Optimization of fed-batch production of the model recombinant protein GFP in Lactococcus lactis

Biotechnology and Bioengineering

Volumn 96, Issue 6, 2007, Pages 1127-1138

  Oddone, Gian M ^a   Lan, Christopher Q ^b,d   Rawsthorne, Helen ^b,c   Mills, David A ^b   Block, David E ^a,b  

^a Davis   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DREXEL UNIVERSITY   (United States)

^d UNIVERSITY OF OTTAWA   (Canada)

Author keywords

GFP; Lactic acid bacteria fermentation; Optimization; Recombinant protein expression; Response surface methodology

Indexed keywords

BACTERIA; BATCH REACTORS; CELL GROWTH; FERMENTATION; GENE EXPRESSION; LACTIC ACID; OPTIMIZATION; VACCINES;

GREEN FLUORESCENT PROTEIN (GFP); LACTIC ACID BACTERIA (LAB); PROTEIN EXPRESSION; RECOMBINANT PROTEINS; RESPONSE SURFACE METHODOLOGY;

PROTEINS;

GREEN FLUORESCENT PROTEIN; HEMIN; NISIN; RECOMBINANT PROTEIN;

ARTICLE; BACTERIAL STRAIN; CELL DENSITY; CONTROLLED STUDY; FED BATCH CULTURE; FERMENTATION; LACTOCOCCUS LACTIS; NONHUMAN; PROTEIN EXPRESSION;

BIOREACTORS; FERMENTATION; GREEN FLUORESCENT PROTEINS; INDUSTRIAL MICROBIOLOGY; LACTOCOCCUS LACTIS; RECOMBINANT PROTEINS;

LACTOCOCCUS LACTIS;

EID: 34247544327     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21192     Document Type: Article

References (34)

