The serotonin transporter gene and alcoholism: The two pathways to suicidal behavior

Medical Hypotheses

Volumn 69, Issue 1, 2007, Pages 232-

  Sher, Leo ^a  

^a Howard Hughes Medical Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AMINO ACID DERIVATIVE; MEMBRANE PROTEIN; SEROTONIN TRANSPORTER; TRYPTOPHAN;

ALCOHOL CONSUMPTION; ALCOHOLISM; ALLELE; ANXIETY; CEREBROSPINAL FLUID; DEPRESSION; DISEASE ASSOCIATION; DNA POLYMORPHISM; GENE CONTROL; GENE FUNCTION; GENE INTERACTION; HOMOZYGOSITY; HUMAN; IMPULSIVENESS; LETTER; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SUICIDAL BEHAVIOR; VIOLENCE;

ALCOHOLISM; BRAIN; HUMANS; MODELS, BIOLOGICAL; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SIGNAL TRANSDUCTION; SUICIDE;

EID: 34247565513     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.11.035     Document Type: Letter

References (9)

1. Sher L., and Mann J.J. Neurobiology of suicide. In: Soares J.C., and Gershon S. (Eds). Textbook of Medical Psychiatry (2003), Marcel Dekker, New York 701-711
2. Bennett A.J., Lesch K.P., Heils A., Jong J.C., Lorenz J.G., Shoaf S.E., et al. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 7 (2002) 118-122
3. Heinz A., Jones D.W., Bissette G., Hommer D., Ragan P., Knable M., et al. Relationship between cortisol and serotonin metabolites and transporters in alcoholism. Pharmacopsychiatry 35 (2002) 127-134
4. Hariri A.R., Mattay V.S., Tessitore A., Kolachana B., Fera F., Goldman D., et al. Serotonin transporter genetic variation and the response of the human amygdale. Science 297 (2002) 400-403
5. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
6. Caspi A., Sugden K., Moffit T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression Moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
7. Hinckers A.S., Laucht M., Schmidt M.H., Mann K.F., Schumann G., Schuckit M.A., et al. Low level of response to alcohol as associated with serotonin transporter genotype and high alcohol intake in adolescents. Biol Psychiatry 60 (2006) 282-287
8. Nilsson K.W., Sjoberg R.L., Damberg M., Alm P.O., Ohrvik J., Leppert J., et al. Role of the serotonin transporter gene and family function in adolescent alcohol consumption. Alcohol Clin Exp Res 29 (2005) 564-570
9. Clark D.B. Serum tryptophan ratio and suicidal behavior in adolescents: a prospective study. Psychiatry Res 119 (2003) 199-204