A strategy for liquid chromatography/tandem mass spectrometric assays of intracellular drugs: Application to the validation of the triphosphorylated anabolite of antiretrovirals in peripheral blood mononuclear cells

Journal of Mass Spectrometry

Volumn 38, Issue 8, 2003, Pages 879-890

  Becher, François ^a   Pruvost, Alain ^a   Gale, Jane ^b   Couerbe, Philippe ^b   Goujard, Cécile ^c   Boutet, Valerie ^d   Ezan, Eric ^a   Grassi, Jacques ^a   Benech, Henri ^a  

^a Institut National de la Recherche Agronomique   (France)

^b BRISTOL MYERS SQUIBB   (United States)

^c BICÊTRE HOSPITAL   (France)

^d SPI BIO   (France)

Author keywords

d4T TP; ddA TP; Intracellular; LC MS MS; Validation

Indexed keywords

ASSAYS; CELLS; DRUG PRODUCTS; EXTRACTION; LIQUID CHROMATOGRAPHY; PHARMACOKINETICS;

INTRACELLULAR DRUGS;

MASS SPECTROMETRY;

2',3' DIDEOXYADENOSINE TRIPHOSPHATE; ANTIRETROVIRUS AGENT; DIDANOSINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE;

ARTICLE; CELL COUNT; CELL LEVEL; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MONONUCLEAR CELL; PHOSPHORYLATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANTI-HIV AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIDANOSINE; DIDEOXYADENOSINE; LEUKOCYTES, MONONUCLEAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STAVUDINE;

EID: 0042856245     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.500     Document Type: Article

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