FTY720 attenuates accumulation of EMAP-II+ and MHC-II+ monocytes in early lesions of rat traumatic brain injury

Journal of Cellular and Molecular Medicine

Volumn 11, Issue 2, 2007, Pages 307-314

  Zhang, Zhiyuan ^a   Zhang, Zhiren ^a   Fauser, Uwe ^a   Artelt, Matthias ^b   Burnet, Michael ^b   Schluesener, Hermann J ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Synovo GmbH   (Germany)

Author keywords

EMAP II; FTY720; MHC II; Monocytes; Traumatic brain injury

Indexed keywords

CYTOKINE; DRUG DERIVATIVE; FINGOLIMOD; HLA ANTIGEN CLASS 2; IMMUNOSUPPRESSIVE AGENT; PROPANEDIOL DERIVATIVE; RNA BINDING PROTEIN; SMALL INDUCIBLE CYTOKINE SUBFAMILY E, MEMBER 1; SPHINGOSINE; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BIOSYNTHESIS; BRAIN INJURY; IMMUNOHISTOCHEMISTRY; LEWIS RAT; METABOLISM; MONOCYTE; PATHOLOGY; PHYSIOLOGY; RAT; TIME;

ANIMALS; BRAIN INJURIES; CYTOKINES; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; MONOCYTES; NEOPLASM PROTEINS; PROPYLENE GLYCOLS; RATS; RATS, INBRED LEW; RNA-BINDING PROTEINS; SPHINGOSINE; TIME FACTORS;

RATTUS;

EID: 34247855783     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2007.00019.x     Document Type: Article

References (46)

