Efficacy of dexamethasone injection for acute bronchiolitis in hospitalized children: A randomized, double-blind, placebo-controlled trial

Pediatric Pulmonology

Volumn 42, Issue 5, 2007, Pages 433-439

  Teeratakulpisarn, Jamaree ^a   Limwattananon, Chulaporn ^b   Tanupattarachai, Sureeporn ^c   Limwattananon, Supon ^b   Teeratakulpisarn, Somrak ^b   Kosalaraksa, Pope ^a  

^a KHON KAEN UNIVERSITY   (Thailand)

^b KHON KAEN UNIVERSITY   (Thailand)

^c KHON KAEN HOSPITAL   (Thailand)

Author keywords

Bronchiolitis; Corticosteroid; Dexamethasone; Lower respiratory tract infection; Randomized controlled trial; Wheezing

Indexed keywords

ADRENALIN; ANTIBIOTIC AGENT; CORTICOSTEROID; DEXAMETHASONE; PLACEBO; PREDNISOLONE; SALBUTAMOL;

ACUTE DISEASE; ARTICLE; BREATHING RATE; BRONCHIOLITIS; CHILD HOSPITALIZATION; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HAZARD RATIO; HUMAN; INFANT; KAPLAN MEIER METHOD; LENGTH OF STAY; LOG RANK TEST; MAJOR CLINICAL STUDY; MALE; OXYGEN SATURATION; PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS; SCORING SYSTEM; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; UNIVERSITY HOSPITAL; WHEEZING;

ACUTE DISEASE; BRONCHIOLITIS; DEXAMETHASONE; DOUBLE-BLIND METHOD; FEMALE; GLUCOCORTICOIDS; HUMANS; INFANT; INJECTIONS, INTRAMUSCULAR; LENGTH OF STAY; MALE; OXYGEN INHALATION THERAPY; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 34247855866     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.20585     Document Type: Article

References (27)

