Highly efficient microwave-assisted fluorous Ugi and post-condensation reactions for benzimidazoles and quinoxalinones

Tetrahedron Letters

Volumn 45, Issue 36, 2004, Pages 6757-6760

  Zhang, Wei ^a   Tempest, Paul ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b AMGEN INC   (United States)

Author keywords

Benzimidazole; Fluorous synthesis; Microwave reaction; Multicomponent reaction; Quinoxalinone; Solid phase extraction; Ugi reaction

Indexed keywords

BENZIMIDAZOLE; CARBONYL DERIVATIVE; DIAMINE; HETEROCYCLIC COMPOUND;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; MICROWAVE RADIATION; POLYMERIZATION; SOLID PHASE EXTRACTION; SYNTHESIS; TECHNOLOGY;

EID: 4344593314     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.07.039     Document Type: Article

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48. FBoc phenylene diamine 1 was prepared by the reaction of 1.2 equiv of phenylene diamine with 1.0 equiv of F-BocON (available from Fluorous Technologies, Inc. www.fluorous.com) in THF at room temperature for 2 h. The crude product was purified by F-SPE
49. TM cartridges, please log onto: http://fluorous.com/download/an_spe.pdf
50. 3b