 686-689
    • Politou, M.1    Terpos, E.2    Anagnostopoulos, A.3
  • 16
    • 0344011473 scopus 로고    scopus 로고
    • Clinical review 165: Markers of bone remodeling in metastatic bone disease
    • Fohr B, Dunstan CR, Seibel MJ. Clinical review 165: markers of bone remodeling in metastatic bone disease. J Clin Endocrinol Metab 2003; 88:5059-5075.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5059-5075
    • Fohr, B.1    Dunstan, C.R.2    Seibel, M.J.3
  • 17
    • 0032952132 scopus 로고    scopus 로고
    • Novel serum markers of bone resorption: Clinical assessment and comparison with established urinary indices
    • Woitge HW, Pecherstorfer M, Li Y, et al. Novel serum markers of bone resorption: clinical assessment and comparison with established urinary indices. J Bone Miner Res 1999; 14:792-801.
    • (1999) J Bone Miner Res , vol.14 , pp. 792-801
    • Woitge, H.W.1    Pecherstorfer, M.2    Li, Y.3
  • 18
    • 0037093808 scopus 로고    scopus 로고
    • The clinical use of bone resorption markers in patients with malignant bone disease
    • Coleman RE. The clinical use of bone resorption markers in patients with malignant bone disease. Cancer 2002; 94:2521-2533.
    • (2002) Cancer , vol.94 , pp. 2521-2533
    • Coleman, R.E.1
  • 19
    • 0025878928 scopus 로고
    • Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis
    • Delmas PD, Schlemmer A, Gineyts E, et al. Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis. J Bone Miner Res 1991; 6:639-644.
    • (1991) J Bone Miner Res , vol.6 , pp. 639-644
    • Delmas, P.D.1    Schlemmer, A.2    Gineyts, E.3
  • 20
    • 0031408477 scopus 로고    scopus 로고
    • Bone biomarkers as tools in osteoporosis management
    • Eyre DR. Bone biomarkers as tools in osteoporosis management. Spine 1997; 22(suppl):17S-24S.
    • (1997) Spine , vol.22 , Issue.SUPPL.
    • Eyre, D.R.1
  • 21
    • 0023935232 scopus 로고
    • Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues
    • Eyre DR, Dickson IR, Van Ness K. Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues. Biochem J 1988; 252:495-500.
    • (1988) Biochem J , vol.252 , pp. 495-500
    • Eyre, D.R.1    Dickson, I.R.2    Van Ness, K.3
  • 22
    • 0032032089 scopus 로고    scopus 로고
    • Collagen cross-links in mineralizing tissues: A review of their chemistry, function, and clinical relevance
    • Knott L, Bailey AJ. Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance. Bone 1998; 22:181-187.
    • (1998) Bone , vol.22 , pp. 181-187
    • Knott, L.1    Bailey, A.J.2
  • 23
    • 0030455389 scopus 로고    scopus 로고
    • Effects of bone metastases on bone metabolism: Implications for diagnosis, imaging and assessment of response to cancer treatment
    • Vinholes J, Coleman R, Eastell R. Effects of bone metastases on bone metabolism: implications for diagnosis, imaging and assessment of response to cancer treatment. Cancer Treat Rev 1996; 22:289-331.
    • (1996) Cancer Treat Rev , vol.22 , pp. 289-331
    • Vinholes, J.1    Coleman, R.2    Eastell, R.3
  • 24
    • 17044446655 scopus 로고    scopus 로고
    • Markers of bone resorption in patients treated with pamidronate
    • Lipton A, Demers L, Curley E, et al. Markers of bone resorption in patients treated with pamidronate. Eur J Cancer 1998; 34:2021-2026.
    • (1998) Eur J Cancer , vol.34 , pp. 2021-2026
    • Lipton, A.1    Demers, L.2    Curley, E.3
  • 25
    • 0028800047 scopus 로고
    • Biochemical markers of bone turnover in patients with metastatic bone disease
    • Demers LM, Costa L, Chinchilli VM, et al. Biochemical markers of bone turnover in patients with metastatic bone disease. Clin Chem 1995; 41:1489-1494.