1. Anderson M, Burnham R, Brostrom S, Gordon S, Herrman G, Murray R, Summer C. 1998. Statistical details: Analysis. Design expert software, version 5.0 user's guide. Minneapolis, MN: Stat-Ease.
2. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K. 1995. Current protocols in molecular biology. New York, NY: Wiley.
3. Bermudez-Humaran LG, Langella P, Miyoshi A, Gruss A, Guerra RT, de Oca-Luna RM, Le Loir Y. 2002. Production of human papillomavirus type 16 E7 protein in Lactococcus lactis. Appl Environ Microbiol 68: 917-922.
4. Bolotin A, Wincker P, Mauger S, Jaillon O, Malarme K, Weissenbach J, Ehrlich SD, Sorokin A. 2001. The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403. Genome Res 11:731-753.
5. Cormack BP, Valdivia RH, Falkow S. 1996. FACS-optimized mutants of the green fluorescent protein (GFP). Gene 173:33-38.
6. Cortes-Perez NG, Bermudez-Humaran LG, Le Loir Y, Rodriguez-Padilla C, Gruss A, Saucedo-Cardenas O, Langella P, Montes-de-Oca-Luna R. 2003. Mice immunization with live lactococci displaying a surface anchored HPV-16 E7 oncoprotein. FEMS Microbiol Lett 229:37-42.
7. Derringer G, Suich R. 1980. Simultaneous-optimization of several response variables. J Qual Technol 12:214-219.
8. Duwat P, Sourice S, Cesselin B, Lamberet G, Vido K, Gaudu P, Le Loir Y, Violet F, Loubiere P, Gruss A. 2001. Respiration capacity of the fermenting bacterium Lactococcus lactis and its positive effects on growth and survival. J Bacteriol 183:4509-4516.
9. Ferrier J, Block D. 2001. Neural-network-assisted optimization of wine blending based on sensory analysis. Amer J Enol Viticult 52:386-395.
10. Gaudu P, Vido K, Cesselin W, Kulakauskas S, Tremblay J, Rezaiki L, Lamberet G, Sourice S, Duwat P, Gruss A. 2002. Respiration capacity and consequences in Lactococcus lactis. Antonie Van Leeuwenhoek Int J Gen Mol 82:263-269.
11. Giuliano M, Schiraldi C, Marotta MR, Hugenholtz J, De RM. 2004. Expression of sulfolobus solfataricus alpha-glucosidase in Lactococcus lactis. Appl Microbiol Biotechnol 64:829-832.
12. Gorbach SL. 2002. Probiotics in the third millennium. Dig Liver Dis 34:S2-S7.
13. Hanniffy S, Wiedermann U, Repa A, Mercenier A, Daniel C, Fioramonti J, Tlaskolova H, Kozakova H, Israelsen H, Madsen S, Vrang A, Hols P, Delcour J, Bron P, Kleerebezem M, Wells J. 2004. Potential and opportunities for use of recombinant lactic acid bacteria in human health. Adv Appl Microbiol 56:1-64.
14. Holo H, Nes IF. 1989. High-frequency transformation, by electroporation, of Lactococcus-Lactis Subsp cremoris grown with glycine in osmotically stabilized media. Appl Environ Microbiol 55:3119-3123.
15. Lan CQ, Oddone G, Mills DA, Block DE. 2006. Kinetics of Lactococcus lactis growth and metabolite formation under aerobic and anaerobic conditions at the presence or absence of hemin. Biotechnol Bioeng 95:1070-1080.
16. Lewington J, Greenaway SD, Spillane BJ. 1987. Rapid small-scale preparation of bacterial genomic Dna, suitable for cloning and hybridization analysis. Lett Appl Microbiol 5:51-53.
17. Lu CH, Albano CR, Bentley WE, Rao G. 2002. Differential rates of gene expression monitored by green fluorescent protein. Biotechnol Bioeng 79:429-437.
18. Lv WH, Zhang XY, Cong W. 2005. Modelling the production of nisin by Lactococcus lactis in fed-batch culture. Appl Microbiol Biotechnol 68:322-326.
19. Mannam P, Jones KF, Geller BL. 2004. Mucosal vaccine made from live, recombinant Lactococcus lactis protects mice against pharyngeal infection with Streptococcus pyogenes. Infect Immun 72:3444-3450.
20. Mierau I, Kleerebezem M. 2005. 10 years of the nisin-controlled gene expression system (NICE) in Lactococcus lactis. Appl Microbiol Biotechnol 68:705-717.
21. Mierau I, Olieman K, Mond J, Smid EJ. 2005. Optimization of the Lactococcus lactis nisin-controlled gene expression system NICE for industrial applications. Microb Cell Fact 4:16.
22. Myers RH, Montgomery DC. 1995. Response surface methodology: Product and process optimization using designed experiments. New York, NY: Wiley Interscience. 697 p.
23. Norton PM, Brown HW, Wells JM, Macpherson AM, Wilson PW, Le Page RW. 1996. Factors affecting the immunogenicity of tetanus toxin fragment C expressed in Lactococcus lactis. FEMS Immunol Med Microbiol 14:167-177.
24. Ravn P, Arnau J, Madsen SM, Vrang A, Israelsen H. 2003. Optimization of signal peptide SP310 for heterologous protein production in Lactococcus lactis. Microbiology 149:2193-2201.
25. Rezaiki L, Cesselin B, Yamamoto Y, Vido K, van West E, Gaudu P, Gruss A. 2004. Respiration metabolism reduces oxidative and acid stress to improve long-term survival of Lactococcus lactis. Mol Microbiol 53: 1331-1342.
26. Robinson K, Chamberlain LM, Lopez MC, Rush CM, Marcotte H, Le Page RWF, Wells JM. 2004. Mucosal and cellular immune responses elicited by recombinant Lactococcus lactis strains expressing tetanus toxin fragment C. Infect Immun 72:2753-2761.
27. Seegers JFML. 2002. Lactobacilli as live vaccine delivery vectors: Progress and prospects. Trends Biotechnol 20:508-515.
28. Sijpesteijn AK. 1970. Induction of cytochrome formation and stimulation of oxidative dissimilation by hemin in Streptococcus lactis and Leuconostoc mesenteroides. Antonie Van Leeuwenhoek 36:335-348.
29. Steidler L, Neirynck S, Huyghebaert N, Snoeck V, Vermeire A, Goddeeris B, Cox E, Remon JP, Remaut E. 2003. Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10. Nat Biotechnol 21:785-789.
30. Strobel RJ, Sullivan GR. 1999. Experimental design for improvement of fermentations. In: Demain AL, Davies JE, editors. Manual of industrial microbiology and biotechnology. Washington, DC: ASM Press. p 80-93.
31. Terzaghi BE, Sandine WE. 1975. Improved medium for lactic streptococci and their bacteriophages. Appl Microbiol 29:807-813.
32. Tuler TR, Callanan MJ, Klaenhammer TR. 2002. Overexpression of peptidases in Lactococcus and evaluation of their release from leaky cells. J Dairy Sci 85:2438-2450.
33. Wells JM, Mercenier A. 2003. Lactic acid bacteria as mucosal delivery vehicles. The genetics of lactic acid bacteria. New York: Kluwer Academic/Plenum Publishers. p 260-291.
34. Xin KQ, Hoshino Y, Toda Y, Igimi S, Kojima Y, Jounai N, Ohba K, Kushiro A, Kiwaki M, Hamajima K, Klinman D, Okuda K. 2003. Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env. Blood 102:223-228.