Decreased pCO2 accumulation by eliminating bicarbonate addition to high cell-density cultures

Biotechnology and Bioengineering

Volumn 96, Issue 6, 2007, Pages 1107-1117

  Goudar, Chetan T ^a,b   Matanguihan, Ricaredo ^a   Long, Edward ^a   Cruz, Christopher ^a   Zhang, Chun ^b   Piret, James M ^b   Konstantinov, Konstantin B ^a  

^a BAYER CORPORATION   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

High concentration; Mammalian cell culture; pCO2; Perfusion; Sodium bicarbonate

Indexed keywords

AGGLOMERATION; BIOREACTORS; CARBON DIOXIDE; CARBONATES; CELL GROWTH; GLYCOSYLATION; PARTIAL PRESSURE; PROTEINS;

CELLULAR RESPIRATION; MAMMALIAN CELLS; PH CONTROL; SODIUM BICARBONATE;

CELL CULTURE;

BICARBONATE; CARBON DIOXIDE; HTK SOLUTION;

ANIMAL CELL; ARTICLE; BIOREACTOR; CARBON DIOXIDE TENSION; CELL CULTURE; CELL DENSITY; CELL GROWTH; CELL METABOLISM; CELL RESPIRATION; DYNAMICS; NONHUMAN; OSMOLALITY; PROTEIN GLYCOSYLATION;

ANIMALS; BIOREACTORS; CARBON DIOXIDE; CELL CULTURE TECHNIQUES; CELL LINE; CELL PROLIFERATION; MAMMALS; PARTIAL PRESSURE; PERFUSION;

MAMMALIA;

EID: 34247523715     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21116     Document Type: Article

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