Effects of chemical ischemia on cerebral cortex slices: Focus on mitogen-activated protein kinase cascade

Annals of the New York Academy of Sciences

Volumn 1090, Issue , 2006, Pages 445-454

  Siniscalchi, Anna ^a   Cavallini, Sabrina ^a   Marino, Silvia ^a   Falzarano, Sofia ^a   Franceschetti, Lara ^a   Selvatici, Rita ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

2 deoxyglucose; Brain ischemia; Cell death; Cerebral cortex slices; Chemical ischemia; Energy failure; ERK1 2 (p44 42); Glutamate; Mitogen activated protein kinase; Neuronal damage; p21Ras; p38; Phosphorylation degree; Reperfusion; SAPK JNK; Sodium azide

Indexed keywords

DEOXYGLUCOSE; DIZOCILPINE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN P21; RAS PROTEIN; SODIUM AZIDE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; BRAIN CORTEX; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; BRAIN PERFUSION; BRAIN SLICE; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROSTIMULATION; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; WESTERN BLOTTING; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; METABOLISM; SPRAGUE DAWLEY RAT; VASCULARIZATION;

RATTUS;

ANIMALS; BLOTTING, WESTERN; BRAIN ISCHEMIA; CEREBRAL CORTEX; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 34247632125     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1378.047     Document Type: Conference Paper

References (36)

1. SEGER, R. & E.G. KREBS. 1995. The MAPK signaling cascade. FASEB J. 9: 726-735.
2. WIDMANN, C., S. GIBSON, et al. 1999. Mitogen activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol. Rev. 79: 143-180.
3. KYRIAKIS, J.M. & J. AVRUCH. 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81: 807-869.
4. 2+ and calmodulin. Cell Signal. 14: 649-654.
5. SWEATT, J.D. 2001. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plastivity and memory. J. Neurochem. 76: 1-10.
6. YUN, H.-Y., M. GONZALEZ-ZULUETA, et al. 1998. Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21. Proc. Natl. Acad. Sci. 95: 5773-5778.
7. CHIHAB, R., C. BOSSENMEYER, et al. 1998. Lack of correlation between the effects of transient exposure to glutamate and those of hypoxia/reoxygenation in immature neurons in vitro. J. Neurochem. 71: 1177-1186.
8. BICKLER, P.E., C.S. FAHLMAN, et al. 2004. Hypoxia increases calcium flux through cortical neuron glutamate receptors via protein kinase C. J. Neurochem. 88: 878-884.
9. SELVATICI, R., S. MARINO, et al. 2003. Protein kinase C activity, translocation, and selective isoformsubcellular redistribution in the rat cerebral cortex after in vitro ischemia. J. Neurosci. Res. 71: 64-71.
10. LIU, R., J.-J. PEI, et al. 2005. Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J. Neurochem. 94: 1125-1234.
11. SBRENNA, S., G. CALO, et al. 1998. Experimental protocol for studying delayed effects of in vitro ischemia on neurotransmitter release from brain slices. Brain Res. Protocols 3: 61-67.
12. CAVALLINI, S., M. MARTI, et al. 2005. Effects of chemical ischemia in cerebral cortex slices. Focus on nitric oxide. Neurochem. Int. 47: 482-490.
13. SELVATICI, R., S. FALZARONO, et al. 2006. Differential activation of protein kinase C isoforms following chemical ischemia in rat cerebral cortex slices. Neurochem. Int. In press.
14. CHOI, D.W. 1990. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurosci. 13: 171-182.
15. HARDINGHAM, G.E. & H. BADING. 2003. The Yin and Yang of NMDA receptor signalling. Trends Neurosci. 26: 81-89.
16. LO, E.H., T. DALKARA, et al. 2003. Mechanism, challenges and opportunities in stroke. Nat. Rev. Neurosci. 4: 399-415.
17. BONDE, J., J. NORABERG, et al. 2005. Ionotropic glutamate receptors and glutamate transporters are involved in necrotic neuronal cell death induced by oxygenglucose deprivation of hippocampal slice cultures. Neuroscience 136: 779-794.
18. BADINI, I., L. Beani, et al. 1997. Post-ischemic recovery of acetylcholine release in vitro: influence of different excitatory amino acid receptor subtype antagonists. Neurochem. Int. 31: 817-824.
19. BRADFORD, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
20. LEE H.-P., Y.-C. JUN, et al. 2005. Dysregulation of MAPK pathways in prion disease J. Neurochem. 95: 584-593.
21. DURANTEAU, J., N.S. CHANDEL, et al. 1998. Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes. J. Biol. Chem. 273: 11619-11624.
22. CHI, M.M., M.E. PUSATERI, et al. 1987. Enzymatic assays for 2-deoxyglucose and 2-deoxyglucose 6-phosphate. Anal. Biochem. 161: 508-513.
23. ANDO, H. 1990. Novel effect of azide on sodium channel of Xenopus oocytes. Biochem. Biophy. Res. Commun. 172: 300-305.
24. VARMING, T., J. DREJER, et al. 1996. Characterization of a chemical anoxia model in cerebellar granule neurons using sodium azide: protection by nifedipine and MK-801. J. Neurosci. Res. 44: 40-46.
25. JORGENSEN, N.K., S.F. PETERSEN, et al. 1999. Increases in [Ca2+]i and changes in intracellular pH during chemical anoxia in mouse neocortical neurons in primary culture. J. Neurosci. Res. 56: 358-370.
26. + ATPase in primary cortical cultures. Neurosci. Res. 50: 299-306.
27. BENNETT, M.C., G.W. MLADY, et al. 1996. Chronic in vivo sodium azide infusion induces selective and stable inhibition of cytochrome c oxidase. J. Neurochem. 66: 2606-2611.
28. VECSEI, L., J. TAJTI, et al. 2001. Sodium azide treatment decreases striatal and cortical concentrations of alpha-tocopherol in rats. J. Neural Transm. 108: 273-278.
29. MAUS, M., Y. TORRENS, et al. 2005. 2-deoxyglucose and NMDA inhibit protein synthesis in neurons and regulate phosphorylation of elongation factor-2 by distinct mechanisms. J. Neurochem. doi 10.1111/J.1471-4159.2005.03601.x
30. HETZMAN, M. & A. GOZDZ. 2004. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur. J. Biochem. 271: 2050-2055.
31. CHU, C.T., D.J. LEVINTHAL, et al. 2004. Oxidative neuronal injury. The dark side of ERK1/2. Eur. J. Biochem. 271: 2060-2066.
32. ZARUBIN, T. & J. HAN. 2005. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 15: 11-18.
33. BRECHT, S., R. KIRCHHOF, et al. 2005. Specific pathophysiological functions of JNK isoforms in the brain. Eur. J. Neurosci. 21: 363-377.
34. WAETZIG, V. & T. HERDENGEN. 2005. Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage. Trends Pharmacol. Sci. 26: 455-461.
35. CHANG, L., Y. JONES, et al. 2003. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev. Cell 4: 521-533.
36. BUTLER, T.L., C.A. KASSED, et al. 2003. Signal transduction and neurosurvival in experimental models of brain injury. Brain Res. Bull. 5: 339-351.