Leydig cell tumors of the testis: A molecular-cytogenetic study based on a large series of patients

Oncology Reports

Volumn 17, Issue 3, 2007, Pages 585-589

  Verdorfer, Irmgard ^a   Horst, D ^a   Hollrigl A ^a   Susani, M ^b   Hartmann, A ^c   Rogatsch, H ^a,d   Mikuz, G ^a  

^a MEDICAL UNIVERSITY OF INNSBRUCK   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d GENERAL HOSPITAL KLAGENFURT   (Austria)

Author keywords

Comparative genomic hybridization; Fluorescence in situ hybridization; Leydig cell tumors; Sex cord stromal tumors

Indexed keywords

DNA;

ARTICLE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; HUMAN; LEYDIG CELL TUMOR; MALE; NUCLEIC ACID HYBRIDIZATION; TESTIS TUMOR;

DNA, NEOPLASM; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEYDIG CELL TUMOR; MALE; NUCLEIC ACID HYBRIDIZATION; TESTICULAR NEOPLASMS;

EID: 34247887511     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.17.3.585     Document Type: Article

References (28)

1. Wilson BE and Netzloff ML: Primary testicular abnormalities causing precocious puberty Leydig cell tumor, Leydig cell hyperplasia and adrenal rest tumor. Ann Clin Lab Sci 13: 315-320, 1983. (Pubitemid 13077454)
2. Ponce de Leon Roca J, Algaba Arrea F, Bassas Arnau L and Villavicencio Mavrich H: Leydig cell tumor of the testis. Arch Esp Urol 53: 453-458, 2000.
3. Papatsoris AG, Triantafyllidis A, Gekas A, Karamouzis MV and Rosenbaum T: Leydig cell tumor of the testis. New cases and review of the current literature. Tumori 90: 422-423, 2004. (Pubitemid 39287242)
4. Bokemeyer C, Kuczyk M, Schoffski P and Schmoll JH: Familial occurrence of Leydig cell tumors: a report of a case in a father and his adult son. J Urol 150: 1509-1510, 1993. (Pubitemid 24356216)
5. Ulbright TM, Amin MB and Young RH: Tumors of the testis, adnexa, spermatic cord and scrotum. In: AFIP Atlas of Tumor Pathology. 3rd Series, Fascicle 25, Washington DC, 1999.
6. Kim I, Young RH and Scully RE: Leydig cell tumors of the testis. A clinicopathological analysis of 40 cases and review of the literature. Am J Surg Pathol 9: 177-192, 1985. (Pubitemid 15045913)
7. Augusto D, Leteurtre E, De La Taille A, Gosselin B and Leroy X: Calretinin: a valuable marker of normal and neoplastic Leydig cells of the testis. Appl Immunohistochem Mol Morphol 10: 159-162, 2002. (Pubitemid 34553173)
8. Cheville JC, Sebo TJ, Lager DJ, Bostwick DG and Farrow GM: Leydig cell tumor of the testis: a clinicopathologic, DNA content and MIB-1 comparison of nonmetastasizing and metastasizing tumors. Am J Surg Pathol 22: 1361-1367, 1998. (Pubitemid 28499126)
9. Padberg BC, Lauritzen I, Achilles E, Holl K, Bressel M, Kloppel G, Dralle H and Schroder S: DNA cytophotometry in adrenocortical tumours: a clinicomorphological study of 66 cases. Virchows Arch A Pathol Anat Histopathol 419: 167-170, 1991.
10. Palazzo JP, Petersen RO, Young RH and Scully RE: Deoxyribonucleic acid flow cytometry of testicular Leydig cell tumors. J Urol 152: 415-417, 1994. (Pubitemid 24221233)
11. McCluggage WG, Shanks JH, Arthur K and Banerjee SS: Cellular proliferation and nuclear ploidy assessments augment established prognostic factors in predicting malignancy in testicular Leydig cell tumours. Histopathology 33: 361-368, 1998. (Pubitemid 28508887)
