Down-regulation of IL-7Rα expression in human T cells via DNA methylation

Journal of Immunology

Volumn 178, Issue 9, 2007, Pages 5473-5479

  Kim, Hang Rae ^a   Hwang, Kyung A ^a   Kim, Ki Chan ^a   Kang, Insoo ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CD8 ANTIGEN; DNA; INTERLEUKIN 7 RECEPTOR ALPHA; LUCIFERASE;

ARTICLE; CELL CULTURE; CELL SURVIVAL; CULTURE MEDIUM; DNA METHYLATION; DOWN REGULATION; GENE; GENE CONTROL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IL 7RALPHA GENE; LEUKEMIA CELL LINE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

EID: 34247639478     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.9.5473     Document Type: Article

References (29)

1. Schluns, K. S., W. C. Kieper, S. C. Jameson, and L. Lefrancois. 2000. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1: 426-432.
2. + T cells. J. Exp. Med. 195: 1515-1522.
3. Kaech, S. M., J. T. Tan, E. J. Wherry, B. T. Konieczny, C. D. Surh, and R. Ahmed. 2003. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4: 1191-1198.
4. Seddon, B., P. Tomlinson, and R. Zamoyska. 2003. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat. Immunol. 4: 680-686.
5. Fry, T. J., and C. L. Mackall. 2005. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J. Immunol. 174: 6571-6576.
6. Surh, C. D., and J. Sprent. 2005. Regulation of mature T cell homeostasis. Semin. Immunol. 17: 183-191.
7. Khaled, A. R., and S. K. Durum. 2003. Death and baxes: mechanisms of lymphotrophic cytokines. Immunol. Rev. 193: 48-57.
8. Jiang, Q., W. Q. Li, R. R. Hofmeister, H. A. Young, D. R. Hodge, J. R. Keller, A. R. Khaled, and S. K. Durum. 2004. Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members. Mol. Cell. Biol. 24: 6501-6513.
9. Fry, T. J., and C. L. Mackall. 2002. Interleukin-7: from bench to clinic. Blood 99: 3892-3904.
10. + T-cell immune responses. Blood 107: 2855-2862.
11. Wilson, C. B., K. W. Makar, M. Shnyreva, and D. R. Fitzpatrick. 2005. DNA methylation and the expanding epigenetics of T cell lineage commitment. Semin. Immunol. 17: 105-119.
12. Bird, A. P., and A. P. Wolffe. 1999. Methylation-induced repression: belts, braces, and chromatin. Cell 99: 451-454.
13. Ansel, K. M., D. U. Lee, and A. Rao. 2003. An epigenetic view of helper T cell differentiation. Nat. Immunol. 4: 616-623.
14. Smale, S. T., and A. G. Fisher. 2002. Chromatin structure and gene regulation in the immune system. Annu. Rev. Immunol. 20: 427-462.
15. Wilson, C. B., K. W. Makar, and M. Perez-Melgosa. 2002. Epigenetic regulation of T cell fate and function. J. Infect. Dis. 185(Suppl. 1): S37-S45.
16. Yano, S., P. Ghosh, H. Kusaba, M. Buchholz, and D. L. Longo. 2003. Effect of promoter methylation on the regulation of IFN-γ gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J. Immunol. 171: 2510-2516.
17. Kersh, E. N., D. R. Fitzpatrick, K. Murali-Krishna, J. Shires, S. H. Speck, J. M. Boss, and R. Ahmed. 2006. Rapid demethylation of the IFN-γ gene occurs in memory but not naive CD8 T cells. J. Immunol. 176: 4083-4093.
18. Holling, T. M., E. Schooten, A. W. Langerak, and P. J. van den Elsen. 2004. Regulation of MHC class II expression in human T-cell malignancies. Blood 103: 1438-1444.
19. Park, J. H., Q. Yu, B. Erman, J. S. Appelbaum, D. Montoya-Durango, H. L. Grimes, and A. Singer. 2004. Suppression of IL-7Rα transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 21: 289-302.
20. + severe combined immunodeficiency. Nat. Genet. 20: 394-397.
21. Teutsch, S. M., D. R. Booth, B. H. Bennetts, R. N. Heard, and G. J. Stewart. 2003. Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-α gene and their associations with multiple sclerosis. Eur. J. Hum. Genet. 11: 509-515.
22. Soderback, E., A. L. Zackrisson, B. Lindblom, and A. Alderborn. 2005. Determination of CYP2D6 gene copy number by pyrosequencing. Clin. Chem. 51: 522-531.
23. Singal, R., J. van Wert, and M. Bashambu. 2001. Cytosine methylation represses glutathione S-transferase P1 (GSTP1) gene expression in human prostate cancer cells. Cancer Res. 61:4820-4826.
24. Abdollahi, A., D. Pisarcik, D. Roberts, J. Weinstein, P. Cairns, and T. C. Hamilton. 2003. LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer. J. Biol. Chem. 278: 6041-6049.
25. Agarwal, S., and A. Rao. 1998. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9: 765-775.
26. Lu, Q., A. Wu, D. Ray, C. Deng, J. Attwood, S. Hanash, M. Pipkin, M. Lichtenheld, and B. Richardson. 2003. DNA methylation and chromatin structure regulate T cell perforin gene expression. J. Immunol. 170: 5124-5132.
27. Xue, H. H., P. E. Kovanen, C. A. Pise-Masison, M. Berg, M. F. Radovich, J. N. Brady, and W. J. Leonard. 2002. IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes. Proc. Natl. Acad. Sci. USA 99: 13759-13764.
28. Issa, J. P., and H. Kantarjian. 2005. Azacitidine. Nat. Rev. Drug Discov. Suppl. 4: S6-S7.
29. Xue, H. H., J. Bollenbacher, V. Rovella, R. Tripuraneni, Y. B. Du, C. Y. Liu, A. Williams, J. P. McCoy, and W. J. Leonard. 2004. GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells. Nat. Immunol. 5: 1036-1044.