Importance of the Hsp70 ATPase domain in yeast prion propagation

Genetics

Volumn 175, Issue 2, 2007, Pages 621-630

  Loovers, Harriët M ^a   Guinan, Emma ^a   Jones, Gary W ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CHAPERONE; HEAT SHOCK PROTEIN 70; PRION PROTEIN; PROTEIN SSA1P; PROTEIN SSA2P; UNCLASSIFIED DRUG; FUNGAL PROTEIN; HEAT SHOCK PROTEIN; HSP104 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SSA1 PROTEIN, S CEREVISIAE; SSA2 PROTEIN, FUNGAL; URE2 PROTEIN, S CEREVISIAE;

ALLELE; ARTICLE; CELL GROWTH; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME REGULATION; FUNGAL CELL; HYDROLYSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; REPORTER GENE; WESTERN BLOTTING; BIOLOGICAL MODEL; CHEMISTRY; CYTOLOGY; GENE REPRESSION; GENETICS; METABOLISM; MUTATION; PRION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION;

SACCHAROMYCES CEREVISIAE;

ADENOSINE TRIPHOSPHATASES; ALLELES; FUNGAL PROTEINS; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; MODELS, BIOLOGICAL; MUTATION; PHENOTYPE; PRIONS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPRESSION, GENETIC;

EID: 34247899009     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.106.066019     Document Type: Article

References (56)

