Clinical utility of biochemical markers of bone remodeling

Clinical Chemistry

Volumn 45, Issue 8 II, 1999, Pages 1359-1368

  Watts, Nelson B ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 CARBOXYGLUTAMIC ACID; ACID PHOSPHATASE; ALENDRONIC ACID; ALKALINE PHOSPHATASE; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; COLLAGEN TYPE 1; DEOXYPYRIDINOLINE; ESTROGEN; HYDROXYPROLINE; OSTEOCALCIN; PROCOLLAGEN; PYRIDINIUM DERIVATIVE; TARTARIC ACID DERIVATIVE;

BONE DISEASE; BONE MASS; BONE REMODELING; CONFERENCE PAPER; ESTROGEN THERAPY; FRACTURE; HIGH RISK POPULATION; HORMONE SUBSTITUTION; HUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOPOROSIS;

BIOLOGICAL MARKERS; BONE AND BONES; BONE DISEASES; BONE REMODELING; BONE RESORPTION; HUMANS; LABORATORY TECHNIQUES AND PROCEDURES;

EID: 0032875860     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (79)

1. Eyre DR. Collagen cross-linking amino acids. Methods Enzymol 1987;144:115-39.
2. Deacon AC, Hulme P, Hesp R, Green JR, Tellez M, Reeve J. Estimation of whole body bone resorption rate: a comparison of urinary total hydroxyproline excretion with two radioisotopic tracer methods in osteoporosis. Clin Chim Acta 1997;166:297-306.
3. Colwell A, Russell RGG, Eastell R. Factors affecting the assay of urinary 3-hydroxy pyridinium crosslinks of collagen as markers of bone resorption. Eur J Clin Investig 1993;23:341-9.
4. Ubelhart D, Gineyts E, Chapuy M-C, Delmas PD. Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease. Bone Miner 1990;8:87-96.
5. Rosano TG, Peaston RT, Bone HG, Woitge HW, Francis RM, Seibel MJ. Urinary free deoxypyridinoline by chemiluminescence immunoassay: analytical and clinical evaluation. Clin Chem 1998;44: 2126-32.
6. Seyedin SM, Kung VT, Daniloff YN, Hesley RP, Gomez B, Nielsen LA, et al. Immunoassay for urinary pyridinoline: a new marker of bone resorption. J Bone Miner Res 1993;8:635-42.
7. Robins SP, Woitge H, Hesley R, Ju J, Seyedin S, Seibel MJ. Direct, enzyme-linked immunoassay for urinary deoxypyridinoline as a specific marker for measuring bone resorption. J Bone Miner Res 1994;9:1643-9.
8. Garnero P, Gineyts E, Riou JP, Delmas PD. Assessment of bone resorption with a new marker of collagen degradation in patients with metabolic bone disease. J Clin Endocrinol Metab 1994;79: 780-5.
9. Hanson DA, Weis MAE, Bollen A-M, Maslan SL, Singer FR, Eyre DR. A specific immunoassay for monitoring human bone resorption: quantitation of type I collagen cross-linked N-telopeptides in urine. J Bone Miner Res 1992;7:1251-8.
10. Bonde M, Qvist P, Fledelius C, Riis BJ, Christiansen C. Applications of an enzyme immunoassay for a new marker of bone resorption (CrossLaps): follow-up on hormone replacement therapy and osteoporosis risk assessment. J Clin Endocrinol Metab 1995;80:864-8.
11. Bonde M, Garnero P, Fledelius C, Qvist P, Delmas PD, Christiansen C. Measurement of bone degradation products in serum using antibodies reactive with an isomerized form of an 8 amino acid sequence of the C-telopeptide of type I collagen. J Bone Miner Res 1997;12:1028-34.
12. Christgau S, Rosenquist C, Alexandersen P, Bjarnason NH, Ravn P, Fledelius C, et al. Clinical evaluation of the serum CrossLaps One Step ELISA, a new assay measuring the serum concentration of bone-derived degradation products of type I collagen C-telopeptides. Clin Chem 1998;44:2290-300.