    • (1995) Clin Chem , vol.41 , pp. 1489-1494
    • Demers, L.M.1    Costa, L.2    Chinchilli, V.M.3
  • 26
    • 0032896513 scopus 로고    scopus 로고
    • Assessment of bone response to systemic therapy in an EORTC trial: Preliminary experience with the use of collagen cross-link excretion. European Organization for Research and Treatment of Cancer
    • Vinholes J, Coleman R, Lacombe D, et al. Assessment of bone response to systemic therapy in an EORTC trial: preliminary experience with the use of collagen cross-link excretion. European Organization for Research and Treatment of Cancer. Br J Cancer 1999; 80:221-228.
    • (1999) Br J Cancer , vol.80 , pp. 221-228
    • Vinholes, J.1    Coleman, R.2    Lacombe, D.3
  • 27
    • 0035022942 scopus 로고    scopus 로고
    • Markers of bone turnover in prostate cancer
    • discussion, 193-196
    • Garnero P. Markers of bone turnover in prostate cancer. Cancer Treat Rev 2001; 27:187-192; discussion, 193-196.
    • (2001) Cancer Treat Rev , vol.27 , pp. 187-192
    • Garnero, P.1
  • 28
    • 0032902720 scopus 로고    scopus 로고
    • Evaluation of bone disease in multiple myeloma: A comparison between the resorption markers urinary deoxypyridinoline/creatinine (DPD) and serum ICTP, and an evaluation of the DPD/osteocalcin and ICTP/osteocalcin ratios
    • Carlson K, Larsson A, Simonsson B, et al. Evaluation of bone disease in multiple myeloma: a comparison between the resorption markers urinary deoxypyridinoline/creatinine (DPD) and serum ICTP, and an evaluation of the DPD/osteocalcin and ICTP/osteocalcin ratios. Eur J Haematol 1999; 62:300-306.
    • (1999) Eur J Haematol , vol.62 , pp. 300-306
    • Carlson, K.1    Larsson, A.2    Simonsson, B.3
  • 29
    • 24644479228 scopus 로고    scopus 로고
    • Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid
    • Coleman RE, Major P, Lipton A, et al. Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid. J Clin Oncol 2005; 23:4925-4935.
    • (2005) J Clin Oncol , vol.23 , pp. 4925-4935
    • Coleman, R.E.1    Major, P.2    Lipton, A.3
  • 30
    • 0034073082 scopus 로고    scopus 로고
    • Prognostic value of serum markers of bone metabolism in untreated multiple myeloma patients
    • Fonseca R, Trendle MC, Leong T, et al. Prognostic value of serum markers of bone metabolism in untreated multiple myeloma patients. Br J Haematol 2000; 109:24-29.
    • (2000) Br J Haematol , vol.109 , pp. 24-29
    • Fonseca, R.1    Trendle, M.C.2    Leong, T.3
  • 31
    • 0037278205 scopus 로고    scopus 로고
    • Comparison of five biochemical markers of bone resorption in multiple myeloma: Elevated pre-treatment levels of S-ICTP and U-Ntx are predictive for early progression of the bone disease during standard chemotherapy
    • Abildgaard N, Brixen K, Kristensen JE, et al. Comparison of five biochemical markers of bone resorption in multiple myeloma: elevated pre-treatment levels of S-ICTP and U-Ntx are predictive for early progression of the bone disease during standard chemotherapy. Br J Haematol 2003; 120:235-242.
    • (2003) Br J Haematol , vol.120 , pp. 235-242
    • Abildgaard, N.1    Brixen, K.2    Kristensen, J.E.3
  • 32
    • 4344588926 scopus 로고    scopus 로고
    • Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma
    • Terpos E, Politou M, Szydlo R, et al. Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma. Leukemia 2004; 18:1420-1426.
