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Volumn 5, Issue 5, 2007, Pages 971-979

Differential effects of high prothrombin levels on thrombin generation depending on the cause of the hyperprothrombinemia

Author keywords

APC resistance; High prothrombin levels; PT A19911G; PT G20210A; Thrombin generation; Thrombosis

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR; PROTEIN S; PROTHROMBIN; THROMBIN;

EID: 34247877798     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2007.02448.x     Document Type: Article
Times cited : (36)

References (38)
  • 1
    • 0242585716 scopus 로고    scopus 로고
    • Blood coagulation
    • Dahlbäck B. Blood coagulation. Lancet 2000; 355: 1627-32.
    • (2000) Lancet , vol.355 , pp. 1627-1632
    • Dahlbäck, B.1
  • 2
    • 0027446268 scopus 로고
    • Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C
    • Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-8.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1004-1008
    • Dahlbäck, B.1    Carlsson, M.2    Svensson, P.J.3
  • 5
    • 0029850530 scopus 로고    scopus 로고
    • A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
    • Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
    • (1996) Blood , vol.88 , pp. 3698-3703
    • Poort, S.R.1    Rosendaal, F.R.2    Reitsma, P.H.3    Bertina, R.M.4
  • 7
    • 0034939628 scopus 로고    scopus 로고
    • Increased efficiency of mRNA 3′ end formation: A new genetic mechanism contributing to hereditary thrombophilia
    • Gehring NH, Frede U, Neu-Yilik G, Hundsdoerfer P, Vetter B, Hentze MW, Kulozik AE. Increased efficiency of mRNA 3′ end formation: A new genetic mechanism contributing to hereditary thrombophilia. Nat Genet 2001; 28: 389-92.
    • (2001) Nat Genet , vol.28 , pp. 389-392
    • Gehring, N.H.1    Frede, U.2    Neu-Yilik, G.3    Hundsdoerfer, P.4    Vetter, B.5    Hentze, M.W.6    Kulozik, A.E.7
  • 8
    • 3142552164 scopus 로고    scopus 로고
    • G20210A is a functional mutation in the prothrombin gene; effect on protein levels and 3′-end formation
    • Ceelie H, Spaargaren-van Riel CC, Bertina RM, Vos HL. G20210A is a functional mutation in the prothrombin gene; effect on protein levels and 3′-end formation. J Thromb Haemost 2004; 2: 119-27.
    • (2004) J Thromb Haemost , vol.2 , pp. 119-127
    • Ceelie, H.1    Spaargaren-van Riel, C.C.2    Bertina, R.M.3    Vos, H.L.4
  • 9
    • 3142585004 scopus 로고    scopus 로고
    • The prothrombin 3′ end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations
    • Danckwardt S, Gehring NH, Neu-Yilik G, Hundsdoerfer P, Pforsich M, Frede U, Hentze MW, Kulozik AE. The prothrombin 3′ end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations. Blood 2004; 104: 428-35.
    • (2004) Blood , vol.104 , pp. 428-435
    • Danckwardt, S.1    Gehring, N.H.2    Neu-Yilik, G.3    Hundsdoerfer, P.4    Pforsich, M.5    Frede, U.6    Hentze, M.W.7    Kulozik, A.E.8
  • 11
    • 0036660170 scopus 로고    scopus 로고
    • The G20210A mutation does not affect the stability of prothrombin mRNA in vivo
    • Pollak ES, Lam HS, Russell JE. The G20210A mutation does not affect the stability of prothrombin mRNA in vivo. Blood 2002; 100: 359-62.
    • (2002) Blood , vol.100 , pp. 359-362
    • Pollak, E.S.1    Lam, H.S.2    Russell, J.E.3
  • 12
  • 15
    • 33750967080 scopus 로고    scopus 로고
    • The association of prothrombin A19911G polymorphism with plasma prothrombin activity and venous thrombosis: Results of the MEGA study, a large population-based case-control study
    • Chinthammitr Y, Vos HL, Rosendaal FR, Doggen CJ. The association of prothrombin A19911G polymorphism with plasma prothrombin activity and venous thrombosis: Results of the MEGA study, a large population-based case-control study. J Thromb Haemost 2006; 4: 2587-92.
    • (2006) J Thromb Haemost , vol.4 , pp. 2587-2592
    • Chinthammitr, Y.1    Vos, H.L.2    Rosendaal, F.R.3    Doggen, C.J.4
  • 16
    • 0942276839 scopus 로고    scopus 로고
    • The intronic prothrombin 19911A > G polymorphism influences splicing efficiency and modulates effects of the 20210G > A polymorphism on mRNA amount and expression in a stable reporter gene assay system
    • von Ahsen N, Oellerich M. The intronic prothrombin 19911A > G polymorphism influences splicing efficiency and modulates effects of the 20210G > A polymorphism on mRNA amount and expression in a stable reporter gene assay system. Blood 2004; 103: 586-93.
    • (2004) Blood , vol.103 , pp. 586-593
    • von Ahsen, N.1    Oellerich, M.2
  • 18
    • 0037534900 scopus 로고    scopus 로고
    • Elevated prothrombin results in clots with an altered fiber structure: A possible mechanism of the increased thrombotic risk
    • Wolberg AS, Monroe DM, Roberts HR, Hoffman M. Elevated prothrombin results in clots with an altered fiber structure: A possible mechanism of the increased thrombotic risk. Blood 2003; 101: 3008-13.
    • (2003) Blood , vol.101 , pp. 3008-3013
    • Wolberg, A.S.1    Monroe, D.M.2    Roberts, H.R.3    Hoffman, M.4
  • 19
    • 0042442202 scopus 로고    scopus 로고
    • The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation
    • Koenen RR, Tans G, van Oerle R, Hamulyák K, Rosing J, Hackeng TM. The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation. Blood 2003; 102: 1686-92.
    • (2003) Blood , vol.102 , pp. 1686-1692
    • Koenen, R.R.1    Tans, G.2    van Oerle, R.3    Hamulyák, K.4    Rosing, J.5    Hackeng, T.M.6
  • 20
    • 9444273450 scopus 로고    scopus 로고
    • Inhibition of thrombin generation by protein S at low procoagulant stimuli: Implications for maintenance of the hemostatic balance
    • SeréKM, Rosing J, Hackeng TM. Inhibition of thrombin generation by protein S at low procoagulant stimuli: Implications for maintenance of the hemostatic balance. Blood 2004; 104: 3624-30.
    • (2004) Blood , vol.104 , pp. 3624-3630
    • Seré, K.M.1    Rosing, J.2    Hackeng, T.M.3
  • 21
    • 1542283733 scopus 로고    scopus 로고
    • Hyperprothrombinemia associated with prothrombin G20210A mutation inhibits plasma fibrinolysis through a TAFI-mediated mechanism
    • Colucci M, Binetti BM, Tripodi A, Chantarangkul V, Semeraro N. Hyperprothrombinemia associated with prothrombin G20210A mutation inhibits plasma fibrinolysis through a TAFI-mediated mechanism. Blood 2004; 103: 2157-61.
    • (2004) Blood , vol.103 , pp. 2157-2161
    • Colucci, M.1    Binetti, B.M.2    Tripodi, A.3    Chantarangkul, V.4    Semeraro, N.5
  • 22
    • 0033485878 scopus 로고    scopus 로고
    • Inhibition of activated protein C anticoagulant activity by prothrombin
    • Smirnov MD, Safa O, Esmon NL, Esmon CT. Inhibition of activated protein C anticoagulant activity by prothrombin. Blood 1999; 94: 3839-46.
    • (1999) Blood , vol.94 , pp. 3839-3846
    • Smirnov, M.D.1    Safa, O.2    Esmon, N.L.3    Esmon, C.T.4
  • 23
    • 0024235858 scopus 로고
    • Inhibition of the anticoagulant activity of protein S by prothrombin
    • Mitchell CA, Jane SM, Salem HH. Inhibition of the anticoagulant activity of protein S by prothrombin. J Clin Invest 1988; 82: 2142-7.
    • (1988) J Clin Invest , vol.82 , pp. 2142-2147
    • Mitchell, C.A.1    Jane, S.M.2    Salem, H.H.3
  • 24
    • 0034310731 scopus 로고    scopus 로고
    • Hyperprothrombinemia may result in acquired activated protein C reistance
    • Tripodi A, Chantarangkul V, Mannucci PM. Hyperprothrombinemia may result in acquired activated protein C reistance. Blood 2000; 96: 3295-6.
    • (2000) Blood , vol.96 , pp. 3295-3296
    • Tripodi, A.1    Chantarangkul, V.2    Mannucci, P.M.3
  • 25
    • 0034839785 scopus 로고    scopus 로고
    • Phenotypic APC resistance in carriers of the A20210 prothrombin mutation is associated with an increased risk of venous thrombosis
    • Castaman G, Tosetto A, Simioni M, Ruggeri M, Madeo D, Rodeghiero F. Phenotypic APC resistance in carriers of the A20210 prothrombin mutation is associated with an increased risk of venous thrombosis. Thromb Haemost 2001; 86: 804-8.
    • (2001) Thromb Haemost , vol.86 , pp. 804-808
    • Castaman, G.1    Tosetto, A.2    Simioni, M.3    Ruggeri, M.4    Madeo, D.5    Rodeghiero, F.6
  • 27
    • 33645546424 scopus 로고    scopus 로고
    • Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels
    • Brugge JM, Tans G, Rosing J, Castoldi E. Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels. Thromb Haemost 2006; 95: 236-42.
    • (2006) Thromb Haemost , vol.95 , pp. 236-242
    • Brugge, J.M.1    Tans, G.2    Rosing, J.3    Castoldi, E.4
  • 28
    • 33645734139 scopus 로고    scopus 로고
