X inactivation in human testicular tumors: XIST expression and androgen receptor methylation status

American Journal of Pathology

Volumn 151, Issue 2, 1997, Pages 581-590

  Looijenga, Leendert H J ^a   Gillis, Ad J M ^a   Van Gurp, Ruud J H L M ^a   Verkerk, Annemieke J M H ^a   Oosterhuis, J Wolter ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; TRANSCRIPTION FACTOR;

ADOLESCENT; ADULT; ARTICLE; CARCINOMA IN SITU; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; GENE EXPRESSION; GERM CELL TUMOR; HUMAN; HUMAN TISSUE; MALE; NON SEMINOMATOUS GERMINOMA; PRIORITY JOURNAL; SEMINOMA; SPERMATOGENESIS; SUPERNUMERARY CHROMOSOME; TESTIS TUMOR; X CHROMOSOME INACTIVATION;

ADULT; CARCINOMA IN SITU; FEMALE; HUMANS; MALE; METHYLATION; RECEPTORS, ANDROGEN; RNA, UNTRANSLATED; TESTICULAR NEOPLASMS; TRANSCRIPTION FACTORS; X CHROMOSOME;

EID: 0030840990     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Lyon MF: Some milestones in the history of X-chromosome inactivation. Annu Rev Genet 1992, 26:17-28
2. Ballabio A, Willard HF: Mammalian X-chromosome inactivation and the XIST gene. Curr Blol 1992, 2:439-447
3. Willard HF: X chromosome inactivation, XIST, and pursuit of the X-inactivation centre. Cell 1996, 86:5-7
4. Brown CJ, Lafreniere RG, Powers VE, Sebastio G, Ballabio A, Pettigrew AL, Ledbetter DH, Levy E, Craig IW, Willard HF: Localization of the X inactivation centre on the human X chromosome in Xq13. Nature 1991, 349:82-84
5. Brown CJ, Ballabio A, Rupert JL, Lafreniere RG, Grompe M, Tonlorenzi R, Willard HF: A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature 1991, 349:38-44
6. Borsani G, Tonlorenzi R, Simmler MC, Dandolo L, Arnaud D, Capra V, Lawrence C, Willard HF, Avner P, Ballabio A: Characterization of a murine gene expressed from the inactive X chromosome, Nature 1991, 351:325-329
7. Penny GD, Kay GF, Sheardown SA, Rastan S, Brockdorff N: Requirement for Xist in X chromosome inactivation, Nature 1996, 379:131-137
8. Lee JT, Strauss WM, Dausman JA, Jaenisch R: A 450 kb transgene displays properties of the mammalian X-inactivation center. Cell 1996, 86:83-94
9. Clemson CM, McNeil JA, Willard HF, Lawrence JB: XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear chromosome structure. J Cell Biol 1996, 132:259-275
10. Panning B, Jaenisch R: DNA hypomethylation can activate Xist expression and silence X-linked genes, Genes Dev 1996, 10:19912002
11. Mutter GL, Chaponot ML, Fletcher JA: A polymerase chain reaction assay for non-random X chromosome inactivation identifies monoclonal endometrial cancers and precancers. Am J Pathol 1995, 146:501-508
12. Brown CJ, Willard HF: The human X-inactivation centre is not required for maintenance of X-chromosome inactivation. Nature 1994, 368:154-155
13. Norris DP, Patel D, Kay GF, Penny GD, Brockdorff N, Sheardown SA, Rastan S: Evidence that random and imprinted Xist expression is controlled by preemptive methylation. Cell 1994, 77:41-51
14. Hendrich B, Brown C, Willard H: Evolutionary conservation of possible functional domains of the human and murine XIST genes, Hum Mol Genet 1993, 2:663-672
15. Tai HH, Gordon J, McBurney MW: Xist is expressed in female embryonal carcinoma cells with two active X chromosomes. Somatic Cell Mol Genet 1994, 20:171-182
16. Richler C: X inactivation in mammalian testis is correlated with inactive X-specific transcription. Nature Genet 1992, 2:192-195
17. Zucotti M, Monk M: Methylation of the mouse Xist gene in sperm and eggs correlates with imprinted Xist expression and paternal X-inactivation, Nature 1995, 9:316-320
18. McCarrey JR, Dilworth DD: Expression of Xist in mouse germ cells correlates with X-chromosome inactivation. Nature Genet 1992, 2:200-203
19. Salido EC, Yen PH, Mohandas TK, Shapiro LJ: Expression of the X-inactivation-associated gene XIST during spermatogenesis. Nature Genet 1992, 2:196-199
20. Grant M, Zucotti M, Monk M: Methylation of CpG sites of two X-linked genes coincides with X-inactivation in the female mouse embryo but not in the germ line. Nature Genet 1992, 2:161-166
21. Ariel M, Cedar H, McCarrey J: Developmental changes in methylation of spermatogenesis-specific genes include reprogramming in the epididymis, Nature Genet 1994, 7:59-63