    • (2004) Leukemia , vol.18 , pp. 1420-1426
    • Terpos, E.1    Politou, M.2    Szydlo, R.3
  • 33
    • 0036842343 scopus 로고    scopus 로고
    • Evaluation of bone disease in multiple myeloma: A correlation between biochemical markers of bone metabolism and other clinical parameters in untreated multiple myeloma patients
    • Alexandrakis MG, Passam FH, Malliaraki N, et al. Evaluation of bone disease in multiple myeloma: a correlation between biochemical markers of bone metabolism and other clinical parameters in untreated multiple myeloma patients. Clin Chim Acta 2002; 325:51-57.
    • (2002) Clin Chim Acta , vol.325 , pp. 51-57
    • Alexandrakis, M.G.1    Passam, F.H.2    Malliaraki, N.3
  • 35
    • 0016207892 scopus 로고
    • Clinical significance of the human acid phosphatases: A review
    • Yam LT. Clinical significance of the human acid phosphatases: a review. Am J Med 1974; 56:604-616.
    • (1974) Am J Med , vol.56 , pp. 604-616
    • Yam, L.T.1
  • 36
    • 0023204752 scopus 로고
    • Characterization and assay of tartrate-resistant acid phosphatase activity in serum: Potential use to assess bone resorption
    • Lau KH, Onishi T, Wergedal JE, et al. Characterization and assay of tartrate-resistant acid phosphatase activity in serum: potential use to assess bone resorption. Clin Chem 1987; 33:458-462.
    • (1987) Clin Chem , vol.33 , pp. 458-462
    • Lau, K.H.1    Onishi, T.2    Wergedal, J.E.3
  • 37
    • 0025988704 scopus 로고
    • Clinical usefulness of serum tartrate-resistant acid phosphatase activity determination to evaluate bone turnover
    • Scarnecchia L, Minisola S, Pacitti MT, et al. Clinical usefulness of serum tartrate-resistant acid phosphatase activity determination to evaluate bone turnover. Scand J Clin Lab Invest 1991; 51:517-524.
    • (1991) Scand J Clin Lab Invest , vol.51 , pp. 517-524
    • Scarnecchia, L.1    Minisola, S.2    Pacitti, M.T.3
  • 38
    • 0034696777 scopus 로고    scopus 로고
    • Breast cancer cell line MDA-231 stimulates osteoclastogenesis and bone resorption in human osteoclasts
    • Grano M, Mori G, Minielli V, et al. Breast cancer cell line MDA-231 stimulates osteoclastogenesis and bone resorption in human osteoclasts. Biochem Biophys Res Commun 2000; 270:1097-1100.
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 1097-1100
    • Grano, M.1    Mori, G.2    Minielli, V.3
  • 39
    • 0038166881 scopus 로고    scopus 로고
    • Tartrate-resistant acid phosphatase isoform 5b: A novel serum marker for monitoring bone disease in multiple myeloma
    • Terpos E, de la Fuente J, Szydlo R, et al. Tartrate-resistant acid phosphatase isoform 5b: a novel serum marker for monitoring bone disease in multiple myeloma. Int J Cancer 2003; 106:455-457.
    • (2003) Int J Cancer , vol.106 , pp. 455-457
    • Terpos, E.1    de la Fuente, J.2    Szydlo, R.3
  • 40
    • 0027080073 scopus 로고
    • Perspectives in alkaline phosphatase research
    • Moss DW. Perspectives in alkaline phosphatase research. Clin Chem 1992; 38:2486-2492.
    • (1992) Clin Chem , vol.38 , pp. 2486-2492
    • Moss, D.W.1
  • 41
    • 0032875860 scopus 로고    scopus 로고
    • Clinical utility of biochemical markers of bone remodeling
    • Watts NB. Clinical utility of biochemical markers of bone remodeling. Clin Chem 1999; 45:1359-1368.
    • (1999) Clin Chem , vol.45 , pp. 1359-1368
    • Watts, N.B.1
  • 42
    • 0034095502 scopus 로고    scopus 로고
    • Bone mineral density and biochemical markers of bone turnover in peri- and postmenopausal women
    • De Leo V, Ditto A, la Marca A, et al. Bone mineral density and biochemical markers of bone turnover in peri- and postmenopausal women. Calcif Tissue Int 2000; 66:263-267.
