Time-dependence of cardiomyocyte differentiation disturbed by peroxisome proliferator-activated receptor α inhibitor GW6471 in murine embryonic stem cells in vitro

Acta Pharmacologica Sinica

Volumn 28, Issue 5, 2007, Pages 634-642

  Ding, Ling ^a   Liang, Xing Guang ^a   Lou, Yi Jia ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Cardio myocytes; Differentiation; Embryonic stem cells; p38 MAPK; Peroxisome proliferator activated receptor

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA ACTININ; GW 6471; MAJOR HISTOCOMPATIBILITY ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; TROPONIN T; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; EMBRYO; EMBRYONIC STEM CELL; ENZYME INHIBITION; FUNCTIONAL PROTEOMICS; GENE OVEREXPRESSION; HEART MUSCLE CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; MICE; MYOCYTES, CARDIAC; OXAZOLES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PPAR ALPHA; TIME FACTORS; TYROSINE;

EID: 34247562789     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00558.x     Document Type: Article

References (36)

1. Depre C, Shipley GL, Chen W, Han Q, Doenst T, Moore ML, et al. Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nat Med 1998 4 : 1269 75.
2. Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 1999 96 : 7473 8.
3. Sack MN, Rader TA, Park S, Bastin J, McCune SA, Kelly DP. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation 1996 94 : 2837 42.
4. Sack MN, Disch DL, Rockman HA, Kelly DP. A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci USA 1997 94 : 6438 43.
5. Brandt JM, Djouadi F, Kelly DP. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J Biol Chem 1998 273 : 23786 92.
6. Mascaro C, Acosta E, Ortiz JA, Marrero PF, Hegardt FG, Haro D, et al. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J Biol Chem 1998 273 : 8560 3.
7. Yu GS, Lu YC, Gulick T. Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase Ibeta gene promoters by fatty acid enzyme substrate. J Biol Chem 1998 273 : 32901 9.
8. Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ, et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci USA 1994 91 : 7355 9.
9. Ono K, Han J. The p38 signal transduction pathway: activation and function. Cell Signal 2000 12 : 1 13.
10. Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990 347 : 645 50.
11. Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 1999 4 : 611 7.
12. Mueller E, Sarraf P, Tontonoz P, Evans RM, Martin KJ, Zhang M, et al. Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell 1998 1 : 465 70.
13. Park KS, Lee RD, Kang SK, Han SY, Park KL, Yang KH, et al. Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. Exp Cell Res 2004 297 : 424 33.
14. Steinmetz M, Quentin T, Poppe A, Paul T, Jux C. Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac development of the rat. Basic Res Cardiol 2005 100 : 263 9.
15. Braissant O, Wahli W. Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development. Endocrinology 1998 139 : 2748 54.
16. Davidson SM, Morange M. Hsp25 and the p38 MAPK pathway are involved in differentiation of cardiomyocytes. Dev Biol 2000 218 : 146 60.
17. Natale DR, Paliga AJ, Beier F, D'Souza SJ, Watson AJ. p38 MAPK signaling during murine preimplantation development. Dev Biol 2004 268 : 76 88.
18. Aouadi M, Bost F, Caron L, Laurent K, Le Marchand Brustel Y, Binetruy B, et al. p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis. Stem Cells 2006 24 : 1399 406.
19. Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, et al. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci USA 2006 103 : 17384 9.
20. Cai B, Chang SH, Becker EB, Bonni A, Xia Z. p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J Biol Chem 2006 281 : 25215 22.
21. Eriksson M, Leppa S. Mitogen-activated protein kinases and activator protein 1 are required for proliferation and cardio-myocyte differentiation of P19 embryonal carcinoma cells. J Biol Chem 2002 277 : 15992 6001.
22. Wobus AM, Wallukat G, Hescheler J. Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing chronotropic responses to adrenergic and cholinergic agents and Ca2+ channel blockers. Differentiation 1991 48 : 173 82.
23. Metzger JM, Lin WI, Samuelson LC. Vital staining of cardiac myocytes during embryonic stem cell cardiogenesis in vitro. Circ Res 1996 78 : 547 52.
24. Hescheler J, Fleischmann BK, Lentini S, Maltsev VA, Rohwedel J, Wobus AM, et al. Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis. Cardiovasc Res 1997 36 : 149 62.
25. Metzger JM, Lin WI, Johnston RA, Westfall MV, Samuelson LC. Myosin heavy chain expression in contracting myocytes isolated during embryonic stem cell cardiogenesis. Circ Res 1995 76 : 710 9.
26. Scholz G, Pohl I, Genschow E, Klemm M, Spielmann H. Embryotoxicity screening using embryonic stem cells in vitro: correlation to in vivo teratogenicity. Cells Tissues Organs 1999 165 : 203 11.
27. Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, Cobb JE, et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature 2002 415 : 813 7.
28. Kraft CS, LeMoine CM, Lyons CN, Michaud D, Mueller CR, Moyes CD, et al. Control of mitochondrial biogenesis during myogenesis. Am J Physiol Cell Physiol 2006 290 : C1119 27.
29. Wei H, Juhasz O, Li J, Tarasova YS, Boheler KR. Embryonic stem cells and cardiomyocyte differentiation: phenotypic and molecular analyses. J Cell Mol Med 2005 9 : 804 17.
30. Attardi G, Schatz G. Biogenesis of mitochondria. Annu Rev Cell Biol 1988 4 : 289 333.
31. Herzberg NH, Middelkoop E, Adorf M, Dekker HL, van Galen MJ, van den Berg M, et al. Mitochondria in cultured human muscle cells depleted of mitochondrial DNA. Eur J Cell Biol 1993 61 : 400 8.
32. Frick MH, Elo O, Haapa K, Heinonen OP, Heinsalmi P, Helo P, et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med 1987 317 : 1237 45.
33. Rubins HB, Robins SJ, Collins D, Fye CL, Anderson JW, Elam MB, et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipo-protein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 1999 341 : 410 8.
34. Kanno S, Kim PK, Sallam K, Lei J, Billiar TR, Shears LL II. Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells. Proc Natl Acad Sci USA 2004 101 : 12277 81.
35. Pineda Torra I, Jamshidi Y, Flavell DM, Fruchart JC, Staels B. Characterization of the human PPARalpha promoter: identification of a functional nuclear receptor response element. Mol Endocrinol 2002 16 : 1013 28.
36. Barger PM, Browning AC, Garner AN, Kelly DP. p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. J Biol Chem 2001 276 : 44495 501.