13. Gertz BJ, Clemens JD, Holland SD, Yuan W, Greenspan S. Application of a new serum assay for type I collagen cross-linked N-telopeptides: assessment of diurnal change in bone turnover with and without alendronate treatment. Calcif Tissue Int 1998; 63:102-6.
14. Scariano JK, Glew RH, Bou-Serhal CE, Clemens JD, Garry PJ, Baumgartner RN. Serum levels of cross-linked N-telopeptides and aminoterminal propeptides of type I collagen indicate low bone mineral density in elderly women. Bone 1998;23:471-7.
15. Moss DW. Diagnostic aspects of alkaline phosphatase and its isoenzymes. Clin Biochem 1987;20:225-30.
16. Lehmann FG. Human alkaline phosphatases. Evidence of three isoenzymes (placental, intestinal and liver-bone-kidney-type) by lectin-binding affinity and immunological specificity. Biochim Biophys Acta 1980;616:41-59.
17. Gomez B Jr, Ardakani S, Ju J, Jenkins D, Cerelli MJ, Daniloff GY, Kung VT. Monoclonal antibody assay for measuring bone-specific alkaline phosphatase in serum. Clin Chem 1995;41:1560-6.
18. Garnero P, Delmas PD. Assessment of serum levels of bone alkaline phosphatase with a new immunoradiometric assay in patients with metabolic bone disease. J Clin Endocrinol Metab 1993;77:1046-53.
19. Farley JR, Chesnut CH, Baylink DJ. Improved method for quantitative determination in serum of alkaline phosphatase of skeletal origin. Clin Chem 1981;27:2002-7.
20. Catherwood BD, Marcus R, Madvig P, Cheung AK. Determinants of bone gamma-carboxyglutamic acid-containing protein in plasma of healthy aging subjects. Bone 1985;6:9-13.
21. Delmas PD. Biochemical markers of bone turnover. I. Theoretical considerations and clinical use in osteoporosis. Am J Med 1993; 95(Suppl 5A):11S-6S.
22. Garnero P, Grimaux M, Seguin P, Delmas PD. Characterization of immunoreactive forms of human osteocalcin generated in vivo and in vitro. J Bone Miner Res 1994;255-64.
23. Taylor AK, Linkhart S, Mohan S, Christenson RA, Singer FR, Baylink DJ. Multiple osteocalcin fragments in human urine and serum as detected by a midmolecule osteocalcin radioimmunoassay. J Clin Endocrinol Metab 1990;70:467-72.
24. Delmas PD, Christiansen C, Mann KO, Price PA. Bone Gla protein (osteocalcin) assay standardization report. J Bone Miner Res 1990;5:5-11.
25. Masters PW, Jones RG, Purves DA, Cooper EH, Cooney JM. Commercial assays for serum osteocalcin give clinically discordant results. Clin Chem 1994;40:358-63.
26. Knapen MHJ, Nieuwenhuijzen Kruseman AC, Wouters RSME, Vermeer C. Correlation of serum osteocalcin fractions with bone mineral density in women during the first 10 years after menopause. Calcif Tissue Int 1998;63:375-9.
27. Minisola S, Rosso R, Romagnoli E, D'Erasmo E, Manfredi G, Damian C, et al. Serum osteocalcin and bone mineral density at various skeletal sites: a study performed with three different assays. J Lab Clin Med 1997;129:422-9.
28. Szulc P, Chapuy M-C, Meunier PJ, Delmas PD. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Investig 1993;91:1769-74.
29. Vergnaud P, Garnero P, Meunier PJ, Breart G, Kamihagi K, Delmas PD. Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS study. J Clin Endocrinol Metab 1997;82:719-24.
