메뉴 건너뛰기




Volumn 132, Issue 4, 2007, Pages 1401-1409

H-ras Inhibits RhoA/ROCK Leading to a Decrease in the Basal Tone in the Internal Anal Sphincter

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PROTEIN ROCK II; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 34247504571     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.01.043     Document Type: Article
Times cited : (8)

References (36)
  • 3
    • 0345363003 scopus 로고    scopus 로고
    • Ras proteins: recent advances and new functions
    • Rebollo A., and Martinez-A C. Ras proteins: recent advances and new functions. Blood 94 (1999) 2971-2980
    • (1999) Blood , vol.94 , pp. 2971-2980
    • Rebollo, A.1    Martinez-A, C.2
  • 4
    • 0034998678 scopus 로고    scopus 로고
    • Compartmentalization of Ras proteins
    • Prior I.A., and Hancock J.F. Compartmentalization of Ras proteins. J Cell Sci 114 (2001) 1603-1608
    • (2001) J Cell Sci , vol.114 , pp. 1603-1608
    • Prior, I.A.1    Hancock, J.F.2
  • 6
    • 0037182579 scopus 로고    scopus 로고
    • Activated K-Ras and H-Ras display different interactions with saturable sites at the surface of live cells
    • Niv H., Gutman O., Kloog Y., and Henis Y.I. Activated K-Ras and H-Ras display different interactions with saturable sites at the surface of live cells. J Biol Chem 157 (2002) 865-872
    • (2002) J Biol Chem , vol.157 , pp. 865-872
    • Niv, H.1    Gutman, O.2    Kloog, Y.3    Henis, Y.I.4
  • 7
    • 0037455589 scopus 로고    scopus 로고
    • Direct visualization of Ras proteins in spatially distinct cell surface microdomains
    • Prior I.A., Muncke C., Parton R.G., and Hancock J.F. Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J Biol Chem 160 (2003) 165-170
    • (2003) J Biol Chem , vol.160 , pp. 165-170
    • Prior, I.A.1    Muncke, C.2    Parton, R.G.3    Hancock, J.F.4
  • 8
    • 0141925661 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor
    • Kaplan-Albuquerque N., Garat C., Desseva C., Jones P.L., and Nemenoff R.A. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. J Biol Chem 278 (2003) 39830-39838
    • (2003) J Biol Chem , vol.278 , pp. 39830-39838
    • Kaplan-Albuquerque, N.1    Garat, C.2    Desseva, C.3    Jones, P.L.4    Nemenoff, R.A.5
  • 9
    • 21244471475 scopus 로고    scopus 로고
    • Patterns of gene expression differentially regulated by platelet-derived growth factor and hypertrophic stimuli in vascular smooth muscle cells: markers for phenotypic modulation and response to injury
    • Kaplan-Albuquerque N., Bogaert Y.E., Van Putten V., Weiser-Evans M.C., and Nemenoff R.A. Patterns of gene expression differentially regulated by platelet-derived growth factor and hypertrophic stimuli in vascular smooth muscle cells: markers for phenotypic modulation and response to injury. J Biol Chem 280 (2005) 19966-19976
    • (2005) J Biol Chem , vol.280 , pp. 19966-19976
    • Kaplan-Albuquerque, N.1    Bogaert, Y.E.2    Van Putten, V.3    Weiser-Evans, M.C.4    Nemenoff, R.A.5
  • 10
    • 0036156469 scopus 로고    scopus 로고
    • Post-transcriptional down-regulation of ROCK/Rho-Kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts
    • Pawlak G., and Helfman D.M. Post-transcriptional down-regulation of ROCK/Rho-Kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts. Mol Biol Cell 13 (2002) 336-347
    • (2002) Mol Biol Cell , vol.13 , pp. 336-347
    • Pawlak, G.1    Helfman, D.M.2
  • 11
    • 0347717882 scopus 로고    scopus 로고
    • cip1 is involved in ras-induced inhibition of the ROCK/LIMK/Cofilin pathway