1. AIGLE, M., and F. LACROUTE, 1975 Genetical aspects of [URE3], a non-mitochondrial, cytoplasmically inherited mutation in yeast. Mol. Gen. Genet. 136: 327-335.
2. ALLEN, K. D., R. D. WEGRZYN, T. A. CHERNOVA, S. MULLER, G. P. NEWNAM et al., 2005 Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI1]. Genetics 169: 1227-1242.
3. BACH, S., N. TALAREK, T. ANDRIEU, J. M. VIERFOND, Y. METTEY et al., 2003 Isolation of drugs active against mammalian prions using a yeast-based screening assay. Nat. Biotechnol. 21: 1075-1081.
4. CHERNOFF, Y. O., S. L. LINDQUIST, B. ONO, S. G. INGE-VECHTOMOV and S. W. LIEBMAN, 1995 Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]. Science 268: 880-884.
5. COLLINGE, J., 2001 Prion diseases of humans and animals: their causes and molecular basis. Annu. Rev. Neurosci. 24: 519-550.
6. COUSTOU, V., C. DELEU, S. SAUPE and J. BEGUERET, 1997 The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog. Proc. Natl. Acad. Sci. USA 94: 9773-9778.
7. COX, B. S., 1965 [PSI+], acytoplasmic suppressor of super-suppressors in yeast. Heredity 20: 505-521.
8. CYR, D. M., X. LU and M. G. DOUGLAS, 1992 Regulation of Hsp70 function by a eukaryotic DnaJ homolog. J. Biol. Chem. 267: 20927-20931.
9. DERKATCH, I. L., M. E. BRADLEY, P. ZHOU, Y. O. CHERNOFF and S. W. LIEBMAN, 1997 Genetic and environmental factors affecting the de novo appearance of the [PSI1] prion in Saccharomyces cerevisiae. Genetics 147: 507-519.
10. DERKATCH, I. L., M. E. BRADLEY, J. Y. HONG and S. W. LIEBMAN, 2001 Prions affect the appearance of other prions: the story of [PIN(+)]. Cell 106: 171-182.
11. DRAGOVIC, Z., S. A. BROADLEY, Y. SHOMURA, A. BRACHER and F. U. HARTL, 2006 Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J. 25: 2519-2528.
12. FERNANDEZ-BELLOT, E., E. GUILLEMET and C. CULLIN, 2000 The yeast prion [URE3] can be greatly induced by a functional mutated URE2 allele. EMBO J. 19: 3215-3222.
13. FLOWER, T. R., L. S. CHESNOKOVA, C. A. FROELICH, C. DIXON and S. N. WITT, 2005 Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease. J. Mol. Biol. 351: 1081-1100.
14. GILBERT, C. S., M. VAN DEN BOSCH, C. M. GREEN, J. E. VIALARD, M. GRENON et al., 2003 The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function. EMBO Rep. 4: 953-958.
15. GLOVER, J. R., and S. LINDQUIST, 1998 Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins. Cell 94: 73-82.
16. GOKHALE, K. C., G. P. NEWNAM, M. Y. SHERMAN and Y. O. CHERNOFF, 2005 Modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model. J. Biol. Chem. 280: 22809-22818.
17. HAINZL, O., H. WEGELE, K. RICHTER and J. BUCHNER, 2004 Cns1 is an activator of the Ssa1 ATPase activity. J. Biol. Chem. 279: 23267-23273.
18. INOUE, Y., H. TAGUCHI, A. KISHIMOTO and M. YOSHIDA, 2004 Hsp104 binds to yeast Sup35 prion fiber but needs other factor(s) to sever it. J. Biol. Chem. 279: 52319-52323.
19. JAMES, P., C. PFUND and E. A. CRAIG, 1997 Functional specificity among Hsp70 molecular chaperones. Science 275: 387-389.
20. JIANG, J., K. PRASAD, E.M. LAFER and R. SOUSA, 2005 Structural basis of interdomain communication in the Hsc70 chaperone. Mol. Cell 20: 513-524.
21. +]. Genetics 163: 495-506.
22. JONES, G. W., and M. F. TUITE, 2005 Chaperonin prions: The cellular machinery for propagating an infectious protein? BioEssays 27: 823-832.
23. JONES, G., Y. SONG, S. CHUNG and D. C. MASISON, 2004 Propagation of Saccharomyces cerevisiae [PSI1] prion is impaired by factors that regulate Hsp70 substrate binding. Mol. Cell. Biol. 24: 3928-3937.
24. +] as a cellular stress. Genetics 156: 559-570.
25. KABANI, M., J. M. BECKERICH and J. L. BRODSKY, 2002a Nucleotide exchange factor for the yeast Hsp70 molecular chaperone Ssa1p. Mol. Cell. Biol. 22: 4677-4689.
26. KABANI, M., C. MCLELLAN, D. A. RAYNES, V. GUERRIERO and J. L. BRODSKY, 2002b HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an Hsc70 nucleotide exchange factor. FEBS Lett. 531: 339-342.
27. KRYNDUSHKIN, D. S., V. N. SMIRNOV, M. D. TER-AVANESYAN and V. V. KUSHNIROV, 2002 Increased expression of Hsp40 chaperones, transcripional factors, and ribosomal protein Rpp0 can cure yeast prions. J. Biol. Chem. 277: 23702-23708.
28. KRZEWSKA, J., and R. MELKI, 2006 Molecular chaperones and the assembly of the prion Sup35p, an in vitro study. EMBO J. 25: 822-833.