    • (2000) Calcif Tissue Int , vol.66 , pp. 263-267
    • De Leo, V.1    Ditto, A.2    la Marca, A.3
  • 43
    • 0027480865 scopus 로고
    • The effect of age on bone collagen turnover as assessed by pyridinium crosslinks and procollagen I C-terminal peptide
    • Eastell R, Peel NF, Hannon RA, et al. The effect of age on bone collagen turnover as assessed by pyridinium crosslinks and procollagen I C-terminal peptide. Osteoporos Int 1993; 3(suppl 1):100-101.
    • (1993) Osteoporos Int , vol.3 , Issue.SUPPL. 1 , pp. 100-101
    • Eastell, R.1    Peel, N.F.2    Hannon, R.A.3
  • 44
    • 0028840178 scopus 로고
    • Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: A longitudinal study
    • Cross NA, Hillman LS, Allen SH, et al. Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study. Am J Clin Nutr 1995; 61:514-523.
    • (1995) Am J Clin Nutr , vol.61 , pp. 514-523
    • Cross, N.A.1    Hillman, L.S.2    Allen, S.H.3
  • 45
    • 0026604489 scopus 로고
    • Serum osteocalcin concentrations in patients with multiple myeloma - correlation with disease stage and survival
    • Carlson K, Ljunghall S, Simonsson B, et al. Serum osteocalcin concentrations in patients with multiple myeloma - correlation with disease stage and survival. J Intern Med 1992; 231:133-137.
    • (1992) J Intern Med , vol.231 , pp. 133-137
    • Carlson, K.1    Ljunghall, S.2    Simonsson, B.3
  • 46
    • 9044243403 scopus 로고    scopus 로고
    • Osteocalcin is not a marker of progress in multiple myeloma. Le Groupe d'Etude et de Recherche sur le Myelome (GERM)
    • Mejjad O, Le Loet X, Basuyau JP, et al. Osteocalcin is not a marker of progress in multiple myeloma. Le Groupe d'Etude et de Recherche sur le Myelome (GERM). Eur J Haematol 1996; 56:30-34.
    • (1996) Eur J Haematol , vol.56 , pp. 30-34
    • Mejjad, O.1    Le Loet, X.2    Basuyau, J.P.3
  • 47
    • 0035004937 scopus 로고    scopus 로고
    • Biochemical markers of bone disease in asymptomatic early stage multiple myeloma. A study on their role in identifying high risk patients
    • Corso A, Arcaini L, Mangiacavalli S, et al. Biochemical markers of bone disease in asymptomatic early stage multiple myeloma. A study on their role in identifying high risk patients. Haematologica 2001; 86:394-398.
    • (2001) Haematologica , vol.86 , pp. 394-398
    • Corso, A.1    Arcaini, L.2    Mangiacavalli, S.3
  • 48
    • 0036659918 scopus 로고    scopus 로고
    • Bone resorption parameters [carboxy-terminal telopeptide of type-I collagen (ICTP), amino-terminal collagen type-I telopeptide (NTx), and deoxypyridinoline (Dpd)] in MGUS and multiple myeloma
    • Jakob C, Zavrski I, Heider U, et al. Bone resorption parameters [carboxy-terminal telopeptide of type-I collagen (ICTP), amino-terminal collagen type-I telopeptide (NTx), and deoxypyridinoline (Dpd)] in MGUS and multiple myeloma. Eur J Haematol 2002; 69:37-42.
    • (2002) Eur J Haematol , vol.69 , pp. 37-42
    • Jakob, C.1    Zavrski, I.2    Heider, U.3
  • 49
    • 12444282685 scopus 로고    scopus 로고
    • Serum levels of carboxy-terminal telopeptide of type-I collagen are elevated in patients with multiple myeloma showing skeletal manifestations in magnetic resonance imaging but lacking lytic bone lesions in conventional radiography
    • Jakob C, Zavrski I, Heider U, et al. Serum levels of carboxy-terminal telopeptide of type-I collagen are elevated in patients with multiple myeloma showing skeletal manifestations in magnetic resonance imaging but lacking lytic bone lesions in conventional radiography. Clin Cancer Res 2003; 9:3047-3051.
