Synthesis and evaluation of Novel Benzimidazole derivative [Bz-Im] and its radio/biological studies

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 10, 2007, Pages 2749-2755

  Tiwari, Anjani K ^a,b   Mishra, Anil K ^b   Bajpai, Aruna ^a   Mishra, Pushpa ^b   Singh, Sweta ^b   Sinha, Deepa ^b   Singh, V K ^a  

^a UNIVERSITY OF LUCKNOW   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

99mTc labeled; Benzimidazole; Biodistribution; Non peptidic; Radiolabeling; Spectroscopy

Indexed keywords

ANTIFUNGAL AGENT; BENZIMIDAZOLE DERIVATIVE; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; RADIOPHARMACEUTICAL AGENT; TECHNETIUM 99M;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS NIGER; BINDING AFFINITY; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; INFRARED SPECTROSCOPY; ISOTOPE LABELING; LIGAND BINDING; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PANCREAS ISLET CELL; SPECTROSCOPY;

ANIMALS; ANTIFUNGAL AGENTS; ASPERGILLUS NIGER; BENZIMIDAZOLES; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; RABBITS; RADIOPHARMACEUTICALS; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ;

ASPERGILLUS FLAVUS; ASPERGILLUS NIGER; RATTUS;

EID: 34247377382     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.071     Document Type: Article

References (33)

1. Orjales A., Mosquera R., Labeaga L., and Rodes R. J. Med. Chem. 40 (1997) 586
2. Grimmett M. Compr. Heterocycl. Chem. 3 (1996) 77
3. Wank S.A. Am. J. Physiol. 274 (1998) 607
4. Turell, D. A. J., et al., 4th J. S. Ed.; London, Academic Press, 1989, pp 265-276.
5. Sullivan O., and Solder P.W. Nature 192 (1961) 314
6. Iship P.J., Closier M.D., and Neville M.C. J. Med. Chem. 15 (1972) 951
7. Walsh J.H. Gastrin. Gut Peptides (1994), RavenPress, New York 75-121
8. Johnson L.R. Trophic Effects of Gut Peptides. In: Makhlouf G.M. (Ed). Handbook of Physiology Section 6 (1989), American Physiological Society, Bethesda, MD 291-310
9. Crawley J.N., and Corwin R.L. Peptides 15 (1994) 731
10. Hakanson R., and Sundler F. Scand. J. Gastroenterol. 70 Suppl. 180 (1991) 130
11. Kopin A.S., Lee Y., McBride E.W., Miller L.J., Lu M., Lin H.Y., Kolakowski L.F., and Beinborn M. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 3605
12. Wank S.A., Pisegna J.R., and de Weerth A. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 8691
13. Mantyh C.R., Pappas T.N., and Vigna S.R. Gastroenterology 107 (1994) 1019
14. Nakamura M., Oda M., Akaiwa K.Y., Tsukada N., Komatsu H., and Tsuchiya M. Gastroenerology 94 (1988) 968
15. Wettstein J.G., and Junien J.L. Pharmacol. Ther. 62 (1994) 267
16. Reubi J.C. J. Nucl. Med. 36 (1995) 1825
17. Krenning, E. P., Kwekkeboon, D. J., Pauwels, S. et al., 1995. Somatostatin receptor scintigraphy. In Freeman, L. M. (Ed.), Nucl. Med. Ann., pp 1-50.
18. Otte A., Mullar-Brand J., Dallas S., et al. Lancet 351 (1998) 417
19. Reubi J.C., and Waser B. Cancer Res. 57 (1997) 1377
20. Pandey V.K., Zehra T., and Bajpai S.K. Indian J. Hetrocycl. Chem. 11 (2002) 309
21. -1) 3385, 3290, 1640, 1715, 1196, 782.
22. +, 160, 105, 77.
23. -1) 3461, 3355, 2988, 1657,1278,742.
24. +, 405, 254, 77.
25. Qun li T.Li., and Keith W. Bioorg. Med. Chem. Lett. 15 (2006) 2918
26. Miyuki T., and kataokal M. Bioorg. Med. Chem.Lett. 14 (2005) 2265
27. Zhang W., and Tempest P. Tetrahedron Lett. 45 (2004) 6757
28. 4Si as an internal standard. EI-MS spectra were recorded on a JEOL SX102/DA (KV 10 mA) instrument. Elemental analysis was done on elemental analyzer GmbH variable system. Radiocomplexation and radiochemical purity were checked by instant strip chromatography (silica gel impregnated paper chromatography) with ITLC-SG (Gellman sciences, Ann Arbor, MI, USA). The gamma scintillation counting was done at ECA (Electronic Corporation of India Ltd.) with Gamma ray spectrometer K 2700 B. All the reaction steps were monitored by thin layer chromatography (TLC) [chloroform/methanol/hexane: 4:3:1]. Distilled water is used during whole of the procedure.
29. +.
30. Giovanetti L.C., and Mennuni J. Med. Chem. 35 (1992) 28
31. Makovec F., and Bradford M.M. Anal. Biochem. 72 (1976) 248
32. Kumari S., Kalra N., Mishra P., Mishra A., and Chopra M. Nucl. Med. Biol. 31 (2004) 1087
33. Verma R.S., and Imam S.A. Ind. J. Microbiol. 13 (1997) 45