메뉴 건너뛰기




Volumn 7, Issue 2, 2007, Pages 70-73

Adenylyl cyclase isoforms as novel therapeutic targets: An exciting example of excitotoxicity neuroprotection

Author keywords

[No Author keywords available]

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; ADENYLATE CYCLASE; ADENYLATE CYCLASE INHIBITOR; ADENYLYL CYCLASE TYPE 1; ADENYLYL CYCLASE TYPE 2; ADENYLYL CYCLASE TYPE 3; ADENYLYL CYCLASE TYPE 4; ADENYLYL CYCLASE TYPE 5; ADENYLYL CYCLASE TYPE 6; ADENYLYL CYCLASE TYPE 7; ADENYLYL CYCLASE TYPE 8; ADENYLYL CYCLASE TYPE 9; CALMIDAZOLIUM; CALMODULIN; CATECHOL ESTROGEN; CYCLIC AMP; FORSKOLIN; GLUTAMATE SODIUM; ISOENZYME; ISOPROTEIN; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE C; TYRPHOSTIN A25; UNCLASSIFIED DRUG;

EID: 34247626753     PISSN: 15340384     EISSN: 15432548     Source Type: Journal    
DOI: 10.1124/mi.7.2.6     Document Type: Review
Times cited : (8)

References (38)
  • 1
    • 33847711874 scopus 로고    scopus 로고
    • Wang, H., Gong, B., Vadakkan, K.I., Toyoda, H., Kaang, B.K., and Zhuo, M. Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors. J. Biol. Chem. 282, 1507-1517 (2007). This study forms the basis for the current viewpoint and suggests that AC1 is involved in excitotoxicity.
    • Wang, H., Gong, B., Vadakkan, K.I., Toyoda, H., Kaang, B.K., and Zhuo, M. Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors. J. Biol. Chem. 282, 1507-1517 (2007). This study forms the basis for the current viewpoint and suggests that AC1 is involved in excitotoxicity.
  • 2
    • 34047100940 scopus 로고    scopus 로고
    • N-Methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease
    • doi:10.1016/j.pneurobio.2006.11.003
    • Fan, M.M. and Raymond, L.A. N-Methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease. Prog. Neurobiol. doi:10.1016/j.pneurobio.2006.11.003 (2006).
    • (2006) Prog. Neurobiol
    • Fan, M.M.1    Raymond, L.A.2
  • 3
    • 1842558602 scopus 로고    scopus 로고
    • Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury
    • Arundine, M. and Tymianski, M. Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell. Mol. Life Sci. 61, 657-668 (2004).
    • (2004) Cell. Mol. Life Sci , vol.61 , pp. 657-668
    • Arundine, M.1    Tymianski, M.2
  • 4
    • 0035040818 scopus 로고    scopus 로고
    • Regulation and role of adenylyl cyclase isoforms
    • Hanoune, J. and Defer, N. Regulation and role of adenylyl cyclase isoforms. Ann. Rev. Pharmacol. Toxicol. 41, 145-174 (2001).
    • (2001) Ann. Rev. Pharmacol. Toxicol , vol.41 , pp. 145-174
    • Hanoune, J.1    Defer, N.2
  • 7
    • 33645391981 scopus 로고    scopus 로고
    • Regulatory properties of adenylate cyclases type 5 and 6: A progress report
    • Beazely, M.A. and Watts, V.J. Regulatory properties of adenylate cyclases type 5 and 6: A progress report. Eur. J. Pharmacol. 535, 1-12 (2006).
    • (2006) Eur. J. Pharmacol , vol.535 , pp. 1-12
    • Beazely, M.A.1    Watts, V.J.2
  • 8
    • 0141541343 scopus 로고    scopus 로고
    • Isoforms of mammalian adenylyl cyclase: Multiplicities of signaling
    • Sunahara, R.K. and Taussig, R. Isoforms of mammalian adenylyl cyclase: Multiplicities of signaling. Mol. Interv. 2, 168-184 (2002).
    • (2002) Mol. Interv , vol.2 , pp. 168-184
    • Sunahara, R.K.1    Taussig, R.2
  • 9
    • 0036839744 scopus 로고    scopus 로고
    • Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: Expression in caveolin-rich and noncaveolin domains
    • Ostrom, R.S., Liu, X., Head, B.P., Gregorian, C., Seasholtz, T.M., and Insel, P.A. Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: Expression in caveolin-rich and noncaveolin domains. Mol. Pharmacol. 62, 983-992 (2002).
    • (2002) Mol. Pharmacol , vol.62 , pp. 983-992
    • Ostrom, R.S.1    Liu, X.2    Head, B.P.3    Gregorian, C.4    Seasholtz, T.M.5    Insel, P.A.6
  • 10
    • 33746046362 scopus 로고    scopus 로고
    • Higher-order organization and regulation of adenylyl cyclases
    • Cooper, D.M. and Crossthwaite, A.J. Higher-order organization and regulation of adenylyl cyclases. Trends Pharmacol. Sci. 27, 426-431 (2006).
    • (2006) Trends Pharmacol. Sci , vol.27 , pp. 426-431
    • Cooper, D.M.1    Crossthwaite, A.J.2
  • 11
    • 0033835813 scopus 로고    scopus 로고
    • Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase
    • Defer, N., Best-Belpomme, M., and Hanoune, J. Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase. Am. J. Physiol. Renal Physiol. 279, F400-F416 (2000).
    • (2000) Am. J. Physiol. Renal Physiol , vol.279
    • Defer, N.1    Best-Belpomme, M.2    Hanoune, J.3
  • 12
    • 0030803695 scopus 로고    scopus 로고
    • CREB (cAMP response element-binding protein) in the locus coeruleus: Biochemical, physiological, and behavioral evidence for a role in opiate dependence
    • Lane-Ladd, S.B., Pineda, J., Boundy, V.A., Pfeuffer, T., Krupinski, J., Aghajanian, G.K., and Nestler, E.J. CREB (cAMP response element-binding protein) in the locus coeruleus: Biochemical, physiological, and behavioral evidence for a role in opiate dependence. J. Neurosci. 17, 7890-7901 (1997).
    • (1997) J. Neurosci , vol.17 , pp. 7890-7901
    • Lane-Ladd, S.B.1    Pineda, J.2    Boundy, V.A.3    Pfeuffer, T.4    Krupinski, J.5    Aghajanian, G.K.6    Nestler, E.J.7
  • 13
    • 0034003405 scopus 로고    scopus 로고
    • Regulation of adenylyl cyclases in the central nervous system
    • Chern, Y. Regulation of adenylyl cyclases in the central nervous system. Cell. Signal. 12, 195-204 (2000).
    • (2000) Cell. Signal , vol.12 , pp. 195-204
    • Chern, Y.1
  • 14
    • 34247280485 scopus 로고    scopus 로고
    • Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain
    • doi:10.1016/j.neuroscience.2007.01.045
    • Conti, A.C., Maas, J.W., Jr., Muglia, L.M., Dave, B.A., Vogt, S.K., Tran, T.T., Rayhel, E.J., and Muglia, L.J. Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain. Neuroscience doi:10.1016/j.neuroscience.2007.01.045 (2007).
    • (2007) Neuroscience
    • Conti, A.C.1    Maas Jr., J.W.2    Muglia, L.M.3    Dave, B.A.4    Vogt, S.K.5    Tran, T.T.6    Rayhel, E.J.7    Muglia, L.J.8
  • 15
    • 1642361691 scopus 로고    scopus 로고
    • Differentiation-induced alterations in cyclic AMP signaling in the Cath.a differentiated (CAD) neuronal cell line
    • Johnston, C.A., Beazely, M.A., Bilodeau, M.L., Andrisani, O., and Watts, V.J. Differentiation-induced alterations in cyclic AMP signaling in the Cath.a differentiated (CAD) neuronal cell line. J. Neurochem. 88, 1497-1508 (2004).
    • (2004) J. Neurochem , vol.88 , pp. 1497-1508
    • Johnston, C.A.1    Beazely, M.A.2    Bilodeau, M.L.3    Andrisani, O.4    Watts, V.J.5
  • 16
    • 33645225418 scopus 로고    scopus 로고
    • s independent. Neuropharmacology doi:10.1016/j.neuropharm.2005.11.004 (2005).
    • s independent. Neuropharmacology doi:10.1016/j.neuropharm.2005.11.004 (2005).
  • 17
    • 8144227521 scopus 로고    scopus 로고
    • -/- , and double knock-out (DKO) animals.
    • -/- , and double knock-out (DKO) animals.
  • 18
    • 0033180362 scopus 로고    scopus 로고
    • Wong, S.T., Athos, J., Figueroa, X.A., Pineda, V.V., Scheafer, M.L., Chavkin, C.C., Muglia, L.J., and Storm, D.R. Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron 23, 787-798 (1999). This report represents the first study using a transgenic mouse model where the genes for both AC1 and AC8 were disrupted (DKO animals) to examine memory and LTP.
    • Wong, S.T., Athos, J., Figueroa, X.A., Pineda, V.V., Scheafer, M.L., Chavkin, C.C., Muglia, L.J., and Storm, D.R. Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron 23, 787-798 (1999). This report represents the first study using a transgenic mouse model where the genes for both AC1 and AC8 were disrupted (DKO animals) to examine memory and LTP.
  • 19
    • 0037107119 scopus 로고    scopus 로고
    • 2 dopamine receptor function in mice lacking type 5 adenylyl cyclase
    • 2 dopamine receptor function in mice lacking type 5 adenylyl cyclase. J. Neurosci. 22, 7931-7940 (2002).
    • (2002) J. Neurosci , vol.22 , pp. 7931-7940
    • Lee, K.W.1    Hong, J.H.2    Choi, I.Y.3
  • 20
    • 0026418426 scopus 로고
    • Type-specific regulation of adenylyl cyclase by G protein α subunits
    • Tang, W.J. and Gilman, A.G. Type-specific regulation of adenylyl cyclase by G protein α subunits. Science 254, 1500-1502 (1991).
    • (1991) Science , vol.254 , pp. 1500-1502
    • Tang, W.J.1    Gilman, A.G.2
  • 21
    • 0026771948 scopus 로고
    • Calcium and muscarinic agonist stimulation of type I adenylyl cyclase in whole cells
    • Choi, E.J., Wong, W.T., Hinds, T.R., and Storm, D.R. Calcium and muscarinic agonist stimulation of type I adenylyl cyclase in whole cells. J. Biol. Chem. 267, 12440-12442 (1992).
    • (1992) J. Biol. Chem , vol.267 , pp. 12440-12442
    • Choi, E.J.1    Wong, W.T.2    Hinds, T.R.3    Storm, D.R.4
  • 23
    • 0027439945 scopus 로고
    • NMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase
    • Chetkovich, D.M. and Sweatt, J.D. NMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase. J. Neurochem. 61, 1933-1942 (1993).
    • (1993) J. Neurochem , vol.61 , pp. 1933-1942
    • Chetkovich, D.M.1    Sweatt, J.D.2
  • 24
    • 18744396642 scopus 로고    scopus 로고
    • 2+-stimulated adenylyl cyclases in behavioral responses to inflammatory stimuli.
    • 2+-stimulated adenylyl cyclases in behavioral responses to inflammatory stimuli.
  • 25
    • 0035017013 scopus 로고    scopus 로고
    • 2+ in HEK293 cells.
    • 2+ in HEK293 cells.
  • 26
    • 0037101970 scopus 로고    scopus 로고
    • Function and regulation of CREB family transcription factors in the nervous system
    • Lonze, B.E. and Ginty, D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 35, 605-623 (2002).
    • (2002) Neuron , vol.35 , pp. 605-623
    • Lonze, B.E.1    Ginty, D.D.2
  • 27
    • 13944252487 scopus 로고    scopus 로고
    • Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): Kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133
    • Lee, B., Butcher, G.Q., Hoyt, K.R., Impey, S., and Obrietan, K. Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133. J. Neurosci. 25, 1137-1148 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 1137-1148
    • Lee, B.1    Butcher, G.Q.2    Hoyt, K.R.3    Impey, S.4    Obrietan, K.5
  • 28
    • 20044365214 scopus 로고    scopus 로고
    • Maas, J.W., Jr., Indacochea, R.A., Muglia, L.M. et al. Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain. J. Neurosci. 25, 2376-2385 (2005). This study reveals a similar level of excitotoxicity in wild type and DKO mice following administration of monosodium glutamate.
    • Maas, J.W., Jr., Indacochea, R.A., Muglia, L.M. et al. Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain. J. Neurosci. 25, 2376-2385 (2005). This study reveals a similar level of excitotoxicity in wild type and DKO mice following administration of monosodium glutamate.
  • 30
    • 1842335067 scopus 로고    scopus 로고
    • Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3′-polyphosphates
    • Johnson, R.A., Desaubry, L., Bianchi, G. et al. Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3′-polyphosphates. J. Biol. Chem. 272, 8962-8966 (1997).
    • (1997) J. Biol. Chem , vol.272 , pp. 8962-8966
    • Johnson, R.A.1    Desaubry, L.2    Bianchi, G.3
  • 31
    • 0035930583 scopus 로고    scopus 로고
    • Type-specific regulation of adenylyl cyclase
    • Onda, T., Hashimoto, Y., Nagai, M. et al. Type-specific regulation of adenylyl cyclase. J. Biol. Chem. 276, 47785-47793 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 47785-47793
    • Onda, T.1    Hashimoto, Y.2    Nagai, M.3
  • 32
    • 0037334541 scopus 로고    scopus 로고
    • Small ligands modulating the activity of mammalian adenylyl cyclases: A novel mode of inhibition by calmidazolium
    • Haunso, A., Simpson, J., and Antoni, F.A. Small ligands modulating the activity of mammalian adenylyl cyclases: A novel mode of inhibition by calmidazolium. Mol. Pharmacol. 63, 624-631 (2003).
    • (2003) Mol. Pharmacol , vol.63 , pp. 624-631
    • Haunso, A.1    Simpson, J.2    Antoni, F.A.3
  • 33
    • 24744448212 scopus 로고    scopus 로고
    • A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen
    • Steegborn, C., Litvin, T.N., Hess, K.C., Capper, A.B., Taussig, R., Buck, J., Levin, L.R., and Wu, H. A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J. Biol. Chem. 280, 31754-31759 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 31754-31759
    • Steegborn, C.1    Litvin, T.N.2    Hess, K.C.3    Capper, A.B.4    Taussig, R.5    Buck, J.6    Levin, L.R.7    Wu, H.8
  • 34
    • 3042604812 scopus 로고    scopus 로고
    • Tyrphostins are inhibitors of guanylyl and adenylyl cyclases
    • Jaleel, M., Shenoy, A.R., and Visweswariah, S.S. Tyrphostins are inhibitors of guanylyl and adenylyl cyclases. Biochemistry 43, 8247-8255 (2004).
    • (2004) Biochemistry , vol.43 , pp. 8247-8255
    • Jaleel, M.1    Shenoy, A.R.2    Visweswariah, S.S.3
  • 35
    • 33746266610 scopus 로고    scopus 로고
    • Cardiac-directed expression of adenylyl cyclase VI facilitates atrioventricular nodal conduction
    • Sastry, A., Arnold, E., Gurji, H. et al. Cardiac-directed expression of adenylyl cyclase VI facilitates atrioventricular nodal conduction. J. Am. Coll. Cardiol. 48, 559-565 (2006).
    • (2006) J. Am. Coll. Cardiol , vol.48 , pp. 559-565
    • Sastry, A.1    Arnold, E.2    Gurji, H.3
  • 36
    • 15944375121 scopus 로고    scopus 로고
    • Effect of ethanol on DARPP-32 phosphorylation in transgenic mice that express human type VII adenylyl cyclase in brain
    • Donohue, T., Hoffman, P.L., and Tabakoff, B. Effect of ethanol on DARPP-32 phosphorylation in transgenic mice that express human type VII adenylyl cyclase in brain. Alcohol Clin. Exp. Res. 29, 310-316 (2005).
    • (2005) Alcohol Clin. Exp. Res , vol.29 , pp. 310-316
    • Donohue, T.1    Hoffman, P.L.2    Tabakoff, B.3
  • 37
    • 2542439651 scopus 로고    scopus 로고
    • Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP
    • Wang, H., Ferguson, G.D., Pineda, V.V., Cundiff, P.E., and Storm, D.R. Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP. Nat. Neurosci. 7, 635-642 (2004).
    • (2004) Nat. Neurosci , vol.7 , pp. 635-642
    • Wang, H.1    Ferguson, G.D.2    Pineda, V.V.3    Cundiff, P.E.4    Storm, D.R.5
  • 38
    • 33749651885 scopus 로고    scopus 로고
    • Lazo, J.S. Roadmap or roadkill: A pharmacologist's analysis of the NIH Molecular Libraries Initiative. Mol. Interv. 6, 240-243 (2006). This short article discusses a recent NIH initiative for academic scientists to identify small molecule probes for novel targets.
    • Lazo, J.S. Roadmap or roadkill: A pharmacologist's analysis of the NIH Molecular Libraries Initiative. Mol. Interv. 6, 240-243 (2006). This short article discusses a recent NIH initiative for academic scientists to identify small molecule probes for novel targets.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.