    • (2003) Clin Cancer Res , vol.9 , pp. 3047-3051
    • Jakob, C.1    Zavrski, I.2    Heider, U.3
  • 50
    • 10244252871 scopus 로고    scopus 로고
    • Prognostic value of urinary pyridinium crosslinks and their derivatives in multiple myeloma
    • Samani KK, Brazier M, Mathiot C, et al. Prognostic value of urinary pyridinium crosslinks and their derivatives in multiple myeloma. Ann Hematol 2005; 84:19-24.
    • (2005) Ann Hematol , vol.84 , pp. 19-24
    • Samani, K.K.1    Brazier, M.2    Mathiot, C.3
  • 51
    • 0029000364 scopus 로고
    • Clinical studies using measurement of N-telopeptides of type 1 collagen (NTx) in patients with bone metastasis - comparison with bone scintigraphy and other metabolic bone markers [in Japanese]
    • Yamamoto I, Morita R, Konishi J, et al. Clinical studies using measurement of N-telopeptides of type 1 collagen (NTx) in patients with bone metastasis - comparison with bone scintigraphy and other metabolic bone markers [in Japanese]. Kaku Igaku 1995; 32:501-510.
    • (1995) Kaku Igaku , vol.32 , pp. 501-510
    • Yamamoto, I.1    Morita, R.2    Konishi, J.3
  • 52
    • 0034021345 scopus 로고    scopus 로고
    • Biochemical markers of bone metabolism reflect osteoclastic and osteoblastic activity in multiple myeloma
    • Abildgaard N, Glerup H, Rungby J, et al. Biochemical markers of bone metabolism reflect osteoclastic and osteoblastic activity in multiple myeloma. Eur J Haematol 2000; 64:121-129.
    • (2000) Eur J Haematol , vol.64 , pp. 121-129
    • Abildgaard, N.1    Glerup, H.2    Rungby, J.3
  • 53
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: Proposal for a novel prognostic index
    • Terpos E, Szydlo R, Apperley JF, et al. Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index. Blood 2003; 102:1064-1069.
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1    Szydlo, R.2    Apperley, J.F.3
  • 54
    • 0036729485 scopus 로고    scopus 로고
    • American Society of Clinical Oncology clinical ptactice guidelines: The role of bisphosphonates in multiple myeloma
    • Berenson JR, Hillner BE, Kyle RA, et al. American Society of Clinical Oncology clinical ptactice guidelines: the role of bisphosphonates in multiple myeloma. J Clin Oncol 2002; 20:3719-3736.
    • (2002) J Clin Oncol , vol.20 , pp. 3719-3736
    • Berenson, J.R.1    Hillner, B.E.2    Kyle, R.A.3
  • 55
    • 0036148405 scopus 로고    scopus 로고
    • Development of bisphosphonates
    • Fleisch H. Development of bisphosphonates. Breast Cancer Res 2002; 4:30-34.
    • (2002) Breast Cancer Res , vol.4 , pp. 30-34
    • Fleisch, H.1
  • 56
    • 0034906503 scopus 로고    scopus 로고
    • A phase I dose-ranging trial of monthly infusions of zoledronic acid for the treatment of osteolytic bone metastases
    • Berenson JR, Vescio RA, Rosen LS, et al. A phase I dose-ranging trial of monthly infusions of zoledronic acid for the treatment of osteolytic bone metastases. Clin Cancer Res 2001; 7:478-485.
    • (2001) Clin Cancer Res , vol.7 , pp. 478-485
    • Berenson, J.R.1    Vescio, R.A.2    Rosen, L.S.3
  • 57
    • 0035178874 scopus 로고    scopus 로고
    • Comparison of the effects of intravenous pamidronate and oral clodronate on symptoms and bone resorption in patients with metastatic bone disease
    • Jagdev SP, Putohit P, Heatley S, et al. Comparison of the effects of intravenous pamidronate and oral clodronate on symptoms and bone resorption in patients with metastatic bone disease. Ann Oncol 2001; 12:1433-1438.