30. Hassager C, Risteli J, Risteli L, Jensen SB, Christiansen C. Diurnal variation in serum markers of type I collagen synthesis and degradation in healthy premenopausal women. J Bone Miner Res 1992;7:1307-11.
31. Melkko J, Kauppila S, Niemi S, Risteli L, Haukipuro K, Jukkola A, Risteli J. Immunoassay for intact amino-terminal propeptide of human type I procollagen. Clin Chem 1996;42:947-54.
32. Jensen CH, Hansen M, Brandt J, Rasmussen HB, Jensen PB, Tiesner B. Quantification of the N-terminal propeptide of human procollagen type I (PINP): comparison of ELISA and RIA with respect to different molecular forms. Clin Chim Acta 1998;269: 31-41.
33. Cheng S, Kovanen V, Heikkinen E, Suominen H. Serum and urine markers of type I collagen metabolism in elderly women with high and low bone turnover. Eur J Clin Investig 1996;26:186-91.
34. Eastell R, Calvo MS, Burritt MF, Offord KP, Russell RGG, Riggs BL. Abnormalities in circadian patterns of bone resorption and renal calcium conservation in type I osteoporosis. J Clin Endocrinol Metab 1992;74:487-94.
35. Blumsohn A, Herrington K, Hannon RA, Shao P, Eyre DR, Eastell R. The effect of calcium supplementation on the circadian rhythm of bone resorption. J Clin Endocrinol Metab 1994;79:730-5.
36. Nielsen HK, Brixen K, Mosekilde L. Diurnal rhythm in serum activity of wheat-germ lectin-precipitable alkaline phosphatase: temporal relationships with the diurnal rhythm of serum osteocalcin. Scand J Clin Lab Investig 1990;50:851-6.
37. Nielsen HK, Brixen K, Mosekilde L. Diurnal rhythm and 24-hour integrated concentrations of serum osteocalcin in normals: influence of age, sex, season, and smoking habits. Calcif Tissue Int 1990;47:284-90.
38. Schlemmer A, Hassager C, Pedersen BJ, Christiansen C. Posture, age, menopause, and osteopenia do not influence the circadian variation in the urinary excretion of pyridinium crosslinks. J Bone Miner Res 1994;9:1883-8.
39. Nielsen HK, Brixen K, Bouillon R, Mosekilde L. Changes in biochemical markers of osteoblastic activity during the menstrual cycle. J Clin Endocrinol Metab 1990;70:1431-7.
40. Woitge HW, Schneidt-Nave C, Kissling C, Ledig-Bruckner G, Mayer K, Grauer A, et al. Seasonal variation of biochemical indexes of bone turnover: results of a population-based study. J Clin Endocrinol Metab 1998;83:68-75.
41. Karlsson R, Edén S, Eriksson L, Von Schoultz B. Osteocalcin 24-hour profiles during normal pregnancy. Gynecol Obstet Investig 1992;34:197-201.
42. Smith SM, Nillen JL, Leblanc A, Demers LM, Lane HW, Leach CS. Collagen cross-link excretion during space flight and bed rest. J Clin Endocrinol Metab 1998;83:3584-91.
43. Lueken SA, Arnaud SB, Taylor AK, Baylink DJ. Changes in markers of bone formation and resorption in a bed rest model of weightlessness. J Bone Miner Res 1993;8:1433-8.
44. Duda JRJ, O'Brien JF, Katzmann JA, Peterson JM, Mann KG, Riggs BL. Concurrent assays of circulating bone Gla-protein and bone alkaline phosphatase: effects of sex, age, and metabolic bone disease. J Clin Endocrinol Metab 1988;66:951-7.
45. Colwell A, Eastell R. The renal clearance of free and conjugated pyridinium cross-links of collagen. J Bone Miner Res 1996;11: 1976-80.
46. Bettica P, Taylor AK, Talbot J, Moro L, Talamini R, Baylink DJ. Clinical performance of galactosyl hydroxylysine, pyridinoline, and deoxypyridinoline in postmenopausal osteoporosis. J Clin Endocrinol Metab 1996;81:542-6.