1. Morganti-Kossman MC, Lenzlinger PM, Hans V, Stahel P, Csuka E, Ammann E, Stocker R, Trentz O, Kossmann T. Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue. Mol Psychiatry. 1997 2 : 133 6.
2. Engel S, Wehner HD, Meyermann R. Expression of microglial markers in the human CNS after closed head injury. Acta Neurochir Suppl. 1996 66 : 89 95.
3. Hausmann R, Kaiser A, Lang C, Bohnert M, Betz P. A quantitative immunohistochemical study on the time-dependent course of acute inflammatory cellular response to human brain injury. Int J Legal Med. 1999 112 : 227 32.
4. Clark RS, Schiding JK, Kaczorowski SL, Marion DW, Kochanek PM. Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models. J Neurotrauma. 1994 11 : 499 506.
5. Soares HD, Hicks RR, Smith D, McIntosh TK. Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury. J Neurosci. 1995 15 : 8223 33.
6. Sandhir R, Puri V, Klein RM, Berman NE. Differential expression of cytokines and chemokines during secondary neuron death following brain injury in old and young mice. Neurosci Lett. 2004 369 : 28 32.
7. Aihara N, Hall JJ, Pitts LH, Fukuda K, Noble LJ. Altered immunoexpression of microglia and macrophages after mild head injury. J Neurotrauma. 1995 12 : 53 63.
8. Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, McLellan DR. Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology. 1989 15 : 49 59.
9. Graeber MB, Streit WJ, Kreutzberg GW. Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells. J Neurosci Res. 1998 21 : 18 24.
10. Mueller CA, Schluesener HJ, Conrad S, Meyermann R, Schwab JM. Lesional expression of a proinflammatory and antiangiogenic cytokine EMAP II confined to endothelium and microglia/ macrophages during secondary damage following experimental traumatic brain injury. J Neuroimmunol. 2003 135 : 1 9.
11. Mueller CA, Schluesener HJ, Conrad S, Meyermann R, Schwab JM. Spinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokine EMAP II. J Neurotrauma. 2003 20 : 1007 15.
12. Graeber MB, Bise K, Mehraein P. CR3/43, a marker for activated human microglia: application to diagnostic neuropathology. Neuropathol Appl Neurobiol. 1994 20 : 406 8.
13. Schmitt AB, Buss A, Breuer S, Brook GA, Pech K, Martin D, Schoenen J, Noth J, Love S, Schroder JM, Kreutzberg GW, Nacimiento W. Major histocompatibility complex class II expression by activated microglia caudal to lesions of descending tracts in the human spinal cord is not associated with a T cell response. Acta Neuropathol. 2000 100 : 528 36.
14. Holmin S, Mathiesen T. Long-term intracerebral inflammatory response after experimental focal brain injury in rat. Neuroreport. 1999 10 : 1889 91.
15. Adachi K, Kohara T, Nakano N, Arita M, Chiba K, Mishina T, Sasaki S, Fujita T. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: discovery of a novel immunosuppressant, FTY720. Bioorg Med Chem. 1995 5 : 853 6.
16. Fujita T, Yoneta M, Hirose R, Sasaki S, Inoue K, Kiuchi M, Hirase S, Adachi K, Arita M, Chiba K. Simple compounds, 2-alkyl-2-amino-1,3-propanediols, have potent immunosuppressive activity. Bioorg Med Chem. 1995 5 : 847 52.
17. Suzuki S, Enosawa S, Kakefuda T, Shinomiya T, Amari M, Naoe S, Hoshino Y, Chiba K. A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allo-transplantation. Transplantation. 1996 61 : 200 5.
18. Kappos L, Antel J, Comi G, Montalban X, O'Connor P, Polman CH, Haas T, Korn AA, Karlsson G, Radue EW. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med. 2006 355 : 1124 40.
19. Brinkmann V, Davis MD, Heise CE. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002 277 : 21453 7.
20. Webb M, Tham CS, Lin FF. Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J Neuroimmunol. 2004, 153 : 108 21.
21. Fujino M, Funeshima N, Kitazawa Y. Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment. J Pharmacol Exp Ther. 2003 305 : 70 7.
22. Rausch M, Hiestand P, Foster CA, Baumann DR, Cannet C, Rudin M. Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging. J Magn Reson Imaging. 2004 20 : 16 24.
23. Kaneider NC, Lindner J, Feistritzer C, Sturn DH, Mosheimer BA, Djanani AM, Wiedermann CJ. The immune modulator FTY720 targets sphingosine-kinase- dependent migration of human monocytes in response to amyloid beta-protein and its precursor. FASEB J. 2004 18 : 1309 11.
24. Feeney DM, Boyeson MG, Linn RT, Murray HM, Dail WG. Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res. 1981 211 : 67 77.
25. Golarai G, Greenwood AC, Feeney DM, Connor JA. Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury. J Neurosci. 2001 21 : 8523 37.
26. Schluesener HJ, Seid K, Zhao Y, Meyermann R. Localization of endothelial-monocyte-activating polypeptide II (EMAP II), a novel proinflammatory cytokine, to lesions of experimental autoimmune encephalomyelitis, neuritis and uveitis: expression by monocytes and activated microglial cells. Glia. 1997 20 : 365 72.
27. Csuka E, Hans VH, Ammann E, Trentz O, Kossmann T, Morganti-Kossmann MC. Cell activation and inflammatory response following traumatic axonal injury in the rat. Neuroreport. 2000 11 : 2587 90.
28. DeSimone R, Giampaolo A, Giometto B, Gallo P, Levi G, Peschle C, Aloisi F. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis lesions. J Neuropathol Exp Neurol. 1995 54 : 175 87.
29. Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996 19 : 312 8.
30. Mattiace LA, Davies P, Dickson WD. Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors. Am J Pathol. 1990 136 : 1101 14.
31. McGeer PL, Itagaki S, McGeer EG. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol. 1988 76 : 550 7.
32. Wekerle H, Linington C, Lassmann H, Meyermann R. Cellular immune reactivity within the CNS. Trends Neurosci. 1986 9 : 271 7.
33. Weinstein DL, Walker DG, Akiyama H, McGeer PL. Herpes simplex virus type infection of the CNS induces major histocompatibility complex antigen expression on rat microglia. J Neurosci Res. 1990 26 : 55 65.
34. Schmitt AB, Brook GA, Buss A, Nacimiento W, Noth J, Kreutzberg GW. Dynamics of microglial activation in the spinal cord after cerebral infarction is revealed by expression of MHC class II antigen. Neuropathol Appl Neurobiol. 1998 24 : 167 76.
35. Streit WJ, Graeber MB, Kreutzberg GW. Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury. Exp Neurol. 1989 105 : 115 26.
36. Gehrmann J, Gold R, Linington C, Lannes-Vieira J, Wekerle H, Kreutzberg GW. Spinal cord microglia in experimental allergic neuritis. Evidence for fast and remote activation. Lab Invest. 1992 67 : 100 13.
37. Cho BP, Song DY, Sugama S, Shin DH, Shimizu Y, Kim SS, Kim YS, Joh TH. Pathological dynamics of activated microglia following medial forebrain bundle transaction, Glia. 2006 53 : 92 102.
38. Brinkmann V, Cyster JG, Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant. 2004 4 : 1019 25.
39. Matloubian M, Lo CG, Cinamon G. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004 427 : 355 60.
40. Kao J, Ryan J, Brett G, Chen J, Shen H, Fan YG, Godman G, Familletti PC, Wang F, Pan YC. Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms. J Biol Chem. 1992 267 : 20239 47.
41. Knies UE, Behrensdorf HA, Mitchell CA, Deutsch U, Risau W, Drexler HC, Clauss M. Regulation of endothelial monocyte-activating polypeptide II release by apoptosis. Proc Natl Acad Sci USA. 1998 95 : 12322 7.
42. Tas MP, Murray JC. Endothelial monocytes activating polypeptide II. Int J Biochem Cell Biol. 1996 28 : 837 41.
43. Wakasugi K, Schimmel P. Two distinct cytokines released from a human aminoacyl-tRNA synthetase. Science. 1999 284 : 147 51.
44. Adelson PD, Whalen MJ, Kochanek PM, Robichaud P, Carlos TM. Blood brain barrier permeability and acute inflammation in two models of traumatic brain injury in the immature rat: a preliminary report. Acta Neurochir Suppl. 1998 71 : 104 6.
45. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood. 1994 84 : 2068 101.
46. Mori N, Fukatsu T. Anticonvulsant effect of DN-1417, a derivative of thyrotropin-releasing hormone, and lipo-some-entrapped DN-1417, on amygdaloid-kindled rats. Epilepsia. 1992 33 : 994 1000.