    • cip1 is involved in ras-induced inhibition of the ROCK/LIMK/Cofilin pathway. J Biol Chem 279 (2004) 1885-1891
    • (2004) J Biol Chem , vol.279 , pp. 1885-1891
    • Lee, S.1    Helfman, D.M.2
  • 12
    • 0141625006 scopus 로고    scopus 로고
    • Involvement of rho and rho-associated kinase in sphincteric smooth muscle contraction by angiotensin II
    • Rattan S., Puri R.N., and Fan Y.-P. Involvement of rho and rho-associated kinase in sphincteric smooth muscle contraction by angiotensin II. Exp Biol Med 228 (2003) 972-981
    • (2003) Exp Biol Med , vol.228 , pp. 972-981
    • Rattan, S.1    Puri, R.N.2    Fan, Y.-P.3
  • 13
    • 33745852280 scopus 로고    scopus 로고
    • Rho kinase as a novel molecular therapeutic target for hypertensive internal anal sphincter
    • Rattan S., De Godoy M.A.F., and Patel C.A. Rho kinase as a novel molecular therapeutic target for hypertensive internal anal sphincter. Gastroenterology 131 (2006) 108-116
    • (2006) Gastroenterology , vol.131 , pp. 108-116
    • Rattan, S.1    De Godoy, M.A.F.2    Patel, C.A.3
  • 15
    • 0037271016 scopus 로고    scopus 로고
    • A prospective evaluation of anorectal function after total mesorectal excision in patients with a rectal carcinoma
    • van Duijvendijk P., Slors F., Taat C.W., Heisterkamp S.H., Obertop H., and Boeckxstaens G.E. A prospective evaluation of anorectal function after total mesorectal excision in patients with a rectal carcinoma. Surgery 133 (2003) 56-65
    • (2003) Surgery , vol.133 , pp. 56-65
    • van Duijvendijk, P.1    Slors, F.2    Taat, C.W.3    Heisterkamp, S.H.4    Obertop, H.5    Boeckxstaens, G.E.6
  • 18
    • 0021808301 scopus 로고
    • Vasoactive intestinal polypeptide: a neurotransmitter for relaxation of the rabbit internal anal sphincter
    • Biancani P., Walsh J.H., and Behar J. Vasoactive intestinal polypeptide: a neurotransmitter for relaxation of the rabbit internal anal sphincter. Gastroenterology 89 (1985) 867-874
    • (1985) Gastroenterology , vol.89 , pp. 867-874
    • Biancani, P.1    Walsh, J.H.2    Behar, J.3
  • 20
    • 0027428932 scopus 로고
    • Inhibitory effect of CO on internal anal sphincter: heme oxygenase inhibitor inhibits NANC relaxation
    • Rattan S., and Chakder S. Inhibitory effect of CO on internal anal sphincter: heme oxygenase inhibitor inhibits NANC relaxation. Am J Physiol Gastrointest Liver Physiol 265 (1993) G799-G804
    • (1993) Am J Physiol Gastrointest Liver Physiol , vol.265
    • Rattan, S.1    Chakder, S.2
  • 21
  • 22
    • 0032545491 scopus 로고    scopus 로고
    • 2 by cyclic nucleotide-dependent protein kinases
    • 2 by cyclic nucleotide-dependent protein kinases. J Biol Chem 273 (1998) 34519-34526
    • (1998) J Biol Chem , vol.273 , pp. 34519-34526
    • Murthy, K.S.1    Makhlouf, G.M.2
  • 23
    • 19444382673 scopus 로고    scopus 로고
    • Single-molecule diffusion measurements of H-Ras at the plasma membrane of live cells reveal microdomain localization upon activation
    • Lommerse P.H., Snaar-Jagalska B.E., Spaink H.P., and Schmidt T. Single-molecule diffusion measurements of H-Ras at the plasma membrane of live cells reveal microdomain localization upon activation. J Cell Sci 118 (2005) 1799-1809
    • (2005) J Cell Sci , vol.118 , pp. 1799-1809
    • Lommerse, P.H.1    Snaar-Jagalska, B.E.2    Spaink, H.P.3    Schmidt, T.4
  • 24
    • 0036087345 scopus 로고    scopus 로고
    • Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action
