Generation of ΔTAp73 proteins by translation from a putative internal ribosome entry site

Annals of the New York Academy of Sciences

Volumn 1095, Issue , 2007, Pages 315-324

  Sayan, A Emre ^a   Roperch, Jean Pierre ^a   Sayan, Berna S ^a   Rossi, Mario ^a   Pinkoski, M J ^a   Knight, Richard A ^a   Willis, Anne E ^b   Melino, Gerry ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

IRES; p53 internal ribosome entry site; p73

Indexed keywords

PROTEIN P73; DNA BINDING PROTEIN; ISOPROTEIN; NUCLEAR PROTEIN; PROTEIN P53; TP53 PROTEIN, HUMAN; TP73 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; CONFERENCE PAPER; CONTROLLED STUDY; EMBRYO; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; PROMOTER REGION; PROTEIN ANALYSIS; REGULATORY MECHANISM; TRANSLATION INITIATION; ARTICLE; BIOSYNTHESIS; CELL LINE; GENE DELETION; GENE VECTOR; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RIBOSOME; TRANSACTIVATION; TUMOR CELL LINE;

BASE SEQUENCE; CELL LINE; CELL LINE, TUMOR; DNA-BINDING PROTEINS; GENETIC VECTORS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RIBOSOMES; SEQUENCE DELETION; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 34247875994     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1397.035     Document Type: Conference Paper

References (34)

1. MELINO, G., V. DE LAURENZI & K.H. VOUSDEN. 2002. p73: friend or foe in tumorigenesis. Nat. Rev. Cancer 2: 605-615.
2. STIEWE, T., S. ZIMMERMANN, A. FRILLING, et al. 2002. Transactivation-deficient DeltaTA-p73 acts as an oncogene. Cancer Res. 62: 3598-3602.
3. CHAN, W.M., W.Y. SIU, A. LAU & R.Y. POON. 2004. How many mutant p53 molecules are needed to inactivate a tetramer? Mol. Cell Biol. 24: 3536-3551.
4. MULLER, M. et al. 2005. TAp73/DeltaNp73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma. Cell Death Differ 12: 1564-1577.
5. TERRINONI, A. et al. 2004. p73-alpha is capable of inducing scotin and ER stress. Oncogene 23: 3721-3725.
6. MELINO, G. et al. 2004. p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J. Biol. Chem. 279: 8076-8083.
7. GONG, J.G. et al. 1999. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-809.
8. GROB, T.J. et al. 2001. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 8: 1213-1223.
9. BERNASSOLA, F. et al. 2004. Ubiquitin-dependent degradation of p73 is inhibited by PML. J. Exp. Med. 199: 1545-1557.
10. ROSSI, M. et al. 2005. The ubiquitin-protein ligase Itch regulates p73 stability. EMBO. J. 24: 836-848.
11. MUNARRIZ, E., D. BANO, A.E. SAYAN, et al. 2005. Calpain cleavage regulates the protein stability of p73. Biochem. Biophys. Res. Commun. 333: 954-960.
12. WILLIS, A.E. 2005. All's well that ends well: translational control and cell death. Cell Death Differ. 12: 533.
13. PERROTTI, D., F. TURTURRO & P. NEVIANI. 2005. BCR/ABL, mRNA translation and apoptosis. Cell Death Differ. 12: 534-540.
14. PROUD, C.G. 2005. The eukaryotic initiation factor 4E-binding proteins and apoptosis. Cell Death Differ. 12: 541-546.
15. LEWIS, S.M. & M. HOLCIK. 2005. IRES in distress: translational regulation of the inhibitor of apoptosis proteins XIAP and HIAP2 during cell stress. Cell Death Differ. 12: 547-553.
16. MARASH, L. & A. KIMCHI. 2005. DAP5 and IRES-mediated translation during programmed cell death. Cell Death Differ. 12: 554-562.
17. MORLEY, S.J., M.J. COLDWELL & M.J. CLEMENS 2005. Initiation factor modifications in the preapoptotic phase. Cell Death Differ. 12: 571-584.
18. SPRIGGS, K.A., M. BUSHELL, S.A. MITCHELL & A.E. WILLIS. 2005. Internal ribosome entry segment-mediated translation during apoptosis: the role of IREStrans-acting factors. Cell Death Differ. 12: 585-591.
19. KOZAK, M. 2003. Alternative ways to think about mRNA sequences and proteins that appear to promote internal initiation of translation. Gene 318: 1-23.
20. JANG, S.K., H.G. KRAUSSLICH, M.J. NICKLIN, et al. 1988. A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J. Virol. 62: 2636-2643.
21. PELLETIER, J. & N. SONENBERG 1988. Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334: 320-325.
22. MACEJAK, D.G. & P. SARNOW 1991. Internal initiation of translation mediated by the 5′ leader of a cellular mRNA. Nature 353: 90-94.
23. STONELEY, M. & A.E. WILLIS 2004. Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression. Oncogene 23: 3200-3207.
24. STONELEY, M., F.E. PAULIN, J.P. LE QUESNE, et al. 1998. C-Myc 5′ untranslated region contains an internal ribosome entry segment. Oncogene 16: 423-428.
25. JOPLING, C.L. & A.E. WILLIS. 2001. N-myc translation is initiated via an internal ribosome entry segment that displays enhanced activity in neuronal cells. Oncogene 20: 2664-2670.
26. JOPLING, C.L., K.A. SPRIGGS, S.A. MITCHELL, et al. 2004. L-Myc protein synthesis is initiated by internal ribosome entry. RNA 10: 287-298.
27. MITCHELL, S.A. et al. 2005. Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry. Genes Dev. 19: 1556-1571.
28. MUNARRIZ, E. et al. 2004. PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. Mol. Cell Biol. 24: 10593-10610.
29. RAY, P.S., R. GROVER & S. DAS 2006. Two internal ribosome entry sites mediate the translation of p53 isoforms. EMBO Rep. 4: 404-410.
30. FILLIPPOVICH, I. et al. 2001. Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53. Oncogene 20: 514-522.
31. SHERRILL, K.W., M.P. BYRD, M.E. VAN EDEN & R.E. LLOYD. 2004. BCL-2 translation is mediated via internal ribosome entry during cell stress. J. Biol. Chem. 279: 29066-29074.
32. DE LAURENZI, V. et al. 2000. Induction of neuronal differentiation by p73 in a neuroblastoma cell line. J. Biol. Chem. 275: 15226-15231.
33. HOSOI, G. et al. 1994. Low frequency of the p53 gene mutations in neuroblastoma. Cancer 73: 3087-3093.
34. VOGAN, K. et al. 1993. Absence of p53 gene mutations in primary neuroblastomas. Cancer Res. 53: 5269-5273.