22. Mostofi FK, Price EBJ: Tumors of the male genital system (fasc 8), Atlas of Tumor Pathology, Washington DC. Armed Forces Institute of Pathology, 1973
23. Walt H, Oosterhuis JW, Stevens LC: Experimental testicular germ cell tumorigenesis in mouse strains with and without spontaneous tumours differs from development of germ cell tumours of the adult human testis. Int J Androl 1993, 16:267-271
24. Skakkebæk NE, Berthelsen JG, Giwercman A, Müller J: Carcinomain-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int J Androl 1987, 10:19-28
25. Jørgensen N, Rajpert-De Meyts E, Graem N, Muller J, Giwercman A, Skakkebæk NE: Expression of immunohistochemical markers for testicular carcinoma in situ by normal fetal germ cells. Lab Invest 1995, 72:223-231
26. Mostofi FK, Sesterhenn IA, Davis CJJ: Immunopathology of germ cell tumors of the testis. Semin Diagn Pathol 1987, 4:320-341
27. Cummings OW, Ulbright TM, Eble JN, Roth LM: Spermatocytic seminoma: an immunohistochemical study. Hum Pathol 1994, 25:54-59
28. Burke AP, Mostofi FK: Spermatocytic seminoma: a clinicopathologic study of 79 cases, J Urol Pathol 1993, 1:21-32
29. Van Echten J, Oosterhuis JW, Looijenga LHJ, Wiersma J, te Meerman G, Schraffordt Koops H, Sleijfer DT, De Jong B: No recurrent structural abnormalities in germ cell tumors of the adult testis apart from i(12p). Genes Chromosomes & Cancer 1995, 14:133-144
30. Mostert MMC, Van de Pol M, Olde Weghuis D, Suijkerbuijk RF, Geurts van Kessel A, Van Echten J, Oosterhuis JW, Looijenga LHJ: Comparative genomic hybridization of germ cell tumors of the adult testis: confirmation of karyotypic findings and identification of a 12p-amplicon. Cancer Genet Cytogenet 1996, 89:146-152
31. Atkin NB, Baker MC: X-chromatin, sex chromosomes, and ploidy in 37 germ cell tumors of the testis. Cancer Genet Cytogenet 1992, 59:54-56
32. Peltomäki P: DMA methylation changes in human testicular cancer. Biochim Biophys Acta 1991, 1096:187-196
33. Rosenberg S, Berard C, Brown B, Burke J, Dorfman R, Glatstein E, Hoppe R, Simon R: National Cancer Institute sponsored study of classification of non-Hodgkin's lymphomas: summary and description of a working formulation for clinical usage, Cancer 1982, 49:2112-2135
34. Gillis AJM, Oosterhuis JW, Schipper MEI, Barten EJ, Van Berlo R, Van Gurp RJHLM, Abraham M, Saunders GF, Looijenga LHJ: Origin and biology of a testicular Wilms' tumor. Genes Chromosomes & Cancer 1994, 11:126-135
35. Mosselman S, Looijenga LHJ, Gillis AJM, Van Rooijen MA, Kraft HJ, Van Zoelen EJJ, Oosterhuis JW: Aberrant platelet-derived growth factor α-receptor transcript as a diagnostic marker for early human germ cell tumors of the adult testis, Proc Natl Acad Sci USA 1996, 93:2884-2888
36. Andrews PW, Nudelman E, Hakomori S, Fenderson BA: Different patterns of glycolipid antigens are expressed following differentiation of TERA-2 human embryonal carcinoma cells induced by retinoic acid, hexamethylene bisacetamide (HMBA) or bromodeoxyuridine (BUdR). Differentiation 1990, 43:131-138
37. Andrews PW, Damjanov I, Simon D, Dignazio M: A pluripotent human stem-cell clone isolated from the TERA-2 teratocarcinoma line lacks antigens SSEA-3 and SSEA-4 in vitro, but expresses these antigens when grown as a xenograft tumor. Differentiation 1985, 29:127-135
38. Wang N, Perkins KL, Bronson DL, Fraley EE: Cytogenetic evidence for premeiotic transformation of human testicular cancers. Cancer Res 1981, 41:2135-2140
39. Damjanov I, Horvat B, Gibas Z: Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumor-derived cell line, NCCIT. Lab Invest 1993, 68:220-232
40. Von Keitz AT, Riedmiller H, Neumann K, Gutschank W, Fonatsch C: Establishment and characterization of a seminoma cell-line (S2), Invest Urol 1994, 5:28-31
41. Mostert MMC, Van de Pol M, Van Echten J, Olde Weghuis D, Geurts van Kessel A, Oosterhuis JW, Looijenga LHJ: Fluorescence in situ hybridization-based approaches for the detection of 12p-overrepresentation, in particular i(12p), in cell lines of human testicular germ cell tumors of adults. Cancer Genet Cytogenet 1996, 87:95-102
42. Mitelman F: ISCN 1995: An International System for Human Cytogenetic Nomenclature, Basel, S Karger, 1995,