    • Fan Y.-P., Puri R.N., and Rattan S. Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action. Am J Physiol Gastrointest Liver Physiol 282 (2002) G461-G469
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.282
    • Fan, Y.-P.1    Puri, R.N.2    Rattan, S.3
  • 26
    • 0037571979 scopus 로고    scopus 로고
    • Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of rhoA
    • Murthy K.S., Zhou H., Grider J.R., and Makhlouf G.M. Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of rhoA. Am J Physiol Gastrointest Liver Physiol 284 (2003) G1006-G1016
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Murthy, K.S.1    Zhou, H.2    Grider, J.R.3    Makhlouf, G.M.4
  • 27
    • 13944277401 scopus 로고    scopus 로고
    • Signal-transduction pathways that regulate smooth muscle function. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles
    • Harnett K.M., Cao W., and Biancani P. Signal-transduction pathways that regulate smooth muscle function. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles. Am J Physiol Gastrointest Liver Physiol 288 (2005) G407-G416
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Harnett, K.M.1    Cao, W.2    Biancani, P.3
  • 30
    • 0037229022 scopus 로고    scopus 로고
    • Aging and neural control of the GI tract: V. Aging and gastrointestinal smooth muscle: from signal transduction to contractile proteins
    • Bitar K.N. Aging and neural control of the GI tract: V. Aging and gastrointestinal smooth muscle: from signal transduction to contractile proteins. Am J Physiol Gastrointest Liver Physiol 284 (2003) G1-G7
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Bitar, K.N.1
  • 31
    • 0037474267 scopus 로고    scopus 로고
    • Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity
    • Chen J.C., Zhang S., Nguyen T.H., Boss G.R., and Pilz R.B. Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity. J Biol Chem 278 (2003) 2807-2818
    • (2003) J Biol Chem , vol.278 , pp. 2807-2818
    • Chen, J.C.1    Zhang, S.2    Nguyen, T.H.3    Boss, G.R.4    Pilz, R.B.5
  • 33
    • 0028863142 scopus 로고
    • A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
    • Leung T., Manser E., Tan L., and Lim L. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J Biol Chem 270 (1995) 29051-29054
    • (1995) J Biol Chem , vol.270 , pp. 29051-29054
    • Leung, T.1    Manser, E.2    Tan, L.3    Lim, L.4
  • 34
    • 0033601250 scopus 로고    scopus 로고
    • Inhibitory phosphorylation site for Rho-associated kiinase on smooth muscle myosin phosphatase
    • Feng J., Ito M., Ichikawa K., Isaka N., Nishikawa M., Hartshorne D.J., and Nakano T. Inhibitory phosphorylation site for Rho-associated kiinase on smooth muscle myosin phosphatase. J Biol Chem (1999) 37385-37390
    • (1999) J Biol Chem , pp. 37385-37390
    • Feng, J.1    Ito, M.2    Ichikawa, K.3    Isaka, N.4    Nishikawa, M.5    Hartshorne, D.J.6    Nakano, T.7
  • 35
    • 0022310829 scopus 로고
    • The mechanism of regulation of smooth muscle myosin by phosphorylation
    • Sellers J.R. The mechanism of regulation of smooth muscle myosin by phosphorylation. Curr Top Cell Regul 27 (1985) 51-62
    • (1985) Curr Top Cell Regul , vol.27 , pp. 51-62
    • Sellers, J.R.1
  • 36
    • 0028043535 scopus 로고
    • Signal transduction and regulation in smooth muscle
    • Somlyo A.P., and Somlyo A.V. Signal transduction and regulation in smooth muscle. Nature 372 (1994) 231-236
    • (1994) Nature , vol.372 , pp. 231-236
    • Somlyo, A.P.1    Somlyo, A.V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.