47. Takeuchi S-I, Arai K, Saitoh H, Yoshida K-I, Miura M. Urinary pyridinoline and deoxypyridinoline as potential markers of bone metastasis in patients with prostate cancer. J Urol 1996;156: 1691-5.
48. Eastell R, Robins SP, Colwell A, Assiri AMA, Riggs BL, Russell RGG. Evaluation of bone turnover in type I osteoporosis using biochemical markers specific for bone formation and bone resorption. Osteoporosis Int 1999;3:255-60.
49. Hannon R, Blumsohn A, Naylor K, Eastell R. Response of biochemical markers of bone turnover to hormone replacement therapy: impact of biological variability. J Bone Miner Res 1998;13:1124-33.
50. Panteghini M, Pagani F. Biological variation in bone-derived biochemical markers in serum. Scand J Clin Lab Investig 1995;55: 609-16.
51. Jensen JEB, Sorensen HA, Kollerup G, Jensen LB, Sorensen OH. Biological variation of biochemical bone markers. Scand J Clin Lab Investig 1994;54(Suppl 219):36-9.
52. Jensen JEB, Kollerup G, Sorensen HA, Sorensen OH. Intraindividual variability in bone markers in the urine. Scand J Clin Lab Investig 1997;57(Suppl 227):29-34.
53. Popp-Snijder C, Lips P, Netelenbos JC. Intra-individual variation in bone resorption markers in urine. Ann Clin Biochem 1996;33: 347-8.
54. Weiss S, Chesnut C, Eastell R, Flessland K, Cain C, Mallinak N. Determination of the intrasubject variability in NTx excretion in postmenopausal women [Abstract]. J Bone Miner Res 1997; 12(Suppl 1):S506.
55. Ravn P, Clemmesen B, Riis BJ, Christiansen C. The effect on bone mass and bone markers of different doses of ibandronate: a new bisphosphonate for prevention and treatment of postmenopausal osteoporosis: a 1-year, randomized, double-blind, placebo-controlled dose-ranging study. Bone 1996;19:527-33.
56. Melton LJ III, Khosla S, Atkinson EJ, O'Fallon WM, Riggs BL. Relationship of bone turnover to bone density and fractures. J Bone Miner Res 1997;12:1083-91.
57. Garnero P, Sornay-Rendu E, Chapuy M-C, Delmas PD. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res 1996;11:337-49.
58. Schneider DL, Barrett-Connor EL. Urinary N-telopeptide levels discriminate normal, osteopenic, and osteoporotic bone mineral density. Arch Intern Med 1997;157:1241-5.
59. Dresner-Pollak R, Parker R, Poku M, Thompson J, Seibel M, Greenspan S. Biochemical markers of bone turnover reflect femoral bone loss in elderly women. Calcif Tissue Int 1996;59: 328-33.
60. Ross PD, Knowlton W. Rapid bone loss is associated with increased levels of biochemical markers. J Bone Miner Res 1997;13:297-302.
61. Chesnut CH III, Bell NH, Clark GS, Drinkwater BL, English SC, Johnson CC Jr, et al. Hormone replacement therapy in postmenopausal women: urinary N-telopeptide of type I collagen monitors therapeutic effect and predicts response of bone mineral density. Am J Med 1997;102:29-37.
62. Marcus R, Holloway L, Wells B. Turnover markers only weakly predict bone response to estrogen: the Postmenopausal Estrogen/Progestin Interventions Trial (PEPI) [Abstract]. J Bone Miner Res 1997;12(Suppl 1):S103.
63. Bauer DC, Black DM, Ott SM, Santora A, Thompson D, Ennis M, Cummings SR. Biochemical markers predict spine but not hip BMD response to alendronate: the Fracture Intervention Trial [Abstract]. J Bone Miner Res 1997;12(Suppl 1):S150.
