The CuI-catalyzed exo-selective asymmetric multicomponent [C+NC+CC] coupling reaction

Tetrahedron Letters

Volumn 48, Issue 22, 2007, Pages 3867-3870

  Garner, Philip ^a   Hu, Jieyu ^a   Parker, Christopher G ^a   Youngs, Wiley J ^b   Medvetz, Doug ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF AKRON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; PROLINE DERIVATIVE; SILVER;

ARTICLE; ASYMMETRIC COUPLING REACTION; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL REACTION;

EID: 34247631632     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.03.145     Document Type: Article

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35. Additional support for this interpretation comes from experiments using N-phenylmaleimide, which led to the endo product exclusively. In this case, the EWG and Y groups in structure III are constrained to be cis to each other.