29. KUSHNIROV, V. V., D. S. KRYNDUSHKIN, M. BOGUTA, V. N. SMIRNOV and M. D. TER-A VANESYAN, 2000 Chaperones that cure yeast artificial [PSI1] and their prion-specific effects. Curr. Biol. 10: 1443-1446.
30. LIAN, H. Y., Y. JIANG, H. ZHANG, G. W. JONES and S. PERRETT, 2006 The yeast prion protein Ure2: structure, function and folding. Biochim. Biophys. Acta 1764: 535-545.
31. MAYER, M. P., D. BREHMER, C. S. GASSLER and B. BUKAU, 2001 Hsp70 chaperone machines. Adv. Protein Chem. 59: 1-44.
32. MORIYAMA, H., H. K. EDSKES and R. B. WICKNER, 2000 [URE3] prion propagation in Saccharomyces cerevisiae: requirement for chaperone Hsp104 and curing by overexpressed chaperone Ydj1p. Mol. Cell. Biol. 20: 8916-8922.
33. NEWNAM, G. P., R. D. WEGRZYN, S. L. LINDQUIST and Y. O. CHERNOFF, 1999 Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing. Mol. Cell. Biol. 19: 1325-1333.
34. PATINO, M. M., J. J. LIU, J. R. GLOVER and S. LINDQUIST, 1996 Support for the prion hypothesis for inheritance of a phenotypic trait in yeast. Science 273: 622-626.
35. PAUSHKIN, S. V., V. V. KUSHNIROV, V. N. SMIRNOV and M. D. TER-AVANESYAN, 1997 Interaction between yeast Sup45p (eRF1) and Sup35p (eRF3) polypeptide chain release factors: implications for prion-dependent regulation. Mol. Cell. Biol. 17: 2798-2805.
36. PRUSINER, S. B., 1982 Novel proteinaceous infectious particles cause scrapie. Science 216: 136-144.
37. RAVIOL, H., H. SADLISH, F. RODRIGUEZ, M. P. MAYER and B. BUKAU, 2006 Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor. EMBO J. 25: 2510-2518.
38. REVINGTON, M., Y. ZHANG, G. N. YIP, A. V. KUROCHKIN and E. R. ZUIDERWEG, 2005 NMR investigations of allosteric processes in a two-domain Thermus thermophilus Hsp70 molecular chaperone. J. Mol. Biol. 349: 163-183.
39. ROBERTS, B. T., H. MORIYAMA and R. B. WICKNER, 2004 [URE3] prion propagation is abolished by a mutation of the primary cytosolic Hsp70 of budding yeast. Yeast 21: 107-117.
40. SATPUTE-KRISHNAN, P., and T. R. SERIO, 2005 Prion protein remodelling confers an immediate phenotypic switch. Nature 437: 262-265.
41. SCHATZ, P. J., F. SOLOMON and D. BOTSTEIN, 1988 Isolation and characterization of conditional-lethal mutations in the TUB1 alphatubulin gene of the yeast Saccharomyces cerevisiae. Genetics 120: 681-695.
42. SCHWIMMER, C., and D. C. MASISON, 2002 Antagonistic interactions between yeast [PSI()] and [URE3] prions and curing of [URE3] by Hsp70 protein chaperone Ssa1p but not by Ssa2p. Mol. Cell. Biol. 22: 3590-3598.
43. SHOMURA, Y., Z. DRAGOVIC, H. C. CHANG, N. TZVETKOV, J. C. YOUNG et al., 2005 Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange. Mol. Cell 17: 367-379.
44. SHORTER, J., and S. LINDQUIST, 2004 Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers. Science 304: 1793-1797.
45. SHORTER, J., and S. LINDQUIST, 2006 Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. Mol. Cell 23: 425-438.
46. SIKORSKI, R. S., and P. HIETER, 1989 A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
47. SONG, Y., Y. X. WU, G. JUNG, Y. TUTAR, E. EISENBERG et al., 2005 Role for Hsp70 chaperone in Saccharomyces cerevisiae prion seed replication. Eukaryot. Cell 4: 289-297.
48. TAYLOR, K. L., and R. B. WICKNER, 2001 [URE3] and [PSI]: prions of Saccharomyces cerevisiae. Contrib. Microbiol. 7: 21-31.
49. TRUE, H. L., 2006 The battle of the fold: chaperones take on prions. Trends Genet. 22: 110-117.
50. TUITE, M. F., 2000 Yeast prions and their prion-folding domain. Cell 100: 289-292.
51. UPTAIN, S. M., G. J. SAWICKI, B. CAUGHEY and S. LINDQUIST, 2001 Strains of [PSI(1)] are distinguished by their efficiencies of prion-mediated conformational conversion. EMBO J. 20: 6236-6245.
52. VOGEL, M., B. BUKAU and M. P. MAYER, 2006 Allosteric regulation of Hsp70 chaperones by a proline switch. Mol. Cell 21: 359-367.
53. WEGELE, H., M. HASLBECK, J. REINSTEIN and J. BUCHNER, 2003 Sti1 is a novel activator of the Ssa proteins. J. Biol. Chem. 278: 25970-25976.
54. WEGELE, H., L. MULLER and J. BUCHNER, 2004 Hsp70 and Hsp90 - a relay team for protein folding. Rev. Physiol. Biochem. Pharmacol. 151: 1-44.
55. WERNER-WASHBURNE, M., J. BECKER, J. KOSIC-SMITHERS and E. A. CRAIG, 1989 Yeast Hsp70 RNA levels vary in response to the physiological status of the cell. J. Bacteriol. 171: 2680-2688.
56. WICKNER, R. B., 1994 [URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae. Science 264: 566-569.