Review article: Regulation of TFF1 (pS2) expression in gastric epithelial cells

Alimentary Pharmacology and Therapeutics Symposium Series

Volumn 2, Issue 1, 2006, Pages 285-291

  Fujii, Y ^a   Shimada, T ^a   Koike, T ^a   Hosaka, K ^a   Tabei, K ^a   Namatame, T ^a   Tajima, A ^a   Yoneda, M ^a   Terano, A ^a   Hiraishi, H ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ESTROGEN; ESTROGEN RECEPTOR; GLYCOPROTEIN GP 130; INTERLEUKIN 6; PROTEIN PS2; TREFOIL PEPTIDE;

BREAST CANCER; CANCER CELL; CONFERENCE PAPER; DNA METHYLATION; EPITHELIUM CELL; GENETIC REGULATION; HORMONE DEPENDENCE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STOMACH; STOMACH EPITHELIUM; STOMACH MUCOSA; TUMOR SUPPRESSOR GENE;

EID: 34247872949     PISSN: 17466334     EISSN: 17466342     Source Type: Journal    
DOI: 10.1111/j.1746-6342.2006.00058.x     Document Type: Conference Paper

References (40)

1. Hoffmann W. Trefoil factor family (TFF) peptides: regulators of mucosal regeneration and repair, and more. Peptides 2004 25:727 30.
2. Taupin D, Podolsky DK. Trefoil factors: initiators of mucosal healing. Nat Rev Mol Cell Biol 2003 4:721 32.
3. Lefebvre O, Chenard MP, Masson R, et al. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science 1996 274:259 62.
4. Machado JC, Carneiro F, Blin N, Sobrinho-Simoes M. Pattern of pS2 protein expression in premalignant and malignant lesions of gastric mucosa. Eur J Cancer Prev 1996 5:169 79.
5. Luqmani Y, Bennett C, Paterson I, et al. Expression of the pS2 gene in normal, benign and neoplastic human stomach. Int J Cancer 1989 44:806 12.
6. Kirikoshi H, Katoh M. Expression of TFF1, TFF2 and TFF3 in gastric cancer. Int J Oncol 2002 21:655 9.
7. Fujimoto J, Yasui W, Tahara H, et al. DNA hypermethylation at the pS2 promoter region is associated with early stage of stomach carcinogenesis. Cancer Lett 2000 149:125 34.
8. Park WS, Oh RR, Park JY, et al. Somatic mutations of the trefoil factor family 1 gene in gastric cancer. Gastroenterology 2000 119:691 8.
9. Masiakowski P, Breathnach R, Bloch J, et al. Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res 1982 10:7895 903.
10. Brown AM, Jeltsch JM, Roberts M, Chambon P. Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7. Proc Natl Acad Sci USA 1984 81:6344 8.
11. Rio MC, Bellocq JP, Gairard B, et al. Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2. Proc Natl Acad Sci USA 1987 84:9243 7.
12. Enmark E, Gustafsson JA. Oestrogen receptors - an overview. J Intern Med 1999 246:133 8.
13. Kong EH, Pike AC, Hubbard RE. Structure and mechanism of the oestrogen receptor. Biochem Soc Trans 2003 31:56 9.
14. Terada T, Sakagami R, Tabuchi Y, Maeda M. Characterization of the mouse TFF1 (pS2) gene promoter region. Biol Pharm Bull 2001 24:135 9.
15. Rio MC, Bellocq JP, Daniel JY, et al. Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. Science 1988 241:705 8.
16. Singh S, Poulsom R, Wright NA, Sheppard MC, Langman MJ. Differential expression of oestrogen receptor and oestrogen inducible genes in gastric mucosa and cancer. Gut 1997 40:516 20.
17. Campbell-Thompson ML. Estrogen receptor alpha and beta expression in upper gastrointestinal tract with regulation of trefoil factor family 2 mRNA levels in ovariectomized rats. Biochem Biophys Res Commun 1997 240:478 83.
18. Kuiper GG, Carlsson B, Grandien K, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997 138:863 70.
19. Taylor AH, Al-Azzawi F. Immunolocalisation of oestrogen receptor beta in human tissues. J Mol Endocrinol 2000 24:145 55.
20. Matsuyama S, Ohkura Y, Eguchi H, et al. Estrogen receptor beta is expressed in human stomach adenocarcinoma. J Cancer Res Clin Oncol 2002 128:319 24.
21. Gustafsson JA. Estrogen receptor beta - a new dimension in estrogen mechanism of action. J Endocrinol 1999 163:379 83.
22. Shimada T, Fujii Y, Koike T, et al. Does estrogen regulate TFF1 expression in gastric epithelial cells Gastroenterology 2005 128:A-347.
23. Nunez AM, Berry M, Imler JL, Chambon P. The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein. EMBO J 1989 8:823 9.
24. Beck S, Fegert P, Gott P. Factors regulating pS2-reporter gene expression in MCF-7 breast cancer cell line. Int J Oncol 1997 10:1051 5.
25. Gott P, Beck S, Machado JC, Carneiro F, Schmitt H, Blin N. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. Eur J Hum Genet 1996 4:308 15.
26. Beck S, Sommer P, Blin N, Gott P. 5′-flanking motifs control cell-specific expression of trefoil factor genes (TFF). Int J Mol Med 1998 2:353 61.
27. Beck S, Sommer P, dos Santos Silva E, Blin N, Gott P. Hepatocyte nuclear factor 3 (winged helix domain) activates trefoil factor gene TFF1 through a binding motif adjacent to the TATAA box. DNA Cell Biol 1999 18:157 64.
28. Yoshida T, Sato R, Mahmood S, Kawasaki S, Futai M, Maeda M. GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells. FEBS Lett 1997 414:333 7.
29. Maeda M, Kubo K, Nishi T, Futai M. Roles of gastric GATA DNA-binding proteins. J Exp Biol 1996 199:513 20.
30. Al-azzeh ED, Fegert P, Blin N, Gott P. Transcription factor GATA-6 activates expression of gastroprotective trefoil genes TFF1 and TFF2. Biochim Biophys Acta 2000 1490:324 32.
31. Dossinger V, Kayademir T, Blin N, Gott P. Down-regulation of TFF expression in gastrointestinal cell lines by cytokines and nuclear factors. Cell Physiol Biochem 2002 12:197 206.
32. Loncar MB, Al-azzeh ED, Sommer PS, et al. Tumour necrosis factor alpha and nuclear factor kappaB inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide. Gut 2003 52:1297 303.
33. Sankpal NV, Mayo MW, Powell SM. Transcriptional repression of TFF1 in gastric epithelial cells by CCAAT/enhancer binding protein-beta. Biochim Biophys Acta 2005 1728:1 10.
34. Khan ZE, Wang TC, Cui G, Chi AL, Dimaline R. Transcriptional regulation of the human trefoil factor, TFF1, by gastrin. Gastroenterology 2003 125:510 21.
35. Taupin D, Wu DC, Jeon WK, Devaney K, Wang TC, Podolsky DK. The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation. J Clin Invest 1999 103:R31 8.
36. Taga T, Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 1997 15:797 819.
37. Tebbutt NC, Giraud AS, Inglese M, et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 2002 8:1089 97.
38. Judd LM, Alderman BM, Howlett M, et al. Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. Gastroenterology 2004 126:196 207.
39. Wright NA, Poulsom R, Stamp GW, et al. Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues. J Pathol 1990 162:279 84.
40. Ribieras S, Lefebvre O, Tomasetto C, Rio MC. Mouse trefoil factor genes: genomic organization, sequences and methylation analyses. Gene 2001 266:67 75.