Estrogen accelerates G1 to S phase transition and induces a G2/M phase-predominant apoptosis in synthetic vascular smooth muscle cells

International Journal of Cardiology

Volumn 118, Issue 3, 2007, Pages 381-388

  Yang, Zhaohui ^a   Cheng, Bei ^a   Song, Jian ^a,b   Wan, Yu ^b   Wang, Qiao ^a   Cheng, Bangchang ^c   Chen, Xichang ^a  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

^c RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle; Estrogen; Proliferation; Vascular smooth muscle cell

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; ESTRADIOL; ESTROGEN; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGENS; FEMALE; FLOW CYTOMETRY; G1 PHASE; G2 PHASE; MODELS, ANIMAL; MUSCLE, SMOOTH, VASCULAR; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROBABILITY; RATS; RATS, SPRAGUE-DAWLEY; S PHASE; SENSITIVITY AND SPECIFICITY;

EID: 34247590441     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2006.07.049     Document Type: Article

References (33)

1. Baker L., Meldrum K.K., Wang M., et al. The role of estrogen in cardiovascular disease. J Surg Res 115 (2003) 325-344
2. Takahashi K., Ohmichi M., Yoshida M., et al. Both estrogen and raloxifene cause G1 arrest of vascular smooth muscle cells. J Endocrinol 178 (2003) 319-329
3. Rhee C.Y., Spaet T.H., Stemerman M.B., et al. Estrogen suppression of surgically induced vascular intimal hyperplasia in rabbits. J Lab Clin Med 90 (1977) 77-84
4. Foegh M.L., Asotra S., Howell M.H., and Ramwell P.W. Estradiol inhibition of arterial neointimal hyperplasia after balloon injury. J Vasc Surg 19 (1994) 722-726
5. Foegh M.L., Khirabadi B.S., Nakanishi T., Vargas R., and Ramwell P.W. Estradiol protects against experimental cardiac transplant atherosclerosis. Transplant Proc 19 (1987) 90-95
6. Foegh M.L., Zhao Y., Farhat M., and Ramwell P.W. Oestradiol inhibition of vascular myointimal proliferation following immune, chemical and mechanism injury. Ciba Found Symp 191 (1995) 139-145
7. Cheng L.P., Kuwahara M., Jacobsson J., and Foegh M.L. Inhibition of myointimal hyperplasia and marophage infiltration by estrogen in aorta allografts. Transplanation 52 (1991) 967-972
8. Sullivan Jr. T.R., Karas R.H., Aronovitz M., et al. Estrogen inhibits the response-to-injury in a mouse carotid artery model. J Clin Invest 96 (1995) 2482-2488
9. Akishita M., Ouchi Y., Miyoshi H., et al. Estrogen inhibits cuff-induced intimal thickening of rat femoral artery: effects on migration and proliferation of vascular smooth muscle cells. Atherosclerosis 130 (1997) 1-10
10. Vargas R., Wroblewska B., Rego A., Hatch J., and Ramwell P.W. Oestrogen inhibits smooth muscle cell proliferation of pig coronary artery. Br J Pharmacol 109 (1993) 612-617
11. Dai-Do D., Espinosa E., Liu G., et al. 17 beta-estradiol inhibits proliferation and migration of human vascular smooth muscle cells: similar effects in cells from postmenopausal females and in males. Cardiovasc Res 32 (1996) 980-985
12. Suzuki A., Mizuno K., Ino Y., et al. Effects of 17 beta-estradiol and progesterone on growth-factor-induced proliferation and migration in human female aortic smooth muscle cells in vitro. Cardiovasc Res 32 (1996) 516-523
13. Bhalla R.C., Toth K.F., Bhatty R.A., Thompson L.P., and Sharma R.V. Estrogen reduces proliferation and agonist-induced calcium increase in coronary artery smooth muscle cells. Am J Physiol 272 (1997) H1996-H2003