1. Springer C, Bar-Yishay E, Uwayyed K, Avital A, Vilozni D, Godfrey S. Corticosteroids do not affect the clinical or physiological status of infants with bronchiolitis. Pediatr Pulmonol 1990;9:181-185.
2. Roosevelt G, Sheehan K, Grupp-Phelan J, Tanz RR, Listernick R. Dexamethasone in bronchiolitis: a randomised controlled trial. Lancet 1996;348:292-295.
3. De Boeck K, Van der Aa N, Van Lierde S, Corbeel L, Eeckels R. Respiratory syncytial virus bronchiolitis: a double-blind dexamethasone efficacy study. J Pediatr 1997;131:919-921.
4. Klassen TP, Sutcliffe T, Watters LK, Wells GA, Allen UD, Li MM. Dexamethasone in salbutamol-treated in patients with acute bronchiolitis: a randomised, controlled trial. J Pediatr 1997;130:191-196.
5. Berger I, Argaman Z, Schwartz SB, Segal E, Kiderman A, Branski D, Kerem E. Efficacy of corticosteroids in acute bronchiolitis: short-term and long-term follow-up. Pediatr Pulmonol 1998;26:162-166.
6. Bulow SM, Nir M, Levin E, Friis B, Thomsen LL, Nielsen JE, Holm JC, Moller T, Bonde-Hansen ME, Nielsen HE. Prednisolone treatment of respiratory syncytial virus infection: a randomised controlled trial of 147 infants. Pediatrics 1999;e77.
7. Csonka P, Kaila M, Laippala P, Iso-Mustajarvi M, Vesikari T, Ashorn P. Oral prednisolone in the acute management of children age 6 to 35 months with viral respiratory infection-induced lower airway disease: a randomised, placebo-controlled trial. J Pediatr 2003;143:725-730.
8. Tal A, Bavilski C, Yohai D, Bearman JE, Gorodischer R, Moses SW. Dexamethasone and salbutamol in the treatment of acute wheezing in infants. Pediatrics 1983;71:13-18.
9. Daugbjerg P, Brenoe E, Forchhammer H, Frederiksen B, Glazowski MJ, Ibsen KK, Knabe N, Leth H, Marner B, Pedersen FK, Ostergaard GZ. A comparison between nebulized terbutaline, nebulized corticosteroid and systemic corticosteroid for acute wheezing in children up to 18 months of age. Acta Paediatr 1993;82:547-551.
10. van Woensel JBM, Wolfs TF, van Aalderen WM, Brand PL, Kimpen JL. Randomised double blind placebo-controlled trial of prednisolone in children admitted to hospital with respiratory syncytial virus bronchiolitis. Thorax 1997;52:634-637.
11. Schuh S, Coates AL, Binnie R, Allin T, Goia C, Corey M, Dick PT. Efficacy of oral dexamethasone in outpatients with acute bronchiolitis. J Pediatr 2002;140:27-32.
12. Garrison MM, Christakis DA, Harvey E, Cummings P, Davis RL. Systemic corticosteroids in infant bronchiolitis: a meta-analysis. Pediatrics 2000;105:e44.
13. Patel H, Platt R, Lozano JM, Wang EE. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev 2004;3:CD004878.
14. American Academy of Pediatrics. Clinical practice guideline: diagnosis and management of bronchiolitis. Pediatrics 2006;118:1774-1793.
15. Sheeran P, Jafri H, Carubelli C, Saavedra J, Johnson C, Krisher K, Sanchez PT, Ramilo O. Elevated cytokine concentrations in the nasopharyngeal and tracheal secretions of children with respiratory syncytial virus disease. Pediatr Infect Dis J 1999;18:115-122.
16. Volovitz B, Faden H, Ogra PL. Release of leukotriene C4 in respiratory tract during acute viral infection. J Pediatr 1988;112:218-222.
17. Garofalo R, Kimpen JL, Welliver RC, Ogra PL. Eosinophil degranulation in respiratory tract during naturally acquired respiratory syncytial virus infection. J Pediatr 1992;120:28-32.
18. Noah TL, Becker S. Respiratory syncytial virus induced cytokine production by human bronchial epithelial cell line. Am J Physiol 1993;265:472-478.
19. Noah TL, Wortman IA, Becker S. The effect of fluticasone propionate on respiratory syncytial virus-induced chemokine release by a human bronchial epithelial cell line. Immunopharmacology 1998;39:193-199.
20. Schimmer BP, Parker KL. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitor of the synthesis and actions of adrenocortical hormones. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, editors. Goodman & Gilman's the pharmacological basis of therapeutics, 9th edition. New York: McGraw-Hill; 1996. pp 1459-1485.
21. McBride JT. Dexamethasone and bronchiolitis: a new look at an old therapy? J Pediatr 2002;140:8-9.
22. Luria JW, Gonzalez-del-Rey JA, DiGiulio GA, McAneney CM, Olson JJ, Ruddy RM. Effectiveness of oral or nebulized dexamethasone for children with mild croup. Arch Pediatr Adolesc Med 2001;155:1340-1345.
23. Johnson DW, Jacobson S, Edney PC, Hadfield P, Mundy ME, Schuh S. A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup. N Engl J Med 1998;339:498-503.
24. Klassen TP, Craig WR, Moher D, Osmond MH, Pasterkamp H, Sutcliffe T, Watters LK, Rowe PC. Nebulized budesonide and oral dexamethasone for treatment of croup: a randomised controlled trial. JAMA 1998;279:1629,-1632.
25. Suwanjutha S, Sunakorn P, Chantarojanasiri T, Siritantikorn S, Nawanoparatkul S, Rattanadilok Na Bhuket T, Teeyapaiboonsilpa P, Preutthipan A, Sareebutr W, Puthavathana P. Respiratory syncytial virus-associated lower respiratory tract infection in under-5-year-old children in a rural community of central Thailand, a population-based study. J Med Assoc Thai 2002;85: S1111-S1119.
26. Ducharme FM, Chabot G, Polychronakos C, Glorieux F, Mazer B. Safety profile of frequent short courses of oral glucocorticoids in acute pediatricasthma: impact on bone metabolism, bone density, and adrenal function. Pediatrics 2003;111:376-383.
27. van Woensel JB, Kimpen JL, Sprikkelman AB, Ouwehand A, van Aalderen WM. Long-term effects of prednisolone in the acute phase of bronchiolitis caused by respiratory syncytial virus. Pediatr Pulmonol 2000;30:92-96.