12. Sesterhenn IA, Cheville J, Wooward PJ, Damjanov I, Jacobsen GK, Nistal M, Paniagua R and Renshaw AA: Germ cell tumours. In: Pathology and Genetics: Tumours of the Urinary System and Male Genital Organs. Eble JN, Sauter G, Epstein JI and Sesterhenn IA (eds). IARC Press, Lyon, pp251-258, 2004.
13. Wolff E, Liehr T, Vorderwulbecke U, Tulusan AH, Husslein EM and Gebhart E: Frequent gains and losses of specific chromosome segments in human ovarian carcinomas shown by comparative genomic hybridization. Int J Oncol 11: 19-23, 1997. (Pubitemid 27287091)
14. Hirakawa T and Ascoli M: A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia. Endocrinology 144: 3872-3878, 2003. (Pubitemid 37088741)
15. Coppes MJ, Ye Y, Rackley R, Zhao XL, Liefers GJ, Casey G and Williams BR: Analysis of WT1 in granulosa cell and other sex cord-stromal tumors. Cancer Res 53: 2712-2714, 1993. (Pubitemid 23180501)
16. Canto P, Söderlund D, Ramón G, Nishimura E and Méndes JP: Mutational analysis of the luteinizing hormone receptor gene in two individuals with Leydig cell tumors. Am J Med Genet 108: 148-152, 2002.
17. Liu G, Duranteau L, Carel JC, Monroe J, Doyle D and Shenker A: Leydig cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. N Engl J Med 341: 1731-1736, 1999.
18. Looijenga LH, Gillis AJ, van Gurp RJ, Verkerk AJ and Oosterhuis JW: X inactivation in human testicular tumors. XIST expression and androgen receptor methylation status. Am J Pathol 151: 581-590, 1997. (Pubitemid 27330078)
19. Looijenga LH and Oosterhuis JW: Pathogenesis of testicular germ cell tumours. Rev Reprod 4: 90-100, 1999. (Pubitemid 29245933)
20. Iwamoto I, Yanazume S, Fujino T, Yoshioka T and Douchi T: Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome. Gynecol Oncol 96: 870-872, 2005. (Pubitemid 40255517)
21. Rosenberg C, Schut TB, Mostert M, Tanke H, Raap A, Oosterhuis JW and Looijenga L: Chromosomal gains and losses in testicular germ cell tumors of adolescents and adults investigated by a modified comparative genomic hybridization approach. Lab Invest 79: 1447-1451, 1999. (Pubitemid 30013909)
22. Looijenga LH and Oosterhuis JW: Clinical value of the X chromosome in testicular germ-cell tumours. Lancet 363: 6-8, 2004. (Pubitemid 38076917)
23. Verdorfer I, Rogatsch H, Tzankov A, Steiner H and Mikuz G: Molecular cytogenetic analysis of human spermatocytic seminomas. J Pathol 204: 277-281, 2004. (Pubitemid 39430086)
24. Kawakami T, Okamoto K, Sugihara H, Hattori T, Reeve AE, Ogawa O and Okada Y: The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors. J Urol 169: 1546-1552, 2003. (Pubitemid 36323841)
25. Alvarez S, MacGrogan D, Calasanz MJ, Nimer SD and Jhanwar SC: Frequent gain of chromosome 19 in mega-karyoblastic leukemias detected by comparative genomic hybridization. Genes Chrom Cancer 32: 285-293, 2001. (Pubitemid 32953983)
26. Zielenska M, Bayani J, Pandita A, Toledo S, Marrano P, Andrade J, Petrilli A, Thorner P, Sorensen P and Squire JA: Comparative genomic hybridization analysis identifies gain of 1p35-p36 and chromosome 19 in osteosarcoma. Cancer Genet Cytogenet 130: 14-21, 2001. (Pubitemid 32979161)
27. Bertram KA, Bratloff B, Hodges GF and Davidson H: Treatment of malignant Leydig cell tumor. Cancer 68: 2324-2329, 1991.
28. Mati W, Lam G, Dahl C, Thorup Andersen J and Balslev E: Leydig cell tumour - a rare testicular tumour. Int Urol Nephrol 33: 103-105, 2002.