    • (2001) Ann Oncol , vol.12 , pp. 1433-1438
    • Jagdev, S.P.1    Putohit, P.2    Heatley, S.3
  • 58
    • 28844506817 scopus 로고    scopus 로고
    • Zoledronic acid to prevent skeletal complications in cancer: Corroborating the evidence
    • Smith MR. Zoledronic acid to prevent skeletal complications in cancer: corroborating the evidence. Cancer Treat Rev 2005; 31(suppl 3): 19-25.
    • (2005) Cancer Treat Rev , vol.31 , Issue.SUPPL. 3 , pp. 19-25
    • Smith, M.R.1
  • 59
    • 6844252283 scopus 로고    scopus 로고
    • Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group
    • Berenson JR, Lichtenstein A, Porter L, et al. Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group. J Clin Oncol 1998; 16:593-602.
    • (1998) J Clin Oncol , vol.16 , pp. 593-602
    • Berenson, J.R.1    Lichtenstein, A.2    Porter, L.3
  • 60
    • 0035463593 scopus 로고    scopus 로고
    • Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: A phase III, double-blind, comparative trial
    • Rosen LS, Gordon D, Kaminski M, et al. Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase III, double-blind, comparative trial. Cancer J 2001; 7:377-387.
    • (2001) Cancer J , vol.7 , pp. 377-387
    • Rosen, L.S.1    Gordon, D.2    Kaminski, M.3
  • 61
    • 19244365106 scopus 로고    scopus 로고
    • Pamidronate is superior to ibandronate in decreasing bone resorption, interleukin-6 and beta 2-microglobulin in multiple myeloma
    • Terpos E, Viniou N, de la Fuente J, et al. Pamidronate is superior to ibandronate in decreasing bone resorption, interleukin-6 and beta 2-microglobulin in multiple myeloma. Eur J Haematol 2003; 70:34-42.
    • (2003) Eur J Haematol , vol.70 , pp. 34-42
    • Terpos, E.1    Viniou, N.2    de la Fuente, J.3
  • 62
    • 27644523704 scopus 로고    scopus 로고
    • The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteoprotegerin ratio
    • Terpos E, Mihou D, Szydlo R, et al. The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteoprotegerin ratio. Leukemia 2005; 19:1969-1976.
    • (2005) Leukemia , vol.19 , pp. 1969-1976
    • Terpos, E.1    Mihou, D.2    Szydlo, R.3
  • 63
    • 0033744201 scopus 로고    scopus 로고
    • Effect of pamidronate administration on markers of bone turnover and disease activity in multiple myeloma
    • Terpos E, Palermos J, Tsionos K, et al. Effect of pamidronate administration on markers of bone turnover and disease activity in multiple myeloma. Eur J Haematol 2000; 65:331-336.
    • (2000) Eur J Haematol , vol.65 , pp. 331-336
    • Terpos, E.1    Palermos, J.2    Tsionos, K.3
  • 64
    • 0036570071 scopus 로고    scopus 로고
    • Effects of long-term intravenous ibandronate therapy on skeletal-related events, survival, and bone resorption markers in patients with advanced multiple myeloma
    • Menssen HD, Sakalova A, Fontana A, et al. Effects of long-term intravenous ibandronate therapy on skeletal-related events, survival, and bone resorption markers in patients with advanced multiple myeloma. J Clin Oncol 2002; 20:2353-2359.
    • (2002) J Clin Oncol , vol.20 , pp. 2353-2359
    • Menssen, H.D.1    Sakalova, A.2    Fontana, A.3
  • 65
    • 33144482079 scopus 로고    scopus 로고
    • Suppression of bone turnover mark ers by zoledronic acid and correlation with clinical outcome
    • 16 suppl):11s Abstract #532
    • Lipton A, Hei Y, Coleman R, et al. Suppression of bone turnover mark ers by zoledronic acid and correlation with clinical outcome. J Clin Oncol 2005; 23(16 suppl):11s (Abstract #532).
