Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: Role of prion protein expression in peripheral nerves and spleen

Journal of Virology

Volumn 74, Issue 2, 2000, Pages 828-833

  Race, Richard ^a   Oldstone, Michael ^b   Chesebro, Bruce ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOVINE SPONGIFORM ENCEPHALOPATHY; BRAIN INFECTION; CONTROLLED STUDY; DISEASE TRANSMISSION; GENE THERAPY; HAMSTER; INOCULATION; NONHUMAN; PERIPHERAL NERVE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCRAPIE AGENT; SPLEEN; TISSUE SPECIFICITY; TRANSGENIC MOUSE;

ANIMALS; CATTLE; CRICETINAE; GENE EXPRESSION; INJECTIONS, INTRAPERITONEAL; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PERIPHERAL NERVES; PRIONS; SCRAPIE; SPLEEN;

EID: 0033987842     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.2.828-833.2000     Document Type: Article

References (45)

1. Beekes, M., P. A. McBride, and E. Baldauf. 1998. Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie. J. Gen. Virol. 79:601-607.
2. Bendheim, P. E., H. R. Brown, R. D. Rudelli, L. J. Scala, N. L. Goller, G. Y. Wen, R. J. Kascsak, N. R. Cashman, and D. C. Bolton. 1992 Nearly ubiquitous tissue distribution of the scrapie agent precursor protein. Neurology 42:149-156.
3. Blättler. T., S. Brandner, A. J. Raeber, M. A. Klein, T. Voigtlander, C. Weissmann, and A. Aguzzi. 1997. PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature 389:69-73.
4. Brandner, S., S. Isenmann, A. Raeber, M. Fischer, A. Sailer, Y. Kobayashi, S. Marino, C. Weissmann, and A. Aguzzi. 1996. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 379:339-343.
5. Brown, K. L., K. Stewart, M. E. Bruce, and H. Fraser. 1997. Severely combined immunodeficient (SClD) mice resist infection with bovine spongiform encephalopathy. J. Gen. Virol. 78:2707-2710.
6. Brown, P. 1997. B lymphocytes and neuroinvasion. Nature 390:662-663.
7. Brown, P., R. G. Rohwer, B. C. Dunstan, C. MacAuley, D. C. Gajdusek, and W. N. Drohan. 1998. The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy. Transfusion 38:810-816.
8. Bueler, H., A. Aguzzi, A. Sailer, R. A. Greiner, P. Autenried, M. Aguet, and C. Weissmann. 1993. Mice devoid of PrP are resistant to scrapie. Cell 73:1339-1347.
9. Carp, R. I., S. M. Callahan, B. A. Patrick, and P. D. Mehta. 1994. Interaction of scrapie agent and cells of the lymphoreticular system. Arch. Virol. 136: 255-268.
10. Caughey, B., and B. Chesebru. 1997. Prion protein and the transmissible spongiform encephalopathies. Trends Cell Biology 7:56-62.
11. Chabry, J., B. Caughey, and B. Chesebro. 1998, Specific inhibition of in vitro formation of protease-resistant prion protein by synthetic peptides. J. Biol. Chem. 273:13203-13207.
12. Clarke, M. C., and D. A. Haig. 1971. Multiplication of scrapie agent in mouse spleen. Res. Vet. Sci. 12:195-197.
13. Clarke, M. C., and R. H. Kimberlin. 1984. Pathogenesis of mouse scrapie: distribution of agent in the pulp and stroma of infected spleens. Vet. Microbiol. 9:215-225.
14. Dickinson, A. G., H. Fraser, I. McConnell, G. W. Outram, I. I. Sales, and D. M. Taylor. 1975. Extraneural competition between different scrapie agents leading to loss of infectivity. Nature 253:556.
15. Eklund, C. M., R. C. Kennedy, and W. J. Hadtow. 1967. Pathogenesis of scrapie virus infection in the mouse. J. Infect. Dis. 117:15-22.
16. Fischer, M., T. Rulicke, A. Raeber, A. Sailer, M. Moser, B. Oesch. S. Brandner, A. Aguzzi, and C. Weissmann. 1996. Prion protein (PrP) with aminoproximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J. 15:1255-1264.
17. Fraser, H., K. L. Brown, K. Siewart, I. McConnell, P. McBride, and A. Williams. 1996. Replication of scrapie in spleens of SCID mice follows reconstitution with wild-type mouse bone marrow. J. Gen. Virol. 77:1935-1940.
18. Fraser, H., M. E. Bruce, B. Davies, C. F. Farquhar, and P. A. McBride. 1992. The lymphoreticular system in the pathogenesis of scrapie, p. 308-317. In S. B. Prusiner. J. Collinge, J. Powell, and B. Anderton (ed.), Prion diseases of humans and animals. Ellis Horwood, New York, N.Y.
19. Fraser, H., and C. F. Farquhar. 1987. Ionising radiation has no influence on scrapie incubation period in mice. Vet. Microbiol. 13:211-223.
20. Fraser, J. R. 1996. Infectivity in extraneural tissues following intraocular scrapie infection. J. Gen. Virol. 77:2663-2668.
21. Goldmann, W., N. Hunter, G. Smith, J. Foster, and J. Hope. 1994. PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. J. Gen. Virol. 75:989-995.
22. Hadlow, W. J., R. C. Kennedy, and R. E. Race. 1982. Natural infection of Suffolk sheep with scrapie virus. J. Infect. Dis. 146:657-664.
