Pharmacokinetics and distribution of clioquinol in golden hamsters

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 3, 2007, Pages 387-393

  Bondiolotti, Gianpietro ^a,c   Sala, Mariaelvina ^b,c   Pollera, Claudia ^b,c   Gervasoni, Marco ^a,c   Puricelli, Maria ^b,c   Ponti, Wilma ^b,c   Bareggi, Silvio R ^a,c,d  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c Centre of Excellence on Neurodegenerative Diseases   (Italy)

^d NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CLIOQUINOL; CHELATING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; FEMALE; NONHUMAN; SYRIAN HAMSTER; ANIMAL; AREA UNDER THE CURVE; FOOD DRUG INTERACTION; HAMSTER; ORAL DRUG ADMINISTRATION; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CHELATING AGENTS; CLIOQUINOL; CRICETINAE; FEMALE; FOOD-DRUG INTERACTIONS; TISSUE DISTRIBUTION;

EID: 34247593490     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.3.0008     Document Type: Article

References (44)

1. Aguzzi, A., Montrasio, F., Kaeser, P. S. (2001) Prions: health scare and biological challenge. Nat. Rev. Mol. Cell Biol. 2: 118-126
2. Bareggi, S. R., Braida, D., Gervasoni, M., Carcassola, G., Pollera, C., Verzoni, C. Sala, M. (2003) Neurochemical and behavioural modifications induced by scrapie infection in golden hamsters. Brain Res. 984: 237-241
3. Beringue, V., Adjou, K. T., Lamoury, F., Maignien, T., Deslys, J. P., Race, R., Dormont, D. (2000) Opposite effects of Dextran Sulfate 500, the polyene antibiotic MS-8209, and Congo Red on accumulation on the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent. J. Virol. 74: 5432-5340
4. Bondiolotti, G. P., Pollera, C., Pirola, R., Bareggi, S. R. (2006) Determination of 5-chloro-7-iodo-8-quinolinol (clioquinol) in plasma and tissues of hamsters by high-performance liquid chromatography and electrochemical detection. J. Chromatogr. B Anal. Tech. Biomed Life Sci. 837: 87-91
5. Bush, A. I. (2003) The metallobiology of Alzheimer's disease. Trends Neurosci. 26: 207-214
6. Caramelli, M., Ru, G., Acutis, P., Forloni, G. (2006) Prion diseases. Current understanding of epidemiology and pathogenesis, and therapeutic advances. CNS Drugs 20: 15-28
7. Caspi, S., Halimi, M., Yanai, A., Sasson, S. B., Taraboulos, A., Gabizon, R. (1998) The antiprion activity of Congo Red. Putative mechanism. J. Biol. Chem. 273: 3484-3489
8. Caughey, B., Chesebro, B. (1997) Prion protein and the transmissible spongiform encephalopathies. Trends Cell Biol. 7: 56-62
9. Caughey, B., Race, R. E. (1992) Potent inhibition of scrapie-associated PrP accumulation by Congo Red. J. Neurochem. 59: 768
10. Caughey, B., Brown, K., Raymond, G. J., Katzenstein, G. E., Thresher, W. (1994) Binding of protease-sensitive form of prion protein PrP to sulfated glycosaminoglycan and Congo Red. J. Virol. 68: 2135-2141
11. Chen, C.-T., Kodama, H., Egashira, Y., Samejima, K., Imanari, T., Tamura, Z. (1976) Serum levels of 5-chloro-7-iodo-8-quinolinol and its toxicity in various animals. Chem. Pharm. Bull. 24: 2007-2013
12. Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., Mclean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y-S., Huang, X., Goldstein, L. E., Moir, R. D., Lim, J. T., Beyreuther, K., Zheng, H., Tanzi, R. E., Masters, C. L., Bush, A. I. (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits b-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30: 665-676
13. Cuajungco, M. P., Faget, K. Y., Huang, X., Tanzi, R. E., Bush, A. I. (2000) Metal chelation as a potential therapy for Alzheimer's disease. Ann. N. Y. Acad. Sci. 920: 292-304
14. Demaimay, R., Harper, J., Gordon, H., Weaver, D., Chesebro, B., Caughey, B. (1998) Structural aspects of Congo Red as an inhibitor of protease-resistant prion protein formation. J. Neurochem. 71: 2534-2541
15. Demaimay, R., Chesebro, B., Caughey, B. (2000) Inhibition of formation of protease-resistant prion protein by Trypan blue, Sirius Red and other Congo Red analogues. Arch. Virol. Suppl. 16: 277-283
16. Farquhar, C., Dickinson, A., Bruce, M. (1999) Prophylactic potential of pentosan polysulphate in transmissible spongiform encephalopathies. Lancet 353: 117
17. Formentin, E. A. M., Puricelli, M., Pollera, C., Ponti, W. (2005) Proceedings of LIX National SISVet, Congress, Viareggio, September, pp 189-190
18. res replication. J. Pharm. Pharmacol. 56: 323-328
19. Glatzel, M., Aguzzi, A. (2000) Peripheral pathogenesis of prion diseases. Microbes Infect. 2: 613-619
20. Hayakawa, K., Imanari, T., Tamura, T., Kuroda, S., Ikeda H., Tateishi, J. (1977) Relationship between neurological symptoms and concentrations of clioquinol in serum and nervous system of beagle dogs. Chem. Pharm. Bull. 25: 2013-2018
21. Hayashi, M., Fuwa, T., Awazu, S., Hanano, M. (1976a) Differences in species of iodochlorohydoxyquin absorption, metabolism and excretion. Chem. Pharm. Bull. 24: 2589-2596
22. Hayashi, M., Fuwa, T., Awazu, S., Hanano, M. (1976b) Various factors affecting intestinal absorption of Iodochlorhydroxyquin in rat and man. Chem. Pharm. Bull. 24: 2603-2609
23. Hill, A. F., Desbruslais, M., Joiner, S., Sidle, K. C. L., Gowland, I., Collinge, J. (1997) The same prion strain cause vCJD and BSE. Nature 389: 448-450
24. Ingrosso, L., Ladogana, A., Pocchiari, M. (1995) Congo red prolongs the incubation period in scrapie-infected hamsters. J. Virol. 69: 506-508
25. Jack, D. B., Riess, W. (1973) Pharmacokinetics of iodochlorhydroxyquin in man. J. Pharm. Sci. 62: 1929-1932
26. Kimberlin, R. H., Walker, C. A. (1977) Characteristics of a short incubation model of scrapie in the golden hamster. J. Gen. Virol. 34: 295-304
27. Kimberlin, R. H., Walker, C. A. (1986a) Pathogenesis of scrapie (strain 263K) in hamsters infected intracerebrally, intraperitoneally or intraocularly. J. Gen. Virol. 67: 255-263
28. Kimberlin, R. H., Walker, C. A. (1986b) Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions. Antimicrob. Agents Chemother. 30: 409-413
29. Klein, M. A., Frigg, R., Raeber, A. J., Flechsig, E., Kalinke, U., Bluethmann, H., Bootz, F., Suter, M., Zinkernagel, R. M., Aguzzi, A. (1997) A crucial role for B cells in neuroinvasive scrapie. Nature 390: 687-690
30. Kotaki, H., Nakajima, K., Tanimura, Y., Saitoh, Y., Nakagawa, F., Tamura, Z., Nagashima, K. (1983a) Appearance of intoxication in rats by intraperitoneal administration of Clioquinol. J. Pharmacobiodyn. 6: 773-783
31. Kotaki, H., Yamamura, Y., Tanimura, Y., Saitoh, Y., Nakagawa, F., Tamura, Z. (1983b) Intestinal absorption and metabolism of clioquinol in the rat. J. Pharmacobiodyn. 6: 881-887
32. Lazmesas, C. I., Cesbron, J. Y., Deslys, J. O., Demamay, R., Adjou, K., Rioux, R., Lemaire, C., Locht, C., Dormont, D. (1996) Immune system-dependent and in-dependent replication of the scrapie agent. J. Virol. 70: 1292-1295
33. Mcbride, P. A., Eikelenboom, P., Kraal, G., Fraser, H., Bruce, M. E. (1992) PrP protein is associated with FDC cells of spleens and lymph nodes in uninfected and scrapie-infected mice. J. Pathol. 168: 413-418
34. Milhavet, O., Mangé, A., Casanova, D. Lehmann, S. (2000) Effect of Congo Red on wild-type and mutated prion proteins in cultured cells. J. Neurochem. 74: 222-230
35. Piccardo, P., Safar, J., Ceroni, M., Gajdusek, D. C., Gibbs, C. J. (1990) Immunohistochemical localization of prion protein in spongiform encephalopathies and normal brain tissues. Neurology 40: 518-522
36. Poli, G., Ponti, W., Carcassola, G., Ceciliani, F., Colombo, L., Dall'Ara, P., Gervasoni, M., Giannino, M.L., Martino, P.A., Pollera, C., Villa S., Salmona, M. (2003) In vitro evaluation of the anti-prionic activity of newly synthesized Congo Red derivatives. Arzneimittelforschung Drug Res. 53: 875-888
37. Poli, G., Martino, P., Ceccarelli, A., Cignarella, G., Carcassola, G., Dall'Ara, P., Giannino, M. L., Pollera, C., Ponti, W., Bareggi, S. R., Mantegazza, P. (2004) Evaluation of anti-prion activity of Congo Red and its derivatives in experimentally infected hamsters. Arzneimittelforschung Drug Res. 54: 406-415
38. Ponti, W., Sala, M., Pollera, C., Braida, D., Poli, G., Bareggi, S. R. (2004) In vivo model for the evaluation of molecules active towards transmissible spongiform encephalopathies. Vet. Res. Comm. 28 (Suppl. 1): 307-310
39. Prusiner, S. B. (1998) Prions. Proc. Natl Acad. Sci. USA 95: 13363-13383
40. Race, R., Oldstone, M., Chesebro, B. (2000) Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen. J. Virol. 74: 828-833
41. Rudyk, H., Vasiljevic, S., Hennion, R. M., Birkett, C. R., Hope, J., Gilbert, I. H. (2000) Screening Congo Red and its analogues for their ability to prevent the formation of PrPres in scrapie-infected cells. J. Gen. Virol. 81: 1155-1164
42. Tateishi, J., Otsuki, S. (1975) Experimental reproduction of SMON in animals by prolonged administration of clioquinol: clinico-pathological findings. Jap. J. Med. Sci. Biol. 26 (Suppl. 1): 165-186
43. Will, R. G., Ironside, J. W., Zeidler, M., Cousens, S. N., Estibeiro, K., Alperovitch, A., Poser, S., Pocchiari, M., Hofman, A., Smith, P. G. (1996) A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 347: 921-925
44. Ye, X., Scallet, A. C., Kascsak, R. J., Carp, R. I. (1998) Astrocytosis and amyloid deposition in scrapie infected hamsters. Brain Res. 809: 277-287