The risk of venous thrombosis associated with a high endogenous thrombin potential in the absence and presence of activated protein C [3]

Journal of Thrombosis and Haemostasis

Volumn 5, Issue 2, 2007, Pages 416-418

  Brandts, A ^a   Van Hylckama Vlieg, A ^a,b   Rosing, J ^c   Baglin, T P ^b   Rosendaal, F R ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; THROMBIN;

ADULT; DIAGNOSTIC VALUE; FEMALE; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; STATISTICAL ANALYSIS; THROMBIN TIME; VEIN THROMBOSIS;

FEMALE; HUMANS; MALE; MIDDLE AGED; PROTEIN C; RISK; THROMBIN; THROMBOPHILIA; VENOUS THROMBOSIS;

EID: 33846407635     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2007.02321.x     Document Type: Letter

References (6)

1. Nicolaes GAF, Thomassen MCLG, Tans G, Rosing J, Hemker HC. Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC-resistant individuals. Blood Coagul Fibrinolysis 1997; 8: 28-38.
2. Tans G, Vlieg AV, Thomassen MCLG, Curvers J, Bertina RM, Rosing J, Rosendaal FR. Activated protein C resistance determined with a thrombin generation-based test predicts for venous thrombosis in men and women. Br J Haematol 2003; 122: 465-70.
3. Koster T, Rosendaal FR, de Ronde H, Briët E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993; 342: 1503-6.
4. Rosing J, Tans G, Nicolaes GA, Thomassen MCLGD, van Oerle R, van der Ploeg PM, Heijnen P, Hamulyak K, Hemker HC. Oral contraceptives and venous thrombosis: Different sensitivities to activated protein C in women using second- and third-generation oral contraceptives. Br J Haematol 1997; 97: 233-8.
5. Luddington R, Baglin T. Clinical measurement of thrombin generation by calibrated automated thrombography requires contact factor inhibition. J Thromb Haemost 2004; 2: 1954-9.
6. Hemker HC, Giesen P, AlDieri R, Regnault V, de Smed E, Wagenvoord R, Lecompte T, Beguin S. The calibrated automated thrombogram (CAT): A universal routine test for hyper- and hypocoagulability. Pathophysiol Haemost Thromb 2002; 32: 249-53.