Prothrombin G20210A is a bifunctional gene polymorphism

Thrombosis and Haemostasis

Volumn 87, Issue 5, 2002, Pages 846-853

  Carter, Angela M ^a   Sachchithananthan, Mythily ^a   Stasinopoulos, Stan ^a   Maurer, Fabienne ^a   Medcalf, Robert L ^a  

^a BOX HILL HOSPITAL   (Australia)

Author keywords

G20210A; mRNA stability; Prothrombin; Thrombosis

Indexed keywords

COMPLEMENTARY DNA; GLOBIN; MESSENGER RNA; PROTHROMBIN; RNA BINDING PROTEIN;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN 3T3; CELL STRAIN HEPG2; CHIMERA; COMPARATIVE STUDY; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SECRETION; REPORTER GENE; RNA PROCESSING; RNA STABILITY; THROMBOSIS;

EID: 0036248005     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613095     Document Type: Article

References (22)

1. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
2. The prothrombin 20210A allele is the most prevalent genetic risk factor for venous thromboembolism in the Spanish population
3. Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis
4. Increased efficiency of mRNA 3′ end formation: A new genetic mechanism contributing to hereditary thrombophilia
5. Plasminogen activator inhibitor type 2 contains mRNA instability elements within exon 4 of the coding region. Sequence homology to coding region instability determinants in other mRNAs
6. Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin
7. Plasminogen activator inhibitor type 2 gene induction by tumor necrosis factor and phorbol ester involves transcriptional and post-transcriptional events. Identification of a functional nonameric AU-rich motif in the 3′-untranslated region
8. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
9. A DNA motif related to the cAMP-responsive element and an exon-located activator protein-2 binding site in the human tissue-type plasminogen activator gene promoter cooperate in basal expression and convey activation by phorbol ester and cAMP
10. Quantitative measurement of Stachybotrys chartarum conidia using real time detection of PCR products with the TaqMan(TM) fluorogenic probe system
11. An AU-rich sequence in the 3′-UTR of plasminogen activator inhibitor type 2 (PAI-2) mRNA promotes PAI-2 mRNA decay and provides a binding site for nuclear HuR
12. The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro
13. The poly(A) tail inhibits the assembly of a 3′-to-5′ exonuclease in an in vitro RNA stability system
14. Interaction between a poly(A)-specific ribonuclease and the 5′ cap influences mRNA deadenylation rates in vitro
15. A tale of two termini: A functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation
16. The prothrombin gene and its liver-specific expression
17. The mRNA Poly(A)-binding protein: Localization, abundance and RNA binding specificity
18. mRNA stability in mammalian cells
19. HuR and mRNA stability
20. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein
21. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR
22. Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs