Strains of [PSI+] are distinguished by their efficiencies of prion-mediated conformational conversion

EMBO Journal

Volumn 20, Issue 22, 2001, Pages 6236-6245

  Uptain, Susan M ^a   Sawicki, George J ^a   Caughey, Byron ^b   Lindquist, Susan ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

PSI+ ; Amyloid; Conformational conversion; Epigenetics; Sup35

Indexed keywords

AMYLOID; PRION PROTEIN; PROTEIN SUP 35; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; MAMMAL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; SOLUBILITY; TRANSLATION REGULATION;

BRAIN; CELL NUCLEUS; DOSE-RESPONSE RELATIONSHIP, DRUG; FUNGAL PROTEINS; IMMUNOBLOTTING; LYASES; PHENOTYPE; PRIONS; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TIME FACTORS;

MAMMALIA;

EID: 0035890264     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.22.6236     Document Type: Article

References (64)

1. Genetic study of interactions between the cytoskeletal assembly protein Slal and prion-forming domain of the release factor Sup35 (eRF3) in Saccharomyces cerevisiae
2. Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent
3. Identification of two biologically distinct strains of transmissible mink encephalopathy in hamsters
4. Non-genetic propagation of strain-specific properties of scrapie prion protein
5. Scrapie strain variation and mutation
6. Biological evidence that scrapie agent has an independent genome
7. Scrapie strain variation and its implications
8. Transmissible spongiform encephalopathies, amyloidoses and yeast prions: Common threads?
9. Strain-dependent differences in β-sheet conformations of abnormal prion protein
10. Interactions and conversions of prion protein isoforms
11. Transcriptional dysregulation in Huntington's disease
12. Mutation processes at the protein level: Is Lamarck back?
13. Multicopy SUP35 gene induces de-novo appearance of psi-like factors in the yeast Saccharomyces cerevisiae
14. +]
15. Evidence for a protein mutator in yeast: Role of the Hsp70-related chaperone Ssb in formation, stability, and toxicity of the [PSI] prion
16. Analysis of prion factors in yeast
17. Conformational diversity in a yeast prion dictates its seeding specificity
18. Prion diseases of humans and animals: Their causes and molecular basis
19. -], a cytoplasmic suppressor of super-suppression in yeast
20. +] strains of yeast: The classification of mutations
21. The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs
22. A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion
23. Genesis and variability of [PSI] prion factors in Saccharomyces cerevisiae
24. +] prion in Saccharomyces cerevisiae
25. +] prion
26. +]
27. The scrapie replication-site hypothesis and its implications for pathogenesis
28. - mutation which eliminates the [PSI] factor of Saccharomyces cerevisiae is the result of a missense mutation in the SUP35 gene
29. Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism
30. +], a heritable prion-like factor of S.cerevisiae
31. A novel multiple affinity purification tag and its use in identification of proteins associated with a cyclin-CDK complex
32. +] as a cellular stress
33. +] prion generation in yeast: Characterization of the 'strain' difference
34. Structure and replication of yeast prions
35. Prion properties of the Sup35 protein of yeast Pichia methanolica
36. +] and their prion-specific effects
37. +] prion: Making sense of nonsense
38. Oligopeptide-repeat expansions modulate 'protein-only' inheritance in yeast
39. -] mutations in Saccharomyces cerevisiae
40. Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing
41. Interference by Huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity
42. +] prion
43. Support for the prion hypothesis for inheritance of a phenotypic trait in yeast
44. +] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor
45. In vitro propagation of the prion-like state of yeast Sup35 protein
46. Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats
47. Prions
48. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
49. Interactions of the chaperone Hsp104 with yeast Sup35 and mammalian PrP
50. Induction of distinct [Ure3] yeast prion strains
51. Transgenic investigations of the species barrier and prion strains
52. +]: An epigenetic modulator of translation termination efficiency
53. +] and its determinant, Sup35p
54. Nucleated conformational conversion and the replication of conformational information by a prion determinant
55. +] prion
56. A mutant allele of the SUP45 (SAL4) gene of Saccharomyces cerevisiae shows temperature-dependent allosuppressor and omnipotent suppressor phenotypes
57. -] in Saccharomyces cerevisiae
58. The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts
59. [URE3] as an altered Ure2 protein: Evidence for a prion analog in Saccharomyces cerevisiae
60. Prions of fungi: [URE3], [PSI], and [Het-s] discovered as heritable traits
61. Sc-dependent cell-free formation of protease-resistant prion protein
62. +], a prion-like form of release factor eRF3
63. +]