    • (2005) J Clin Oncol , pp. 23
    • Lipton, A.1    Hei, Y.2    Coleman, R.3
  • 66
    • 0037009822 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma
    • Saad F, Gleason DM, Murray R, et al. A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma. J Natl Cancer Inst 2002; 94:1458-1468.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1458-1468
    • Saad, F.1    Gleason, D.M.2    Murray, R.3
  • 67
    • 10744233021 scopus 로고    scopus 로고
    • Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: A randomized, double-blind, multicenter, comparative trial
    • Rosen LS, Gordon D, Kaminski M, et al. Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trial. Cancer 2003; 98:1735-1744.
    • (2003) Cancer , vol.98 , pp. 1735-1744
    • Rosen, L.S.1    Gordon, D.2    Kaminski, M.3
  • 68
    • 2642521168 scopus 로고    scopus 로고
    • Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors: A randomized, phase III, double-blind, placebo-controlled trial
    • Rosen LS, Gordon D, Tchekmedyian NS, et al. Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors: a randomized, phase III, double-blind, placebo-controlled trial. Cancer 2004; 100:2613-2621.
    • (2004) Cancer , vol.100 , pp. 2613-2621
    • Rosen, L.S.1    Gordon, D.2    Tchekmedyian, N.S.3
  • 69
    • 34248159012 scopus 로고    scopus 로고
    • Prognostic significance of persistently elevated N-telopeptide levels in patients with bone metastases from solid tumors
    • Abstract #870P
    • Lipton A, Cook R, Coleman R, et al. Prognostic significance of persistently elevated N-telopeptide levels in patients with bone metastases from solid tumors. Ann Oncol 2006; 17(suppl 9):ix254 (Abstract #870P).
    • (2006) Ann Oncol , vol.17 , Issue.SUPPL. 9
    • Lipton, A.1    Cook, R.2    Coleman, R.3
  • 70
    • 85030516655 scopus 로고    scopus 로고
    • Zoledronic acid may improve survival in lung cancer patients with high baseline bone marker levels
    • Abstract #739PD
    • Major P, Hirsh V, Lipton A, et al. Zoledronic acid may improve survival in lung cancer patients with high baseline bone marker levels. Ann Oncol 2006; 17(suppl 9):ix221 (Abstract #739PD).
    • (2006) Ann Oncol , vol.17 , Issue.SUPPL. 9
    • Major, P.1    Hirsh, V.2    Lipton, A.3
  • 71
    • 34248650866 scopus 로고    scopus 로고
    • Zoledronic acid is associated with a survival benefit in patients with multiple myeloma stratified by baseline bone alkaline phosphatase levels
    • Presented at: June 22-24, Toronto, Ontario, Canada. Abstract
    • Berenson J, Shirina N, Chen Y-M. Zoledronic acid is associated with a survival benefit in patients with multiple myeloma stratified by baseline bone alkaline phosphatase levels. Presented at: MASCC/ISOO 18th International Symposium; June 22-24, 2006; Toronto, Ontario, Canada. Abstract #1621.
    • (2006) MASCC/ISOO 18th International Symposium , Issue.1621
    • Berenson, J.1    Shirina, N.2    Chen, Y.-M.3
  • 72
    • 85030509913 scopus 로고    scopus 로고
    • Berenson JR, Shirina N, Chen Y-M, et al. Survival in patients with multiple myeloma receiving zoledronic acid: stratification by baseline bone alkaline phosphatase levels. J Clin Oncol 2006; 24(18 suppl):423s (Abstract #7505).
    • Berenson JR, Shirina N, Chen Y-M, et al. Survival in patients with multiple myeloma receiving zoledronic acid: stratification by baseline bone alkaline phosphatase levels. J Clin Oncol 2006; 24(18 suppl):423s (Abstract #7505).


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