Expression of Microglial Markers in the Human CNS after Closed Head Injury

Acta Neurochirurgica, Supplement

Volumn 1996, Issue 66, 1996, Pages 87-95

  Engel, S ^a   Wehner, H D ^a   Meyermann, R ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Head injury; Macrophages; Microglia

Indexed keywords

ANTIBODY; CD45 ANTIGEN; CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; HAM 56 ANTIBODY; HAM-56 ANTIBODY; HLA ANTIGEN CLASS 2; LECTIN; LEUKOCYTE ANTIGEN; MONOCLONAL ANTIBODY; PLANT LECTIN; RICINUS COMMUNIS AGGLUTININ 1; RICINUS COMMUNIS AGGLUTININ-1;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN; BRAIN DEATH; BRAIN EDEMA; CHRONIC BRAIN DISEASE; FEMALE; HEAD INJURY; HUMAN; IMMUNOLOGY; MALE; MICROGLIA; MIDDLE AGED; PATHOLOGY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BRAIN; BRAIN DAMAGE, CHRONIC; BRAIN DEATH; BRAIN EDEMA; FEMALE; HEAD INJURIES, CLOSED; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LECTINS; MALE; MICROGLIA; MIDDLE AGED; PLANT LECTINS;

EID: 0029686414     PISSN: 00651419     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-9465-2_16     Document Type: Article

References (26)

1. Banati RB, Gehrmann J, Schubert P, Kreutzberg GW (1993) Cytotoxicity of microglia. Glia 7: 111-118
2. Colton CA, Abel C, Patchett J, Keri J, Yao J (1992) Lectin staining of cultured CNS microglia. J Histochem Cytochem 40: 505-512
3. del Rio-Hortega P (1932) Microglia. In: Penfield W (ed) Cytology and cellular pathology of the nervous system, Vol 2. Hoeber, New York, pp 481-534
4. Esiri MM, Morris CS (1991) Immunocytochemical study of macrophages and microglial cells and extracellular matrix components in human CNS disease. J Neurol Sci 101: 59-72
5. Finch CE, Laping NJ, Morgan TE, Nichols NR, Pasinetti (1993) TGF-β1 is an organizer of reponse to neurodegeneration. J Cell Biochem 53: 314-322
6. Gehrmann J, Bonnekoh P, Miyazawa T, Hossmann KA, Kreutzberg GW (1992) Immunocytochemical study of an early microglial activation in ischemia J Cereb Blood Flow Metab 12: 257-269
7. Gehrmann J, Banati R, Kreutzberg GW (1993) Microglia in the immune surveillance of the brain: human microglia constitutively express HLA-DR molecules. J Neuroimmunol 48: 189-198
8. Gehrmann J, Gold R, Linington C, Lannes-Vieira J, Wekerle H, Kreutzberg GW (1993) Microglial involvement in experimental autoimmune inflammation of the central and peripheral nervous system. Glia 7: 50-59
9. Gehrmann J, Kreutzberg GW (1993) Monoclonal antibodies against macrophages/microglia: immunocytochemical studies of early microglial activation in experimental neuropathology. Clin Neuropathol 12: 301-305
10. Gentlemann S, Nash MJ, Sweeting CJ, Graham DI, Roberts GW (1993) β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury. Neurosci Lett 160: 139-144
11. Grady MS, McLaughlin MR, Christman CW, Valadka AB, Fligner CL, Povlishock JT (1993) The use of antibodies targeted against the neurofilament subunits for the detection of diffuse axonal injury in humans. J Neuropathol Exp Neurol 52: 143-152
12. Graeber MB, Streit WJ (1990) Microglia: immune network in the brain. Brain Pathol 1: 2-5
13. Hulette CM, Downey BT, Burger PC (1992) Macrophage markers in diagnostic neuropathology. Am J Surg Pathol 16: 493-499
14. Itagaki S, McGeer PL, Akiyama H (1988) Presence of T-cytotoxic suppressor and leukocyte common antigen positive cells in Alzheimer's disease brain tissue. Neurosci Lett 91: 259-264
15. Kettenmann H, Hoppe D, Gottmann K, Banati R, Kreutzberg GW (1990) Cultured microglial cells have a distinct pattern of membrane channels different from peritoneal macrophages. J Neurosci Res 26: 278-287
16. Lawson LJ, Perry VH, Dri P, Gordon S (1990) Heterogeneity in the distribution and morphology of microglia in the normal, adult mouse brain. Neuroscience 39: 151-170
17. Mannoji H, Yeger H, Becker LE (1986) A specific histochemical marker (lectin ricinus communis agglutinin-1) for normal human microglia and application to routine histopathology. Acta Neuropathol 71: 341-343
18. McGeer PL, Itagaki S, McGeer EG (1988) Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol 76: 550-557
19. Nissl F (1894) Über die Untersuchungsmethode des Zentral-organs speziell zur Feststellung der Lokalisation der Nervenzellen. Zentralbl Nervenheilkunde Psychiatr 17: 337-334
20. Olero GC, Merrill JE (1994) Cytokine receptors on glial cells. Glia 11: 117-128
21. Perry VH, Andersson PB, Gordon S (1993) Macrophages and inflammation in the central nervous system. TINS 16: 268-273
22. Sasaki A, Nakazalo Y (1992) The identity of cells expressing MHC class II antigens in normal and pathological human brain. Neuropathol Appl Neurobiol 18: 13-26
23. Sievers J, Parwaresch R, Wottke HU (1994) Blood monocytes and spleen macrophages differentiate into microglia-like cells on monolayers of astrocytes: morphology. Glia 12: 245-258
24. Streit WJ, Graeber MB (1993) Heterogeneity of microglial and perivascular cell populations: insights gained from the facial nucleus paradigm. Glia 7: 68-74
25. Thomas WE (1992) Brain macrophages: elevation of microglia and their functions. Brain Res 510: 154-157
26. Unterharnscheidt F (1993) Stadien der sogenannten Rindenprellungsherde. In: Doerr W, Seifert G (eds) Pathologie des Nervensystems VI. Springer, Berlin Heidelberg New York, Tokyo, pp 397-423