    • Hyperprothrombinaemia-induced APC resistance: Differential influence on fibrin formation and fibrinolysis
    • Binetti BM, Rotunno C, Tripodi A, Asti D, Semeraro F, Semeraro N, Colucci M. Hyperprothrombinaemia-induced APC resistance: Differential influence on fibrin formation and fibrinolysis. Thromb Haemost 2006; 95: 606-11.
    • (2006) Thromb Haemost , vol.95 , pp. 606-611
    • Binetti, B.M.1    Rotunno, C.2    Tripodi, A.3    Asti, D.4    Semeraro, F.5    Semeraro, N.6    Colucci, M.7
  • 29
    • 0037160755 scopus 로고    scopus 로고
    • Heritability of clotting factors and the revival of the prothrombotic state
    • Rosendaal FR, Bovill EG. Heritability of clotting factors and the revival of the prothrombotic state. Lancet 2002; 359: 638-9.
    • (2002) , vol.359 , pp. 638-639
    • Rosendaal, F.R.1    Bovill, E.G.2
  • 30
    • 0035160177 scopus 로고    scopus 로고
    • Genetic regulation of plasma levels of vitamin K-dependent proteins involved in hematostatis: Results from the GAIT Project. Genetic Analysis of Idiopathic Thrombophilia
    • Souto JC, Almasy L, Blangero J, Stone W, Borrell M, Urrutia T, Mateo J, Fontcuberta J. Genetic regulation of plasma levels of vitamin K-dependent proteins involved in hematostatis: Results from the GAIT Project. Genetic Analysis of Idiopathic Thrombophilia. Thromb Haemost 2001; 85: 88-92.
    • (2001) Thromb Haemost , vol.85 , pp. 88-92
    • Souto, J.C.1    Almasy, L.2    Blangero, J.3    Stone, W.4    Borrell, M.5    Urrutia, T.6    Mateo, J.7    Fontcuberta, J.8
  • 34
    • 33746453363 scopus 로고    scopus 로고
    • Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation
    • Hron G, Kollars M, Binder BR, Eichinger S, Kyrle PA. Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation. JAMA 2006; 296: 397-402.
    • (2006) JAMA , vol.296 , pp. 397-402
    • Hron, G.1    Kollars, M.2    Binder, B.R.3    Eichinger, S.4    Kyrle, P.A.5
  • 35
    • 33846407635 scopus 로고    scopus 로고
    • The risk of venous thrombosis associated with a high endogenous thrombin potential in the absence and presence of activated protein C
    • Brandts A, van Hylckama Vlieg A, Rosing J, Baglin TP, Rosendaal FR. The risk of venous thrombosis associated with a high endogenous thrombin potential in the absence and presence of activated protein C. J Thromb Haemost 2007; 5: 416-8.
    • (2007) J Thromb Haemost , vol.5 , pp. 416-418
    • Brandts, A.1    van Hylckama Vlieg, A.2    Rosing, J.3    Baglin, T.P.4    Rosendaal, F.R.5
  • 36
    • 0042629609 scopus 로고    scopus 로고
    • Activated protein C resistance determined with a thrombin generation-based test predicts for venous thrombosis in men and women
    • Tans G, van Hylckama Vlieg A, Thomassen MC, Curvers J, Bertina RM, Rosing J, Rosendaal FR. Activated protein C resistance determined with a thrombin generation-based test predicts for venous thrombosis in men and women. Br J Haematol 2003; 122: 465-70.
    • (2003) Br J Haematol , vol.122 , pp. 465-470
    • Tans, G.1    van Hylckama Vlieg, A.2    Thomassen, M.C.3    Curvers, J.4    Bertina, R.M.5    Rosing, J.6    Rosendaal, F.R.7
  • 37
    • 33645458000 scopus 로고    scopus 로고
    • Utility of thrombin-generation assay in the screening of factor V G1691A (Leiden) and prothrombin G20210A mutations and protein S deficiency
    • Hézard N, Bouaziz-Borgi L, Remy MG, Nguyen P. Utility of thrombin-generation assay in the screening of factor V G1691A (Leiden) and prothrombin G20210A mutations and protein S deficiency. Clin Chem 2006; 52: 665-70.
    • (2006) Clin Chem , vol.52 , pp. 665-670
    • Hézard, N.1    Bouaziz-Borgi, L.2    Remy, M.G.3    Nguyen, P.4
  • 38
    • 0036891940 scopus 로고    scopus 로고
    • Prospective study of the G20210A polymorphism in the prothrombin gene, plasma prothrombin concentration, and incidence of venous thromboembolism
    • Folsom AR, Cushman M, Tsai MY, Heckbert SR, Aleksic N. Prospective study of the G20210A polymorphism in the prothrombin gene, plasma prothrombin concentration, and incidence of venous thromboembolism. Am J Hematol 2002; 71: 285-90.
    • (2002) Am J Hematol , vol.71 , pp. 285-290
    • Folsom, A.R.1    Cushman, M.2    Tsai, M.Y.3    Heckbert, S.R.4    Aleksic, N.5


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