23. Kasesak, R. J., R. Rubenstein, P. A. Merz, M. Tonna-DeMasi, R. Fersko, R. I. Carp, H. M. Wisniewski, and H. Diringer. 1987. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J. Virol. 61:3688-3693.
24. Kimberlin, R. H., and C. A. Walker. 1980. Pathogenesis of mouse scrapie: evidence for neural spread of infection to the CNS. J. Gen. Virol. 51:183-187.
25. Kimberlin, R. H., and C. A. Walker. 1986. Pathogenesis of scrapie (strain 263K) in hamsters infected intracerebrally, intraperitoneally or intraocularly. J. Gen.Virol. 67:255-263.
26. Kimberlin, R. H., and C. A. Walker. 1988. Incubation periods in six models of intraperitoneally injected scrapie depend mainly tin the dynamics of agent replication within the nervous system and not the lymphoreticular system. J. Gen. Virol. 69:2953-2960.
27. Kimberlin, R. H., and C. A. Walker. 1989. Pathogenesis of scrapie in mice after intragastric infection. Virus Res. 12:213-220.
28. Kimherlin, R. H., and C. A. Walker. 1989. The roe of the spleen in the neuroinvasion of scrapie in mice. Virus Res. 12:201-211.
29. Klein, M. A., R. Frigg, E. Flechsig, A. J. Raeber, U. Kalinke, H. Bluethmann, F. Bootz, M. Suter, R. M. Zinkernagel, and A. Aguzzi. 1997. A crucial role for B cells in neuroinvasive scrapie. Nature 390:687-690.
30. Klein, M. A., R. Frigg, A. J. Raeber, E. Flechsig, I. Hegyi, R. M. Zinkernagel, C. Weissman, and A. Aguzzi. 1998. PrP expression in B lymphocytes is not required for prion neuroinvasion. Nat. Med 4:1429-1433.
31. Lasmezas, C. I., J. Y. Cesbron, J. P. Deslys, R. Demaimay, K. T. Adjou, R. Rioux, C. Lemaire, C. Locht, and D. Dormont. 1996. Immune system-dependent and-independent replication of the scrapie agent. J. Virol. 70:1292-1295.
32. Manson, J. C., A. R. Clarke, M. L. Hooper, L. Aitchison, I. McConnell, and J. Hope. 1994. 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal. Mol. Neurohiol. 8:121-127.
33. Manuelidis, L. 1918. Vaccination with an attenuated Creutzfeldt-Jakob disease strain prevents expression of a virulent agent. Proc. Natl. Acad. Sci. USA 95:2520-2525.
34. Palmer, M. S., A. J. Dryden, J. T. Hughes, and J. Collinge. 1991. Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob discase. Nature 352:340-342.
35. Race, R., and B. Chesebro. 1998. Scrapie infectivity found in resistant species. Nature 392:770.
36. Race, R., A. Jenny, and D. Sutton. 1998. Scrapie infectivity and proteinase K-resistant prion protein in sheep placenta, brain, spleen, and lymph node: implications for transmission and antemortem diagnosis. J. Infect. Dis. 178: 949-953.
37. Race, R. E., S. A. Priola, R. A. Bessen, D. R. Ernst, J. Dockter, G. F. Rall, L. Mucke, B. Chesebro, and M. B. A. Oldstone. 1995. Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent. Neuron 15:1183-1191.
38. Raeber, A. J., R. E. Race, S. Brandner, S. A. Priola, A. Sailer, R. A. Bessen, L. Mucke, J. Manson, A. Aguzzi, M. B. A. Oldstone, C. Weissman, and B. Chesebro. 1997. Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. EMBO J. 16: 6057-6065.
39. Rall, G. F., M. Manchester, L. R. Daniels, E. M. Callahan, A. R. Belman, and M. B. Oldstone. 1997. A transgenic mouse model for measles virus infection of the brain. Proc. Natl. Acad. Sci. USA 94:4659-4663.
40. Rall, G. F., L. Mucke, and M. B. Oldstone. 1995. Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo. J. Exp. Med. 182:1201-1212.
41. Robakis, N. K., P. R. Sawh, G. C. Wolfe, R. Rubenstein, R. I. Carp, and M. A. Innis. 1986. Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues. Proc. Natl. Acad. Sci. USA 83:6377-6381.
42. Sakaguchi, S., S. Katamine, N. Nishida, R. Moriuchi, K. Shigematsu, T. Sugimoto, A. Nakatani, Y. Kataoka, T. Houtani, S. Shirabe, H. Okada, S. Hasegawa, T. Miyamoto, and T. Noda. 1996. Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene. Nature 380:528-531.
43. Scott, J. R., D. Davies, and H. Fraser. 1992. Scrapie in the central nervous system: neuroanatomical spread of infection and Sinc control of pathogenesis. J. Gen. Virol. 73:1637-1644.
44. Scott, M., D. Foster, C. Mirenda, D. Serban, F. Coufal, M. Walchli, M. Torchia, D. Groth, G. Carlson, S. J. DeArmond, D. Westaway, and S. B. Prusiner. 1989. Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell 59:847-857.
45. Shmerling, D., I. Hegyi, M. Fischer, T. Blättler, S. Brandner, J. Gotz, T. Rulicke, E. Flechsig, A. Cozzio, C. von Mering, C. Hangartner, A. Aguzzi, and C. Weissmann. 1998. Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell 93:203-214.