43. Gibbs RA, Ngyuen P-N, McBride LJ, Koepf SM, Caskey CT: Identification of mutations leading to the Lesch-Nyhan syndrome by auto- mated direct DNA sequencing of in vitro amplified cDNA. Proc Natl Acad Sci USA 1989, 1923, 86:1919
44. Willard H. Smith KD, Sutherland J: Isolation and characterization of a major tandem repeat family from the human X chromosome. Nucleic Acids Res 1983, 11:2017-2033
45. Gillis AJM, Looijenga LHJ, De Jong B. Oosterhuis JW: Clonality of combined testicular germ cell tumors of adults. Lab Invest 1994. 71:874-878
46. Looijenga LHJ, Gillis AJM, Van Putten WLJ, Oosterhuis JW: In situ numeric analysis of centromeric regions of chromosomes 1, 12, and 15 of seminomas, nonseminomatous germ cell tumors, and carcinoma in situ of human testis. Lab Invest 1993, 68:211-219
47. Maniatis T, Fritsch EF, Sambrook J: Isolation of high-molecular-weight, eukaryotic DNA from cells grown in tissue culture, Molecular Cloning, ch 9. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1982, p 280
48. Verkerk AJMH, Ariel I, Dekker MC, Schneider T, Van Gurp RJLM, de Groot N, Gillis AJM, Oosterhuis JW, Hochberg AA, Looijenga LHJ: Unique expression patterns of H19 in human testicular cancers of different etiology. Oncogene 1997, 14/1:95-107
49. Brown CJ, Hendrich BD, Rupert JL, Lafreniere RG, Xing Y, Lawrence J, Willard HF: The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus, Cell 1992, 71:527-542
50. Oosterhuis JW, Looijenga LHJ: The biology of human germ cell tumours: retrospective speculations and new prospectives. Eur Urol 1993, 23:245-250
51. Nakashima N, Murakami S, Fukatsu T, NagasakaT, Fukata S, Ohiwa N, Nara Y, Sobue M, Takeuchi J: Characteristics of "embryoid body" inhuman gonadal germ cell tumors. Hum Pathol 1988, 19:1144-1154
52. Andrews PW, Casper J, Damjanov I, Duggan-Keen M, Giwercman A, Hata J-l, Von Keitz A, Looijenga LHJ, Oosterhuis JW, Pera M, Sawada M, Schmoll H-J, Skakkebæk NE, Van Putten W, Stern P: A comparative analysis of cell surface antigens expressed by cell lines derived from human germ cell tumors. Int J Cancer 1996, 66:806-816
53. Oosterhuis JW, De Jong B, Dmitrovsky E, Looijenga LHJ: Testicular germ cell tumors: molecular biology and genetics, Principles and Practice of Genitourinary Oncology. Edited by D Raghavan, HI Scher, SA Leibel, P Lange. Philadelphia, Lippincott-Raven, 1997, pp 631-642
54. Roach S, Cooper S, Bennett W, Pera MF: Cultured cell lines from human teratomas: windows into tumour growth and differentiation and early human development, Eur Urol 1993, 23:82-88
55. Oosterhuis JW, Castedo SMMJ, De Jong B, Cornelisse CJ, Dam A, Sleijfer DT, Schraffordt Koops H: Ploidy of primary germ cell tumors of the testis: pathogenetic and clinical relevance. Lab Invest 1989, 60:14-20
56. El-Naggar AK, Ro JY, McLemore D, Ayala AG, Batsakis JG: DNA ploidy in testicular germ cell neoplasms: histogenetic and clinical implications. Am J Surg Pathol 1992, 16:611-618
57. Hittmair A, Rogatsch H, Feichtinger H, Hobisch A, Mikuz G: Testicular seminomas are aneuploid tumors, Lab Invest 1995, 72:70-74
58. Hittmair A, Rogatsch H, Feichtinger H, Hobisch A, Mikuz G: Carcinoma in situ of the testis detected by DNA flow cytometry of testicular fine-needle aspirates. Cytometry 1994, 17:327-331
59. Looijenga LHJ, Olie RA, Van der Gaag I, van Sluijs FJ, Matoska J, Ploem-Zaaijer J, Knepfle C, Oosterhuis JW: Seminomas of the canine testis: counterpart of spermatocytic seminoma of men? Lab Invest 1994, 71:490-496
60. Kysela B, Matoska J: Flow cytometry analysis of ploidy and proliferation activity in classical and spermatocytic seminoma. Neoplasma 1991, 38:3-11
61. Brockdorff N, Ashworth A, Kay GF, McCabe VM, Morris DP, Cooper PJ, Swift S, Rastan S: The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell 1992, 71:515-526
62. Mutter GL, Boynton KA: X chromosome inactivation in the normal female genital tract: implications for identification of neoplasia. Cancer Res 1995, 55:5080-5084
63. Carrel L, Clemson CM, Dunn JM, Miller AP, Hunt PA, Lawrence JB, Willard HF: X inactivation analysis and DNA metnylation studies of the ubtquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse. Hum Mol Genet 1996, 5:391-401
64. Beard C, Li E, Jaenisch R: Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev 1995, 9:2325-2334