TCF7L2 in the Go-DARTS study: Evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels

Diabetologia

Volumn 50, Issue 6, 2007, Pages 1186-1191

  Kimber, C H ^a   Doney, A S F ^a   Pearson, E R ^a   McCarthy, M I ^b   Hattersley, A T ^c   Leese, G P ^a   Morris, A D ^a   Palmer, C N A ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c PENINSULA MEDICAL SCHOOL   (United Kingdom)

Author keywords

Body mass index; Disease severity; Genetics; Glucose control; HbA1c; Insulin; Susceptibility; Transcription factor; Type 2 diabetes

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN; ORAL ANTIDIABETIC AGENT;

ADULT; AGE DISTRIBUTION; ALLELE; ARTICLE; BODY MASS; CONTROLLED STUDY; DIET THERAPY; DISEASE PREDISPOSITION; FEMALE; GENE; GENE DOSAGE; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; SEX RATIO; TRANSCRIPTION FACTOR 7 LIKE 2 GENE; UNITED KINGDOM; WAIST CIRCUMFERENCE;

AGED; BLOOD GLUCOSE; BODY MASS INDEX; BODY SIZE; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; GENE DOSAGE; GENETIC PREDISPOSITION TO DISEASE; HOMEOSTASIS; HUMANS; LIPIDS; MIDDLE AGED; ODDS RATIO; REFERENCE VALUES; TCF TRANSCRIPTION FACTORS; VARIATION (GENETICS);

EID: 34247884375     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0661-9     Document Type: Article

References (24)

1. McCarthy MI, Zeggini E (2006) Genetics of type 2 diabetes. Curr Diab Rep 6:147-154
2. Reynisdottir I, Thorleifsson G, Benediktsson R et al (2003) Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2. Am J Hum Genet 73:323-335
3. Grant SF, Thorleifsson G, Reynisdottir I et al (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-323
4. Damcott CM, Pollin TI, Reinhart LJ et al (2006) Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 55:2654-2659
5. Scott LJ, Bonnycastle LL, Willer CJ et al (2006) Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes 55:2649-2653
6. Zhang C, Qi L, Hunter DJ et al (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. Diabetes 55:2645-2648
7. Groves CJ, Zeggini E, Minton J et al (2006) Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 55:2640-2644
8. Florez JC, Jablonski KA, Bayley N et al (2006) TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241-250
9. Cauchi S, Meyre D, Dina C et al (2006) Transcription factor TCF7L2 genetic study in the french population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 55:2903-2908
10. Saxena R, Gianniny L, Burtt NP et al (2006) Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes 55:2890-2895
11. Doney A, Fischer B, Frew D et al (2002) Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight. BMC Genet 3:21
12. Doney AS, Fischer B, Cecil JE et al (2004) Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes. Diabetologia 47:555-558
13. Doney AS, Fischer B, Cecil JE et al (2003) Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus. BMC Genet 4:11
14. Doney AS, Fischer B, Lee SP, Morris AD, Leese G, Palmer CN (2005) Association of common variation in the PPARA gene with incident myocardial infarction in individuals with type 2 diabetes: a Go-DARTS study. Nucl Recept 3:4
15. Doney AS, Fischer B, Leese G, Morris AD, Palmer CN (2004) Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study. Arterioscler Thromb Vasc Biol 24:2403-2407
16. Doney AS, Lee S, Leese GP, Morris AD, Palmer CN (2005) Increased cardiovascular morbidity and mortality in type 2 diabetes is associated with the glutathione S transferase theta-null genotype: a Go-DARTS study. Circulation 111:2927-2934
17. Morris AD, Boyle DI, MacAlpine R et al (1997) The diabetes audit and research in Tayside Scotland (DARTS) study: electronic record linkage to create a diabetes register. DARTS/MEMO Collaboration. Br Med J 315:524-528
18. Helgason A, Palsson S, Thorleifsson G et al (2007) Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 39:218-225
19. Chandak GR, Janipalli CS, Bhaskar S et al (2007) Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia 50:63-67
20. Humphries SE, Gable D, Cooper JA et al (2006) Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women. J Mol Med 84(12 Suppl):1-10
21. van Vliet-Ostaptchouk JV, Shiri-Sverdlov R, Zhernakova A et al (2007) Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort. Diabetologia 50:59-62
22. Sladek, R, Rocheleau G, Rung J et al (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881-885
23. Lehman DM, Hunt KJ, Leach RJ et al (2007) Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans. Diabetes 56:389-393
24. Janssens AC, Gwinn M, Valdez R, Narayan KM, Khoury MJ (2006) Predictive genetic testing for type 2 diabetes. BMJ 333:509-510