64. Hirsch L, Watts N, McIlwain H, Rodriguez J, Romanowicz A, Daifotis A, et al. Efficacy of alendronate is similar irrespective of baseline bone turnover, BMD, and age [Abstract]. J Bone Miner Res 1995;10(Suppl 1):S350.
65. Keen RW, Nguyen T, Sobnack R, Perry LA, Thompson PW, Spector TD. Can biochemical markers predict bone loss at the hip and spine? A 4-year prospective study of 141 early postmenopausal women Osteoporosis Int 1996;6:399-406.
66. Cosman F, Nieves J, Wilkinson C, Schnering D, Shen V, Lindsay R. Bone density change and biochemical indices of skeletal turnover. Calcif Tissue Int 1996;58:236-43.
67. Garnero P, Hausherr E, Chapuy M-C, Marcelli C, Grandjean H, Muller C, et al. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS prospective study. J Bone Miner Res 1996;11:1531-8.
68. van Daele PLA, Seibel MJ, Burger H, Hofman A, Gobbee DE, van Leeuwen JP, et al. Case-control analysis of bone resorption markers, disability, and hip fracture risk: the Rotterdam study. Br Med J 1996;312:482-3.
69. Civitelli R, Gonnelli S, Zacchei F, Bigazzi S, Vattimo A, Aivola LV, Gennari C. Bone turnover in postmenopausal osteoporosis. Effect of calcitonin treatment. J Clin Investig 1988;82:1268-74.
70. Greenspan SL, Parker RA, Ferguson L, Rosen HN, Maitland-Ramsey L, Karpf DB. Early changes in biochemical markers of bone turnover predict the long-term response to alendronate therapy in representative elderly women: a randomized clinical trial. J Bone Miner Res 1998;13:1431-8.
71. Bone HG, Downs RW Jr, Tucci JR, Harris ST, Weinstein RS, Licata M, et al. Dose-response relationships for alendronate treatment in osteoporotic elderly women. J Clin Endocrinol Metab 1997;82: 265-74.
72. Rosen C, Chesnut CH, Mallinak NJS. The predictive value of biochemical markers of bone turnover for bone mineral density in early postmenopausal women treated with hormone replacement therapy or calcium supplementation. J Clin Endocrinol Metab 1997;82:1904-10.
73. Garnero P, Shih WJ, Gineyts E, Karpf DB, Delmas PD. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab 1994;79:1693-700.
74. Ravn P, Christensen JO, Baumann M, Clemmesen B. Changes in biochemical markers and bone mass after withdrawal of ibandronate treatment: prediction of bone mass changes during treatment. Bone 1998;22:559-64.
75. Garnero P, Gineyts E, Arbault P, Christiansen C, Delmas PD. Different effects of bisphosphonate and estrogen therapy on free and peptide-bound bone cross-links excretion. J Bone Miner Res 1995;10:641-9.
76. Rosen HN, Moses AC, Garber J, Ross DS, Lee SL, Greenspan SL. Utility of biochemical markers Of bone turnover in the follow-up of patients treated with bisphosphonates. Calcif Tissue Int 1998; 63:363-8.
77. Cummings SR, Black DM, Vogt TM, for the FIT Research Group. Changes in BMD substantially underestimate the anti-fracture effects of alendronate and other antiresorptive drugs [Abstract]. J Bone Miner Res 1996;11:S102.
78. Riggs BL, Melton LJ III, O'Fallon WM. Drug therapy for vertebral fractures in osteoporosis: evidence that decreases in bone turnover and increases in bone mass both determine antifracture efficacy. Bone 1996;18(Suppl 3):197S-201S.
79. Orwoll ES, Bell NH, Nanes MS, Flessland KA, Pettinger MB, Mallinak NJ, Cain DF. Collagen N-telopeptide excretion in men: the effects of age and intrasubject variability. J Clin Endocrinol Metab 1998;83:3930-5.