14. Ling S., Dai A., Dilley R.J., et al. Endogenous estrogen deficiency reduces proliferation and enhances apoptosis-related death in vascular smooth muscle cells: insights from the aromatase-knockout mouse. Circulation 109 (2004) 537-543
15. Keyes L.E., Moore L.G., Walchak S.J., and Dempsey E.C. Pregnancy stimulated growth of vascular smooth muscle cells: importance of protein kinase C-dependent synergy between estrogen and platelet-derived growth factors. J Cell Physiol 166 (1996) 22-32
16. Farhat M.Y., Vargas R., Dingaan B., and Ramwell P.W. In vitro effect of oestradiol on thymidine uptake in pulmonary vascular smooth muscle cell: role of the endothelium. Br J Pharmacol 107 (1992) 679-683
17. Song J., Wan Y., Rolfe B.E., Campbell J.H., and Campbell G.R. Effects of estrogen on vascular smooth muscle cells is dependent upon cellular phenotype. Atherosclerosis 140 (1998) 97-104
18. Mori-Abe A., Tsutsumi S., Takahashi K., et al. Estrogen and raloxifene induce apoptosis by activating p38 mitogen-activated protein kinase cascade in synthetic vascular smooth muscle cells. J Endocrinol 178 (2003) 417-426
19. Braun-Dullaeus R.C., Mann M.J., Sedding D.G., Sherwood S.W., von der Leyen H.E., and Dzau V.J. Cell cycle-dependent regulation of smooth muscle cell activation. Arterioscler Thromb Vasc Biol 24 (2004) 845-850
20. Campbell J.H., Kocher O., Skalli O., Gabbiani G., and Campbell G.R. Cytodifferentiation and expression of alpha-smooth muscle actin mRNA and protein during primary culture of aortic smooth muscle cells: correlation with cell density and proliferative state. Arteriosclerosis 9 (1989) 633-643
21. Gorczyca W., Gong J., and Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 53 (1993) 1945-1951
22. Donnellan R., and Chetty R. Cyclin D1 and human neoplasia. Mol Pathol 51 (1998) 1-7
23. Evan G.I., and Vousden K.H. Proliferation, cell cycle and apoptosis in cancer. Nature 411 (2001) 342-348
24. Paech K., Webb P., Kuiper G.G., et al. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 277 (1997) 1508-1510
25. Liu M.M., Albanese C., Anderson C.M., et al. Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem 277 (2002) 24353-24360
26. Ghatan S., Larner S., Kinoshita Y., et al. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J Cell Biol 150 (2000) 335-347
27. Bulavin D.V., Saito S., Hollander M.C., et al. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 18 (1999) 6845-6854
28. Somjen D., Kohen F., Jaffe A., Amir-Zaltsman Y., Knoll E., and Stern N. Effects of gonadal steroids and their antagonists on DNA synthesis in human vascular cells. Hypertension 32 (1998) 39-45
29. Somjen D., Kohen F., Amir-Zaltsman Y., Knoll E., and Stern N. Vitamin D analogs modulate the action of gonadal steroids in human vascular cells in vitro. Am J Hypertens 13 (2000) 396-403
30. Challis J.R., Porter D.G., and Ryan K.J. The effects of prostaglandin F2 alpha and ovariectomy on the peripheral plasma steroid concentrations and the evolution of myometrial activity in the pregnant rabbit. Endocrinology 95 (1974) 783-792
31. Lau I.F., Saksena S.K., and Chang M.C. Temporal changes in circulating steroids during prostaglandin F2alpha induced abortion in the rat and rabbit. Prostaglandins 11 (1976) 859-869
32. Walsh K., Smith R.C., and Kim H.S. Vascular cell apoptosis in remodeling, restenosis, and plaque rupture. Circ Res 87 (2000) 184-188
33. Wan S., George S.J., Nicklin S.A., Yim A.P., and Baker A.H. Overexpression of p53 increases lumen size and blocks neointima formation in porcine interposition vein grafts. Mol Ther 9 (2004) 689-698